Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Karen M. Puopolo, Jeffrey D. Horbar
Summary: This study investigated the epidemiology and microbiology of early-onset sepsis (EOS) among very preterm infants from 2018 to 2019. The findings revealed an incidence rate of 13.5 per 1000 very preterm births, with Escherichia coli and group B Streptococcus being the most common pathogens. Infected infants had longer hospital stays and lower survival rates, emphasizing the need for novel preventive strategies.
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Sarah A. Coggins, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study examines the epidemiology, microbiology, and outcomes of late-onset sepsis among very preterm infants in the United States. The findings reveal a significant proportion of infants suffering from late-onset sepsis, particularly those born at the lowest gestational ages. Infected infants have higher mortality rates and survivors are at increased risk of technology-dependent chronic morbidities.
Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Infectious Diseases
Zuzana Huncikova, Hans Jorgen Stensvold, Knut Asbjorn Alexander Oymar, Anlaug Vatne, Astri Maria Lang, Ragnhild Stoen, Anne Karin Brigtsen, Dag Moster, Beate Horsberg Eriksen, Terje Selberg, Arild Ronnestad, Claus Klingenberg
Summary: Despite similar rates of infection, there are wide variations in antibiotic use among very preterm infants in Norway. The overall antibiotic consumption decreased during the study period, but regional differences in the use of broad-spectrum beta-lactams and vancomycin remained.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Medicine, General & Internal
Sahar Sharif, Sam J. Oddie, Paul T. Heath, William McGuire
Summary: This review aims to evaluate the effectiveness of enteral supplementation with prebiotic oligosaccharides on the risk of necrotising enterocolitis, and associated morbidity and mortality, in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
Mathilde Letouzey, Laurence Foix-L'Helias, Heloise Torchin, Ayoub Mitha, Andrei S. Morgan, Jennifer Zeitlin, Gilles Kayem, Emeline Maisonneuve, Pierre Delorme, Babak Khoshnood, Monique Kaminski, Pierre-Yves Ancel, Pascal Boileau, Elsa Lorthe
Summary: The study found that the risk of late-onset sepsis in very preterm infants differs according to the cause of preterm birth, with infants born after hypertensive disorders or fetal growth restriction having a higher risk compared to those born after preterm labor. Antenatal factors, particularly the various causes leading to preterm birth, should be considered to better prevent and manage neonatal infectious morbidity and inform parents.
PEDIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Michaela Minarski, Christoph Maas, Christine Heinrich, Katrin A. Boeckmann, Wolfgang Bernhard, Anna Shunova, Christian F. Poets, Axel R. Franz, Steven Zeisel
Summary: Choline is essential for the development of infants, especially very low birth weight infants. However, the choline content in breast milk is lower after preterm delivery, and current formulas and fortified breast milk do not provide sufficient choline to achieve physiological concentrations. Increasing enteral choline intake is suggested to improve the growth and long-term development of very low birth weight infants.
Article
Pediatrics
Alicia J. Spittle, Deborah Dewey, Thi-Nhu-Ngoc Nguyen, Rachel Ellis, Alice Burnett, Amanda Kwong, Katherine Lee, Jeanie L. Y. Cheong, Lex W. Doyle, Peter J. Anderson
Summary: The study found that premature children had a higher risk of DCD throughout childhood compared to term-born children, despite a decrease in the proportion of DCD with age. At 13 years old, premature children with persistent DCD performed poorly in cognitive domains compared to those with typical motor development.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Noa Ofek Shlomai, Brian Reichman, Inna Zaslavsky-Paltiel, Liat Lerner-Geva, Smadar Eventov-Friedman
Summary: This study aimed to assess postnatal growth in infants with and without major neonatal morbidities. The results showed that despite advances in neonatal care, postnatal growth remains a challenge in very low birth weight infants, particularly those with major neonatal morbidities.
