Article
Cardiac & Cardiovascular Systems
Ryusuke Ae, Ryan A. Maddox, Joseph Y. Abrams, Lawrence B. Schonberger, Yosikazu Nakamura, Masanari Kuwabara, Nobuko Makino, Koki Kosami, Yuri Matsubara, Daisuke Matsubara, Teppei Sasahara, Ermias D. Belay
Summary: Detection of CALs at initial echocardiography in patients with KD was associated with younger age, delayed hospital visits, and having 3 or 4 principal KD signs. Timely diagnosis could be beneficial for patients, but those with specific risk factors were still at higher risk of CAL detection.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Computer Science, Interdisciplinary Applications
Haeyun Lee, Yongsoon Eun, Jae Youn Hwang, Lucy Youngmin Eun
Summary: This study aimed to validate a deep learning algorithm for distinguishing Kawasaki disease from other acute febrile diseases. The results showed that the algorithm performed well in terms of accuracy, specificity, and precision.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Marianna Fabi, Emanuele Filice, Laura Andreozzi, Bianca Elisa Mattesini, Alessia Rizzello, Daniela Palleri, Elton Dajti, Rocco Maurizio Zagari, Marcello Lanari
Summary: This study found that the combination of FC > 250 µg/g and z-score > 2 during the acute phase of Kawasaki Disease (KD) is associated with the persistence of coronary artery lesions (CALs). A z-score > 2 alone during the acute phase is not related to CALs during the subacute stage. Neutrophil percentage > 70% and WBC > 15,000/mmc during the acute phase significantly correlate with the presence of CALs during the subacute phase. C-reactive protein (CRP) > 13 mg/dL at KD onset is significantly associated with the presence of CALs during both the acute and subacute phase.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Hongying Shi, Fengfeng Weng, Chen Li, Zengyou Jin, Junyong Hu, Maoping Chu, Huixian Qiu
Summary: The study found that the prevalence of overweight/obesity among KD patients was 18.5%, and overweight/obesity was significantly associated with CAL. Some laboratory indices may modify this association.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Pediatrics
Maoling Yang, Qiongfei Pei, Jing Zhang, Haobo Weng, Fengchuan Jing, Qijian Yi
Summary: Kawasaki disease (KD) is an acute systemic vasculitis in children. Adropin, a new biopeptide, seems to be involved in the pathogenesis of KD and CALs. Serum adropin level can be used as an auxiliary diagnostic biomarker to predict CALs in children with KD.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Mindy Ming-Huey Guo, Ying-Hsien Huang, Feng-Sheng Wang, Ling-Sai Chang, Kuang-Den Chen, Ho-Chang Kuo
Summary: CD36 plays a crucial role in the immunopathogenesis of Kawasaki disease by clearing plasma mitochondrial DNA and amplifying the immune response via the AIM2 pathway. Additionally, the expression level of CD36 is associated with the development of coronary artery lesions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Chao Yang, Yinan Yang, Shuting Cao, Zhibin Ma, Hongmei Du, Jianjian Li, Feng Dou, Yini Zhao, Xiaomin Li, Xiaobin Hu
Summary: This study evaluated the predictive value of the monocyte-to-high-density lipoprotein ratio (MHR) in Kawasaki disease (KD) complicated with coronary artery lesions (CALs) and constructed a nomogram prediction model. The results showed that MHR has predictive value in predicting CALs in KD.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Ilaria Maccora, Giovanni Battista Calabri, Silvia Favilli, Alice Brambilla, Sandra Trapani, Edoardo Marrani, Gabriele Simonini
Summary: The study described the clinical and epidemiological characteristics of a Kawasaki syndrome cohort, identified risk factors for coronary artery lesions, and demonstrated the benign course of the syndrome with timely treatment in long-term follow-up over 36 years.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Hongbiao Huang, Jinfeng Dong, Shuhui Wang, Yueping Shen, Yiming Zheng, Jiaqi Jiang, Bihe Zeng, Xuan Li, Fang Yang, Shurong Ma, Ying He, Fan Lin, Chunqiang Chen, Qiaobin Chen, Haitao Lv
Summary: This study aimed to review and critically appraise prediction models for coronary artery lesions (CALs) in Kawasaki disease. The majority of the models used univariable logistic regression for model development, and the most commonly included predictors were C-reactive protein level, male sex, and fever duration. However, all studies had a high bias risk and were poorly effective in other populations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Jie Liu, Danyan Su, Piaoliu Yuan, Yuqin Huang, Bingbing Ye, Kaizhi Liang, Yusheng Pang
Summary: The Prognostic Nutritional Index (PNI) is a predictor for persistent coronary artery aneurysm (CAA) in patients with Kawasaki disease (KD). This study confirmed the correlation between PNI and CAA persistency, and suggested that PNI can be used to predict persistent CAA within two years.
