Article
Biochemistry & Molecular Biology
Uwe Thorsten Lux, Johanna Ehrenberg, Anneka Joachimsthaler, Jenny Atorf, Bianca Pircher, Kerstin Reim, Jan Kremers, Andreas Giessl, Johann Helmut Brandstaetter
Summary: The study found that Cplx 2, not Cplx 1, is the main isoform expressed in mouse retinas, and knockout of Cplx 1 altered retinal function. These results provide an important basis for future research on the function of Cplxs 1 and 2 in processing visual signals in the mammalian retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlo E. Sotelo-Ramirez, Beatriz Camarena, Marco Antonio Sanabrais-Jimenez, Julio Uriel Zaragoza-Hoyos, Bruno Ordonez-Martinez, Raul Escamilla-Orozco, Beatriz Gomez-Gonzalez
Summary: This study analyzed the association between TLR1, TLR2, and TLR6 gene polymorphisms and the etiology of schizophrenia. The results showed significant differences in genotype and allele frequencies of these genes between patients and controls, and an interaction between TLR1/rs4833093 and TLR2/rs5743709 genes that increased the risk of developing schizophrenia.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Pharmacology & Pharmacy
Xueli Yu, Xueyu Qi, Long Wei, Liansheng Zhao, Wei Deng, Wanjun Guo, Qiang Wang, Xiaohong Ma, Xun Hu, Peiyan Ni, Tao Li
Summary: Fingolimod shows potential in ameliorating cognitive deficits in a rat model of schizophrenia by inhibiting inflammation and promoting neurogenesis. This study provides new insights into the use of immunomodulatory strategies to improve cognitive function in schizophrenia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Psychiatry
Adriana Farcas, Charles Hindmarch, Felicia Iftene
Summary: This article reviews recent research findings on the contribution of the BDNF gene Val66Met polymorphisms to schizophrenia. The Met/Met genotype is associated with higher positive symptom scores, while increased BDNF levels under Risperidone treatment correlate with weight gain in Val/Val genotype carriers.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Jiesi Wang, Hang Xu, Dongmei Wang, Gaoxia Wei, Huixia Zhou, Li Wang, Yongjie Zhou, Xiangyang Zhang
Summary: The study revealed an interactive effect between IL-10 and COMT genetic polymorphisms on cognitive function in patients with chronic schizophrenia and healthy controls. This suggests an important role of their interaction in cognitive deficits associated with schizophrenia and highlights the potential for further investigations and drug administrations targeting both systems.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Yanxiang Cao, Chuanliang Han, Xing Peng, Ziyao Su, Gan Liu, Yixi Xie, Yiting Zhang, Jun Liu, Pei Zhang, Wen Dong, Michel Gao, Sha Sha, Xixi Zhao
Summary: This study aimed to explore the correlation between resting theta power and cognitive performance in patients with schizophrenia. The findings showed increased theta activity in certain brain regions during resting state in schizophrenia, with negative associations between theta power and cognitive performance.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Psychiatry
Yash B. Joshi, Christopher E. Gonzalez, Juan L. Molina, Laura R. MacDonald, Jenny Min Din, Jessica Minhas, Taylor Leposke, Bethany Nordberg, Francesca Li, Jo Talledo, Joyce Sprock, Neal R. Swerdlow, Gregory A. Light
Summary: Auditory-based targeted cognitive training (ATCT) programs aim to attenuate cognitive impairment by improving auditory processing. This study found that early auditory information processing (EAIP) biomarkers, such as mismatch negativity (MMN), can predict ATCT performance in a diverse neuropsychiatric population. MMN and cognition scores were strongly correlated with most ATCT measures, while diagnosis was not a significant predictor. These findings suggest that MMN should be considered in ATCT studies across different diagnoses.
PSYCHIATRY RESEARCH
(2023)
Article
Cell Biology
Hao Wang, Carolina Makowski, Yanxiao Zhang, Anna Qi, Tobias Kaufmann, Olav B. Smeland, Mark Fiecas, Jian Yang, Peter M. Visscher, Chi-Hua Chen
Summary: The study investigates the impact of chromosomal inversions on human brain morphology by analyzing genotypes of adults with European ancestry. Several common inversions, including 2p22.3, 16p11.2, and 17q21.31, show significant associations with cortical and subcortical morphology. The inverted orientations of these regions have a noticeable effect on brain size and motor cortex. These findings contribute to understanding the role of inversions in shaping human brain phenotypes.
Article
Biotechnology & Applied Microbiology
Mimi Wang, Jingyun Wu, Shufeng Lei, Xingbo Mo
Summary: This study identified RNAm-SNPs related to rheumatoid arthritis (RA) and suggested that they may affect the expression levels of corresponding genes and proteins.
