Article
Pharmacology & Pharmacy
Francesco Petragnano, Irene Fasciani, Clotilde Mannoury la Cour, Benjamin di Cara, Gabriella Aloisi, Marco Carli, Shivakumar Kolachalam, Mario Rossi, Francesco Marampon, Marco Scarselli, Mark J. Millan, Roberto Maggio
Summary: This study investigates the affinity and activation of (+)-4-Propyl-9-hydroxynaphthoxazine on various monoamine receptors. It is found to have high affinity for hD(4.4), h5-HT1A, and h5-HT7 receptors, as well as hD(3) and hD(2L) receptors. It also strongly activates dopamine hD(3)-hD(2L) heterodimers. These findings are important for interpreting PET studies and may have implications for the treatment of Parkinson's disease and other disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Takeshi Sakayori, Amane Tateno, Ryosuke Arakawa, Woo-chan Kim, Yoshiro Okubo
Summary: The study showed that blonanserin occupied both D-2 and D-3 receptors in patients with schizophrenia.
PSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Patricia Di Ciano, Harriet de Wit, Esmaeil Mansouri, Sylvain Houle, Isabelle Boileau, Bernard Le Foll
Summary: PET imaging with [C-11]-(+)-PHNO was used to measure changes in dopamine levels in regions of interest in smokers who had maintained abstinence for 7-10 days. Results showed that smoking cues did not increase craving, and there were no significant changes in dopamine binding potential in most regions except for a decrease in the substantia nigra. Further research with a larger sample size is needed to validate these preliminary findings.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Eugenii A. Rabiner, Tolga Uz, Ayla Mansur, Terry Brown, Grace Chen, Jingtao Wu, Joy Atienza, Adam J. Schwarz, Wei Yin, Yvonne Lewis, Graham E. Searle, Jeremy M. T. J. Dennison, Jan Passchier, Roger N. Gunn, Johannes Tauscher
Summary: The study demonstrated that TAK-041 attenuated d-amphetamine-induced dopamine release, offering a potential mechanism for treating schizophrenia and related disorders. Using [C-11]PHNO PET scans, researchers found that TAK-041 enters the human brain and interacts with GPR139.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Chidera C. Chukwueke, Christina N. Nona, Matthew D. McPhee, Esmaeil Mansouri, Dafna S. Rubin-Kahana, Diana Martinez, Isabelle Boileau, Christian S. Hendershot, Bernard Le Foll
Summary: Preclinical studies suggest a role of DRD3 receptors in AUD, but this study found lower levels of DRD2/3 binding in AUD subjects compared to healthy controls. Despite no specific regional differences, there were reductions in binding levels in certain areas, and a positive association between binding in the SN and alcohol demand. Further research is needed to explore the implications of these findings.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Melodie Ferrat, Kenneth Dahl, Magnus Schou
Summary: The preparation of electrophilic C-11-labelled aroyl dimethylaminopyridinium salts through carbonylative cross-coupling provides valuable intermediates for synthesizing primary [C-11]benzamides. This method yields benzamide model compounds, including PARP inhibitors, with moderate to excellent radiochemical yields, paving the way for potential application in PET tracer synthesis.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ragy R. Girgis, Mark Slifstein, Gary Brucato, Lawrence S. Kegeles, Tiziano Colibazzi, Jeffrey A. Lieberman, Anissa Abi-Dargham
Summary: Patients at clinical high-risk (CHR) for psychosis show increased synaptic dopamine availability in the ventral striatum, which is negatively correlated with severity of negative symptoms. Longitudinal studies are needed to further understand the significance of these findings in CHR.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Hiroshi Yamauchi, Shinya Kagawa, Kuninori Kusano, Miki Ito, Chio Okuyama
Summary: This study found that secondary thalamic neuronal damage may result in a decrease in central benzodiazepine receptors in patients with cerebral infarction and artery disease. This decrease may be associated with frontal lobe dysfunction.
