Article
Psychiatry
Eleonora Iob, Jessie R. Baldwin, Robert Plomin, Andrew Steptoe
Summary: This study suggests that the dysregulated function of the hypothalamic-pituitary-adrenal (HPA) axis might play a role in the relationship between adverse childhood experiences (ACEs) and depression, especially in individuals exposed to multiple ACEs. Lower cortisol levels in early adolescence were found to mediate the association between ACEs and elevated depressive symptoms in early adulthood, independent of genetic factors.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Madeline Peterson, Molly B. D. Prigge, Erin D. Bigler, Brandon Zielinski, Jace B. King, Nicholas Lange, Andrew Alexander, Janet E. Lainhart, Jared A. Nielsen
Summary: The study found no significant increase in extra-axial cerebrospinal fluid volume in autistic individuals beyond the age of four, compared to controls.
Article
Business
Lijuan Chen, Wei Guo, Miaomiao Liu
Summary: The study shows that childhood migration experience affects adults' work motivation, making those with such experience more driven by social factors and less driven by economic factors. Social integration plays a significant moderating role in how childhood migration experience impacts adults' levels of work motivation, particularly more pronounced among male and rural adults.
JOURNAL OF BUSINESS RESEARCH
(2021)
Article
Family Studies
Kristin S. Lynch, Cathy Spatz Widom
Summary: This study examined the relationship between childhood maltreatment and cognitive functioning change during adulthood. The findings suggest that childhood maltreatment is associated with cognitive deficits in adulthood, and the type of maltreatment may differentially impact cognitive change. The initial cognitive deficit caused by childhood neglect was largely compensated for over a 10-year period.
CHILD ABUSE & NEGLECT
(2022)
Article
Family Studies
Kristin S. Lynch, Cathy Spatz Widom
Summary: This study investigates the relationship between childhood maltreatment and changes in cognitive functioning during adulthood. The results indicate that childhood maltreatment is associated with cognitive deficits in adulthood, and the impact of maltreatment may vary depending on the type.
CHILD ABUSE & NEGLECT
(2022)
Article
Psychology, Developmental
Timothy Matthews, Avshalom Caspi, Andrea Danese, Helen L. Fisher, Terrie E. Moffitt, Louise Arseneault
Summary: This study used a longitudinal and discordant twin design to explore the developmental associations between victimization and loneliness. The results showed that different forms of victimization were associated with loneliness in a dose-response manner. Childhood bullying victimization was uniquely associated with loneliness, and this association continued into young adulthood. The findings indicate that vulnerability to loneliness varies depending on the specific form of victimization and the developmental period in which it is experienced.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Adolfo G. Cuevas, Frank D. Mann, Robert F. Krueger
Summary: This study examines the interactive effects of genetic risks and childhood adversity on obesity, finding that the predictive effect of genetic risk on waist circumference increases with the severity of childhood adversity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Psychiatry
Fatemeh Fereidooni, Judith K. Daniels, Anne D. Krause-Utz, Muriel A. Hagenaars, Tom Smeets, Jenna Heins, Martin J. Dorahy, Arnold. A. P. van Emmerik, Peter J. de Jong, Steven Hoekstra, Matthijs J. Warrens, Miriam. J. J. Lommen
Summary: There is ample evidence showing that childhood maltreatment significantly increases the risk of adult victimization. Various factors such as post-traumatic stress disorder symptoms, dissociation, self-blame, and alcohol abuse are associated with revictimization. However, previous research on revictimization risk factors has been limited, with proposed models including only a few factors. Therefore, it is important to investigate a more comprehensive model that explains the link between childhood maltreatment and adult (re)victimization.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Alexander Testa, Dylan B. Jackson, Michael G. Vaughn, Kyle T. Ganson, Jason M. Nagata
Summary: The study indicates that exposure to adverse childhood experiences has a negative impact on adult health insurance status and healthcare utilization. Adult socioeconomic status plays a mediating role in this association.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Iob, Rebecca Lacey, Valentina Giunchiglia, Andrew Steptoe
Summary: Adverse childhood experiences (ACEs) are associated with depression and systemic inflammation in adults. Limited longitudinal research has been conducted on children and young people, and it is unclear if inflammation is an underlying mechanism through which ACEs influence depression. This study found that most types of ACEs were associated with elevated depression trajectories, with larger associations for threat-related adversities. However, inflammation was weakly associated with ACEs and depression and did not mediate the relationship.
