Article
Endocrinology & Metabolism
Clemens Kamrath, Sascha R. Tittel, Desiree Dunstheimer, Elke Froehlich-Reiterer, Markus Freff, Claudia Boettcher, Nadine Scheffler, Stefanie Lenze, Elke Gericke, Susanne Thiele, Reinhard W. Holl
Summary: The study aims to analyze whether the confirmation of coeliac disease can be postponed in children with new-onset type 1 diabetes and positive screening results.
Article
Nutrition & Dietetics
Anna Szaflarska-Poplawska, Aleksandra Dolinska, Magdalena Kusmierek
Summary: The aim of this study was to evaluate nutritional imbalances in children with coeliac disease (CD) on a strict gluten-free diet (GFD). The results showed that children with CD had lower levels of folic acid and vitamin B-1, lower calcium levels, and lower intake of calcium, folic acid, and vitamin D compared to dietary recommendations. However, their intake of proteins and carbohydrates exceeded the recommended levels. Additionally, a significantly higher number of CD children were classified as underweight.
Article
Gastroenterology & Hepatology
Anais Levescot, Georgia Malamut, Nadine Cerf-Bensussan
Summary: Coeliac disease is an immune enteropathy induced by genetic and environmental factors. The antigluten immune response and epithelial damage are key events in its pathogenesis, with the JAK/STAT pathway playing a crucial role. However, there are still many unanswered questions and challenges, such as the variability of the disease and improving the patients' quality of life.
Article
Nutrition & Dietetics
Marco Crocco, Angela Calvi, Paolo Gandullia, Federica Malerba, Anthea Mariani, Sonia Di Profio, Barbara Tappino, Stefano Bonassi
Summary: This study aimed to assess the Health-Related Quality of Life (HRQoL) of Italian children and their parents with coeliac disease using the Coeliac Disease Dutch Questionnaire (CDDUX). The Italian version of the CDDUX questionnaire was found to be a valid and reliable tool for evaluating HRQoL in children and adolescents with CD, showing significant differences in HRQoL among populations of different nationalities. The main clinical variable affecting HRQoL in both children and parents was found to be lower age.
Article
Pediatrics
Sara Sila, Mario Masic, Drazenka Kranjcec, Tena Niseteo, Lucija Maric, Ana Radunic, Iva Hojsak, Oleg Jadresin, Zrinjka Misak
Summary: A strict gluten-free diet is the only available treatment for coeliac disease, and this study found that patients with CD showed better compliance with dietary recommendations and nutrient intake compared to healthy controls. A well-balanced gluten-free diet can provide necessary nutrients.
Article
Chemistry, Analytical
Michael McFarlane, Ramesh P. Arasaradnam, Beryl Reed, Emma Daulton, Alfian Wicaksono, Heena Tyagi, James A. Covington, Chuka Nwokolo
Summary: Coeliac disease patients can be distinguished from healthy individuals through the analysis of urinary volatile organic compounds (VOCs). This analysis method can also be used to monitor dietary compliance in coeliac disease patients.
Article
Nutrition & Dietetics
Lorcan McGrogan, Mary Mackinder, Fiona Stefanowicz, Maria Aroutiounova, Anthony Catchpole, John Wadsworth, Elaine Buchanan, Tracey Cardigan, Hazel Duncan, Richard Hansen, Richard K. Russell, Christine A. Edwards, Dinesh Talwar, Paraic McGrogan, Konstantinos Gerasimidis
Summary: This study assessed the micronutrient status in children with CD at diagnosis and follow-up, finding that several micronutrient deficiencies in CD respond to a GFD but others need to be monitored long-term and supplemented where indicated.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Fernando Fernandez-Banares, Beatriz Arau, Agnes Raga, Montserrat Aceituno, Eva Tristan, Anna Carrasco, Laura Ruiz, Albert Martin-Cardona, Pablo Ruiz-Ramirez, Maria Esteve
Summary: This study showed that a gluten-free diet is effective in treating patients with FBD, especially in those with a positive low-grade coeliac score and coeliac lymphogram.
Article
Medicine, General & Internal
Anupam Rej, David S. Sanders
Summary: Coeliac disease is a common autoimmune-mediated gastrointestinal disorder with a prevalence of around 1%, but many cases remain undiagnosed. The cornerstone of management is strict adherence to a gluten-free diet with support and education from a gastrointestinal dietitian, sometimes requiring re-evaluation of symptoms and repeat biopsies. Refractory CD affects a small subset of individuals and requires specialist intervention.