Article
Pediatrics
Olukemi O. Tongo, Macrine A. Olwala, Alison W. Talbert, Helen M. Nabwera, Abimbola E. Akindolire, Walter Otieno, Grace M. Nalwa, Pauline E. A. Andang'o, Martha K. Mwangome, Isa Abdulkadir, Chinyere V. Ezeaka, Beatrice N. Ezenwa, Iretiola B. Fajolu, Zainab O. Imam, Dominic D. Umoru, Ismaela Abubakar, Nicholas D. Embleton, Stephen J. Allen
Summary: Feeding practices for very preterm and VLBW infants vary widely within Nigeria and Kenya, likely due to the lack of locally generated evidence.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Erik A. Jensen, Erika M. Edwards, Lucy T. Greenberg, Roger F. Soll, Danielle E. Y. Ehret, Jeffrey D. Horbar
Summary: This study provides epidemiological data on very preterm infants born in the US based on severity-based diagnostic criteria for bronchopulmonary dysplasia (BPD). The study found that greater BPD severity was associated with more frequent development of major neonatal morbidities, in-hospital mortality, and use of supplemental respiratory support at discharge.
Article
Pediatrics
Marie Camerota, Elisabeth C. McGowan, Brian S. Carter, Jennifer Check, Lynne M. Dansereau, Sheri A. DellaGrotta, Jennifer B. Helderman, Julie A. Hofheimer, Charles R. Neal, T. Michael O'Shea, Steven L. Pastyrnak, Lynne M. Smith, Barry M. Lester
Summary: This study found that prenatal risk phenotypes are associated with neurobehavioral impairment in children born very preterm. Infants born to mothers in the psychological risk group had increased risk of dysregulated neurobehavior at discharge and motor delay and externalizing problems at 24 months. Infants born to mothers in the physical risk group had increased risk of motor delay at 24 months.
JOURNAL OF PEDIATRICS
(2023)
Article
Nursing
Leslie A. Parker, Sandra Sullivan, Nicole Cacho, Clara Engelmann, Charlene Krueger, Martina Mueller
Summary: The study compared three indicators for secretory activation in mothers of very low birth weight infants and found no correlation in the time to secretory activation between indicators. Earlier volume attainment was associated with increased milk production, and frequent expression in the first 5 days postpartum may promote earlier secretory activation.
JOURNAL OF HUMAN LACTATION
(2021)
Review
Medicine, General & Internal
Nor Rosidah Ibrahim, Hans Van Rostenberghe, Jacqueline J. Ho, Ariffin Nasir
Summary: The study found no significant differences in the time taken to achieve full feeding between two-hourly and three-hourly feeding intervals. However, there is insufficient information on potential feeding complications and the risk of NEC. No long-term data on neurodevelopment or growth were available.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
Coral L. Shuster, Stephen J. Sheinkopf, Elisabeth C. Mcgowan, Julie A. Hofheimer, T. Michael O'Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Cynthia Loncar, Lynne M. Dansereau, Sheri A. Dellagrotta, Carmen Marsit, Barry M. Lester
Summary: This study aimed to identify neonatal characteristics and 2-year neurodevelopmental outcomes associated with positive screening for risk of autism. The study found that infants with hypoaroused profiles and multiple medical morbidities were more likely to have a positive screening result. These positive screening results were associated with developmental and behavioral issues in the toddlers.
JOURNAL OF PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Sung Wook Kim, Lazaros Andronis, Anna-Veera Seppanen, Adrien M. Aubert, Henrique Barros, Elizabeth S. Draper, Mariane Sentenac, Jennifer Zeitlin, Stavros Petrou
Summary: This study aims to describe the health-related quality of life outcomes of children born very preterm and extremely preterm at five years of age, and explores the mediation effects of bronchopulmonary dysplasia and severe non-respiratory neonatal morbidity on those outcomes. The results suggest that extremely preterm birth and complications such as bronchopulmonary dysplasia and severe non-respiratory morbidity significantly impair health-related quality of life.
