Article
Environmental Sciences
Bondi Gevao, Karell Martinez-Guijarro, Perihan Binnur Kurt-Karakus, Carol Sukhn, Roland Weber, Divya Krishnan, Smitha Rajagopalan, Askin Birgul, Hassan Alshemmari, Mariam Hajeyah, Majed Bahloul, Mohamed I. Orif
Summary: The study monitored the concentrations of PCDD/F in the Middle East using passive air samplers at 12 sites across four countries. The highest concentrations were found in Oman and Kuwait, with a potential additional source involving the use of elemental chlorine. The study provides reliable measurements for assessing time trends in PCDD/F in the air.
ATMOSPHERIC POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Shuai Sun, Rong Cao, Jing Jin, Yichi Zhang, Yuan Gao, Xianbo Lu, Jiping Chen, Haijun Zhang
Summary: This study investigated the levels and accumulation characteristics of PCDD/Fs and PCBs in nine pools of representative plant-origin foodstuffs from markets in five regions of the Chinese mainland. The results showed that cereals and vegetable oil contributed the most to the estimated dietary intakes of WHO-TEQ.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Grazia Barone, Arianna Storelli, Rita Garofalo, Maria Maddalena Storelli
Summary: The levels of non-dioxin-like PCB indicators were determined in food samples to evaluate the exposure of adult and elderly population. The results showed that none of the samples exceeded the maximum permissible limits for human consumption established by the European Union legislation, except for salami samples. Seafood was found to be the major contributor to PCB exposure, indicating the need for further efforts to protect consumers from these harmful chemicals.
JOURNAL OF FOOD QUALITY
(2022)
Article
Medicine, Legal
Caroline Ring, Alexander Blanchette, William D. Klaren, Seneca Fitch, Laurie Haws, Matthew W. Wheeler, Michael DeVito, Nigel Walker, Daniele Wikoff
Summary: In 2005, the WHO re-evaluated the TEFs for dioxin-like compounds based on an updated database, which identified the need for a consistent approach for dose-response modeling and addressed the heterogeneity and quality issues of the database. To address this, a multi-tiered approach combining Bayesian modeling and machine learning was developed to predict the relationship between each congener and its reference and derive TEF uncertainty distributions. This workflow improved the TEF methodology by incorporating expert panel recommendations and providing transparent and reproducible results.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Anna Pouch, Agata Zaborska, Ksenia Pazdro
Summary: The study provides initial results on the occurrence of seventeen polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and twelve dioxin-like polychlorinated biphenyls in arctic fjord seawater, with highly chlorinated PCDFs and PCB118 as dominant compounds. The samples showed varying toxicity equivalent levels for Sigma PCDD/Fs and Sigma dl-PCBs, indicating a potential threat to marine biota from high concentrations of dioxins and dl-PCBs in some samples.
MARINE POLLUTION BULLETIN
(2021)
Review
Environmental Sciences
Tomoya Takiguchi, Hoa Thi Vu, Yoshikazu Nishino
Summary: Bone metabolism is regulated by endocrine systems, and exposure to PCDD/Fs can have adverse effects on bones and teeth. Previous studies have shown that exposure to PCDD/Fs can affect odontogenesis and bone genesis, particularly enamel formation and palatine bone. It is also found that exposure to PCDD/Fs in milk can affect both teeth and bones, with reversible effects on bones. Furthermore, high concentrations of PCDD/Fs can adversely affect teeth even in adulthood, but exposure to PCDD/Fs may also induce osteogenesis and improve bone properties. Further human studies are needed to investigate the associations between PCDD/F concentrations and biological markers for teeth and bones.
