期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 63, 期 29, 页码 6525-6534出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b00614
关键词
Dictyophora indusiata polysaccharides; zinc chloride; antiproliferative activity; apoptosis; human breast adenocarcinoma cells
资金
- National Key Technology R&D Program of China in the 12th five-year period [2012BAD33B11]
- Guangdong Natural Science Funds for Distinguished Young Scholars [S2013050013954]
- Program for New Century Excellent Talents in University [NCET-13-0213]
- Fundamental Research Funds for the Central Universities, SCUT [2014ZZ0058, 2014ZZ0063]
Dictyophora indusiata polysaccharide (DP1) was successfully chelated with zinc chloride to achieve its enhanced antiproliferative activity. The Obtained DP1-Zn complex showed significant antiproliferative activity (18.1 +/- 2.84% viability of MCF-7 tells at 250 mu g/mL) on a group of human cancer cell lines through induction of apoptosis. The pro-apoptotic action of DP1-Zn was confirmed by morphological changes including chromatin condensation, DNA breakage, and S phase cell cycle arrest in human breast adenocarcinoma cells (MCF-7) The DP1-Zn-induced apoptotic pathways were characterized by the activation of caspases-3, -8, and -9, mitochondrial dysfunction, and reactive oxygen species (ROS) overproduction (305 +/- 7.06% production of control at 250 mu g/mL). This study suggested that DP1-Zn can be developed as a candidate for cancer treatment and prevention, especially human breast adenocarcinoma.
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