QUALITY OF LIFE RESEARCH
(2023)
Article
Urology & Nephrology
Chandana Guha, Anita van Zwieten, Rabia Khalid, Siah Kim, Amanda Walker, Anna Francis, Madeleine Didsbury, Armando Teixeira-Pinto, Belinda Barton, Chanel Prestidge, Emily Lancsar, Fiona Mackie, Joseph Kwon, Kirsten Howard, Kylie-Ann Mallitt, Martin Howell, Allison Jaure, Alison Hayes, Rakhee Raghunandan, Stavros Petrou, Suncica Lah, Steven McTaggart, Jonathan C. Craig, Germaine Wong
Summary: This multi-center longitudinal cohort study aimed to assess the trajectories of health-related quality of life (HRQoL) in children with chronic kidney disease (CKD) over time. The results showed that the HRQoL scores differed between children with different CKD stages, and the transition from dialysis to transplantation was significantly associated with the improvement in HRQoL. Children with CKD stage 1-5 and transplant recipients at baseline had stable HRQoL over time.
KIDNEY INTERNATIONAL
(2023)
Article
Economics
Corneliu Bolbocean, Sylvia van der Pal, Stef van Buuren, Peter J. Anderson, Peter Bartmann, Nicole Baumann, Jeanie L. Y. Cheong, Brian A. Darlow, Lex W. Doyle, Kari Anne Evensen, John Horwood, Marit S. Indredavik, Samantha Johnson, Neil Marlow, Marina Mendonca, Yanyan Ni, Dieter Wolke, Lianne Woodward, Erik Verrips, Stavros Petrou
Summary: This study aims to examine the associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. The results showed that VP/VLBW status is associated with lower overall health-related quality of life, particularly in terms of physical and cognitive functioning. Further studies are needed to estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood.
Article
Obstetrics & Gynecology
Melissa Amyx, Jennifer Zeitlin, Beatrice Blondel, Camille Le Ray
Summary: This study aimed to evaluate the association between gestational weight gain (GWG) and intrapartum obstetric interventions (oxytocin administration and cesarean section). The study found that excessive GWG was associated with oxytocin use and cesarean section, while inadequate GWG was also associated with oxytocin use. This suggests that maintaining a healthy GWG is important for normal labor progression.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Anne Ego, Isabelle Monier, Antoine Vilotitch, Gilles Kayem, Christophe Vayssiere, Eric Verspyck, Jennifer Zeitlin
Summary: Standardised longitudinal reporting of growth monitoring information did not improve antenatal detection of infants who are small for gestational age (SGA) compared to usual care.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Orthopedics
S. Petrou, M. E. Png, D. Metcalfe
Summary: Economic evaluation provides a framework for assessing costs and consequences of alternative interventions, and decision-analytic models are commonly used in healthcare for this purpose. This article discusses key issues in interpreting evidence from decision-analytic modeling-based economic evaluations of orthopedic interventions, providing guidance for readers, reviewers, and decision-makers.
