Article
Cell Biology
Michiko Tashiro, Masato Konishi, Makino Watanabe, Utako Yokoyama
Summary: The intracellular concentration of free Mg2+ ([Mg2+]i) plays a crucial role in cellular functions. Reactive oxygen species (ROS) can affect [Mg2+]i homeostasis and lead to cellular damage. This study demonstrates that ROS decrease intracellular Mg2+ levels in cardiomyocytes through a Na+-independent Mg2+ efflux system, potentially contributing to ROS-induced cardiac dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Susanne Flor, Claudia R. Oliva, Md Yousuf Ali, Kristen L. Coleman, Jeremy D. Greenlee, Karra A. Jones, Varun Monga, Corinne E. Griguer
Summary: Glioblastoma, the deadliest form of brain cancer, often becomes resistant to standard treatments due to the upregulation of antioxidant catalase (CAT) which enhances resistance to chemotherapy and radiation, decreases survival rates, and enriches glioma stem cell populations.
Article
Chemistry, Physical
Sihan Jia, Sunkui Ke, Li Tu, Shengqiang Chen, Bingkun Luo, Yeqi Xiong, Yang Li, Peiyuan Wang, Shefang Ye
Summary: In this study, a tumor microenvironment (TME)-responsive Cu-based metal-mesoporous organosilica nanoplatform incorporating vitamin k3 (VK3) was developed for enhanced chemodynamic therapy (CDT) of cancer. The nanoplatform could deplete glutathione (GSH) and specifically regenerate hydrogen peroxide (H2O2), resulting in synergistic CDT against tumors. Both in vitro and in vivo studies demonstrated the excellent biosafety and highly efficient tumor therapy potential of the CuO@MON-PEG/VK3 nanoplatform with multiple oxidative stress amplification.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Plant Sciences
Taras Pasternak, Klaus Palme, Jose Manuel Perez-Perez
Summary: Reactive oxygen species (ROS) play a dual role in plant biology, acting as important signal transduction molecules and as toxic byproducts of aerobic metabolism that accumulate in cells upon exposure to different stressors and lead to cell death. In this study, it was found that ROS is an important modulator of auxin distribution and response in plant roots. Genetic alterations in ROS balance led to defective auxin distribution and growth-related responses in roots.
Article
Biotechnology & Applied Microbiology
Javier Espinoza-Vergara, Paulo Molina, Mariana Walter, Miguel Gulppi, Nelson Vejar, Francisco Melo, Marcela Urzua, Hugo Munoz, Jose H. Zagal, Xiaorong Zhou, Manuel I. Azocar, Maritza A. Paez
Summary: The study investigated the influence of pH on the electrochemical behavior of hydrogen peroxide in the presence of Pseudomonas aeruginosa. It was found that the enzymatic activity exhibited maximum activity at pH 7.5, with oxygen reduction reaction (ORR) occurring at higher overpotentials at higher or lower pHs. Atomic force microscopy was also used to assess the influence of bacterial adhesion on the electrochemical behavior.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Chemical
Yaru Wang, Yeqing Lyu, