Article
Oncology
S. Morteza Seyed Jafari, Flavia Folini-Huesser, Simone Cazzaniga, Robert E. Hunger
Summary: The study aimed to investigate the long-term efficacy of imiquimod 5% cream for the management of lentigo maligna (LM), with a focus on disease recurrence and prognostic factors of disease-free survival (DFS). If surgical excision is not possible due to age/comorbidities or critical cosmetic localization, imiquimod could provide optimal outcomes with a low risk of relapse.
Article
Dermatology
Anouk Soenen, Morgane Vourc'h, Amir Khammari, Jean-Michel Nguyen, Celine Bossard, Marie Denis Musquer, Beatrice Vergier, Brigitte Dreno
Summary: The study demonstrates that Imiquimod treatment can significantly improve the condition of lentigo maligna (LM), and reflectance confocal microscopy (RCM) is an effective method for assessing the treatment response.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
R. Kwak, C. Joyce, A. E. Werchniak, J. Y. Lin, H. C. Tsibris
Summary: Adjuvant imiquimod treatment can reduce LM recurrence rates in cases with background melanocytic dysplasia or close margins. Positive surgical margins are associated with decreased clinical clearance, while the presence of an inflammatory response during treatment is associated with increased clearance. Close clinical follow-up is necessary for LM cases with positive surgical margins due to higher recurrence rates.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Magdalena Misiak-Galazka, Joanna Czuwara, Adam Galazka, Anna Czaplicka, Lidia Rudnicka
Summary: This article presents a case where interval treatment with topical imiquimod was implemented for severe inflammatory response in a patient with lentigo maligna. The treatment resulted in total clearance of the lesion without relapse during a 2-year follow-up.
DERMATOLOGY AND THERAPY
(2022)
Review
Dermatology
Silvia Vaienti, Paolo Calzari, Gianluca Nazzaro
Summary: Topical imiquimod may be a therapeutic option for the treatment of melanoma in situ and lentigo maligna melanoma, but further evidence from controlled studies is needed.
DERMATOLOGY AND THERAPY
(2023)
Review
Dermatology
Ajay N. Sharma, Delila P. Foulad, Linda Doan, Patrick K. Lee, Natasha Atanaskova Mesinkovska
Summary: This study compares the efficacy of Mohs micrographic surgery (MMS) with traditional surgical and nonsurgical therapies for lentigo maligna (LM) and lentigo maligna melanoma (LMM). Results indicate that MMS has a lower recurrence rate compared to other treatment options, making it a successful choice for these conditions. Further clinical trials are needed to better understand the role of MMS in the treatment algorithm for LM and LMM.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Dermatology
Pascale Guitera, Andreanne Waddell, Elizabeth Paton, Gerald B. Fogarty, Angela Hong, Richard A. Scolyer, Jonathan R. Stretch, Brett A. O'Donnell, Giovanni Pellacani
Summary: Lentigo maligna (LM) is a subtype of in situ melanoma that often affects the head and neck region. Alternative treatments such as radiotherapy and imiquimod have been explored due to challenges in surgical management, particularly for LM in cosmetically sensitive areas. Challenges in using imiquimod include the complex nature of the disease, unpredictable side effects, and patient compliance.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2021)
Letter
Dermatology
Usamah M. Afzal, Sina J. Ghadiri, Pavan Sambi, Andrew Muinonen-Martin, Angana Mitra
Summary: Lentigo maligna (LM) is an in situ melanoma that occurs on chronically sun-damaged skin, primarily on the head and neck. Imiquimod 5% (Aldara(R)), an immune response modifier, has been widely reported as an off-label treatment for both primary and adjuvant therapy, although there are currently no formal guidelines.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Dimitrios Karponis, Ioannis A. Stratigos, Jilse Joshy, Paul J. Craig, Khaylen Mistry, Birgitta van Bodegraven, Zoe C. Venables, Nick J. Levell
