Article
Food Science & Technology
Lei Bao, Xiaxia Cai, Mingyuan Zhang, Yang Xiao, Jin Jin, Tong Qin, Yong Li
Summary: This study evaluated the effects of BCOP on wound healing and found that it could accelerate the healing process by promoting fibroblast proliferation, migration, and collagen metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Shiyan Li, Xiaofeng Ding, Hao Zhang, Youjun Ding, Qian Tan
Summary: IL-25 plays a role in the treatment of diabetic wounds by promoting macrophage and fibroblast activation, affecting inflammation resolution through multiple signaling pathways, and improving angiogenesis and collagen alignment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fa-Wei Xu, Ying-Li Lv, Yu-Fan Zhong, Ya-Nan Xue, Yong Wang, Li-Yun Zhang, Xian Hu, Wei-Qiang Tan
Summary: This review summarizes the effects of EGCG and its wound dressings on skin wound healing, including various types of EGCG-containing wound dressings and their beneficial effects at different stages of wound healing. It also explains the rationale for using EGCG to promote skin wound healing and prevent scar formation, providing a future clinical application direction.
Article
Cell Biology
Liuhanghang Cheng, Xiaoxuan Lei, Zengjun Yang, Yanan Kong, Pengcheng Xu, Shiya Peng, Jue Wang, Cheng Chen, Yunqing Dong, Xiaohong Hu, Xiaorong Zhang, Tymour Forouzanfar, Gang Wu, Xiaobing Fu
Summary: Histatin 1 has been found to accelerate wound healing and improve the mechanical properties of healed skin by promoting the function of fibroblasts. In vitro experiments showed that fibroblasts stimulated by Hst 1 exhibited enhanced migration ability and transformation into myofibroblasts, leading to improved contraction and collagen secretion functions. Additionally, the study identified activation of the mTOR signaling pathway by Hst 1 in fibroblasts.
CELL PROLIFERATION
(2021)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Biochemistry & Molecular Biology
Shihab Uddin Ahmad, Nor-Ashila Binti Aladdin, Jamia Azdina Jamal, Ahmad Nazrun Shuid, Isa Naina Mohamed
Summary: The study found that wounds treated with MP extracts healed significantly faster compared to untreated and control groups. Histological analysis among MP-treated groups revealed better re-epithelialization, higher collagen deposition, enhanced fibronectin content and fibroblast cells, and higher fiber transformation from collagen-III to collagen-I.
Review
Dermatology
Andrzej Hecker, Marlies Schellnegger, Elisabeth Hofmann, Hanna Luze, Sebastian Philipp Nischwitz, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Resveratrol is a powerful antioxidant that may aid in wound healing and prevent skin aging. Current research suggests that resveratrol could be a feasible treatment approach, but further studies are needed to confirm its effects.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Yizhao Ma, Zhifang Liu, LinLin Miao, Xinyu Jiang, Hongyu Ruan, Rongrong Xuan, Suling Xu
Summary: Pathological scarring is caused by excessive proliferation and transdifferentiation of fibroblasts, as well as excessive deposition of extracellular matrix during wound healing. Factors that promote pathological scar formation affect the proliferation and function of fibroblasts. This study explores the microenvironment, signaling pathways, epigenetics, and autophagy related to the abnormal formation of fibroblasts in pathological scarring. Understanding the causes of abnormal fibroblast formation may lead to improved prevention and treatment strategies for pathological scarring and enhance patients' quality of life.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
He-chen Huang, Yan Chen, Jie Hu, Xiu-tian Guo, Shao-rong Zhou, Qi-qi Yang, Yu-qing Du, Yu Jin, Guo-bin Liu, Yun-hua Peng
Summary: This meta-analysis examined the effect of quercetin and its derivatives on wound healing in animal experiments. The results showed that quercetin promoted faster wound closure in animals compared to the control group. The study also found that quercetin inhibited inflammatory response, accelerated angiogenesis, fibroblast proliferation, and collagen deposition. These findings suggest that quercetin and its derivatives can promote the recovery of cutaneous wounds in animals.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Surgery
Walker D. Short, Xinyi Wang, Hui Li, Ling Yu, Aditya Kaul, Gisele A. Calderon, Jamie Gilley, Paul L. Bollyky, Swathi Balaji, Sundeep G. Keswani
Summary: The study aimed to demonstrate the impact of IL-10 producing T lymphocytes on mediating dermal scarring. The results showed that IL-10 producing CD4(+) T lymphocyte subsets can promote wound healing and reduce fibrosis.
Article
Dermatology
Shakti N. Menon, Jennifer A. Flegg
Summary: This article reviews the development of mathematical models for investigating wound healing mechanisms, the contributions in epidermal, dermal, and corneal wound healing, and the influence of mathematical models on biological experiments. It also highlights the key advances made in recent decades and discusses the future direction of the field, emphasizing the importance of a common language between scientists for cross-collaboration.
ADVANCES IN WOUND CARE
(2021)
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ane Nishitha Vijayan, Anbuthiruselvan Solaimuthu, Padmaja Murali, Janani Gopi, Teja Y. Madhan, Priya R. Akshaya, Purna Sai Korrapati
Summary: Scars occur as a result of tissue damage or surgery, and excessive TGF-beta activity can lead to progressive fibrosis. This study developed PCL-Gelatin biomimetic scaffolds for sustained delivery of Decorin to reduce TGF-beta levels and subsequent scar formation. In vitro experiments and a fibrotic model demonstrated that the Decorin-loaded nanofiber could effectively decrease the expression of ECM-related proteins, potentially obstructing scar formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)