Article
Dermatology
Maryam Nasimi, Robabeh Abedini, Narges Ghandi, Hadis Hajinamaki, Mahgol Sadat Hasan Zadeh Tabatabaei, Mahshid Sadat Ansari
Summary: This study evaluated adherence to topical drugs in patients with psoriasis and found that severe disease, involvement of lower extremity, and positive family history of psoriasis were associated with poor adherence to treatment, whereas patients with a history of diabetes mellitus had better adherence.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Mathias Tiedemann Svendsen, Klaus Ejner Andersen, Steven R. Feldman, Anna Mejldal, Soren Moller, Line Planck Kongstad
Summary: This study evaluates a randomized controlled trial for psoriasis, where dermatology nurses provide regular long-term support. The intervention showed an increase of 0.08 QALYs per patient with an incremental cost of £462, resulting in a cost-effectiveness ratio of £5999/QALY. At a willingness-to-pay threshold of £30,000 per QALY, the intervention had an almost 100% probability of being cost-effective.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ana Teixeira, Maribel Teixeira, Vera Almeida, Rita Gaio, Tiago Torres, Sofia Magina, Catia Cunha, Jose M. Sousa Lobo, Isabel F. Almeida
Summary: This study analyzed the impact of pharmaceutical dosage forms on adherence to topical treatment in psoriasis patients, revealing a complex relationship influenced by the affected area and medication formulation. Patients applying gels and creams showed higher adherence compared to those using ointments, indicating potential benefits of mechanical properties and patient preferences in treatment adherence.
Review
Dermatology
Andreas Pinter, Peter van de Kerkhof
Summary: This article summarizes a presentation on the role of topical therapies in managing psoriasis, highlighting current unmet needs and data gaps. Psoriasis has a significant impact on patients' daily lives, both physically and psychologically. Topical treatments play a crucial role in managing psoriasis, especially for mild-to-moderate cases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Health Care Sciences & Services
Hassan Tarek Hakam, Jonathan Lettner, Hannes Hofmann, Sebastian Kersten, Felix Muehlensiepen, Roland Becker, Robert Prill
Summary: The objective of this study was to cross-culturally adapt a non-compliance questionnaire into German. The questionnaire was translated, back-translated, and refined by an expert committee, resulting in the German version. The quality of the questionnaire was satisfactory according to statistical analysis. The German version will be made available for researchers and used for evaluating a mobile-application-based physical therapy regimen.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ronnaug Eline Larsen, Are Hugo Pripp, Tonje Krogstad, Cecilie Johannessen Landmark, Lene Berge Holm
Summary: This study developed a new non-disease-specific survey tool to assess self-reported medication-taking behavior, barriers, and beliefs in order to quantify the causes of non-adherence and measure adherence.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
A. Pinter, L. J. Green, J. Selmer, M. Praestegaard, L. S. Gold, M. Augustin
Summary: The study compared the superiority of CAL/BDP PAD-cream and CAL/BDP TS in the treatment of psoriasis, and the results showed that CAL/BDP PAD-cream demonstrated better efficacy, safety, and patient quality of life.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Nwanneka Okwundu, Leah Cardwell, Abigail Cline, Irma Richardson, Steven R. Feldman
Summary: The study found that under conditions promoting adherence, topical treatment can effectively improve symptoms in psoriasis patients. While the sample size was small and treatment duration short, there were significant improvements in itching, PASI, TLSS, and IGA scores.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Medicine, General & Internal
Elias A. T. Koch, Theresa Steeb, Sophia Bender-Saebelkampf, Dorothee Busch, Janina Feustel, Matthias D. Kaufmann, Andreas Maronna, Christine Meder, Moritz Ronicke, Frederic Toussaint, Hedwig Wellein, Carola Berking, Markus V. Heppt
Summary: This study investigated patient adherence to self-applied topical interventions for actinic keratosis (AK) and explored factors associated with adherence. The study found that approximately 46.9% of patients were non-adherent to the treatment plan, and only 30.9% of patients used the topical treatments according to the summary of product characteristics (SmPC). Patients who received sufficient pre-treatment consultation and were well-informed were more likely to comply with the treatment requirements.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Isabella Luiz Suzuki, Margarete Moreno de Araujo, Vanderlei Salvador Bagnato, Maria Vitoria Lopes Badra Bentley
Summary: A delivery system for TNF alpha siRNA based on hybrid polymer-lipid nanoparticles was developed and successfully optimized with photochemical internalization (PCI) to decrease TNF alpha levels in a psoriasis animal model. The results demonstrate the potential of this approach for topical treatment of psoriasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Dermatology
Anna Lis-Swiety, Aleksandra Fratczak
Summary: Mild to moderate psoriasis is commonly treated with topical therapy. This article reviews literature on topical treatments that have been evaluated in clinical trials and real-life studies lasting at least 12 months. The use of calcipotriol/bethamethasone dipropionate foam as maintenance treatment can improve the efficacy and safety of topical therapy in psoriatic patients. Introducing new nonsteroidal topical drugs and adopting proactive therapy appear to be crucial for achieving satisfactory long-term outcomes in psoriasis.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Mathias Tiedemann Svendsen, Steven R. Feldman, Anna Mejldal, Soren Moller, Line Planck Kongstad, Klaus E. Andersen
Summary: Regular support from dermatological nurses can improve the efficacy of treatment and adherence, as well as enhance the quality of life for patients with psoriasis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Mark G. Lebwohl, Linda Stein Gold, Bruce Strober, Kim A. Papp, April W. Armstrong, Jerry Bagel, Leon Kircik, Benjamin Ehst, H. Chih-ho Hong, Jennifer Soung, Jeff Fromowitz, Scott Guenthner, Stephen C. Piscitelli, David S. Rubenstein, Philip M. Brown, Anna M. Tallman, Robert Bissonnette
Summary: Tapinarof cream used once daily was more effective in reducing the severity of plaque psoriasis over 12 weeks compared to vehicle control, but was associated with local adverse events and headache. Larger and longer trials are needed to evaluate the efficacy and safety of tapinarof cream.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Paavani S. Reddy, Margaret Locke, Sherif M. Badawy
Summary: This article reviews and analyzes the adherence to iron chelation therapy (ICT) in children and adolescents. The results show that there is a variety of methods to assess adherence, and the adherence rates vary. Limited studies have focused on interventions to improve adherence, with successful interventions emphasizing consistent, long-term engagement with patients.
ANNALS OF MEDICINE
(2022)
Review
Dermatology
Ayman Grada, Steven R. Feldman, Nicola Luigi Bragazzi, Giovanni Damiani
Summary: A systematic review found that patients' perspectives on actinic keratosis treatments can impact treatment adherence and satisfaction. Short-duration treatments like ingenol mebutate gel were associated with better adherence and satisfaction, while there were conflicting results regarding the impact of imiquimod on quality of life.
DERMATOLOGIC THERAPY
(2021)
Article
Psychiatry
Odeta Gelezelyte, Malgorzata Dragan, Piotr Grajewski, Monika Kvedaraite, Annett Lotzin, Magdalena Skrodzka, Auguste Nomeikaite, Evaldas Kazlauskas
Summary: This study identified pandemic-related factors associated with suicidal ideation in Lithuania and Poland amid the COVID-19 pandemic. High levels of adjustment problems, loneliness, and burden due to staying at home more were significantly associated with suicide ideation in both countries, highlighting the importance of addressing these factors in suicide prevention efforts during the pandemic.
CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION
(2022)
Article
Psychiatry
Caroline Meyer, Rayan El-Haj-Mohamad, Nadine Stammel, Annett Lotzin, Ingo Schaefer, Christine Knaevelsrud, Maria Boettche
Summary: This study examined the associations between COVID-19-related stressors, coping strategies, and depressive symptoms in highly urbanized vs. less urbanized environments. The results showed that city inhabitants had significantly higher depression scores and used certain coping strategies more frequently.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Annett Lotzin, Imke Hinrichsen, Laura Kenntemich, Renee-Christine Freyberg, Winnie Lau, Meaghan O'Donnell
Summary: The SOLAR program, originally designed for Australian bushfire survivors, has shown promising results in a pilot study with German trauma survivors. The feasibility study demonstrated high participant satisfaction and preliminary evidence of effectiveness in reducing distress and improving quality of life. Further testing in larger trials is recommended to confirm its efficacy.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2022)
Article
Behavioral Sciences
Xiang Zhou, Viann N. Nguyen-Feng, Rachel Wamser-Nanney, Annett Lotzin
Summary: The study found that people of color reported higher levels of PTSS during COVID-19 compared to White Americans, and this racial disparity was primarily due to the influence of direct and indirect racism rather than the stressors specific to COVID-19.