MOLECULAR PSYCHIATRY
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Goncalves Soares, Annie Zimmerman, Stan Zammit, Anke Karl, Sarah L. Halligan, Abigail Fraser
Summary: Childhood abuse is associated with negative cardiometabolic outcomes in young adulthood, affecting factors such as body mass index, cholesterol, heart rate, and insulin levels. Sex differences in the associations are minimal.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Psychology, Developmental
Roni Pener-Tessler, Noam Markovitch, Ariel Knafo-Noam
Summary: The development of self-control from early childhood to early adolescence is relatively understudied. This study found that middle childhood is a period of potential transition and change, and genetic and environmental factors play important roles in the change and stability of self-control.
DEVELOPMENTAL SCIENCE
(2022)
Review
Public, Environmental & Occupational Health
Poppy Alice Carson Mallinson, Judith Lieber, Sanjay Kinra
Summary: This study examined the association between childhood socioeconomic position and the risk of cardiovascular disease in adulthood in low- and middle-income countries. The results showed little support for this association in middle-income countries, and evidence from low-income countries is lacking. It may be premature to consider childhood poverty as a target for cardiovascular disease prevention in these settings.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Isabel Morales-Munoz, Rachel Upthegrove, Pavan K. Mallikarjun, Matthew R. Broome, Steven Marwaha
Summary: The study found that childhood cognitive factors were associated with subsequent psychopathological symptoms in young people, with higher sustained attention at age 8 years being linked to decreased risk of certain mental disorders at different ages. This suggests that specific cognitive deficits could be targeted for prediction and intervention in mental disorders such as borderline personality disorder, depression, and psychosis.
Article
Public, Environmental & Occupational Health
Vanessa De Rubeis, Andrea Gonzalez, Jean-Eric Tarride, Lauren E. Griffith, Laura N. Anderson
Summary: This study investigated the impact of adverse childhood experiences (ACEs) on adulthood obesity and whether the association was mediated by nutrition and stress. The study found a strong association between ACEs and obesity among Canadian adults. However, stress and nutrition did not mediate this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruyue Zhang, Janne Tidselbak Larsen, Ralf Kuja-Halkola, Laura Thornton, Shuyang Yao, Henrik Larsson, Paul Lichtenstein, Liselotte Vogdrup Petersen, Cynthia M. Bulik, Sarah E. Bergen
Summary: The study found that eating disorders and schizophrenia co-occur and co-aggregate within the Swedish and Danish populations, indicating a familial contribution to the association between the two disorders. Individuals with anorexia nervosa or other eating disorders were more likely to have schizophrenia, and this risk varied among different relatives.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Developmental
Lauren M. O'Reilly, Erik Pettersson, Patrick D. Quinn, E. David Klonsky, Jessie R. Baldwin, Sebastian Lundstrom, Henrik Larsson, Paul Lichtenstein, Brian M. D'Onofrio
Summary: The study revealed an independent association between bullying victimization and self-harm/suicide attempt in adolescence, with small effect sizes, indicating the need for additional interventions beyond bullying prevention.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Psychology, Clinical
Amir Sariaslan, Stefan Leucht, Johan Zetterqvist, Paul Lichtenstein, Seena Fazel
Summary: In individuals with psychiatric disorders, the use of specific antipsychotic medications such as clozapine, olanzapine, and risperidone is associated with lower risks of arrests and convictions for drug-related and violent crimes compared to other antipsychotics. Long-acting injectables, particularly risperidone, also show lower risks of these criminal outcomes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Substance Abuse
Suvi Virtanen, Tyra Lagerberg, Lotfi Khemiri, Jaana Suvisaari, Henrik Larsson, Paul Lichtenstein, Zheng Chang, Antti Latvala
Summary: The cohort study in Sweden found that individuals with anxiety/depression had a higher risk of substance misuse before starting SSRI treatment, but the risk decreased after treatment initiation.
Article
Psychology, Developmental
Paul Lichtenstein, Magnus Tideman, Patrick F. Sullivan, Eva Serlachius, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: The study found that intellectual disability (ID) aggregates in families, with relatives of ID individuals at increased risk of ID in proportion to their degree of genetic relatedness. Genetic factors play a significant role in the development of ID, while male sex of relatives and maternal line of relationship with proband are associated with higher risk.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Neurosciences
Tyra Lagerberg, Seena Fazel, Arvid Sjoelander, Clara Hellner, Paul Lichtenstein, Zheng Chang
Summary: Using nationwide Swedish registers, researchers found that SSRI treatment did not increase the risk of suicidal behavior, but may actually reduce it. The risk of suicidal behavior decreased over time after SSRI treatment initiation, across different age groups and history of suicide attempts. Further research with different study designs and populations is warranted to confirm these findings.
