Review
Endocrinology & Metabolism
Marcela Moraes Mendes, Patricia Borges Botelho, Helena Ribeiro
Summary: Vitamin D is crucial for musculoskeletal health, enhancing calcium absorption and bone mineralization and promoting muscle function. However, low vitamin D levels can lead to bone loss and muscle weakness. There is a need for consistent data to establish realistic recommendations for vitamin D status, as there is currently a lack of consensus on thresholds for deficiency and optimal levels, as well as the best intake and supplementation strategies and the extra-skeletal effects of vitamin D.
ENDOCRINE CONNECTIONS
(2022)
Review
Biochemistry & Molecular Biology
Clara Crescioli
Summary: Skeletal muscle cells are finely controlled by vitamin D through genomic and non-genomic mechanisms, constantly undergoing cell remodeling to maintain tissue integrity. Vitamin D insufficiency promotes cell maladaptation, while restoring vitamin D levels can enhance myogenic programming.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Clara Crescioli
Summary: Vitamin D plays an important role in immune regulation and skeletal muscle cells. The status of vitamin D has significant effects on immune surveillance and health. Excessive exercise and vitamin D deficiency can lead to immune depression and increased vulnerability to diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Shohei Kuraoka, Masako Oda, Hiroshi Mitsubuchi, Kimitoshi Nakamura, Takahiko Katoh
Summary: There is a link between vitamin D deficiency and impaired height growth in young children, regardless of stature. Reduced outdoor activity, especially during winter, increases the risk of vitamin D deficiency.
Review
Endocrinology & Metabolism
John P. Bilezikian, Neil Binkley, Hector F. De Luca, Angelo Fassio, Anna Maria Formenti, Ghada El-Hajj Fuleihan, Annemieke C. Heijboer, Andrea Giustina
Summary: This work reviews and discusses controversial topics regarding vitamin D, SARS-CoV-2 infection, and COVID-19. The International Conferences Controversies in Vitamin D are workshops that started in 2017 and feature international experts and leaders in the field. The fifth annual conference was held in Stresa, Italy, in September 2021.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Joshua P. Sutherland, Ang Zhou, Elina Hypponen
Summary: This study used genetic methods to explore the causal relationship between vitamin D and skeletal muscle-related traits, as well as to investigate the potential pathophysiology of probable sarcopenia and sarcopenic obesity. The results suggested a causal relationship between vitamin D and skeletal muscle health, but a weaker association with the risk of sarcopenic obesity.
Article
Biochemistry & Molecular Biology
Luisa Pellegrino, Franca Marangoni, Giovanna Muscogiuri, Paolo D'Incecco, Guillaume T. Duval, Cedric Annweiler, Annamaria Colao
Summary: Vitamin D is crucial for bone health as well as overall health, but its deficiency is common worldwide. Fortifying food such as milk is recommended to address this issue and promote adequate intake of this essential vitamin.
Article
Medicine, General & Internal
Antonio Corsello, Giulia C. I. Spolidoro, Gregorio P. Milani, Carlo Agostoni
Summary: In recent years, researchers have focused on the potential role of vitamin D in various disorders, including autoimmune and infectious diseases. Although vitamin D deficiency remains a major public health problem, its symptomatic manifestations are becoming less common in clinical practice, particularly in pediatric age. However, there is a lack of consensus among clinicians regarding the definitions of deficiency and insufficiency, especially after the first year of life. This opinion paper aims to summarize recent evidence on vitamin D status and supplementation in pediatrics, in order to establish a common definition of deficiency and raise awareness among clinicians.
FRONTIERS IN MEDICINE
(2023)
Review
Nutrition & Dietetics
Miguel Agoncillo, Josephine Yu, Jenny E. Gunton
Summary: Vitamin D is strongly associated with skeletal muscle regeneration and function, with studies showing its role in regulating muscle cell growth and gene expression. Animal experiments and human studies support the benefits of vitamin D in muscle function and recovery, particularly in the elderly and post-operative patients. However, its role may be less significant in muscle/ligament tear repair.
Article
Nutrition & Dietetics
Jan Mieszkowski, Paulina Brzezinska, Blazej Stankiewicz, Andrzej Kochanowicz, Bartlomiej Niespodzinski, Joanna Reczkowicz, Tomasz Waldzinski, Bartlomiej Kacprzak, Natalia Siuba-Jarosz, Miroslav Petr, Jedrzej Antosiewicz
Summary: This study analyzed the impact of vitamin D supplementation on tryptophan metabolism in runners after an ultramarathon. The results showed that vitamin D supplementation can attenuate the increase in KPM levels and the decrease in tryptophan, tyrosine, and phenylalanine levels induced by exercise, indicating a regulatory role of vitamin D in exercise-induced metabolic changes.
Review
Physiology
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Summary: Vitamin D plays a crucial role in muscle regeneration and maintenance, protecting muscle structure and mitochondrial function, and promoting the activity of muscle stem cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Stephen P. Ashcroft, Gareth Fletcher, Ashleigh M. Philp, Carl Jenkinson, Shatarupa Das, Philip M. Hansbro, Philip J. Atherton, Andrew Philp
Summary: The study found that diet-induced vitamin D deficiency reduced skeletal muscle mitochondrial respiration in C57BL/6J mice, indicating a potential role of vitamin D in regulating muscle fatigue and performance deficits.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Glenville Jones
Summary: This article provides a unique perspective on the discovery of vitamin D and its deficiency disease, rickets, covering four distinct historical phases and highlighting major developments in the field.
ENDOCRINE CONNECTIONS
(2022)
Article
Nutrition & Dietetics
Lorena Villalba-Heredia, Cristina Comeras-Chueca, Alejandro Gonzalez-Aguero, Daniel Domingo-del-Val, Pilar Calmarza, German Vicente-Rodriguez, Jose A. Casajus, Angel Matute-Llorente
Summary: The study found no significant relationship between serum 25-hydroxyvitamin D and cardiorespiratory fitness parameters in prepubertal obese and overweight children. However, the cardiorespiratory fitness of these children was found to be relatively poor compared to normal-weight children.
Article
Endocrinology & Metabolism
Nina Lenherr-Taube, Edwin J. Young, Michelle Furman, Yesmino Elia, Esther Assor, David Chitayat, Tami Uster, Susan Kirwin, Katherine Robbins, Kathleen M. B. Vinette, Alan Daneman, Christian R. Marshall, Carol Collins, Kenneth Thummel, Etienne Sochett, Michael A. Levine
Summary: Mild idiopathic infantile hypercalcemia (IIH) is a common disorder in children with a distinctive vitamin D metabolite profile, primarily associated with heterozygous variants in SLC34A1 and SLC34A3. Most patients have common genetic variants, with only a minority showing variants in genes related to hypercalciuria.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)