FRONTIERS IN NUTRITION
(2023)
Article
Pediatrics
Dan Xu, Ye-Shi Chen, Chen-Hui Feng, Ai-Mei Cao, Xiao-Hui Li
Summary: This study aimed to identify risk factors for the progression of coronary artery lesions (CALs) in children with Kawasaki disease (KD) and developed a prediction model. Six independent factors associated with CALs progression were identified, and a prediction model with an accuracy of 81.7% was developed.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Lei Cao, Yun-Jia Tang, Miao Gang, Jin Ma, Wei-Guo Qian, Qiu-Qin Xu, Hai-Tao Lv
Summary: The study found that a lower AST/ALT ratio was associated with an increased risk of CALs on admission, but not with the development of new CALs after intravenous immunoglobulin (IVIG) treatment.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Alexandre Persu, Marilucy Lopez-Sublet, Abtehale Al-Hussaini, Marco Pappaccogli, Ibtissem Radhouani, Patricia van der Niepen, William Adair, Christophe Beauloye, Pierre-Yves Brillet, Nathan Chan, Patrick Chenu, Hannes Devos, Javier Escaned, Marcos Garcia-Guimaraes, Frank Hammer, Robert Jackson, Salma Jebri, Deevia Kotecha, Fernando Macaya, Ciara Mahon, Nalin Natarajan, Kandiyil Neghal, Edward D. Nicol, Kelly S. Parke, Diluka Premawardhana, Averachan Sajitha, Joanne Wormleighton, Nilesh J. Samani, Gerry P. McCann, David Adlam
Summary: In this study, the prevalence of FMD in patients with SCAD was found to be 31.8%, with involvement of multiple vascular beds also being common. However, the prevalence and degree of arterial tortuosity were similar in patients and controls. This suggests that extracoronary vascular events appear to be rare in SCAD patients.
Article
Cardiac & Cardiovascular Systems
Jie Chen, Jing Li, Yang-hua Yue, Yu Liu, Tian Xie, Jian-qiao Peng, Zhong-hua Deng, You-de Cao
Summary: This study aimed to evaluate the risk factors for coronary artery lesions in Kawasaki disease and construct a nomogram for predicting the likelihood of developing such lesions. The study found that IVIG resistance, delayed IVIG treatment, C-reactive protein, and neutrophil/lymphocyte ratio were independent risk factors for developing coronary artery lesions. The constructed nomogram demonstrated a strong and reliable performance in predicting coronary artery lesions, enabling clinicians to make timely and tailored clinical decisions.
CLINICAL CARDIOLOGY
(2023)
Article
Rheumatology
Jialei Chen, Ping Liu, Wenguang Hu, Yang Xu, Jia Deng
Summary: Facial nerve palsy (FNP) in Kawasaki disease is rare but may indicate an increased risk of coronary artery lesions (CALs). Patients tend to be young, with most cases showing unilateral FNP. Treatment with intravenous immunoglobulin therapy and follow-up showed complete recovery of both FNP and CALs in all patients. The occurrence of CALs was significantly higher in patients with FNP compared to those without FNP.
CLINICAL RHEUMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alessandra Bettiol, Giuseppe Lopalco, Giacomo Emmi, Luca Cantarini, Maria Letizia Urban, Antonio Vitale, Nunzio Denora, Antonio Lopalco, Annalisa Cutrignelli, Angela Lopedota, Vincenzo Venerito, Marco Fornaro, Alfredo Vannacci, Donato Rigante, Rolando Cimaz, Florenzo Iannone
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Rheumatology
Nienke M. Ter Haar, Charlotte Eijkelboom, Luca Cantarini, Riccardo Papa, Paul A. Brogan, Isabelle Kone-Paut, Consuelo Modesto, Michael Hofer, Nicolae Iagaru, Sarka Fingerhutova, Antonella Insalaco, Francesco Licciardi, Yosef Uziel, Marija Jelusic, Irina Nikishina, Susan Nielsen, Efimia Papadopoulou-Alataki, Alma Nunzia Olivieri, Rolando Cimaz, Gordana Susic, Valda Stanevica, Marielle van Gijn, Antonio Vitale, Nicolino Ruperto, Joost Frenkel, Marco Gattorno
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Editorial Material
Rheumatology
Rolando Cimaz, Teresa Giani, Roberto Caporali
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Review
Rheumatology
Teresa Giani, Anna Madera, Rolando Cimaz
CLINICAL RHEUMATOLOGY
(2020)
Article
Rheumatology
Nicolino Ruperto, Hermine Brunner, Nikolay Tzaribachev, Gabriel Vega-Cornejo, Ingrid Louw, Rolando Cimaz, Jason Dare, Graciela Espada, Enrique Faugier, Manuel Ferrandiz, Valeria Gerloni, Pierre Quartier, Clovis Artur Silva, Linda Wagner-Weiner, Yash Gandhi, Julie Passarell, Marleen Nys, Robert Wong, Alberto Martini, Daniel J. Lovell
Summary: In patients aged 2-17 years with pJIA, no evidence of association between higher levels of exposure to IV ABA or SC ABA and incidence of infection was observed.