Article
Clinical Neurology
Lin Fan, Yiwen You, Yao Fan, Chong Shen, Yong Xue
Summary: The study found a significant association between the ApoA1 gene rs5072 variant and dyslipidemia in schizophrenia patients treated with antipsychotic drugs, potentially increasing susceptibility to lipid metabolism disorders.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Elia Vila, Raquel Pinacho, Roger Prades, Teresa Tarrago, Elena Castro, Eva Munarriz-Cuezva, J. Javier Meana, Ania Eugui-Anta, Monica Roldan, America Vera-Montecinos, Belen Ramos
Summary: Cognitive impairment is a core feature of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia. The mitochondrial and nuclear protein Prohibitin 2 (PHB2) could be dysregulated in schizophrenia, and its link to N-methyl-D-aspartate receptor (NMDAR) activity and cognitive deficits is still unknown. This study found that PHB2 levels increased in the dorsolateral prefrontal cortex of chronic schizophrenia cases, and were associated with cognitive impairments. NMDAR antagonists also increased PHB2 levels in mice and rat astrocytes and neurons, and IPR19 restored PHB2 levels in acute NMDAR inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychiatry
Rafaella Georgiou, Demetris Lamnisos, Konstantinos Giannakou
Summary: The study found that medications with increased anticholinergic burden negatively affect the cognitive performance of patients with schizophrenia. However, the clinical and methodological heterogeneity of the included studies limited the accuracy of interpretation and conclusions.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Engineering, Chemical
Ariel J. Atkinson, Mikayla D. Armstrong, John T. Eskew, Orlando Coronell
Summary: Biofouling is a challenge in membrane applications, particularly in the purification of natural waters. The study found that the 2-AI membrane effectively inhibited biofilm formation, resulting in weaker biofouling that was easier to remove. Despite initially lower water permeance, the 2-AI membranes outperformed controls after biofilm formation, fouling less without compromising water productivity and solute rejection.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Geriatrics & Gerontology
Yi Fang, Shaobing Dai, Chongyao Jin, Xiaoli Si, Luyan Gu, Zhe Song, Ting Gao, Ying Chen, Yaping Yan, Xinzhen Yin, Jiali Pu, Baorong Zhang
Summary: This study investigated the clinical implication of AQP4 polymorphisms in Parkinson's disease (PD) by analyzing patients and controls. The results showed that genetic variations of AQP4 might contribute to altered cognitive decline in PD, with rs162009 likely being a novel genetic prognostic marker of cognitive decline in the disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Gordana Nedic Erjavec, Mirko Grubor, Maja Zivkovic, Nada Bozina, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dubravka Svob Strac
Summary: Antipsychotic-induced parkinsonism is the most common extrapyramidal side effect caused by the blockage of dopamine receptors. This study found significant associations between HTR6 gene polymorphism and tremor and rigidity induced by haloperidol. Additionally, a combined effect of HTR6 T and SLC6A3 9R alleles on AIP was observed.
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda AdIi, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Bernhard T. Baune
Summary: The study found a significant association between polygenic susceptibility to major depression and response to lithium treatment in patients with bipolar disorder. Patients with a lower polygenic load for depression were more likely to respond well to lithium. This highlights the genetic contribution to lithium response in bipolar disorder and supports the concept of a lithium-responsive biotype.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Justus Wilke, Agnes A. Steixner-Kumar
MOLECULAR PSYCHIATRY
(2021)
Article
Oncology
Rayjean J. Hung, Matthew T. Warkentin, Yonathan Brhane, Nilanjan Chatterjee, David C. Christiani, Maria Teresa Landi, Neil E. Caporaso, Geoffrey Liu, Mattias Johansson, Demetrius Albanes, Loic Le Marchand, Adonina Tardon, Gad Rennert, Stig E. Bojesen, Chu Chen, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Shanbeth Zienolddiny, Stephen Lam, Angeline S. Andrew, Susanne M. Arnold, Melinda C. Aldrich, Heike Bickeboeller, Angela Risch, Matthew B. Schabath, James D. McKay, Paul Brennan, Christopher Amos
Summary: Research suggests that an individual's genetic background may play a role in risk stratification for lung cancer and optimizing LDCT screening.
Article
Biochemistry & Molecular Biology
Agnes A. Steixner-Kumar, Vinicius Daguano Gastaldi, Jan Seidel, Albert Rosenberger, Martin Begemann, Hannelore Ehrenreich
Summary: Accumulation of early-life environmental risks, including cannabis and alcohol, strongly predicts the development of polytoxicomania, while genetic predisposition to this condition remains largely unexplored.
MOLECULAR PSYCHIATRY
(2021)
Article
Substance Abuse
Daniela Reichl, Niklas Enewoldsen, Kiona K. Weisel, Sebastian Saur, Lukas Fuhrmann, Catharina Lang, Matthias Berking, Mathias Zink, Andreas Ahnert, Peter Falkai, Thomas Kraus, Thomas Hillemacher, Felix-N Muller, Stephan Lins, Dominikus Bonsch, Linda Kerkemeyer, Sabine Steins-Loeber
Summary: There is evidence that craving mediates the relationship between Impulsive Personality Traits (IPTs) and relapse during the treatment of an Alcohol Use Disorder (AUD). Lower emotion regulation competencies were found to mediate the relationship between attentional as well as non-planning IPTs and craving. These findings contribute to a deeper understanding of the underlying processes and may inform tailored interventions for AUD treatment.
