Article
Environmental Sciences
Anteneh Assefa Desalegn, Nina Iszatt, Hein Stigum, Tina K. Jensen, Merete Eggesbo
Summary: Perinatal exposure to PCB-74, PCB-114, PCB-194, and beta-HCH in breast milk was associated with increased odds of congenital cryptorchidism in male infants. However, the associations of most PCB congeners with cryptorchidism may be confounded by co-exposure to other highly correlated chemicals. Experimental studies are needed to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
Daniel Lindbo, Linn Hakonsen Arendt, Andreas Ernst, Lea Lykke Harrits Lunddorf, Nis Brix, Cecilia Host Ramlau-Hansen
Summary: This study investigated the association between cigarette smoking during pregnancy and the risk of two genital anomalies (cryptorchidism and hypospadias) using Danish register-based data. The study found that boys exposed to cigarette smoking had a higher risk of cryptorchidism and a lower risk of hypospadias. The findings from sibling-matched analyses were consistent with the results from the cohort study.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Miguel A. Sanchez-Lastra, Ding Ding, Knut-Eirik Dalene, Borja del Pozo Cruz, Ulf Ekelund, Jakob Tarp
Summary: Regular stair climbing, especially climbing more than five flights per day at home, is associated with a lower risk of premature all-cause and cancer mortality. However, it does not show significant impact on cardiovascular disease mortality. These findings suggest that at-home stair climbing alone may not be sufficient to reduce the risk of premature death.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Critical Care Medicine
Marya D. Zilberberg, Brian H. Nathanson, Laura A. Puzniak, Andrew F. Shorr
Summary: Study in a large U.S. database explored the epidemiology and outcomes of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Findings revealed that patients with ventilated hospital-acquired bacterial pneumonia had the highest mortality rate, while ventilator-associated bacterial pneumonia incurred the highest costs.
CRITICAL CARE MEDICINE
(2022)
Article
Pediatrics
Paul Krogstad, Deisy Contreras, Hwee Ng, Nicole Tobin, Christina D. Chambers, Kerri Bertrand, Lars Bode, Grace M. Aldrovandi
Summary: This study found that SARS-CoV-2 RNA can be detected in breastmilk after recent infection, but there is no evidence of the presence of infectious virus. Breastfeeding does not appear to be a risk factor for transmitting the infection to infants.
PEDIATRIC RESEARCH
(2022)
Article
Respiratory System
Hanna Creese, Eric Lai, Kate Mason, Daniela K. Schlueter, Sejal Saglani, David Taylor-Robinson, Sonia Saxena
Summary: The study found through causal mediation analysis that perinatal characteristics and early home environment factors are more important in explaining socioeconomic inequalities in persistent asthma in British adolescents.
Article
Behavioral Sciences
Johan Zelano, Mikael Dellborg, Peter Eriksson, Zacharias Mandalenakis
Summary: This study from Sweden found that patients with congenital heart disease (CHD) have a nearly fourfold increased risk of epilepsy compared to controls, although the absolute risk is low. Among patients with CHD, several brain comorbidities, including intellectual disability and stroke, as well as having undergone more than two cardiac interventions, were significantly associated with epilepsy.
BRAIN AND BEHAVIOR
(2022)
Article
Medicine, General & Internal
Ruth J. Matthews, Elizabeth S. Draper, Bradley N. Manktelow, Jennifer J. Kurinczuk, Alan C. Fenton, Jacqueline Dunkley-Bent, Ian Gallimore, Lucy K. Smith
Summary: Stillbirth rates in the UK have decreased, but babies of black and Asian ethnicities still face higher risks. There are larger differences in stillbirth rates for black African, black Caribbean, and Pakistani babies compared to white babies. Additionally, babies from the most deprived areas, including Bangladeshis, black Africans, other black ethnicities, and black Caribbeans, have higher stillbirth risks. The main causes of stillbirths are congenital anomalies and placental causes, and a significant proportion of stillbirths remain unexplained, particularly among other Asian, Bangladeshi, and Indian babies.
