Article
Radiology, Nuclear Medicine & Medical Imaging
Huseyin Bilgin, Ercan Ayaz
Summary: By examining radiographs of children with mucopolysaccharidosis, early diagnosis can be achieved before clinical symptoms become prominent. Therefore, X-ray screening of children in endemic regions of mucopolysaccharidosis is feasible.
Article
Veterinary Sciences
Mirabela Oana Dumitrache, Adriana Gyorke, Gianluca D'Amico, Viorica Mircean
Summary: This case report describes a clinical case of a 14-month-old cat with dermatitis linked to L. gibbus, which is the first report of L. gibbus-related dermatitis in cats. L. gibbus infestation should be considered as a possible differential diagnosis of pruritic skin conditions in cats.
BMC VETERINARY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lauri Weman, Henri Salo, Laura Kuusalo, Johanna Huhtakangas, Johanna Karki, Paula Vahasalo, Maria Backstrom, Tuulikki Sokka-Isler
Summary: The study aims to assess the joint distribution and clinical presentation of rheumatoid arthritis (RA) in seropositive and negative patients at the initial stage, as well as the impact of symptom duration on the clinical picture. The results showed that symmetrical swelling was observed in 75% of the patients. Seronegative patients had higher values for disease activity measures and patient reported outcomes (PROs) compared to seropositive patients. Patients diagnosed within three months had more severe pain and functional impairment, while those diagnosed after six months were more likely to be ACPA-positive.
Article
Microbiology
N. V. V. Jouppila, J. Lehtonen, E. Seppala, L. Puustinen, S. Oikarinen, O. H. Laitinen, M. Knip, H. Hyoty, V. P. Hytonen
Summary: This study demonstrates the use of a customizable multiplexed assay based on structural and nonstructural enterovirus proteins to study antibody responses in a cohort of 58 children from birth to 3 years of age. The study reveals that declining maternal antibody levels can obscure the serological detection of enteroviruses before the age of six months and highlights the potential of antibody responses to nonstructural enterovirus proteins as interesting targets for serodiagnosis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Haya Abdulkarim, Mohamed Siaj
Summary: Researchers have developed an electrochemical immunosensor for the multiplexed detection of GAA, GBA and GALC. The sensor showed good selectivity, sensitivity and recovery, and successfully detected these substances at the femtomolar level. The results of this study suggest that the sensor holds promise for the early diagnosis of LSDs.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Salvatore Citraro, Michael S. Vitevitch, Massimo Stella, Giulio Rossetti
Summary: This article introduces a new framework called FERMULEX, which combines network structure and word vector features for unprecedented exploration of cognitive knowledge. By using FERMULEX networks to model language acquisition in 1000 toddlers aged 18 to 30 months, researchers discovered a language kernel in which basic sentence constructs emerge at 30 months, which is invisible to traditional network detection and feature-only clustering. By modeling word acquisition as random walks on FERMULEX topology, biased random walkers accurately predict early word learning in communicative developmental inventories (CDIs).
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Katherine Abell, Robert J. Hopkin, Patricia L. Bender, Farrah Jackson, Kelly Smallwood, Bonnie Sullivan, Rolf W. Stottmann, Howard M. Saal, K. Nicole Weaver
Summary: This study surveyed parents of individuals with Mandibulofacial dysostosis with microcephaly (MFDM) to expand knowledge about the condition. The study identified common features, new information, and family concerns associated with MFDM. Additionally, targeted Sanger sequencing revealed de novo variants in a majority of cases, highlighting the importance of understanding the genetic basis of MFDM.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Chemistry, Analytical
Preethika Murugan, Gayathri Jeevanandham, Ashok K. Sundramoorthy
Summary: This study investigated the sorption capacity of polyethylene microplastics on fish scales. The results showed that microplastics have the ability to sorb onto fish scales. Additionally, the study revealed that marine water may be a suitable medium for polymer sorption on aquatic organisms.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ziqi Liu, Junqing Liu, Tiancheng Sun, Deke Zeng, Chengduan Yang, Hao Wang, Cheng Yang, Jun Guo, Qianni Wu, Hui-Jiuan Chen, Xi Xie
Summary: Infection is the most common complication of chronic wounds, and tracking wound markers for accurate diagnosis holds great potential. A multiplex sensing bandage system has been developed for real-time monitoring of various indicators, showing promising applications in wound management and other diseases.