Summary: Lentigo maligna (LM) is an in situ melanoma with distinct clinical features and histology, primarily affecting men after the age of 60. The incidence of LM has increased, with fair skin and cumulative sun exposure as the most important risk factors. Diagnosis and management of LM pose challenges, with histopathological assessment as the gold standard. Treatment options include Mohs micrographic surgery, excision, and imiquimod cream.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Cristian Navarrete-Dechent, Miguel Cordova, Saud Aleissa, Konstantinos Liopyris, Stephen W. Dusza, Kivanc Kose, Klaus J. Busam, Travis Hollman, Cecilia Lezcano, Melissa Pulitzer, Chih-Shan J. Chen, Erica H. Lee, Anthony M. Rossi, Kishwer S. Nehal
Summary: The study evaluated the correlation between subclinical extension of lentigo maligna/lentigo maligna melanoma (LM/LMM) defined by reflectance confocal microscopy (RCM) and histopathology. The results showed that RCM had high sensitivity and moderate specificity in detecting residual melanoma, with good overall agreement with histopathology.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Oncology
Gareth Crouch, Shiba Sinha, Serigne Lo, Robyn P. M. Saw, Kenneth K. Lee, Jonathan Stretch, Kerwin Shannon, Pascale Guitera, Richard A. Scolyer, John F. Thompson, Sydney Ch'ng
Summary: This study assessed clinical outcomes of wide local excision for lentigo maligna in head and neck region, finding that a histological margin of >= 3.0 mm is required to minimize recurrence, which necessitates a surgical margin of >= 6.5 mm. Careful long-term follow-up is necessary for all patients to prevent recurrence.
Article
Dermatology
Marie Daude, Monica Dinulescu, Jean-Michel Nguyen, Herve Maillard, Florence Le Duff, Laurent Machet, Marie Beylot-Barry, Delphine Legoupil, Ewa Wierzbicka-Hainaut, Christophe Bedane, Marie Therese Leccia, Sebastien Debarbieux, Nicolas Meyer, Sandrine Monestier, Guido Bens, Marc G. Denis, Celine Bossard, Beatrice Vergier, Amir Khammari, Brigitte Dreno
Summary: This study investigated the effect of imiquimod versus placebo in neoadjuvant settings. The results showed that after 1 month of treatment, Imiquimod significantly reduced the surface area of Lentigo maligna without a higher risk of intralesional excision, and with a positive aesthetic outcome.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Obstetrics & Gynecology
Michelle van der Linden, Colette L. van Hees, Marc van Beurden, Johan Bulten, Eleonora B. van Dorst, Martha D. Esajas, Kim A. Meeuwis, Dorry Boll, Mariette van Poelgeest, Joanne A. de Hullu
Summary: This study investigated the effectiveness, safety, and impact on quality of life of a standardized treatment using 5% imiquimod cream for noninvasive vulvar Paget disease. The study included 24 patients who were treated with topical 5% imiquimod cream three times a week for 16 weeks. The results showed that 82.6% of the patients responded to the treatment, with a complete response reported in 52.2% of the patients. Adverse effects such as fatigue and headaches were observed, and some patients needed painkillers during treatment. The treatment improved patients' quality of life, but a slight temporary negative impact was observed during treatment. Recurrence of the disease was observed in some patients after 1 year.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Dermatology
Manel Martinez-Molina, Nina Richarz, Ane Jaka, Juli Bassas-Vila, Veronica Mora-Fernandez, Ariadna Quer Pi-Sunyer, Sebastian Podlipnik, Jose Manuel Carrascosa, Aram Boada
Summary: This study evaluated the outcomes of lentigo maligna cases treated with either wide local excision (WLE) or spaghetti technique (ST) in the head and neck area, and described the demographic and clinical characteristics of the patients. The results showed that both WLE and ST were appropriate surgical approaches for lentigo maligna, and ST offered an efficient alternative to Mohs surgery for treating lentigo maligna in the head and neck area.