Article
Nutrition & Dietetics
Hugo A. Penny, Anupam Rej, Elisabeth M. R. Baggus, Sarah. H. Coleman, Rosalie Ward, Graeme Wild, Gerd Bouma, Nick Trott, John A. Snowden, Josh Wright, Simon S. Cross, Marios Hadjivassiliou, David S. Sanders
Summary: This study characterized the causes of non-responsive coeliac disease (NRCD) and provided contemporary mortality data in refractory coeliac disease (RCD). The study also found a high frequency of positive urine gluten immunogenic peptides (GIPs) in patients with RCD1, suggesting common gluten exposure in this group.
Review
Nutrition & Dietetics
Iwona Kaliciak, Konstanty Drogowski, Aleksandra Garczyk, Stanislaw Kopec, Paulina Horwat, Pawel Bogdanski, Marta Stelmach-Mardas, Marcin Mardas
Summary: This study aimed to examine the changes in microbiota composition during a gluten-free diet in coeliac disease patients. The results showed that the abundance of Bifidobacterium was lower in CD patients on a gluten-free diet compared to healthy individuals and untreated CD patients, while the abundance of Bacteroides was higher in CD patients on a gluten-free diet.
Review
Gastroenterology & Hepatology
Pilvi Laurikka, Laura Kivela, Kalle Kurppa, Katri Kaukinen
Summary: The systemic consequences of coeliac disease have a significant impact on the overall health of patients, affecting multiple organ systems including skeletal, reproductive, cardiovascular, and neurological systems. Early diagnosis and treatment with a gluten-free diet are beneficial for most conditions, but potential negative metabolic and psychosocial effects should be considered.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Nutrition & Dietetics
Mohammad Rostami-Nejad, Nastaran Asri, Meysam Olfatifar, Babak Khorsand, Hamidreza Houri, Kamran Rostami
Summary: This study investigated the association between different gluten doses administered and the risk of coeliac disease (CD) relapse. It found that even a very low dose of gluten can lead to CD relapse and the duration of gluten exposure is also an important factor. More randomized clinical trials are needed to confirm these findings.
Review
Nutrition & Dietetics
Anna Szaflarska-Poplawska
Summary: Potential celiac disease (PCD) is a heterogeneous disease with few accurate prognostic factors for progression. Therapeutic decisions should be individualized, and patients with clinical gastroenterological symptoms may benefit from a gluten-free diet.
Article
Gastroenterology & Hepatology
Marta Garzon-Benavides, Angela Ruiz-Carnicer, Veronica Segura, Blanca Fombuena, Francisco Garcia-Fernandez, Salvador Sobrino-Rodriguez, Lourdes Gomez-Izquierdo, Marco Antonio Montes-Cano, Raquel Millan-Dominguez, Maria del Carmen Rico, Carmen Gonzalez-Naranjo, Juan Manuel Bozada-Garcia, Cristobal Coronel-Rodriguez, Beatriz Espin, Jacobo Diaz, Isabel Comino, Federico Arguelles-Arias, Angel Cebolla, Manuel Romero-Gomez, Alfonso Rodriguez-Herrera, Carolina Sousa, Angeles Pizarro-Moreno
Summary: This study analyzed the effects of gluten exposures on coeliac patients following a gluten-free diet for at least 24 months. The results showed that regular monitoring of urinary gluten immunogenic peptides (u-GIP) can accurately detect gluten transgressions and more frequent follow-up visits provide useful data for assessing adherence to the diet and mucosal healing.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pediatrics
Giulia M. Martone, Heather K. Lehman, Todd C. Rideout, Divya Choudhary, Claire E. Cameron, Emily Oken, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Diane R. Gold, Xiaozhong Wen
Summary: The study found that children who had delayed introduction of eggs after 12 months had a significantly higher risk of egg allergy at 2 years and the risk persisted into early adolescence at 12 years. This suggests that introducing eggs before 12 months could help prevent egg allergy.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Critical Care Medicine
Brandon-R. Bedell, Krislyn-M. Boggs, Janice-A. Espinola, Ashley-F. Sullivan, Kohei Hasegawa, Margaret Samuels-Kalow, Kori -S. Zachrison, Carlos-A. Camargo Jr
Summary: There are discrepancies between trauma center certifications in the U.S., with many states maintaining unique certification systems. This study investigates the similarity between the national trauma certification program established by the American College of Surgeons (ACS) and state certifications, and creates a unified national trauma center database.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Nutrition & Dietetics
Raphaelle Varraso, Orianne Dumas, Fred K. Tabung, Krislyn M. Boggs, Teresa T. Fung, Frank Hu, Edward Giovannucci, Frank E. Speizer, Walter C. Willett, Carlos A. Camargo
Summary: This study aimed to determine if adherence to a healthful plant-based diet is associated with a lower risk of COPD, while adherence to an unhealthful plant-based diet is associated with a higher risk of COPD. Findings showed that participants with the highest hPDI score had a 46% lower risk of COPD, while those with the highest uPDI score had a 39% higher risk of COPD.
