期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 20, 页码 10671-10676出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b03087
关键词
aminolevulinic acid; hollow mesoporous silica nanoparticles; photodynamic therapy; skin cancer; targeted delivery
资金
- National Research Foundation (NRF)
- Prime Minister's Office, Singapore, under its NRF Fellowship [NRF2009NRF-RF001-015]
- Campus for Research Excellence and Technological Enterprise (CREATE) Programme-Singapore Peking University Research Centre for a Sustainable Low-Carbon Future
- NTU-A*STAR Silicon Technologies Centre of Excellence [1123510003]
- NTU-Northwestern Institute for Nanomedicine
5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro.
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