DERMATOLOGY PRACTICAL & CONCEPTUAL
(2023)
Article
Dermatology
Johann de Wet, Pieter J. du Plessis, Johann W. W. Schneider
Summary: This study examines the utility of SOX10 and PRAME immunohistochemical staining in diagnosing lentigo maligna (LM) on excision margins compared with conventional hematoxylin and eosin and Melan A staining. The results suggest that SOX10 is a more specific and sensitive marker for melanocytes, providing accurate diagnosis of LM on excision margins.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Article
Geriatrics & Gerontology
Sara E. Espinoza, Robyn L. Woods, A. R. M. Saifuddin Ekram, Michael E. Ernst, Galina Polekhina, Rory Wolfe, Raj C. Shah, Stephanie A. Ward, Elsdon Storey, Mark R. Nelson, Christopher M. Reid, Jessica E. Lockery, Suzanne G. Orchard, Ruth Trevaks, Sharyn M. Fitzgerald, Nigel P. Stocks, Andy Chan, John J. McNeil, Anne M. Murray, Anne B. Newman, Joanne Ryan
Summary: Low-dose aspirin use in healthy older adults does not reduce the risk of incident frailty or alter the trajectory of frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jonathan C. Broder, Joanne Ryan, Raj C. Shah, Jessica E. Lockery, Suzanne G. Orchard, Julia F. M. Gilmartin-Thomas, Michelle A. Fravel, Alice J. Owen, Robyn L. Woods, Rory Wolfe, Elsdon Storey, Anne M. Murray, Michael E. Ernst
Summary: The study found that anticholinergic burden is associated with cognitive decline in older adults, particularly affecting executive function and memory function.
Article
Medicine, General & Internal
Claire Felmingham, Samantha MacNamara, William Cranwell, Narelle Williams, Miki Wada, Nikki R. Adler, Zongyuan Ge, Alastair Sharfe, Adrian Bowling, Martin Haskett, Rory Wolfe, Victoria Mar
Summary: This article presents a clinical study on the use of convolutional neural networks (CNNs) in diagnosing skin cancers. Participants from dermatology clinics were recruited and skin lesions were classified using an AI algorithm. The impact of the algorithm on clinical decision-making was evaluated. The study assessed the safety and accuracy of the algorithm by measuring its agreement with histopathology results and comparing its performance to that of teledermatologists.
Letter
Cardiac & Cardiovascular Systems
Johannes T. Neumann, Rosanne Freak-Poli, Suzanne G. Orchard, Rory Wolfe, Christopher M. Reid, Andrew M. Tonkin, Lawrence J. Beilin, John J. McNeil, Joanne Ryan, Robyn L. Woods
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Letter
Urology & Nephrology
Kevan R. Polkinghorne, James B. Wetmore, Le Thi Phuong Thao, Rory Wolfe, Robyn L. Woods, Michael E. Ernst, Mark R. Nelson, Christopher M. Reid, Raj C. Shah, John J. McNeil, Anne M. Murray
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Letter
Medicine, General & Internal
Mark R. Nelson, Galina Polekhina, Robyn L. Woods, Christopher M. Reid, Andrew M. Tonkin, Rory Wolfe, Anne M. Murray, Brenda Kirpach, Michael E. Ernst, Jessica E. Lockery, Raj C. Shah, Nigel Stocks, Suzanne G. Orchard, Zhen Zhou
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Dermatology
Katrina Tan, Serigne N. Lo, Anne E. Cust, Rory Wolfe, Victoria Mar
Summary: This study compared two online melanoma risk prediction tools and found that both tools had high sensitivity for identifying high-risk individuals. The choice of tool depends on the purpose of risk prediction.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Oncology
Mabel K. Yan, Suzanne G. Orchard, Nikki R. Adler, Rory Wolfe, Catriona McLean, Luz Maria Rodriguez, Robyn L. Woods, Peter Gibbs, Andrew T. Chan, Andrew Haydon, Victoria J. Mar
Summary: The effects of aspirin on melanoma are unclear, with this study finding no strong support for a reduced risk of invasive melanoma in older individuals associated with aspirin exposure.