Article
Environmental Sciences
Shuai Sun, Rong Cao, Xianbo Lu, Yichi Zhang, Yuan Gao, Jiping Chen, Haijun Zhang
Summary: During 2018-2019, concentrations and distribution profiles of PCDD/Fs and PCBs in animal origin food-stuffs from five regions in China were studied. Results showed higher levels of PCDD/Fs and PCBs in coastal regions compared to inland regions. Significant differences in homologue and congener distribution of PCDD/Fs and PCBs were observed between terrestrial and aquatic animal foods. Estimated dietary intakes of WHO-TEQ from consuming animal foods ranged from 3.57-19.63 pg WHO-TEQ/kg body weight/month in the five regions, with aquatic animal food and pork being major sources in coastal regions and beef, mutton, and milk in the Northwest region.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Loreto Santa-Marina, Ziortza Barroeta, Amaia Irizar, Jon Inaki Alvarez, Esteban Abad, Juan Munoz-Arnanz, Begona Jimenez, Jesus Ibarluzea, Nerea Urbieta, Alba Jimeno-Romero, Miren Begona Zubero, Aitana Lertxundi
Summary: This research examines the levels and trends of pollutants, specifically 17 congeners of PCDD/Fs and 12 dl-PCBs, in the air measured in the province of Gipuzkoa (Basque Country, Spain). The study found that the toxic equivalents (TEQs) for PCDD/Fs were 12.29 fg TEQm(-3) and for dl-PCBs were 1.63 fg TEQm(-3), which were in a similar range or lower than those observed in other national and international studies in industrial areas. The findings of this study can serve as an indicator of the potential impact of ERP on the health of the resident population and the environment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Shuai Sun, Baoqin Zhang, Yun Luo, Xindong Ma, Rong Cao, Yichi Zhang, Yuan Gao, Jiping Chen, Haijun Zhang
Summary: This study collected breast milk samples from 51 mothers in Dalian, China, and found that they had higher exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) due to their higher consumption of seafood. The study also observed differences in the accumulation potentials of different PCDD/F and PCB congeners in breast milk and highlighted the higher exposure risk of infants to these chemicals.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Haena Chu, Jungmin Jo, Younggyu Son, Ji Yi Lee, Yun Gyong Ahn
Summary: In this study, a one-step cleanup method was developed for the efficient determination of PCDDs/Fs and dl-PCBs in contaminated soils. By combining a multilayer silica gel column and Florisil micro-column with gas chromatography and triple quadrupole mass spectrometry, the method showed advantages of low cost and simplified sample preparation. The findings provide a new approach for large-scale sample analysis.
Article
Environmental Sciences
David Vernez, Christelle Oltramare, Baptiste Sauvaget, Helene Demougeot-Renard, Lothar Aicher, Nicolas Roth, Isabelle Rossi, Arianna Radaelli, Sylvain Lerch, Vincent Marolf, Aurelie Berthet
Summary: High concentrations of PCDDs and PCDFs were found in the soil in Lausanne, Switzerland, possibly from a former waste incinerator. A three-step approach was taken to assess the human health risks and identify preventive measures. The results highlighted concerns about the consumption of food products derived from contaminated land.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Sirichai Sunya, Aekgphoonnada Yenuthok, Piyawat Paengphua, Supat Sangsuay
Summary: The dietary intakes of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like poly-chlorinated biphenyls (DL-PCBs) were assessed in the Thai Total Diet Study (TDS) in 2019. The study found that the major contributors to the dietary intake of these compounds in the Thai population were marine animals, milk and milk products, freshwater animals, pork and pork products, and eggs. The intakes did not exceed the provisional tolerable monthly intake set by JECFA in 2001.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Energy & Fuels
Jun-Ik Son, Seung-Jae Lee, Se-In Park, Eun-Hye Kwon, Hueon Namkung, Jun-Gu Kang, Wonseok Lee
Summary: This study evaluated the emission of PCDD/DFs in seven incineration plants in Korea using SRF and bio-SRF. The results showed that all seven plants effectively managed their dioxin emissions, but both SRF and bio-SRF plants produced a large amount of highly chlorinated dioxins. The SRF plants had a high ratio of OCDF and showed a low ratio of OCDF to 1,2,3,4,6,7,8-HpCDF.