Article
Medicine, Research & Experimental
Kavya Prasad, Erik F. J. de Vries, Jurgen W. A. Sijbesma, Lara Garcia-Varela, Daniel A. Vazquez-Matias, Rodrigo Moraga-Amaro, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Aren van Waarde
Summary: This study investigates the regulation of A(2A) receptors on D-2 receptor binding using positron emission tomography (PET) technique. It shows that the A(2A) agonist CGS21680 can reduce the availability of D2 receptors in the striatum.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Organic
Jonas Rydfjord, Silav Al-Bazaz, Sara Roslin
Summary: Positron emission tomography (PET) is an important imaging technique with various clinical applications. This study presents a method for labeling acyl amidines and 1,2,4-oxadiazoles with carbon-11 using palladium-mediated carbonylation synthesis. The method demonstrated good radiochemical yields and high molar activity, indicating its utility for incorporating carbon-11 into pharmacologically relevant structural motifs.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Michael R. Kilbourn
Summary: The application of positron emission tomography (PET) imaging to study brain biochemistry, especially dopamine neurotransmission, has significantly grown over the past 40 years. PET imaging of dopaminergic functions in the central nervous system is routinely used for research in neurology, psychiatry, drug abuse and addiction, as well as drug development. The key advancement in PET imaging is the development of unique radiotracers labeled with positron-emitting radionuclides like carbon-11 and fluorine-18, which have greatly contributed to the progress in this field.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasuyuki Kimura, Keisuke Takahata, Toshiharu Shimazaki, Soichiro Kitamura, Chie Seki, Yoko Ikoma, Masanori Ichise, Kazunori Kawamura, Makiko Yamada, Ming-Rong Zhang, Makoto Higuchi, Izumi Nishino, Tetsuya Suhara
Summary: This study aimed to evaluate the pharmacokinetics and pharmacodynamics of enerisant, a novel antagonist and inverse agonist for histamine H-3 receptors. The results showed dose-dependent receptor occupancy of enerisant in the brain and its variation over time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Xiaotian T. Fang, Takuya Toyonaga, Ansel T. Hillmer, David Matuskey, Sophie E. Holmes, Rajiv Radhakrishnan, Adam P. Mecca, Christopher H. van Dyck, Deepak Cyril D'Souza, Irina Esterlis, Patrick D. Worhunsky, Richard E. Carson
Summary: This study demonstrates that human brain synaptic density can be characterized into organized covariance patterns. Additionally, the findings suggest that multiple synaptic density source networks are associated with age, highlighting the potential utility of ICA in identifying biologically relevant synaptic density source networks.
Article
Chemistry, Multidisciplinary
Tatsuya Kikuchi, Masanao Ogawa, Toshimitsu Okamura, Antony D. Gee, Ming-Rong Zhang
Summary: This study reports a simple and efficient method for the production of [C-11]HCN that can be easily implemented in C-11 production facilities, eliminating the need for a dedicated infrastructure.
Article
Clinical Neurology
Alison R. Weiss, Daniele Bertoglio, William A. Liguore, Kristin Brandon, John Templon, Jeanne Link, Jodi L. McBride
Summary: This study investigates alterations in dopamine receptor density and glucose utilization in a newly developed AAV-mediated NHP model of Huntington's disease (HD). The results show significantly reduced dopamine receptor densities and glucose hypometabolism in HD macaques compared to controls. PET imaging with [F-18]fallypride and [F-18]FDG can serve as noninvasive outcome measures for therapeutic studies with this HD macaque model.
MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Gausiha Rathitharan, Jennifer Truong, Junchao Tong, Tina McCluskey, Jeffrey H. Meyer, Romina Mizrahi, Jerry Warsh, Pablo Rusjan, James L. Kennedy, Sylvain Houle, Stephen J. Kish, Isabelle Boileau
Summary: Research on the brains of chronic MA users suggests that while there is activation of microglial cells, there is no significant increase in microgliosis. This indicates that microglia may not be a substantial therapeutic target for MA addiction, despite their involvement in MA-seeking behavior.
Letter
Neurosciences
Pontus Plaven-Sigray, Granville J. Matheson, Jennifer M. Coughlin, Sina Hafizi, Heikki Laurikainen, Julie Ottoy, Livia De Picker, Pablo Rusjan, Jarmo Hietala, Oliver D. Howes, Romina Mizrahi, Manuel Morrens, Martin G. Pomper, Simon Cervenka
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Nathan J. Kolla, Isabelle Boileau, Karolina Karas, Jeremy J. Watts, Pablo Rusjan, Sylvain Houle, Romina Mizrahi
Summary: Individuals with ASPD have lower FAAH density in the amygdala, while FAAH expression in the cerebellum and striatum is inversely related to impulsivity. Cerebellar FAAH density is also negatively associated with assaultive aggression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Marion Criaud, Jin-Hee Kim, Mateusz Zurowski, Nancy Lobaugh, Sofia Chavez, Sylvain Houle, Antonio P. Strafella
Summary: The study found that anxiety symptoms in Parkinson's disease patients are associated with over-activation of the amygdala and impaired inter-relationship among regions involved in behavior and motor control.
