Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Camille Togo, Ana Paula Zidorio, Vivian Goncalves, Patricia Botelho, Kenia de Carvalho, Eliane Dutra
Summary: This systematic review summarizes the current evidence on the effect of oral or enteral probiotic therapy on wound healing in humans. The results indicate that probiotic therapy may have a positive impact on wound improvement, but strong evidence is still lacking. Further controlled clinical research is needed to explore the effects of specific probiotic strains, wound types, and target populations.
Review
Immunology
Arnolda Jakovija, Tatyana Chtanova
Summary: The skin, as the body's largest organ, serves as a barrier to pathogens and the first line of immune defense. In the event of skin injury, a series of events contribute to wound repair, including inflammation, tissue formation, and tissue remodeling. Immune cells in the skin work alongside non-immune cells to clear pathogens, debris, and guide tissue regeneration. Disruption to the wound repair process can lead to chronic inflammation and non-healing wounds, which can promote skin cancer development by hijacking the wound healing response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Joseph D. Tanfani, Jasmin D. Monpara, Sriramakamal Jonnalagadda
Summary: 3D printing is widely used by independent researchers in various fields, with 3D bioprinting being a specific form that utilizes bioinks to create complex, bioactive structures such as artificial skin for wound regeneration. Despite the wide range of available materials and cell types, an ideal bioink for printing artificial skin has yet to be found. This review will discuss the different types of 3D printing, commonly used bioinks, challenges in 3D bioprinting of skin, and future directions for the field.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Pharmacology & Pharmacy
Fabiola V. Borbolla-Jimenez, Sheila I. Pena-Corona, Sonia J. Farah, Maria Teresa Jimenez-Valdes, Emiliano Pineda-Perez, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Jonathan J. Magana, Gerardo Leyva-Gomez
Summary: Wound healing is a complex process involving four phases: hemostasis, inflammation, proliferation, and remodeling. Polymeric films have been widely used as wound dressings due to their biocompatibility, low immunogenicity, ease of application, and gas exchange capabilities. Among various methods for designing polymeric films, solvent casting is a reliable and cost-effective technique. This review focuses on polymeric dressings obtained using solvent casting, discussing the manufacturing factors necessary for effective wound dressing performance.
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Polymer Science
N. Disha Moholkar, S. Priyadarshani Sadalage, Diana Peixoto, Ana Claudia Paiva-Santos, D. Kiran Pawar
Summary: Researchers worldwide have shown immense interest in the field of wound healing for decades, aiming to develop effective techniques to accelerate healing process and prevent scar formation. Biopolymeric nanosystems have emerged as alternatives for conventional wound dressings, potentially providing an improved wound healing environment.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Jinli Zhang, Changling Liu, Xiaojian Li, Zhihe Liu, Zhi Zhang
Summary: Hydrogels play a significant role in wound nursing by promoting wound healing and tissue remodeling through reducing inflammation, facilitating vascularization, and supporting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Massimiliano Marvasi, Monica Monici, Desiree Pantalone, Duccio Cavalieri
Summary: Wound healing is slowed in Space due to microgravity, physical factors, and alterations in the skin microbial community. To improve wound healing in Space, the application of human skin microbiota in four domains, including antimicrobial properties, immune system interaction, precision medicine, and gut-skin/gut-brain axes, is proposed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi
Summary: Tregs play a critical role in skin wound healing, helping to balance immune homeostasis and promote healthy wound repair. Understanding the function and mechanisms of Tregs is important for understanding wound pathologies and developing new treatment strategies.
MILITARY MEDICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.
BIOACTIVE MATERIALS
(2022)
Review
Biology
Lucas Fernando Sergio Gushiken, Fernando Pereira Beserra, Jairo Kenupp Bastos, Christopher John Jackson, Claudia Helena Pellizzon
Summary: The article discusses the physiological mechanisms, interfering factors, and treatment methods of skin wound healing. The success of wound healing depends on the correct balance and is influenced by various factors.
Article
Dermatology
Okensama M. La-Anyane, Richard S. Feinn, David J. Hill, Lynn Copes, Gifty Kwakye, Bernard K. Seshie
Summary: Skin-bleaching is a common practice globally and is associated with various health risks. A survey conducted among healthcare professionals in the Greater Accra Region of Ghana found that wounds in skin-bleaching patients tend to heal more slowly, are more prone to infection, bleeding, and wound dehiscence, and are more challenging to manage. The study also revealed a need for guidelines to properly identify these patients and facilitate early risk prevention.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Shushen Li, Zhiyuan Zhao, Qingwei Li, Jun Li, Yue Pang
Summary: The skin serves as a natural barrier with multiple functions and plays a crucial role in body temperature regulation, sensory stimulation, mucus secretion, metabolite excretion, and immune defense. Lampreys, as ancient vertebrates, have the ability to efficiently heal skin wounds and prevent infections. However, the underlying mechanisms of lamprey skin wound healing and regeneration are not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Clinical Neurology
Julia Kondo, Priscila K. Morelhao, Sergio Tufik, Monica L. Andersen
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Tathiana A. Alvarenga, Guilherme L. Fernandes, Lia R. Bittencourt, Sergio Tufik, Monica Levy Andersen
Summary: Sleep is crucial for maintaining health and stability, and lack of sleep and poor sleep quality are associated with various diseases. This study found that obstructive sleep apnea (OSA) and sleep deprivation have negative effects on male reproductive function, leading to hormone imbalance and abnormal sperm.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Clinical Neurology
Vinicius Dokkedal-Silva, Priscila K. Morelhao, Gustavo A. Moreira, Sergio Tufik, Monica L. Andersen
SLEEP AND BREATHING
(2023)
Article
Endocrinology & Metabolism
Kirsten N. Redman, Katie E. O'Brien, Francieli S. Ruiz, Dale E. Rae, F. Xavier Gomez-Olive, Malcolm von Schantz, Karine Scheuermaier
Summary: People living with HIV have poorer sleep quality, shorter sleep duration, and earlier sleep phase, which has significant implications for their health and well-being.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Anesthesiology
Leandro Lucena, Gilles Lavigne, Cibele Dal Fabbro, Monica Levy Andersen, Sergio Tufik, Helena Hachul
Summary: Nighttime pain in women is associated with decreased quality of life, worsening mood, and increased fatigue. This study highlights the negative effects of pain on women's health and emphasizes the importance of addressing nighttime pain in clinical care to improve overall well-being and quality of life.