BONE & JOINT JOURNAL
(2023)
Article
Pediatrics
Rym El Rafei, Rolf Felix Maier, Pierre Henri Jarreau, Mikael Norman, Henrique Barros, Patrick Van Reempts, Arno Van Heijst, Pernille Pedersen, Marina Cuttini, Samantha Johnson, Raquel Costa, Michael Zemlin, Elizabeth S. Draper, Jennifer Zeitlin
Summary: This study aimed to investigate whether extrauterine growth restriction (EUGR) during neonatal hospitalisation in extremely preterm infants is associated with cerebral palsy (CP) and cognitive and motor abilities at 5 years of age. The findings suggested that severe EUGR among extremely preterm infants was associated with decreased IQ at 5 years of age.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Clinical Neurology
Raquel Costa, Adrien M. Aubert, Anna-Veera Seppanen, Ulrika Aden, Iemke Sarrechia, Michael Zemlin, Marina Cuttini, Mairi Mannamaa, Veronique Pierrat, Arno van Heijst, Henrique Barros, Jennifer Zeitlin, Samantha Johnson
Summary: This study aimed to assess the accuracy of parent-reported gross motor impairment (GMI) at age 2 in predicting significant movement difficulties at age 5 in extremely preterm children. The results showed that parent reports of GMI at age 2 accurately classified movement difficulties at age 5 in most children. However, there were some cases where children with movement difficulties at age 5 were not identified at age 2.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Adrien M. Aubert, Raquel Costa, Samantha Johnson, Ulrika Aden, Veronique Pierrat, Marina Cuttini, Mairi Mannamaa, Iemke Sarrechia, Jo F. Lebeer, Arno F. F. Van Heijst, Rolf F. Maier, Mariane Sentenac, Jennifer Zeitlin
Summary: This study aimed to measure the association between cerebral palsy (CP) and non-CP-related movement difficulties and health-related quality of life (HRQoL) among 5-year-old children born extremely preterm. The results showed that children with CP and non-CP-related movement difficulties had lower HRQoL compared to children without movement difficulties. The decrease in HRQoL was more pronounced at lower centiles for children with non-CP-related movement difficulties.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Obstetrics & Gynecology
Olivia Anselem, Francois Goffinet, Pierre-Henri Jarreau, Jennifer Zeitlin, Isabelle Monier
Summary: This study in France investigated the management and survival of very preterm singletons born because of fetal growth restriction (FGR) with or without maternal hypertensive disorders. The results showed that the proportion of terminations of pregnancy (TOP) was higher when FGR was associated with hypertensive disorders, while the proportion of stillbirths was higher in isolated FGR.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Victoire Pauphilet, Francois Goffinet, Diane Korb, Jennifer Zeitlin, Heloise Torchin, Thomas Schmitz
Summary: This study evaluated the rate of mother-child separation in twin pregnancies delivered in maternity units offering an appropriate level of neonatal care. The study found that the rate of mother-child separation was 2.1%, and it differed by level of care in the maternity units.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Clinical Neurology
May Ee Png, Matthew L. Costa, Stavros Petrou, Juul Achten, Ruth Knight, Julie Bruce, David J. Keene
Summary: This study estimates the financial cost and pain medication use associated with neuropathic pain after lower limb fracture surgery. It found that healthcare costs were higher among patients with chronic neuropathic pain and opioids, rather than neuropathic pain medications, were commonly prescribed contrary to clinical guidelines.
BRITISH JOURNAL OF PAIN
(2023)
Article
Psychology, Developmental
Jennifer Larsen, Puja Kochhar, Dieter Wolke, Elizabeth S. Draper, Neil Marlow, Samantha Johnson
Summary: This study investigates whether the behavioral outcomes of extremely preterm (EP) children have changed over time with increasing survival rates. It compares the behavioral outcomes at age 11 for two national cohorts of EP children born in 1995 (EPICure) and 2006 (EPICure2), along with term-born children. The results show that EP children have higher mean scores and more clinically significant difficulties compared to term-born children in almost all measures. Furthermore, the behavioral outcomes for EP children born in 2006 are worse than those born in 1995. Long-term clinical follow-up and psychological support are needed for EP children.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Economics
Rakhee Raghunandan, Kirsten Howard, Sarah Smith, Anagha Killedar, Erin Cvejic, Martin Howell, Stavros Petrou, Emily Lancsar, Germaine Wong, Jonathan Craig, Alison Hayes
Summary: This study evaluated the psychometric properties of the PedsQL GCS and CHU9D in children and adolescents with common chronic health problems. Both instruments showed strong internal consistency, but weak convergent validity. Known group validity was demonstrated for PedsQL GCS, while CHU9D was only able to discriminate between certain health conditions.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)