Article
Psychiatry
Vivian Tanios, Antonio Terracciano, Martina Luchetti, Yannick Stephan, Angelina R. Sutin
Summary: This study found that neuroticism and conscientiousness assessed at age 16 were related to the risk of metabolic syndrome at age 46. Conscientiousness assessed by mothers accounted for 10% of the relationship between childhood social class and metabolic health at age 46.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Edurne Lecumberri, Lia Nattero-Chavez, Jhonatan Quinones Silva, Sara Alonso Diaz, Elena Fernandez-Duran, Beatriz Dorado Avendano, Hector F. Escobar-Morreale, Manuel Luque-Ramirez
Summary: This study aimed to evaluate the impact of excluding hyperglycemia from the definition of MetS in T1DM patients and its association with complications and inflammation markers. The results showed that excluding hyperglycemia significantly decreased the prevalence of MetS, and the modified definition showed better predictive performance for complications and inflammation markers.
Article
Endocrinology & Metabolism
Liying Li, Ziqiong Wang, Haiyan Ruan, Muxin Zhang, Linxia Zhou, Xin Wei, Ye Zhu, Jiafu Wei, Xiaoping Chen, Sen He
Summary: This study aimed to investigate the predictive values of the new metabolic health (MH) definition compared to the metabolic syndrome (MetS) MH definition for future diabetes in a nonobese Chinese population. The study found that the new MH definition was not a reliable predictor for future diabetes in nonobese Chinese individuals compared to the MH definition from MetS.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Nutrition & Dietetics
Chiara Mameli, Giulia Fiore, Arianna Sangiorgio, Marta Agostinelli, Giulia Zichichi, Gianvincenzo Zuccotti, Elvira Verduci
Summary: Klinefelter syndrome is the most common sex chromosomal aneuploidy in males, and patients have a higher mortality and morbidity. This increased risk is due to both hypogonadism and the syndrome itself. Therefore, correct hormonal replacement therapy and early prevention are crucial for these patients.
Article
Nutrition & Dietetics
Stefano Stagi, Valeria Papacciuoli, Daniele Ciofi, Barbara Piccini, Giovanni Farello, Sonia Toni, Marta Ferrari, Francesco Chiarelli
Summary: The study retrospectively evaluated the effects of a new complex of polysaccharide macromolecules, PGR, on pediatric patients with type 1 diabetes and Metabolic Syndrome (MetS). Results showed that PGR produced a good auxological and metabolic response in obese patients with MetS affected by type 1 diabetes, leading to significant improvements in glucose control and variability as well as other MetS parameters. The use of polysaccharide compounds, especially in combination with appropriate dietary changes, may help achieve treatment targets in type 1 diabetes and reduce the risk of developing metabolic syndrome.
Article
Gastroenterology & Hepatology
Mohammed Eslam, Naim Alkhouri, Pietro Vajro, Ulrich Baumann, Ram Weiss, Piotr Socha, Claude Marcus, Way Seah Lee, Deirdre Kelly, Gilda Porta, Mohamed A. El-Guindi, Anna Alisi, Jake P. Mann, Nezha Mouane, Louise A. Baur, Anil Dhawan, Jacob George
Summary: The proposed framework for pediatric fatty liver diseases includes an age-appropriate MAFLD definition based on sex and age percentiles, recognizing the possibility of other coexisting systemic fatty liver diseases in children. This new MAFLD diagnostic criteria provide pediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, aligning with a definition that is valid across the lifespan.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniel Chan, Cherie Chua, Carin Loh, Rehena Sultana, Rashida Farhad Vasanwala
Summary: In this retrospective cohort study of 715 children, risk factors such as preterm birth, hypertension, hyperlipidemia, and fatty liver disease were found to be associated with increased BMI and the development of dysglycemia. Other risk factors for worsening glycemic status included age >10 years, BMI rise, and comorbidities of hyperlipidemia and fatty liver disease.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Biochemistry & Molecular Biology
Bato Korac, Andjelika Kalezic, Vanja Pekovic-Vaughan, Aleksandra Korac, Aleksandra Jankovic
Summary: Life is defined as an instantaneous encounter of circulating matter and flowing energy, and the relationship between redox biology and metabolism forms a dynamic balance in health, but disruption can lead to disease. The rising prevalence of metabolic diseases presents challenges in understanding, diagnosing, and treating them, emphasizing the need for research on novel redox-metabolic biomarkers.
Article
Nutrition & Dietetics
Monika Grabia, Renata Markiewicz-Zukowska, Katarzyna Socha, Agnieszka Polkowska, Aneta Zasim, Karolina Boruch, Artur Bossowski
Summary: The occurrence of metabolic syndrome significantly affects the course of diabetes mellitus, leading to deterioration of insulin sensitivity and metabolic control, as well as cardiometabolic complications. This study investigated the relationships between cardiovascular biomarkers, nutritional status, dietary factors, and the occurrence of metabolic syndrome in adolescents with type 1 diabetes and healthy peers from northeast Poland.