SUBSTANCE USE & MISUSE
(2022)
Article
Cell Biology
Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner
Summary: Compared with SOX10 alone, the combination of SON increases the number of induced oligodendrocytes (iOLs) and enhances their complexity and myelin-marker gene expression levels. RNA velocity analysis shows that SOX10 generates OPCs that are apparently more immature than those generated by SON, with distinct molecular properties.
Article
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Justus B. H. Wilke, Umer Javed Butt
Summary: Executive functions, learning, attention, and processing speed are important aspects of cognitive performance, which can be affected in neuropsychiatric disorders. Studies have shown that recombinant human erythropoietin (rhEPO) can improve cognitive abilities and reduce brain matter loss. The administration of rhEPO leads to an increase in pyramidal neurons and oligodendrocytes, while decreasing the number and activity of microglia. This process promotes neurogenesis and increases dendritic spine density, which may contribute to improved cognitive function.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Kolja A. Thormann, Viola Tozzi, Paula Starke, Heike Bickeboeller, Marcus Baum, Albert Rosenberger
Summary: ImputAccur is a software tool that measures genotype-imputation accuracy. It provides accuracy measures from standard output files of imputation software and supports sample and marker filtering.
BMC BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Laurens Winkelmeier, Carla Filosa, Renee Hartig, Max Scheller, Markus Sack, Jonathan R. Reinwald, Robert Becker, David Wolf, Martin Fungisai Gerchen, Alexander Sartorius, Andreas Meyer-Lindenberg, Wolfgang Weber-Fahr, Christian Clemm von Hohenberg, Eleonora Russo, Wolfgang Kelsch
Summary: The authors used a hierarchical approach to investigate brain mechanisms for history informed updating of future predictions. Through behavioral modeling, systems fMRI, and cellular coding, they identified the circuits responsible for cognition and revealed the contributions of different brain areas in olfactory reinforcement learning. The findings validate the use of a cross-scale approach in understanding higher cognitive functions in rodents.
NATURE COMMUNICATIONS
(2022)
Article
Psychology, Educational
Ulrich Dettweiler, Martin Gerchen, Christoph Mall, Perikles Simon, Peter Kirsch
Summary: This study experimentally explored the effects of autonomy support and physical activity on the biological stress responses and brain development of students in education outside the classroom (EOtC). The results showed that EOtC students exhibited more efficient regulation of biological stress-reactivity and a reduction of cortisol associated with light physical activity in the forest. Additionally, the maturation of the anterior cingulate cortex (ACC) was positively influenced by autonomy support, especially in EOtC.
BRITISH JOURNAL OF EDUCATIONAL PSYCHOLOGY
(2023)
Article
Hospitality, Leisure, Sport & Tourism
A. Lassner, I Papazova, B. Pross, J. Scherr, J. Schoenfeld, M. Halle, B. Haller, P. Falkai, A. Hasan, A. Roeh
Summary: Endurance sports carry a higher risk of exercise addiction compared to other physical activities. This study evaluated the risk of exercise addiction among amateur marathon runners and investigated its relationship with fitness measures, affect, and general level of functioning.
INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY
(2022)
Article
Cell Biology
Andrea Schmitt, Laura Tatsch, Alisa Vollhardt, Thomas Schneider-Axmann, Florian J. Raabe, Lukas Roell, Helmut Heinsen, Patrick R. Hof, Peter Falkai, Christoph Schmitz
Summary: This study utilized stereology to investigate the numbers and densities of different cell types in the brains of individuals with schizophrenia. The results indicated a reduction in oligodendrocytes in the CA4 region in schizophrenia patients, which was absent in the control group.
Editorial Material
Neurosciences
David Popovic, Peter Falkai
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Andrea Fiorillo, Antonio Ventriglio, Gaia Sampogna, Peter Falkai
INTERNATIONAL REVIEW OF PSYCHIATRY
(2022)
Article
Biology
Sahab Arinrad, Constanze Depp, Sophie B. Siems, Andrew Octavian Sasmita, Maria A. Eichel, Anja Ronnenberg, Kurt Hammerschmidt, Katja A. Lueders, Hauke B. Werner, Hannelore Ehrenreich, Klaus-Armin Nave
Summary: The study shows that structural defects of intracortical myelin associated with neuroinflammation are key features of advanced brain aging. A mouse model with similar pathology exhibits behavioral abnormalities, but cognitive assessment is challenging due to motor-sensory functions. However, mice lacking Plp1 gene in ventricular zone stem cells exhibit subtle myelin defects only in certain brain regions and show no basic motor-sensory performance impairments. Interestingly, novel behavioral paradigms reveal catatonia-like symptoms and executive dysfunction.