Article
Agriculture, Multidisciplinary
Ever Hernandez-Olivas, Sara Munoz-Pina, Ana Andres, Ana Heredia
Summary: This study found that the extent of protein degradation during digestion of omelet was significantly reduced in elderly individuals, recommending hard-boiled and poached eggs for enhancing protein digestibility. Changes in gastrointestinal conditions did not significantly affect the absorbable lipid fraction or cholesterol stability, but there was a slight decrease in vitamin D3 bioaccessibility in the elderly.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Marta Coelho, Carla Oliveira, Ezequiel R. Coscueta, Joao Fernandes, Ricardo N. Pereira, Jose A. Teixeira, Antonio Sebastiao Rodrigues, Manuela E. Pintado
Summary: A nutrient-rich diet is important for improving chemical signals in the gut and preventing diseases. This study found that using OH technology for extraction can increase the recovery of bioactive compounds from tomato bagasse and have positive effects on health, such as antioxidant, anti-hypertensive, prebiotic, and anti-inflammatory properties. Additionally, this study demonstrated for the first time that tomato bagasse has anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Yang Liu, Shaozhan Chen, Qianyu Li, Liping Liu
Summary: Arsenic is enriched in wild edible fungi, which contribute significantly to the dietary intake of humans. This study investigated the changes in arsenic content and speciation in two wild edible fungi, Pleurotus citrinipileatus and Agaricus blazei Murill, after different cooking methods. The results showed that soaking plus stir-frying reduced the arsenic content by 55.4% and 72.9% in Pleurotus citrinipileatus and Agaricus blazei Murill, respectively. Furthermore, soaking plus boiling resulted in a reduction of arsenic content by 79.4% and 93.4% in the two fungi, respectively. The bioaccessibility of arsenic was found to be relatively high in uncooked, boiled, or stir-fried fungi, with gastric bioaccessibility ranging from 51.7% to 93.0% and gastrointestinal bioaccessibility ranging from 63.5% to 98.1%. The bioaccessibility of inorganic arsenic was as high as 94.6% to 151%, indicating the need for further evaluation of the potential health risks associated with wild edible fungi.
Article
Chemistry, Applied
Sibel Yagci, Rukiye Caliskan, Zeynep Saliha Gunes, Esra Capanoglu, Merve Tomas
Summary: The study found that incorporating tomato pomace powder into extruded snacks increased the content of phenolics and lycopene, with higher bioaccessibility. Snacks enriched with 10% TPP had acceptable physical and sensory properties.
Article
Food Science & Technology
Li Pan, Hua Li, Lifen Hou, Zhengang Chang, Yuanyuan Li, Xueqin Li
Summary: The whey protein isolate coated astaxanthin-loaded liposomes showed maintained particle shape and improved bioaccessibility during in vitro digestion, indicating potential applications in enhancing the stability and efficacy of astaxanthin in nutraceuticals and pharmaceutics.
Article
Biochemistry & Molecular Biology
Julia Teixe-Roig, Gemma Oms-Oliu, Isabel Odriozola-Serrano, Olga Martin-Belloso
Summary: The addition of alginate at different concentrations (0-1.5%) has significant effects on the digestion and stability of curcumin-loaded nanoemulsions. Results show that the addition of alginate can prevent curcumin degradation during digestion and improve the stability of the nanoemulsions. However, it also reduces lipid digestibility and curcumin bioaccessibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Sheliang Zhao, David Julian Mcclements, Xuebo Liu, Fuguo Liu
Summary: The low oral bioavailability of some bioactive ingredients is a challenge in the supplement and functional food areas. This study designs natural carriers that can simultaneously deliver both hydrophobic and hydrophilic bioactive ingredients, thereby increasing their ability to exert synergistic effects.
FOOD HYDROCOLLOIDS
(2024)
Article
Medicine, Research & Experimental
Inese Sarcevica, Bart Hens, Irena Tomaszewska, Mark McAllister
Summary: The TIM-1 gastrointestinal model is an advanced in vitro system used in the pharmaceutical industry for drug product design and biopredictive assessment. To enhance its utility, a computational tool called TIM-1 Data Explorer was developed to describe fluid and mass balance within the system. The tool was validated in two case studies, demonstrating its ability to accurately describe mass transfer events and dissolution and precipitation processes.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Xingming Li, Qian He, Genyi Zhang
Summary: The study showed that the physical form of torularhodin plays a significant role in its metabolic fate in the gastrointestinal tract, and designing the physical form of torularhodin or other nutraceuticals with health outcomes in mind can lead to the development of functional foods with enhanced health benefits.