NEUROPSYCHOPHARMACOLOGY
(2022)
Letter
Neurosciences
Tyra Lagerberg, Seena Fazel, Paul Lichtenstein, Zheng Chang
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ashley E. Tate, Hanna Sahlin, Shengxin Liu, Yi Lu, Sebastian Lundstrom, Henrik Larsson, Paul Lichtenstein, Ralf Kuja-Halkola
Summary: This article presents one of the largest and most comprehensive studies on borderline personality disorder (BPD) to date. The study reveals that individuals diagnosed with BPD have higher risks of various psychiatric disorders, violent crime victimization, and self-harm. The study also finds that the risks are similar for both males and females with BPD. Additionally, having a sibling with BPD increases the risk for psychiatric disorders, trauma, and adverse behaviors.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jie Song, Shuyang Yao, Kaarina Kowalec, Yi Lu, Amir Sariaslan, Jin P. Szatkiewicz, Henrik Larsson, Paul Lichtenstein, Christina M. Hultman, Patrick F. Sullivan
Summary: Schizophrenia is a highly heterogeneous disorder with no well-characterized subtypes for treatment response or longitudinal course. Cognitive impairment, a core clinical feature of schizophrenia, is strongly associated with poorer outcomes. This study investigates the complex genetic overlap between schizophrenia and cognitive traits using comprehensive epidemiological and genomic evidence. The findings highlight the robust relationship between cognitive traits and schizophrenia, emphasizing the importance of cognition in understanding the heterogeneity of the disorder.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Miguel Garcia-Argibay, Ebba du Rietz, Yi Lu, Joanna Martin, Elis Haan, Kelli Letho, Sarah E. Bergen, Paul Lichtenstein, Henrik Larsson, Isabell Brikell
Summary: Growing evidence suggests that ADHD is associated with poor somatic health in adulthood, but the mechanisms underlying these associations are poorly understood. This study found that ADHD polygenic risk scores (PRS) are associated with multiple somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observed in the general population and appear to be partially mediated by life-course risk factors.
TRANSLATIONAL PSYCHIATRY
(2022)
Correction
Psychiatry
Miguel Garcia-Argibay, Ebba du Rietz, Yi Lu, Joanna Martin, Elis Haan, Kelli Lehto, Sarah E. Bergen, Paul Lichtenstein, Henrik Larsson, Isabell Brikell
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Miguel Garcia-Argibay, Ebba Du Rietz, Catharina A. Hartman, Paul Lichtenstein, Zheng Chang, Cristiano Fava, Samuele Cortese, Henrik Larsson
Summary: This study found that there is an association between cardiovascular risk factors and ADHD, and this association is not influenced by medication treatment for ADHD, but is partly due to shared familial risk factors.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson, Stephen V. V. Faraone
Summary: This study examined the use of different machine learning techniques to assess the feasibility of using registry data for diagnosing ADHD in children and adolescents in Sweden. The findings showed that a DNN model achieved good predictive ability for ADHD and identified several important features for classification. If validated and proven to be cost-effective in external samples, this model could potentially serve as a useful tool in clinical practice to aid in ADHD screening and decision-making.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Ashley E. Tate, Wonuola A. Akingbuwa, Robert Karlsson, Jouke-Jan Hottenga, Rene Pool, Magnus Boman, Henrik Larsson, Sebastian Lundstrom, Paul Lichtenstein, Christel M. Middeldorp, Meike Bartels, Ralf Kuja-Halkola
Summary: This study aimed to create a model that predicted if individuals will exhibit suicidal behaviour, aggressive behaviour, both, or neither in late adolescence. The model was validated using twin samples from Sweden and the Netherlands, and showed generalizability across Northern Europe. However, the model's prediction performance for suicidal behavior in the Netherlands sample was not better than chance.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Aleksandra Kanina, Henrik Larsson, Arvid Sjolander, Agnieszka Butwicka, Mark J. J. Taylor, Miriam I. I. Martini, Paul Lichtenstein, Frida E. E. Lundberg, Brian M. D. Onofrio, Mina A. A. Rosenqvist
Summary: Cumulative exposure to psychosocial adversity at an early age has been found to increase the risk of ADHD and autism, but it is unclear if this association is causal or due to familial confounding. This study used a population-based cohort in Sweden to examine the relationship between cumulative psychosocial adversity and neurodevelopmental conditions. The results showed a dose-response relationship between psychosocial adversity and ADHD, but no clear dose-response relationship for autism. The findings also highlighted the importance of accounting for familial confounding in studies of psychosocial adversity and neurodevelopmental conditions.
TRANSLATIONAL PSYCHIATRY
(2023)