BEHAVIORAL MEDICINE
(2022)
Letter
Psychology, Clinical
Jana D. Javakhishvili, Filip Arnberg, Neil Greenberg, Evaldas Kazlauskas, Annett Lotzin, Miguel Xavier
Summary: The paper provides insights into the mental health consequences of the COVID-19 pandemic in European countries and proposes five lessons learned. It highlights the differential impact of the pandemic on mental health depending on factors such as exposure levels, management policies, and healthcare resources. The paper also emphasizes the need for a stress- and trauma-informed response and suggests a stepped-care public mental health model for preventing adverse mental health outcomes during pandemics.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Review
Psychology, Clinical
Neil P. Roberts, Annett Lotzin, Ingo Schaefer
Summary: The psychological treatment of comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) is challenging and often ineffective. Trauma-focused therapy and integrated cognitive behavioural therapy (ICBT) have shown modest improvements in PTSD, but engagement in treatment is a common issue, and overall treatment effects are limited.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Psychology, Applied
Laura Kenntemich, Leonie von Huelsen, Ingo Schaefer, Maria Boettche, Annett Lotzin
Summary: This study aimed to identify latent coping profiles in the German general population during the COVID-19 pandemic and investigate their differences in well-being. Five coping profiles were identified, and high functional coping profiles were associated with higher levels of well-being. These results provide insight into the differences in coping strategies among individuals during the early phase of the pandemic and suggest the importance of promoting functional coping strategies for well-being.
Article
Psychology, Clinical
Annett Lotzin, Ronja Ketelsen, Linda Krause, Ann-Kathrin Ozga, Maria Boettche, Ingo Schaefer
Summary: This study assessed the validity and reliability of a new brief measure of coping with pandemic-related stressors. Results showed that the measure has good reliability and validity, making it suitable for assessing coping behaviors during a pandemic.
HEALTH PSYCHOLOGY AND BEHAVIORAL MEDICINE
(2022)
Article
Psychiatry
Piotr A. A. Gidzgier, Melav Bari, Mayte Lopez-Atanes, Annett Lotzin, Johanna Grundmann, Philipp Hiller, Barbara Schneider, Ingo Schaefer
Summary: This study analyzed 343 female patients with substance use disorder (SUD) and posttraumatic stress disorder (PTSD), and found that childhood trauma is associated with suicidal behaviors, with dissociation mediating the relationship between childhood sexual abuse and suicidal behavior. These findings highlight the importance of addressing dissociative symptoms and the complex consequences of childhood trauma in the treatment of SUD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Laura Kenntemich, Leonie von Huelsen, Ingo Schaefer, Maria Boettche, Annett Lotzin
Summary: The COVID-19 pandemic has led to a significant burden on the general population, with the accumulation of various risk factors associated with higher levels of depressive and anxiety symptoms. This study aimed to identify different risk profiles and examine differences in symptom levels among German participants. The findings revealed three risk profiles, with individuals in the high sociodemographic risk group reporting significantly higher levels of depression and anxiety symptoms. Understanding risk factor profiles can facilitate the development of targeted prevention and intervention programs during pandemics.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Leonie von Huelsen, Laura Kenntemich, Ingo Schaefer, Maria Boettche, Brigitte Lueger-Schuster, Juergen Gallinat, Annett Lotzin
Summary: This study aimed to investigate the associations between pandemic-related risk factors, stressors, and clinical symptoms, with special reference to gender. The findings showed that men and women had comparable networks of risk factors, stressors, and clinical symptoms, although there were differences in individual connections and levels of clinical symptoms and burdens.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Laura Eggert, Johanna Schroeder, Annett Lotzin
Summary: Living alone may increase the risk for depression, regardless of the level of emotional or instrumental support.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Psychology, Clinical
Neil P. Roberts, Annett Lotzin, Ingo Schaefer
Summary: This paper presents the methodology used to develop expert recommendations for the assessment and treatment of comorbid PTSD and SUD. The two-stage process included a systematic review of relevant trials and the collation of existing guidance. The resulting expert recommendations will provide guidance for clinicians and service providers in addiction and mental health settings.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Review
Psychology, Clinical
Liselotte Banz, Mina Stefanovic, Maria von Boeselager, Ingo Schaefer, Annett Lotzin, Birgit Kleim, Thomas Ehring
Summary: The aim of this meta-analysis was to synthesize evidence on the effects of psychological interventions for PTSD on negative self-concept. The results showed that psychological interventions significantly improve a negative self-concept, but there was considerable heterogeneity between studies. Further research is needed to identify moderators and interventions that are most effective for reducing negative self-concept.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Psychology, Multidisciplinary
Annett Lotzin, Ronja Ketelsen, Irina Zrnic, Brigitte Lueger-Schuster, Maria Boettche, Ingo Schaefer
Summary: This study aimed to assess the validity and reliability of a new scale for measuring distress caused by different stressors during a pandemic or epidemic. The results showed that the scale demonstrated sufficient validity and reliability in measuring stressors during the current COVID-19 pandemic.