Article
Food Science & Technology
Nitasha Thakur, Pinky Raigond, Sastry S. Jayanty, Gunjan Goel, Som Dutt, Brajesh Singh
Summary: The effect of processing method on the bioaccessibility of carbohydrates and polyphenolics in Indian potato varieties was investigated. Boiling and microwaving were found to break down starch to a high extent and increase the bioaccessibility of sugars. Microwaving also increased the release of polyphenolics. These findings suggest that microwaving is the best cooking method for maximizing bioaccessibility, but the high sugar content should be considered.
Article
Biochemistry & Molecular Biology
Hannah Oduro-Obeng, Franklin B. Apea-Bah, Kun Wang, Bin Xiao Fu, Trust Beta
Summary: The bioaccessibility and antioxidant activity of pasta made from refined semolina and whole wheat flour is significantly influenced by the wheat cultivar and cooking duration.
Article
Food Science & Technology
Marta C. Coelho, Tania B. Ribeiro, Carla Oliveira, Patricia Batista, Pedro Castro, Ana Rita Monforte, Antonio Sebastiao Rodrigues, Jose Teixeira, Manuela Pintado
Summary: This study compared the effects of different extraction methods on tomato byproducts, finding that the ohmic method resulted in higher fiber content but lower phenolic compounds and antioxidant activity compared to the conventional method. Additionally, the ohmic flours showed greater bioaccessibility and antioxidant capacity in a simulated gastrointestinal environment, indicating the potential of ohmic heating to enhance the bioactive properties of tomato byproducts.
Article
Food Science & Technology
Oya Irmak Sahin, Ayse Neslihan Dundar, Sebahat Ozdemir, Kubra Uzuner, Mahmud Ekrem Parlak, Adnan Fatih Dagdelen, Furkan Turker Saricaoglu
Summary: This study successfully encapsulated phycocyanin using lipid-based nano-carriers, called nano-phytosomes, to overcome the issues of low bioavailability and stability. The nano-phytosomes showed good characteristics and exhibited significant bioaccessibility in the intestinal tract.
Article
Medicine, Research & Experimental
Bart Hens, Inese Sarcevica, Irena Tomaszewska, Mark Mcallister
Summary: The TIM-1 model is an in vitro gastrointestinal simulator used to evaluate drug release in the body. The digital TIM-1 model has been shown to accurately reflect drug concentrations and bioaccessible fractions under different dietary conditions. Experimental and simulated data also indicate that the absence of stomach acid leads to a decrease in the bioaccessible fraction of drugs.
MOLECULAR PHARMACEUTICS
(2023)
Article
Agriculture, Dairy & Animal Science
Fayiz M. Reda, Mahmoud Madkour, Nafisa Abd El-Azeem, Osama Aboelazab, Sarah Y. A. Ahmed, Mahmoud Alagawany
Summary: The study demonstrated that supplementing Japanese quail breeders' diet with tomato pomace can significantly enhance immune response, antioxidant response, and digestive enzymes, decrease cholesterol and LDL, and increase HDL. The inclusion of tomato pomace positively affected the deposition of lycopene into the egg yolk, benefiting human health.
Article
Agronomy
Liang Zhang, Zhiyu Zhu, Fangfang Chen, Yueqing Zhu, Xiaocan Guo, Minjie Fu, Jiahong Chen, Jianguo Wu, Zhujun Zhu
Summary: In this study, distant hybridization between radish and kohlrabi was successfully achieved using tissue culture and chromosome doubling technology, resulting in the production of xBrassicoraphanus allotetraploids. The allotetraploid hybrids exhibited normal morphology and fertility, providing a basis for the production of new radish germplasm and serving as a bridge for gene transfer between Brassica and Raphanus vegetable species.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Article
Statistics & Probability
Ruiyu Xu, Jianguo Wu, Xiaowei Yue, Yongxiang Li
Summary: This article proposes an online structural change-point detection method for high-dimensional streaming data through dynamic sparse subspace learning and an efficient Pruned Exact Linear Time algorithm. The effectiveness of the method is demonstrated through simulation studies and a real case study.