Article
Medicine, General & Internal
Mitana Purkayastha, Stephen A. Roberts, Julian Gardiner, Daniel R. Brison, Scott M. Nelson, Deborah Lawlor, Barbara Luke, Alastair Sutcliffe
Summary: A large cohort of ART children, their NCS, and matched NCP controls were studied to explore the effects of ART. The study found that infants born after fresh embryo transfers were lighter, while those born after frozen embryo transfers were heavier than NCP controls.
Article
Medicine, General & Internal
Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee, Catherine A. O'Donnell
Summary: This study found that both functional and structural components of social connection are independently associated with mortality. It also suggests that the beneficial associations for some types of social connection might not be felt when other types of social connection are absent. Additionally, individuals who live alone with additional structural markers of isolation may represent a high-risk population.
Article
Dermatology
Richard B. Warren, Victoria Basey, Anita Lynam, Charlotte Curtis, Michael R. Ardern-Jones
Summary: A UK study found that people with atopic dermatitis (AD) have a 30% higher risk of deep-vein thrombosis and a 17% higher risk of venous thromboembolism (VTE). The increased VTE risk is lower in younger individuals and those without obesity. Identifying AD patients at higher VTE risk could impact clinical decision-making.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Adel S. Alhlayl, Haitham A. Alzghaibi, Qazi Mohammad Sajid Jamal
Summary: This study examined the current trends in medicines used by people with Multiple Sclerosis in the UK MS register. The results showed that disease modifying drugs (DMDs), muscle relaxants, and anticonvulsants were the most commonly used medicine types by people with MS. The study also identified amitriptyline as a subject medicine for further investigation due to its high frequency use and the high online content related to it.
Article
Medicine, General & Internal
Shabina Hayat, Robert Luben, Kay-Tee Khaw, Nicholas Wareham, Carol Brayne
Summary: This study aims to evaluate the characteristics of individuals recorded as having a dementia diagnosis in different routinely collected records and to examine the extent of overlap of dementia coding across data sources. The findings suggest that there are differences in recorded dementia diagnosis in different parts of the NHS system, indicating variations in identifying dementia to varying extents. However, there is considerable variation and limited overlap in those identified. Researchers must be aware of potential biases and inaccuracies when using routinely collected health data from different sources and report carefully on the limitations and challenges of the data they use.
Article
Critical Care Medicine
Shinya Miura, Nobuaki Michihata, Yohei Hashimoto, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Summary: This study aimed to describe the mortality, timing, and risk factors in children with community-acquired septic shock. The study found that children with community-acquired septic shock had high mortality, and early death was common. These findings suggest the need to enhance the quality of initial resuscitation for sepsis in low-volume hospitals and ensure a healthcare system in which children with sepsis can be treated in accredited intensive care units.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Respiratory System
Sara De Matteis, Debbie Jarvis, Lucy Darnton, Dario Consonni, Hans Kromhout, Sally Hutchings, Steven S. Sadhra, David Fishwick, Roel Vermeulen, Lesley Rushton, Paul Cullinan
Summary: This large population-based study found an association between occupational exposure to pesticides and risk of COPD. The risk was particularly pronounced among non-smokers and individuals without asthma.