JOURNAL OF RHEUMATOLOGY
(2021)
Editorial Material
Rheumatology
Teresa Giani, Maurizio Gattinara, Rolando Cimaz
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Review
Pediatrics
Stefania Costi, Teresa Giani, Francesco Orsini, Rolando Cimaz
Summary: Osteoporosis can affect young individuals, although it is rare. Bone mass increases during childhood and peaks between the second and third decades, then gradually declines. Various factors, such as genetic disorders, chronic illnesses, and certain medications, can impact bone health. Diagnosis in young patients is based on the criteria defined by the International Society for Clinical Densitometry (ISCD) in 2013. Identification and monitoring of high-risk factors are important. Simple interventions, such as addressing underlying causes, minimizing negative effects of medications on bone, or increasing calcium and vitamin D intake, can protect bone mass. Pharmacological treatment may be necessary in selected cases. Bisphosphonates are the main therapeutic agent for children with significant skeletal fragility and can also be used for other bone conditions. Denosumab, an anti-RANKL antibody, could be an alternative treatment option. Long-term effects and safety of denosumab in children are currently being evaluated in clinical trials.
Review
Acoustics
Orazio De Lucia, Teresa Giani, Roberto Caporali, Rolando Cimaz
Summary: This systematic review analyzed the predictive value of ultrasound (US) in assessing subclinical synovitis in juvenile idiopathic arthritis (JIA). The study found that US may have the potential to predict flare in JIA, but more research is needed to draw definitive conclusions.
MEDICAL ULTRASONOGRAPHY
(2022)
Article
Rheumatology
Sabrina Acierno, Francesca Angrisani, Achille Marino, Roberto Felice Caporali, Rolando Cimaz, Teresa Giani
Summary: CRMO is a bone inflammatory disorder characterized by osteolytic lesions, with no standardized therapies available. Treatment with an anti-IL-1 beta antibody may show promise in managing the condition.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
Marco Marinelli, Achille Marino, Gabriele Simonini, Rolando Cimaz, Teresa Giani
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
Edoardo Marrani, Gabriele Simonini, Eleonora Fusco, Ilaria Maccora, Anna Rosati, Rolando Cimaz, Teresa Giani
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
Vera Mars, Joost F. Swart, Gabriella Giancane, Sytze De Roock, Anne Estmann, Marija Jelusic, Estefania Moreno Ruzafa, Jaime de Inocencio, Jelena Vojinovic, Agustin Remesal, M. Laday, Rolando Cimaz, A. V. Cochino, Inmaculada Calvo, M. Harjacek, Nico Wulffraat, Nicolino Ruperto
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
T. Giani, F. Margheri, M. Del Rosso, L. Maggi, F. Annunziato, R. Cimaz
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Article
Medicine, General & Internal
M. C. Maggio, R. Cimaz, A. Alaimo, C. Comparato, D. Di Lisi, G. Corsello
JOURNAL OF MEDICAL CASE REPORTS
(2019)
Article
Immunology
Sietse Q. Nagelkerke, Carline E. Tacke, Willemijn B. Breunis, Michael W. T. Tanck, Judy Geissler, Eileen Png, Long T. Hoang, Joris van der Heijden, Ahmad N. M. Naim, Rae S. M. Yeung, Michael L. Levin, Victoria J. Wright, David P. Burgner, Anne-Louise Ponsonby, Justine A. Ellis, Rolando Cimaz, Chisato Shimizu, Jane C. Burns, Karin Fijnyandraat, C. Ellen van der Schoot, Timo K. van den Berg, Martin de Boer, Sonia Davila, Martin L. Hibberd, Taco W. Kuijpers, Nagib Dahdah, Isabelle Kone-Paut
FRONTIERS IN IMMUNOLOGY
(2019)