Article
Endocrinology & Metabolism
Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagstrom, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Laine, Koji Miyanishi, Martina U. Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D. Ryan, Laura Silvestri, C. Wendy Spearman, Per Stal, Emmanuel A. Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller
Summary: Hyperferritinaemia is often associated with metabolic dysfunction and fatty liver and is linked to an increased risk of cardiometabolic and liver diseases. The main determinants of ferritin levels in individuals with metabolic dysfunction are genetic variants that affect iron metabolism. However, there is currently a lack of validated criteria for the diagnosis and staging of metabolic hyperferritinaemia, and the benefits of iron depletion therapy remain unclear. In this article, the authors provide an overview of the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction and propose updated definitions and staging systems, highlighting research gaps and suggesting future study designs and outcome measures.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Christine E. S. Jovanovic, Deanna M. Hoelscher, Baojiang Chen, Nalini Ranjit, Alexandra E. van den Berg
Summary: Based on the analysis of the National Health and Nutrition Examination Survey (NHANES) data from 2015 to 2016, this study found that the relationship between consumption of plant-based foods (both healthy and all types) and the risk of metabolic syndrome and chronic disease is unknown. Consumption of healthy plant-based foods is negatively associated with the risk of elevated waist circumference and metabolic syndrome, especially for females aged 60 and above.
JOURNAL OF PUBLIC HEALTH
(2023)
Review
Endocrinology & Metabolism
Rebuma Belete, Zerihun Ataro, Ahmedmenewer Abdu, Merga Sheleme
Summary: This study aimed to estimate the prevalence of metabolic syndrome among type 1 diabetes mellitus patients. The pooled prevalence was 23.7%, with variations across geographical regions and genders. Attention should be given to prevention and control strategies to reduce the morbidity and mortality associated with metabolic syndrome in this population.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Psychiatry
Feyissa Challa, Tigist Getahun, Meron Sileshi, Zeleke Geto, Teshome S. Kelkile, Sintayehu Gurmessa, Girmay Medhin, Miraf Mesfin, Melkam Alemayehu, Tigist Shumet, Anwar Mulugeta, Desalegn Bekele, Christina P. C. Borba, Claire E. Oppenheim, David C. Henderson, Abebaw Fekadu, Anna Carobene, Solomon Teferra
Summary: The study investigated the prevalence of MetS among patients with schizophrenia in Ethiopia, finding an overall prevalence of 21.5%. Low HDL-cholesterol was the most common metabolic disorder component. Multivariate analysis showed that PANSS scores were associated factors with MetS.
Review
Oncology
Shuwen Dong, Zheng Wang, Kunwei Shen, Xiaosong Chen
Summary: Metabolic syndrome and its related components significantly impact the onset, progression, treatment response, and prognosis of breast cancer. The biochemical reactions caused by metabolic abnormalities affect both the host state and organ-specific tumor microenvironment, leading to increased rates of recurrence and mortality.
FRONTIERS IN ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Monika Grabia, Renata Markiewicz-Zukowska, Katarzyna Socha
Summary: This article discusses the prevalence of metabolic syndrome in children and adolescents with type 1 diabetes, as well as prevention and treatment options. It highlights the increasing prevalence of overweight and obesity in this population, as well as the rising incidence of MetS.
Article
Pediatrics
Julia Suikkanen, Satu Miettola, Kati Heinonen, Marja Vaarasmaki, Marjaana Tikanmaki, Marika Sipola, Hanna-Maria Matinolli, Marjo-Riitta Jarvelin, Katri Raikkonen, Petteri Hovi, Eero Kajantie
Summary: This study found that adults born across the range of prematurity generally have similar cognitive abilities compared to full-term controls, with the exception of weaker spatial memory efficiency in early preterm and late preterm with small for gestational age (SGA) participants. Cognitive problems may persist to adulthood only among those born very preterm or preterm and SGA. Despite the risk of preterm birth for the developing brain, many individuals born preterm show the potential to catch up with those born at term in cognitive abilities with a supportive environment.
PEDIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Sonja Strang-Karlsson, Suvi Alenius, Pieta Nasanen-Gilmore, Markku Nurhonen, Peija Haaramo, Kari Anne Evensen, Marja Vaarasmaki, Mika Gissler, Petteri Hovi, Eero Kajantie
Summary: The study found no evidence for a higher risk of migraine among individuals born preterm.