Article
Obstetrics & Gynecology
Shelley Macaulay, Eckhart J. Buchmann, David B. Dunger, Shane A. Norris
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Endocrinology & Metabolism
Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
PEDIATRIC DIABETES
(2019)
Article
Obstetrics & Gynecology
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, Carlo L. Acerini, David B. Dunger
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2019)
Article
Endocrinology & Metabolism
Clive J. Petry, Benjamin G. Fisher, Ken K. Ong, Ieuan A. Hughes, Carlo L. Acerini, David B. Dunger
ACTA DIABETOLOGICA
(2019)
Article
Endocrinology & Metabolism
M. Loredana Marcovecchio, R. Neil Dalton, Denis Daneman, John Deanfield, Timothy W. Jones, Andrew W. Neil, David B. Dunger, C. Acerini, F. Ackland, B. Anand, T. Barrett, V. Birrell, F. Campbell, M. Charakida, T. Cheetham, T. Chiesa, J. Deanfield, C. Cooper, I. Doughty, A. Dutta, J. Edge, A. Gray, J. Hamilton-Shield, N. Mann, M. L. Marcovecchio, S. Marshall, G. Rayman, J. M. Robinson, M. Russell-Taylor, V. Sankar, A. Smith, N. Thalange, C. Yaliwal, P. Benitez-Aguirre, F. Cameron, A. Cotterill, J. Couper, M. Craig, E. Davis, K. Donaghue, T. W. Jones, B. King, C. Verge, P. Bergman, C. Rodda, C. Clarson, J. Curtis, D. Daneman, F. Mahmud, E. Sochett
NATURE REVIEWS ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Veena Mazarello Paes, Jessica K. Barrett, David C. Taylor-Robinson, Heather Chesters, Dimitrios Charalampopoulos, David B. Dunger, Russell M. Viner, Terence J. Stephenson
PEDIATRIC DIABETES
(2019)
Article
Endocrinology & Metabolism
Anna Prats-Puig, Silvia Xargay-Torrent, Gemma Carreras-Badosa, Berta Mas-Pares, Judit Bassols, Clive J. Petry, Michael Girardot, Francis D. E. Zegher, Lourdes Ibanez, David B. Dunger, Robert Feil, Abel Lopez-Bermejo
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Review
Endocrinology & Metabolism
David Dunger, Feyza Darendeliler, Nurgun Kandemir, Mark Harris, Ali Rabbani, Anne-Marie Kappelgaard
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Veena Mazarello Paes, Jessica K. Barrett, David B. Dunger, Evelien F. Gevers, David C. Taylor-Robinson, Russell M. Viner, Terence J. Stephenson
PEDIATRIC DIABETES
(2020)
Article
Medicine, General & Internal
Charlotte Boughton, Janet M. Allen, Martin Tauschmann, Sara Hartnell, Malgorzata E. Wilinska, Gianluca Musolino, Carlo L. Acerini, David Dunger, Fiona Campbell, Atrayee Ghatak, Tabitha Randell, Rachel Besser, Nicola Trevelyan, Daniela Elleri, Elizabeth Northam, Korey Hood, Eleanor Scott, Julia Lawton, Stephane Roze, Judy Sibayan, Craig Kollman, Nate Cohen, John Todd, Roman Hovorka
Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Clive J. Petry, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study found variable associations of DR3, DR4, and DQ8 alleles with growth measures and IGF-I levels in infants from the general population, which could explain the heterogeneous growth trajectories observed in genetically at-risk cohorts. These findings suggest distinct mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes risk.
Article
Nutrition & Dietetics
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, David B. Dunger
Summary: Iron supplementation during pregnancy was found to be associated with an increased risk of developing GDM and impacting offspring birth weight and adiposity. These findings suggest that iron supplementation may mediate the effects of multiple micronutrient supplementation during pregnancy in a high-income country.
Article
Nutrition & Dietetics
Laurentya Olga, Clive J. Petry, Janna A. van Diepen, Philippa M. Prentice, Ieuan A. Hughes, Jacques Vervoort, Jos Boekhorst, Maciej Chichlowski, Gabriele Gross, David B. Dunger, Ken K. Ong
Summary: The study aims to investigate the impact of early growth and nutrition on future health and metabolic risks through long-term observation and data collection of 2229 mother-infant pairs. Strict inclusion criteria were applied, only retaining exclusively breastfed infants meeting the requirements for analysis.
Article
Endocrinology & Metabolism
Robert Moulder, Tommi Valikangas, M. Karoliina Hirvonen, Tomi A. Suomi, Caroline A. Brorsson, Niina Lietzen, Sylvaine F. A. Bruggraber, Lut Overbergh, David B. Dunger, Mark Peakman, Piotr J. Chmura, Soren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa
Summary: There is a growing need for markers that could indicate the decline in beta cell function in type 1 diabetes. This study evaluated a panel of proteins in serum from newly diagnosed individuals and found associations between certain proteins and beta cell function. The findings suggest that these proteins may be useful in future studies of beta cell function in type 1 diabetes.
Article
Nutrition & Dietetics
Clive J. Petry, Ken K. Ong, Ieuan A. Hughes, David B. Dunger