期刊
ARCHIVES OF DERMATOLOGICAL RESEARCH
卷 303, 期 7, 页码 527-531出版社
SPRINGER
DOI: 10.1007/s00403-011-1135-y
关键词
Bifidobacterium bifidum; Tyrosinase; Melanin; Antioxidant
类别
资金
- Ministry of Economic Affairs, R. O. C. [98-EC-17-A-17-S1-128, S09900074-603]
Various skin hyperpigmentation disorders consist in accumulation and overproduction of melanin. In this report, we investigated the melanogenesis inhibitory and antioxidant effects of Bifidobacterium bifidum culture filtrate. The results revealed that B. bifidum culture filtrate effectively suppresses murine tyrosinase activity and decreases the amount of intracellular melanin in a dose-dependent manner. Additionally, the bacterial culture filtrate-scavenged DPPH and ABTS radicals, and shows potent-reducing power in a dose-dependent pattern. Our results expand the application of B. bifidum culture filtrate in the development and research of skin-whitening ingredients.
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