EUROPEAN JOURNAL OF PAIN
(2023)
Letter
Clinical Neurology
Viviane A. A. Kakazu, Priscila K. K. Morelhao, Sergio B. B. Tufik, Sergio Tufik, Monica L. L. Andersen
SLEEP AND BREATHING
(2023)
Article
Obstetrics & Gynecology
M. Moyses-Oliveira, A. M. C. Scaff, L. N. G. Adami, H. Hachul, M. L. Andersen, S. Tufik
Summary: Premature ovarian insufficiency (POI) is a condition where women below the age of 40 experience a loss of regular hormone production and egg release, leading to infertility, vaginal dryness, and dysfunctional sleep. A study found overlapping genes between POI and insomnia, particularly in pathways related to DNA replication, homologous recombination, and Fanconi anemia. The overlap may be due to oxidative stress and dysregulated DNA repair mechanisms, which could be potential targets for treatment. This study provides a new understanding of the relationship between insomnia and POI.
Article
Clinical Neurology
Thiprawee Chattrattrai, Ghizlane Aarab, Tessa F. Blanken, Gabriel N. Pires, Alberto Herrero Babiloni, Cibele Dal Fabbro, Eus van Someren, Gilles Lavigne, Milton Maluly, Monica L. Andersen, Sergio Tufik, Frank Lobbezoo
Summary: This study investigated the associations of self-reported sleep bruxism with other sleep disorders and demographic, psychological, and lifestyle factors in the adult general population. The results showed that self-reported sleep bruxism was only significantly associated with sex, anxiety, and depression, while polysomnographically confirmed sleep bruxism was not associated with any of the included factors.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Guilherme Luiz Fernandes, Julia Ribeiro da Silva Vallim, Vania D'Almeida, Sergio Tufik, Monica Levy Andersen
Summary: Sleepiness is influenced by multiple factors including social jetlag and sleep variability. This study found that the effects of social jetlag on sleepiness may be mediated by sleep debt, highlighting the importance of circadian misalignment and sleep debt for sleep health on a population level.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Maingredy Rodrigues Souza, Daniela Santoro Rosa, Tathiana A. Alvarenga, Priscila K. Morelhao, Sergio Tufik, Monica L. Andersen
Summary: This study evaluated the effects of nocturnal asthma on sleep parameters and inflammatory markers according to the severity of the condition in participants of the EPISONO study. It found that individuals with persistent nocturnal symptoms had higher BMI, more respiratory symptoms, worse lung function, higher AHI, and higher desaturation index compared to those with intermittent symptoms. Additionally, there were positive associations between nocturnal asthma and obstructive sleep apnea (OSA).
SLEEP AND BREATHING
(2023)
Editorial Material
Clinical Neurology
Luana Nayara Gallego Adami, Mariana Moyses-Oliveira, Sergio Tufik, Monica L. Andersen
Article
Clinical Neurology
Fernanda Veruska Narciso, Ana R. Damaso, Jose A. Barela, Adriana N. S. Carvalho, Francieli Ruiz, Sandra Souza de Queiroz, Vanessa Silva Lemos, Andre Gustavo P. de-Andrade, Sergio Tufik, Marco Tulio De-Mello
Summary: Objectives: This study aimed to examine the relationship between sleep duration and postural control of female night workers before and after shift. In addition, the impact of body mass index (BMI) on postural control was investigated.Methods: Fourteen female night workers participated in this study. Sleep-wake cycle was evaluated using an actigraph. BMI was calculated based on body mass and height measurements. Postural control was assessed using a force platform with eyes opened and closed before and after a 12-hour workday.Results: BMI significantly affected velocity and center of pressure path with eyes opened before and after night work. BMI also impaired velocity and center of pressure path with eyes closed before and after night work. High BMI was associated with increased postural sway in female workers.Conclusion: High BMI adversely affects postural control of female night workers, leading to postural instability before and after night work.
Article
Urology & Nephrology
Luana N. G. Adami, Mariana Moyses-Oliveira, Lais Amanda Souza-Cunha, Matheus Brandao Vasco, Sergio Tufik, Monica L. Andersen
Summary: This study found that ED and OSA may share genetic variants of risk and have molecular and biological interactions. The highlighted biological pathways from the shared genes may provide preliminary findings for future functional investigations on the association between OSA and ED.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Clinical Neurology
Guilherme Luiz Fernandes, Sergio Tufik, Monica Levy Andersen
Summary: Recent evidence suggests that sleepiness has multiple dimensions, including sleep propensity and sleepiness perception. The widely used Epworth Sleepiness Scale might not be able to detect sleep health impairments. Further research with large sample sizes and both objective and subjective methods is needed to investigate the dimensions of sleepiness.