Article
Neurosciences
Duncan G. J. Green, Jinhee Kim, Stephen J. Kish, Rachel F. Tyndale, Matthew N. Hill, Antonio P. Strafella, Junchao Tong, Tina McCluskey, Duncan J. Westwood, Sylvain Houle, Nancy J. Lobaugh, Isabelle Boileau
Summary: This study revealed a negative correlation between levels of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) in the amygdala and functional connectivity in frontoamygdalar circuits involved in stress and affect control. The findings provide preliminary evidence supporting the role of FAAH in regulating brain circuits underlying fear and emotion processing in humans.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Correction
Neurosciences
J. Kolla Nathan, R. Mizrahi, K. Karas, C. Wang, R. M. Bagby, S. McMain, A. I. Simpson, P. M. Rusjan, R. Tyndale, S. Houle, I. Boileau
Summary: The correction to this paper has been published.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Patricia Di Ciano, Harriet de Wit, Esmaeil Mansouri, Sylvain Houle, Isabelle Boileau, Bernard Le Foll
Summary: PET imaging with [C-11]-(+)-PHNO was used to measure changes in dopamine levels in regions of interest in smokers who had maintained abstinence for 7-10 days. Results showed that smoking cues did not increase craving, and there were no significant changes in dopamine binding potential in most regions except for a decrease in the substantia nigra. Further research with a larger sample size is needed to validate these preliminary findings.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Talwinder Gill, Sarah E. Watling, J. Don Richardson, Tina McCluskey, Junchao Tong, Jeffrey H. Meyer, Jerry Warsh, Rakesh Jetly, Michael G. Hutchison, Shawn G. Rhind, Sylvain Houle, Neil Vasdev, Stephen J. Kish, Isabelle Boileau
Summary: Posttraumatic stress disorder (PTSD) may be associated with astrocyte pathology and a decrease in MAO-B levels. Preliminary results suggest a potential reduction in [C-11]SL25.1188 availability in PTSD patients, especially those with comorbid major depressive disorder (MDD). These findings are partly consistent with preclinical studies and recent PET observations, but further replication in a larger PTSD cohort is needed.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Dominic Simpson, Avideh Gharehgazlou, Tania Da Silva, Charlotte Labrie-Cleary, Alan A. Wilson, Jeffrey H. Meyer, Romina Mizrahi, Pablo M. Rusjan
Summary: Converging evidence suggests the involvement of immune system in autism spectrum disorders (ASD). A preliminary study using positron emission tomography (PET) explored whether the binding of translocator protein 18 kDa (TSPO) was altered in ASD participants. The findings show lower TSPO binding in ASD participants compared to controls, indicating an atypical neuroimmune state in ASD.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Anna Vasilevskaya, Foad Taghdiri, Namita Multani, Miracle Ozzoude, Apameh Tarazi, Mozhgan Khodadadi, Richard Wennberg, Pablo Rusjan, Sylvain Houle, Robin Green, Brenda Colella, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, David Mikulis, Lili-Naz Hazrati, Gabor G. Kovacs, Karen Deborah Davis, Charles Tator, Maria Carmela Tartaglia
Summary: This study investigated the use of plasma pTau181 as a non-invasive measure to assess the risk of neurodegenerative diseases in retired athletes. The results showed that retired athletes had higher levels of plasma pTau181 and its levels were associated with abnormalities in certain brain regions. However, baseline pTau181 levels were not predictive of longitudinal changes in brain volumes or white-matter integrity in the athletes.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Jeremy J. Watts, Elisa Guma, Sofia Chavez, Rachel F. Tyndale, Ruth A. Ross, Sylvain Houle, Alan A. Wilson, Mallar Chakravarty, Pablo M. Rusjan, Romina Mizrahi
Summary: Dysregulation of hippocampus neurotransmission and volume has been associated with psychiatric disorders, and anandamide and FAAH are related to normal hippocampus function.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Sarah E. Watling, Samantha Jagasar, Tina McCluskey, Jerry Warsh, Shawn G. Rhind, Peter Truong, Sofia Chavez, Sylvain Houle, Junchao Tong, Stephen J. Kish, Isabelle Boileau
Summary: Preliminary data suggests that chronic methamphetamine (MA) use may cause oxidative stress and inflammation in the brain. This study aimed to investigate the levels of the antioxidant glutathione (GSH) in the brains of chronic MA users and explore the relationship between peripheral immunoinflammatory biomarkers and brain GSH concentrations. The results showed that GSH levels did not differ between MA users and healthy controls, but several immunoinflammatory biomarkers were significantly elevated in MA users and correlated with brain GSH levels.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Substance Abuse
Zac J. S. Yeap, Justine Marsault, Tony P. George, Romina Mizrahi, Rachel A. Rabin
Summary: Rates of cannabis use disorder (CUD) are higher in people with schizophrenia than in the general population, and tobacco co-use is prevalent in those with CUD. Individuals with high tobacco dependence experience greater cannabis withdrawal severity compared to those with no/low tobacco dependence.
AMERICAN JOURNAL ON ADDICTIONS
(2023)
Article
Psychiatry
Colleen E. Charlton, Jennifer R. Lepock, Daniel J. Hauke, Romina Mizrahi, Michael Kiang, Andreea O. Diaconescu
Summary: This study confirms the reductions in auditory mismatch negativity (MMN) in schizophrenia and proposes the predictive coding theory to explain this phenomenon. The results demonstrate the correlation between increased sensory precision-weighted prediction errors (pwPEs) and higher-level belief uncertainty with the occurrence of auditory MMN. Moreover, the severity of prodromal positive symptoms is associated with the expression of sensory pwPEs and higher-level belief uncertainty. These findings highlight the importance of computational models in understanding the pathophysiological mechanisms of psychosis.