Review
Chemistry, Multidisciplinary
Xiao-Fan Chen, Zhi-Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi-Feng Chen
Summary: Exposure to pollutants can cause damage to the eyes of aquatic organisms. Zebrafish is a commonly used model to study ocular toxicity and has shown morphological changes, retinal damage, and abnormalities in visual signal processes. The underlying mechanisms involve thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. This review discusses the phenotypes and signaling pathways associated with ocular toxicity from contaminants, detection methods, and a predictive model for potential ocular toxicity.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Environmental Sciences
Guangmei Wu, Guitao Shi, Chuanjin Li, Ye Hu, Hongmei Ma, Zhenlou Chen
Summary: During the 2015-2016 Chinese Antarctic Research Expedition, a study was conducted on Particulate-bound mercury (PBM) in the boundary layer. The study found a significant latitudinal gradient in PBM, with higher levels over the Northern Hemisphere influenced by both continental and oceanic sources. Over the Southern Ocean, PBM levels were extremely low, while elevated PBM was observed across the Antarctic Ice Sheet, particularly at Dome A. The study also revealed the role of inland Antarctic snow in influencing atmospheric PBM concentrations over the Antarctic coastal seas.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Geosciences, Multidisciplinary
Yongjie Wang, Guitao Shi, Danhe Wang, Qian Zhao, Su Jiang, Yangjie Li, Dongqi Wang, Chuanjin Li, Zhenlou Chen, Roberto Bargagli
Summary: This study investigated soil mercury levels in different areas of Antarctica and found a close relationship between mercury distribution and organic carbon content. The findings contribute to a better understanding of the biogeochemical cycle of mercury in Antarctic terrestrial ecosystems.
Article
Plant Sciences
Yan Wang, Wei Dong, Qin Zhang, Zhen-Peng Li, Yue-Xing Wang, Xiu-Fen Li, Long-Jiang Huang
Summary: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was developed, achieving a total yield of 34.5%, which is significantly higher than the previously reported process (11.0% total yield). The plausible ring-opening mechanism of the 6,19-epoxy bridge in compound 7 was proposed, and the structures of intermediates were confirmed by LC-MS analysis.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Alejandro Gallegos, Jianzhong Wu
Summary: In this work, a hierarchical method that incorporates liquid-state theories with the site-binding model is proposed to quantify the charging behavior of weak polyelectrolytes over a broad range of solution conditions.
Article
Engineering, Biomedical
Yuanrong Li, Jianguo Wu, Chuanjiang He, Honghui He, Mingjun Xie, Ke Yao, Jing He, Yan Duan, Liujing Zhaung, Ping Wang, Yong He
Summary: Many mammalian tissues have specific cellular arrangements under stress stimulus, but conventional 3D encapsulation fails to replicate these arrangements accurately, so advanced cellular arrangement approaches are needed. In this study, a novel 3D prestress bioprinting approach is developed, using static sustained tensile stress, molecular chain orientation, and slow crosslinking in bioink to guide tissue construction. The semi-crosslinking state of the bioink provides excellent elasticity for applying stress on cells during the printing process. After printing, the bioink gradually crosslinks and maintains the applied stress force to induce cell-orientated growth. This approach allows for directional arrangement of multiple cell types, with adjustable internal stress in the hydrogel filament, and has potential applications in engineering skeletal muscles, tendons, ligaments, vascular networks, or combinations thereof.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Environmental Sciences
Guanghui Zhao, Taihu Sun, Dongqi Wang, Shu Chen, Yan Ding, Yilan Li, Guitao Shi, Hechen Sun, Shengnan Wu, Yizhe Li, Chenyang Wu, Yufang Li, Zhongjie Yu, Zhenlou Chen
Summary: This study used stable isotopes to investigate the sources and transformation processes of nitrate in Suzhou Creek. The results showed that treated wastewater, soil nitrogen, and nitrogen fertilizer were the main sources of nitrate in the river. Reducing nitrate concentrations in treated wastewater is crucial for addressing nitrogen pollution in urban rivers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)