Article
Biochemistry & Molecular Biology
Justiina Ronkainen, Anni Heiskala, Florianne O. L. Vehmeijer, Estelle Lowry, Doretta Caramaschi, Guadalupe Estrada Gutierrez, Jonathan A. Heiss, Nadine Hummel, Elina Keikkala, Tuomas Kvist, Allison Kupsco, Phillip E. Melton, Giancarlo Pesce, Munawar H. Soomro, Marta Vives-Usano, Nour Baiz, Elisabeth Binder, Darina Czamara, Monica Guxens, Sanna Mustaniemi, Stephanie J. London, Sebastian Rauschert, Marja Vaarasmaki, Martine Vrijheid, Anette-G. Ziegler, Isabella Annesi-Maesano, Mariona Bustamante, Rae-Chi Huang, Sandra Hummel, Allan C. Just, Eero Kajantie, Jari Lahti, Deborah Lawlor, Katri Raikkonen, Marjo-Riitta Jarvelin, Janine F. Felix, Sylvain Sebert
Summary: This study did not find evidence for an association between maternal hemoglobin levels during pregnancy and offspring DNA methylation. However, it does not rule out the possibility that such associations could be seen in studies with more extreme maternal hemoglobin levels. Most participants had maternal hemoglobin levels within the normal range, while adverse perinatal outcomes typically arise in extreme cases.
Article
Peripheral Vascular Disease
Juhani S. S. Rantakallio, Jaana E. Nevalainen, Sammeli West, Meri-Maija Ollila, Katri Puukka, Aini H. Bloigu, Marjo-Riitta Jarvelin, Juha S. Tapanainen, Stephen Franks, Leo Dunkel, Terhi T. Piltonen, Marja S. Vaarasmaki, Laure C. Morin-Papunen
Summary: This study found that obesity, especially abdominal obesity, and weight gain from adolescence to age 46 were associated with an increased risk of hypertensive disorders of pregnancy (HDP), while self-reported PCOS or hyperandrogenemia were not.
Article
Endocrinology & Metabolism
Suvi Turunen, Marja Vaarasmaki, Maarit Leinonen, Mika Gissler, Tuija Mannisto, Eila Suvanto
Summary: The study found a significant increase in the use of levothyroxine in pregnant women over recent years, while the use of antithyroid drugs during pregnancy remained very rare.
EUROPEAN THYROID JOURNAL
(2021)
Article
Obstetrics & Gynecology
Riina Jernman, Camilla Isaksson, Katri Haimila, Malla Kuosmanen, Kaarin Makikallio-Anttila, Suvi Toivonen, Maija-Riitta Orden, Kati Sulin, Kati Tihtonen, Marja Vaarasmaki, Susanna Sainio
Summary: After the implementation of routine antenatal anti-D prophylaxis in Finland, the prevalence of pregnancies with anti-D antibodies decreased from 1.52% in 2014 to 0.88% in 2017, and the corresponding incidence of new immunizations decreased from 0.33% to 0.10%. The time-points for detection of new anti-D antibodies also changed, indicating the effectiveness of the current targeted anti-D prophylaxis program.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Pediatrics
Julia Suikkanen, Markku Nurhonen, Tim J. Cole, Marika Paalanne, Hanna-Maria Matinolli, Marjaana Tikanmaki, Marja Vaarasmaki, Marjo-Riitta Jarvelin, Petteri Hovi, Eero Kajantie
Summary: The study found that pubertal growth and timing were similar in preterm and term participants, indicating that preterm children were not at increased risk for early puberty compared to term children.
PEDIATRIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Elmar W. Tobi, Diana L. Juvinao-Quintero, Justiina Ronkainen, Raffael Ott, Rossella Alfano, Mickael Canouil, Madelon L. Geurtsen, Amna Khamis, Leanne K. Kupers, Ives Y. Lim, Patrice Perron, Giancarlo Pesce, Johanna Tuhkanen, Anne P. Starling, Toby Andrew, Elisabeth Binder, Robert Caiazzo, Jerry K. Y. Chan, Romy Gaillard, Peter D. Gluckman, Elina Keikkala, Neerja Karnani, Sanna Mustaniemi, Tim S. Nawrot, Francois Pattou, Michelle Plusquin, Violeta Raverdy, Kok Hian Tan, Evangelia Tzala, Katri Raikkonen, Christiane Winkler, Anette-G Ziegler, Isabella Annesi-Maesano, Luigi Bouchard, Yap Seng Chong, Dana Dabelea, Janine F. Felix, Barbara Heude, Vincent W. V. Jaddoe, Jari Lahti, Brigitte Reimann, Marja Vaarasmaki, Amelie Bonnefond, Philippe Froguel, Sandra Hummel, Eero Kajantie, Marjo-Riita Jarvelin, Regine P. M. Steegers-Theunissen, Caitlin G. Howe, Marie-France Hivert, Sylvain Sebert
Summary: Maternal hyperglycemia is associated with lower cord blood DNAm at TXNIP, and these CpGs may be candidate loci for future causal and mediation analyses.