Article
Allergy
Rachel L. Miller, Holly Schuh, Aruna Chandran, Izzuddin M. Aris, Casper Bendixsen, Jeffrey Blossom, Carrie Breton, Carlos A. Camargo Jr, Glorisa Canino, Kecia N. Carroll, Sarah Commodore, Jose F. Cordero, Dana M. Dabelea, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, James E. Gern, Frank D. Gilliland, Diane R. Gold, Rima Habre, Marion E. Hare, Robyn N. Harte, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Daniel J. Jackson, Christine Joseph, Jean M. Kerver, Haejin Kim, Augusto A. Litonjua, Carmen J. Marsit, Cindy McEvoy, Eneida A. Mendonca, Paul E. Moore, Flory L. Nkoy, Thomas G. O'Connor, Emily Oken, Dennis Ownby, Matthew Perzanowski, Katherine Rivera-Spoljaric, Patrick H. Ryan, Anne Marie Singh, Joseph B. Stanford, Rosalind J. Wright, Robert O. Wright, Antonella Zanobetti, Edward Zoratti, Christine C. Johnson
Summary: This study found that the incidence rates of asthma with recurrent exacerbations (ARE) are influenced by time, geography, age, race and ethnicity, sex, and parental history. Children aged 2-4 years, Hispanic Black and non-Hispanic Black children, and those with a parental history of asthma had the highest rates of ARE.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Michihito Kyo, Zhaozhong Zhu, Ryohei Shibata, Michimasa Fujiogi, Jonathan M. Mansbach, Carlos A. Camargo, Kohei Hasegawa
Summary: This study identified specific nasopharyngeal lipids that can differentiate between respiratory syncytial virus (RSV) and rhinovirus (RV) bronchiolitis in infants. These lipids, including phosphatidylcholine (18:2/18:2), dihydroceramide (16:0), and eicosapentaenoic acid, are also associated with the severity of bronchiolitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Heidi Makrinioti, Zhaozhong Zhu, Carlos A. Camargo, Valentina Fainardi, Kohei Hasegawa, Andrew Bush, Sejal Saglani
Summary: Obesity-related asthma in childhood is a heterogeneous phenotype, with prevalence increasing. Observational studies have found that early-life obesity or weight gain are risk factors for childhood asthma development, and the reverse association is also described. Obese children with asthma have poorer symptom control and more asthma attacks compared to non-obese children with asthma. Clinical trials have found that some obese children with asthma do not respond well to usual treatment.
Letter
Medicine, General & Internal
Christopher L. Bennett, Krislyn M. Boggs, Cameron J. Gettel, Wendy W. Sun, Arjun K. Venkatesh, Carlos A. Camargo
Article
Emergency Medicine
Son H. McLaren, Ying Shelly Qi, Janice A. Espinola, Jonathan M. Mansbach, Peter S. Dayan, Carlos A. Camargo
Summary: This article aims to identify characteristics associated with mild bronchiolitis in infants <= 90 days old. The results show that older age (61-90 days), adequate oral intake, and oxygen saturation >= 94% are factors associated with mild bronchiolitis.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2023)
Article
Emergency Medicine
Scott A. Goldberg, Emma Chadwick, Supriya Makam, Hridaya J. Shah, Michelle B. Bass, Mohammad A. Hasdianda, Gregory Peters, Carlos A. Camargo Jr, Rebecca E. Cash
Summary: Since the publication of the National EMS Research Agenda in 2001, there has been an increase in EMS-specific research and NIH-funded grants. EMS-related publications have tripled and the number of funded EMS research grants has nearly quintupled in the United States over the past 20 years.