Article
Environmental Sciences
Peter Gresner, Marek Zielinski, Danuta Ligocka, Kinga Polanska, Wojciech Wasowicz, Jolanta Gromadzinska
Summary: This study analyzed the concentrations of PCDDs, PCDFs, and dl-PCBs in breast milk samples of 110 breastfeeding women from an urban area. The results showed significant correlations between dl-PCBs concentration and toxicity equivalent with mothers' age, as well as a positive association between total toxicity equivalent of all substances analyzed and the frequency of fish and dairy products consumption. These findings may provide a basis for further research on exposure to these pollutants and their mechanisms of action.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Shijian Xiong, Yaqi Peng, Ken Chen, Shengyong Lu, Wenqian Jiang, Xiaodong Li, Fei Wang, Kefa Cen
Summary: This study investigated the distribution, migration, and relationship of PCDD/F and heavy metals in a typical hazardous waste incinerator. The results showed that the air control pollution devices effectively reduced PCDD/F concentrations, and the sulfur content in hazardous waste played a role in emissions. The migration analysis revealed that PCDD/F mainly migrated to mixtures with sodium bicarbonate and activated carbon, and heavy metals were classified based on their volatility. The findings also showed correlations between PCDD/F emissions and certain heavy metals.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemical Research Methods
Dilek Battal, Ayca Aktas Sukuroglu, Kumsal Kocadal, Ismet Cok, Irfan Unlusayin
Summary: A method for the trace analysis of endocrine disruptors such as Bisphenol A, 4-t-octylphenol, and 4-nonylphenol in human urine using liquid chromatography-mass spectrometry was developed and shown to be accurate and sensitive. The method was successfully applied for the determination of these compounds in 15 human urine samples, demonstrating its effectiveness in detecting these chemicals.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Public, Environmental & Occupational Health
Maximilian Schwarz, Kathrin Wolf, Alexandra Schneider, Karl-Werner Schramm, Brenda Bongaerts, Bernhard Henkelmann, Christian Herder, Michael Roden, Annette Peters, Dan Ziegler, Wolfgang Rathmann
Summary: This study found no association between low-dose concentrations of persistent organic pollutants (POPs) and distal sensorimotor polyneuropathy (DSPN) in individuals with type 2 diabetes, prediabetes and normal glucose tolerance (NGT). In fact, some POPs may even decrease the odds of developing DSPN.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Heqing Shen, Yike Zhang, Karl -Werner Schramm
Summary: Exploring the etiology of diseases is a key objective in epidemiological studies. Biomonitoring and molecular analysis can help uncover the links between environmental exposure and diseases, providing new research opportunities.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Toxicology
Elena Kozlova, Matthew C. Valdez, Maximillian E. Denys, Anthony E. Bishay, Julia M. Krum, Kayhon M. Rabbani, Valeria Carrillo, Gwendolyn M. Gonzalez, Gregory Lampel, Jasmin D. Tran, Brigitte M. Vazquez, Laura M. Anchondo, Syed A. Uddin, Nicole M. Huffman, Eduardo Monarrez, Duraan S. Olomi, Bhuvaneswari D. Chinthirla, Richard E. Hartman, Prasada Rao S. Kodavanti, Gladys Chompre, Allison L. Phillips, Heather M. Stapleton, Bernhard Henkelmann, Karl-Werner Schramm, Margarita C. Curras-Collazo
Summary: The study demonstrated that maternal exposure to DE-71 PBDEs can produce adverse effects on offspring's neurobehavioral and neurochemical functions, resulting in ASD-like phenotypes. These effects may stem from early neurodevelopmental reprogramming within central social and memory networks.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Ayca Aktas Sukuroglu, Dilek Battal, Kumsal Kocadal, Mehmet Ali Sungur, Ismet Cok, Irfan Unlusayin
Summary: This study conducted biomonitoring and risk assessment on the Turkish population for the first time, measuring urinary levels of Bisphenol A, 4-nonylphenol, and 4-t-octylphenol. While no potential health risk was observed from BPA and 4-NP exposure, there might be health risks associated with 4-t-OP exposure in the Turkish population.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Joachim Nagler, Sonja C. Schriever, Artem Romanov, Daniela Vogt-Weisenhorn, Wolfgang Wurst, Paul T. Pfluger, Karl-Werner Schramm
Summary: The study presents a novel method for the simultaneous extraction and detection of morphine and norlaudanosoline in single murine brain regions. By utilizing a variant of dispersive liquid-liquid microextraction and HPLC with electrochemical detection, the compounds were successfully detected in the thalamus of C57Bl/6J mice.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Alexander S. Hausl, Thomas Bajaj, Lea M. Brix, Max L. Pohlmann, Kathrin Hafner, Meri De Angelis, Joachim Nagler, Frederik Dethloff, Georgia Balsevich, Karl-Werner Schramm, Patrick Giavalisco, Alon Chen, Mathias Schmidt, Nils C. Gassen
Summary: The study revealed FKBP51 as a central node regulating the balance between autophagy and mTOR signaling in response to metabolic challenges. FKBP51 knockout induces obesity, while its overexpression protects against high-fat diet-induced obesity.