Article
Endocrinology & Metabolism
Elisa Paavilainen, Kristiina Tertti, Hilkka Nikkinen, Riitta Veijola, Marja Vaarasmaki, Britt-Marie Loo, Paivi Tossavainen, Tapani Ronnemaa, Harri Niinikoski
Summary: The offspring of mothers treated with metformin for gestational diabetes mellitus showed similar growth and glucose metabolism at age 9 compared to those treated with insulin, but had a more favorable lipid profile, including higher HDL cholesterol, lower LDL cholesterol, and lower apolipoprotein B concentrations.
DIABETES OBESITY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Niina Sissala, Sanna Mustaniemi, Eero Kajantie, Marja Vaarasmaki, Peppi Koivunen
Summary: Higher maternal hemoglobin levels are an independent risk factor for gestational diabetes, but have little effect on perinatal outcome.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Kerstin M. G. Brand, Laura Saarelainen, Jaak Sonajalg, Emmanuelle Boutmy, Caroline Foch, Marja Vaarasmaki, Laure Morin-Papunen, Judith Schlachter, Katja M. Hakkarainen, Pasi Korhonen
Summary: The study found that maternal exposure to metformin during pregnancy did not increase the risk of long-term adverse outcomes in offspring compared to insulin. However, metformin and combination treatment were associated with increased risks of adverse outcomes at birth, indicating the need for caution in pregnancies with potential fetal undernutrition risks.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Obstetrics & Gynecology
Mikael Huhtala, Hilkka Nikkinen, Elisa Paavilainen, Harri Niinikoski, Marja Vaarasmaki, Britt-Marie Loo, Tapani Ronnemaa, Kristiina Tertti
Summary: This study compared the long-term effects of metformin and insulin treatments on women with gestational diabetes. The results showed that there were no significant differences in the incidences of pre-diabetes, type 2 diabetes, metabolic syndrome, anthropometry, glucose metabolism, serum lipids, or inflammatory markers between the metformin and insulin groups during the treatment period and 9-year follow-up.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
Aliisa Laitala, Timo Saarela, Marja Vaarasmaki, Mikko Hallman, Outi Aikio
Summary: The use of paracetamol in pregnancy does not have adverse effects on extremely or very preterm infants and may have acute benefits for preterm infants during perinatal transition.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Environmental Sciences
Jenni Pukkila, Sanna Mustaniemi, Shilpa Lingaiah, Olli-Pekka Lappalainen, Eero Kajantie, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Marja Vaarasmaki, Elina Keikkala
Summary: Gestational diabetes mellitus (GDM) is associated with increased oral health care needs and symptoms, especially third molar symptoms, during pregnancy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Justiina Ronkainen, Rozenn Nedelec, Angelica Atehortua, Zhanna Balkhiyarova, Anna Cascarano, Vien Ngoc Dang, Ahmed Elhakeem, Esther van Enckevort, Ana Goncalves Soares, Sido Haakma, Miia Halonen, Katharina F. Heil, Anni Heiskala, Eleanor Hyde, Benedicte Jacquemin, Elina Keikkala, Jules Kerckhoffs, Anton Klavus, Joanna A. Kopinska, Johanna Lepeule, Francesca Marazzi, Irina Motoc, Mari Naatanen, Anton Ribbenstedt, Amanda Rundblad, Otto Savolainen, Valentina Simonetti, Nina de Toro Eadie, Evangelia Tzala, Anna Ulrich, Thomas Wright, Iman Zarei, Enrico d'Amico, Federico Belotti, Carl Brunius, Christopher Castleton, Marie-Aline Charles, Romy Gaillard, Kati Hanhineva, Gerard Hoek, Kirsten B. Holven, Vincent W. V. Jaddoe, Marika A. Kaakinen, Eero Kajantie, Maryam Kavousi, Timo Lakka, Jason Matthews, Andrea Piano Mortari, Marja Vaarasmaki, Trudy Voortman, Claire Webster, Marie Zins, Vincenzo Atella, Maria Bulgheroni, Marc Chadeau-Hyam, Gabriella Conti, Jayne Evans, Janine F. Felix, Barbara Heude, Marjo-Riitta Jarvelin, Marjukka Kolehmainen, Rikard Landberg, Karim Lekadir, Stefano Parusso, Inga Prokopenko, Susanne R. de Rooij, Tessa Roseboom, Morris Swertz, Nicholas Timpson, Stine M. Ulven, Roel Vermeulen, Teija Juola, Sylvain Sebert
Summary: The current epidemics of cardiovascular and metabolic noncommunicable diseases are associated with changes in modern postwar societies, including rural-to-urban migration, modernization of agricultural practices and transportation, climate change, and aging. The LongITools project aims to investigate the link between multidimensional environmental exposures and the occurrence of these diseases.
ENVIRONMENTAL EPIDEMIOLOGY
(2022)