Article
Multidisciplinary Sciences
Tiantian Wang, Peilong Li, Qiuchen Qi, Shujun Zhang, Yan Xie, Jing Wang, Shibiao Liu, Suhong Ma, Shijun Li, Tingting Gong, Huiting Xu, Mengqiu Xiong, Guanghua Li, Chongge You, Zhaofan Luo, Juan Li, Lutao Du, Chuanxin Wang
Summary: The study shows that DNA methylation plays an important role in the immune alterations of breast cancer. Researchers have identified four specific methylation markers in peripheral blood mononuclear cells and developed an efficient and convenient multiplex methylation-specific quantitative PCR assay for early detection of breast cancer. This assay outperforms existing clinical diagnostic methods, especially in the detection of early-stage and minimal tumors.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Se Chang Oh, Soo Min Park, Jian Hur, Eun Young Choi, Hyun Jung Jin, Yu Kyung Kim, Jong Ho Lee, Ji Young Ahn, Jae Min Lee
Summary: The study investigated the effectiveness of mPCR for early diagnosis of pertussis, revealing that most patients were diagnosed within two weeks from symptom onset and required hospitalization and antibiotic treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Mathematics, Applied
Shu-hong Xue, Yun-yun Yang, Biao Feng, Hai-long Yu, Li Wang
Summary: This research focuses on the robustness of multiplex networks and proposes a new index to measure their stability under malicious attacks. The effectiveness of this method is verified in real multiplex networks.
PHYSICA D-NONLINEAR PHENOMENA
(2024)
Article
Medicine, General & Internal
Federico Baronio, Stefano Zucchini, Francesco Zulian, Mariacarolina Salerno, Rossella Parini, Alessandro Cattoni, Federica Deodato, Alberto Gaeta, Carla Bizzarri, Serena Gasperini, Andrea Pession
Summary: Diagnostic delay is common in MPS Ia due to the rarity of the disease and the variability of clinical presentation. A multidisciplinary panel developed an algorithm to improve awareness and reduce diagnostic delay of MPS Ia in pediatric endocrinologists.
MEDICINA-LITHUANIA
(2022)
Article
Virology
Yusuke Goto, Kazuhiro Fukunari, Tohru Suzuki
Summary: Bovine respiratory diseases (BRD) are influenced by stress factors and viral and bacterial pathogens, which suppress immune defenses and lead to bacterial growth in the respiratory tract. In this study, we continuously monitored the dynamics of BRD-associated pathogens in healthy calves using multiplex real-time RT-PCR and virus neutralization test (VNT). We also analyzed nasal swab samples from BRD-infected calves to detect the dominant pathogens in the region. The results showed that positive results by multiplex RT-qPCR were closely related to increased antibody titers in bovine coronavirus (BCoV), bovine torovirus (BToV), and bovine respiratory syncytial virus (BRSV). Additionally, certain pathogens were more frequently detected in BRD-infected calves compared to clinically healthy ones, and co-infections of viral and bacterial pathogens were closely involved in the onset of BRD. Overall, multiplex RT-qPCR is a useful tool for early detection of BRD.
Article
Medicine, General & Internal
Hao Zhang, Chuanli Zhou, Chao Wang, Kai Zhu, Qihao Tu, Meng Kong, Chong Zhao, Xuexiao Ma
Summary: This study compared the preliminary postoperative outcomes of Endo-TLIF and MIS-TLIF in treating lumbar spondylolisthesis, finding that Endo-TLIF had less blood loss and shorter ambulation time, with significant early improvement. There were no significant differences in terms of interbody fusion rates between the two groups, and no serious postoperative complications were observed.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Infectious Diseases
Vivek B. Mundada
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
(2012)
Article
Clinical Neurology
Joseph D. Symonds, Shelagh Joss, Kay A. Metcalfe, Suresh Somarathi, Jamie Cruden, Anita M. Devlin, Alan Donaldson, Nataliya DiDonato, David Fitzpatrick, Frank J. Kaiser, Anne K. Lampe, Melissa M. Lees, Ailsa McLellan, Tara Montgomery, Vivek Mundada, Lesley Nairn, Ajoy Sarkar, Jens Schallner, Jelena Pozojevic, Ilaria Parenti, Jeen Tan, Peter Turnpenny, William P. Whitehouse, Sameer M. Zuberi
Letter
Pediatrics
V. Mundada, N. Brown
ARCHIVES OF DISEASE IN CHILDHOOD
(2009)
Correction
Pediatrics
V Mundada, N. D'Souza
ARCHIVES OF DISEASE IN CHILDHOOD
(2010)
Meeting Abstract
Pediatrics
V. Mundada, T. Hildebrandt
PEDIATRIC RESEARCH
(2010)
Editorial Material
Pediatrics
Vivek Mundada, Pawankumar Maniyar
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Editorial Material
Pediatrics
Prabhakar Patil, Vivek Mundada
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Letter
Pediatrics
Nidhi Beri, Lekha Kapoor, Deepak Parashar, Vivek Mundada
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Pediatrics
Vivek B. Mundada, Torsten Hildebrandt
JOURNAL OF PEDIATRIC NEUROLOGY
(2011)