Article
Chemistry, Analytical
Meri De Angelis, Gandhari Maity-Kumar, Sonja C. Schriever, Elena Kozlova, Timo D. Mueller, Paul T. Pfluger, Margarita C. Curras-Collazo, Karl-Werner Schramm
Summary: The Allan-Herndon Dudley Syndrome (AHDS) is a rare disease caused by the progressive loss of monocarboxylate transporter 8 (MCT8). A new analytical method using liquid chromatography tandem mass-spectrometry (LC-MS/MS) was developed to measure thyroid hormone levels in mouse brains.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Substance Abuse
Ismet Cok, Irem Iyigundogdu
Summary: This review evaluates the existing literature on how COVID-19 has affected people's alcohol consumption, smoking, and vaping use in different societies. It was found that the pandemic may result in no alterations in substance use or lead to a decrease or quit attempt due to health concerns, or an increase in alcohol or cigarette consumption. The aim is to provide detailed information on the impact of the pandemic on substance use from various studies conducted globally and highlight the importance of further research on this topic.
JOURNAL OF SUBSTANCE USE
(2023)
Article
Environmental Sciences
Ersin Göl, Ismet Cok, Dilek Battal, Ayca Aktas Süküroglu
Summary: Pesticides are products developed to prevent, destroy, repel or control certain forms of plant or animal life that are considered to be pests. However, now they are one of the critical risk factors threatening the environment, and they create a significant threat to the health of children.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Environmental Sciences
Hongying Gao, Chuan Liu, Heng Wang, Heqing Shen
Summary: This study investigated the flocculation and/or sedimentation of polystyrene nano-plastics (PS-NPs) in salt solutions and protein solutions. The results showed that salt solutions significantly promoted the aggregation of PS-NPs, while protein-coated PS-NPs also aggregated. Moreover, 500 nm PS-CHO particles settled into sedimentation without flocculation. Therefore, Raman spectrometry is suitable for analyzing assembled PS-NPs but not normal PS-NPs.
Article
Biochemistry & Molecular Biology
Beril Altun, Ismet Cok, Cemal Onur Noyan, Ela Kadioglu, Alptekin Cetin, Tijen Sengezer, Merih Altintas, Samet Kurnaz, Nesrin Dilbaz
Summary: This population-based case-control study evaluated the genetic susceptibility to synthetic cannabinoid use disorder in the Turkish population. The results indicate that the CNR1, FAAH, and MGLL gene polymorphisms are not associated with the risk of synthetic cannabinoid use disorder in this population.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Review
Pharmacology & Pharmacy
Ismet Cok, Irem Iyigundogdu, Mesut Yildirim
Summary: The use of electronic cigarettes may increase the risk for critical complications of COVID-19 by causing airway inflammation and affecting lung health. E-cigarette users have a five times higher risk of COVID-19 infection compared to non-smokers, and even higher risk compared to tobacco users.
JOURNAL OF RESEARCH IN PHARMACY
(2021)
Article
Medicine, Research & Experimental
Jie Wei, Qiongyu Hao, Chengkun Chen, Juan Li, Xikui Han, Zhao Lei, Tao Wang, Yinan Wang, Xiang You, Xiaoxuan Chen, Huasheng Li, Yuxin Ding, Weihao Huang, Yangyang Hu, Shuirong Lin, Heqing Shen, Yi Lin