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Medical Informatics
Jeffrey A. Kline, Brian Reed, Alex Frost, Naomi Alanis, Meylakh Barshay, Andrew Melzer, James W. Galbraith, Alicia Budd, Amber Winn, Eugene Pun, Carlos A. Camargo Jr
Summary: This study describes the development and operation of a national network dedicated to surveillance of acute respiratory infections in emergency departments, providing a valuable public health resource for monitoring the epidemiology, viral causes, and outcomes of ED patients with ARIs.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Virology
Yury A. Bochkov, Mark Devries, Kaitlin Tetreault, Ronald Gangnon, Sujin Lee, Leonard B. Bacharier, William W. Busse, Carlos A. Camargo, Timothy Choi, Robyn Cohen, Ramyani De, Gregory P. DeMuri, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn Kercsmar, Haejin Kim, Ingrid A. Laing, Peter N. Le Souef, Andrew H. Liu, David T. Mauger, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Robert F. Lemanske, Daniel J. Jackson, James E. Gern
Summary: This study examined cross-neutralization reactions and antibody duration of rhinovirus type A (RV-A) and type C (RV-C). The results showed limited cross-neutralization reactions between the two types, which are limited to genetically similar strains. However, the duration of antibody response during childhood is similar for both types.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Christopher L. Bennett, Allan S. Detsky, Carson E. Clay, Janice A. Espinola, Julie Parsonnet, Carlos A. Camargo
Summary: This study found that emergency departments (EDs) in HIV priority jurisdictions in the United States serve populations emphasized in HIV-related efforts, such as Black or African American or Hispanic or Latino populations, as well as communities with higher proportions uninsured and living in poverty, and higher rates of chlamydia, gonorrhea, and syphilis. EDs with teaching hospital affiliations had the highest visit volumes and steady growth. The findings suggest that geographically targeted screening in EDs with a teaching hospital affiliation could efficiently reach vulnerable populations and reduce the burden of undiagnosed HIV in the US.
Article
Cardiac & Cardiovascular Systems
Geneva D. Mehta, Anna Chen Arroyo, Zhaozhong Zhu, Janice A. Espinola, Jonathan M. Mansbach, Kohei Hasegawa, Carlos A. Camargo Jr
Summary: The history of severe bronchiolitis in infancy is associated with decreased lung function at the age of 6, potentially increasing the risk of chronic respiratory illnesses in the future.
RESPIRATORY MEDICINE
(2023)
Article
Pediatrics
Songpon Getsuwan, Ekawat Pasomsub, Pichet Yutthanakarnwikom, Chutatip Tongsook, Napapat Butsriphum, Pornthep Tanpowpong, Pareena Janchompoo, Suporn Treepongkaruna, Chatmanee Lertudomphonwanit
Summary: This study conducted in Thailand found that hepatitis E virus (HEV) infection is endemic in Southeast Asia and is associated with chronic infection after pediatric liver transplantation. The seroprevalence of HEV IgG and IgM was 15% and 4%, respectively. The presence of HEV IgM was associated with a history of elevated transaminases within 6 months. Two patients were diagnosed with chronic HEV infection and responded well to ribavirin treatment.
JOURNAL OF TROPICAL PEDIATRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tanapong Panpikoon, Tharintorn Treesit, Chinnarat Bua-Ngam, Sasikorn Feinggumloon, Kaewpitcha Pichitpichatkul, Apichaya Sriprachyakul, Satita Aimprasittichai, Apinya Chimcherd, Chollasak Thirapattaraphan, Chatmanee Lertudomphonwanit, Pornthep Tanpowpong
Summary: The purpose of this study was to evaluate the duplex US findings of vascular complications in pediatric liver transplant (LT) patients and determine helpful secondary signs for early detection. The study found that extrahepatic peak systolic velocity (PSV) was associated with hepatic artery (HA) complications, while non-significantly decreased intrahepatic resistive index (RI) and PSV may correlate with the occurrence of vascular complications.
JOURNAL OF ULTRASOUND
(2023)