CANCER PREVENTION RESEARCH
(2022)
Letter
Dermatology
Claire Felmingham, Yan Pan, Yonatan Kok, John Kelly, Douglas Gin, Jennifer Nguyen, Michelle Gob, Alex Chamberlain, Amanda Oakley, Simon Tucker, William Berry, Mark Darling, Dale Jobson, Aaron Robinson, Sara de Menezes, Charlie Wang, Anneliese Willems, Catriona McLean, William Cranwell, Nikki Adler, Miki Wada, Peter Foley, Jane Brack, Simon Cumming, Gabrielle Byars, Adrian Bowling, Zongyuan Ge, Martin Haskett, Rory Wolfe, Victoria Mar
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Urology & Nephrology
Rowan G. Walker, Rory Wolfe, Elisa Bongetti, Kevan R. Polkinghorne, Robyn L. Woods, Joanne Ryan, Sara Espinoza, Anne Murray, Michael E. Ernst, John J. Mcneil
Summary: This study examined the relationship between frailty and kidney function impairment in older adults. It found that albuminuria was associated with prefrailty and frailty, while CKD and reduced eGFR were not.
Review
Dermatology
Mabel K. Yan, Charlie Wang, Rory Wolfe, Victoria J. Mar, Anita E. Wluka
Summary: In this systematic review and meta-analysis, low-dose methotrexate exposure was associated with a slight increase in melanoma risk, but the absolute risk increase could be considered negligible.
Article
Medicine, General & Internal
Anna L. Barker, Renata Morello, Le Thi Phuong Thao, Ego Seeman, Stephanie A. Ward, Kerrie M. Sanders, Robert G. Cumming, Julie A. Pasco, Peter R. Ebeling, Robyn L. Woods, Rory Wolfe, Sundeep Khosla, Sultana Monira Hussain, Kathlyn Ronaldson, Anne B. Newman, Jeff D. Williamson, John J. McNeil
Summary: In this study, low-dose aspirin did not reduce the risk of fractures but increased the risk of serious falls in older adults.
JAMA INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Suzanne G. Orchard, Galina Polekhina, Joanne Ryan, Raj C. Shah, Elsdon Storey, Trevor T. -J. Chong, Jessica E. Lockery, Stephanie A. Ward, Rory Wolfe, Mark R. Nelson, Christopher M. Reid, Anne M. Murray, Sara E. Espinoza, Anne B. Newman, John J. McNeil, Taya A. Collyer, Michele L. Callisaya, Robyn L. Woods
Summary: This study suggests that slow gait and weakened grip strength are independently associated with the risk of dementia and cognitive decline, and when combined, they provide a more accurate prediction of risk.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Article
Oncology
Charlie Wang, Sophia Zoungas, Mabel Yan, Rory Wolfe, Andrew Haydon, Mark Shackleton, Mark Voskoboynik, Maggie Moore, Miles C. Andrews, Stephen J. Nicholls, Victoria Mar
Summary: This study characterizes the incidence and risk of major atherosclerotic cardiovascular events (MACE) associated with immune checkpoint inhibitor (ICI) use in patients with high-risk and advanced melanoma. The results show that ICI treatment increases the risk of MACE, especially in patients with a history of cardiovascular disease.
Article
Geriatrics & Gerontology
Johannes T. Neumann, Le T. P. Thao, Emily Callander, Prudence R. Carr, Vazhma Qaderi, Mark R. Nelson, Christopher M. Reid, Robyn L. Woods, Suzanne G. Orchard, Rory Wolfe, Galina Polekhina, Jeff D. Williamson, James M. Trauer, Anne B. Newman, Anne M. Murray, Michael E. Ernst, Andrew M. Tonkin, John J. McNeil
Summary: This study investigated the trajectories of disease and disability in a population of healthy older people, finding that cancer was the most common transition. The results have implications for preventive health interventions and planning for appropriate levels of residential care in healthy aging populations.
LANCET HEALTHY LONGEVITY
(2022)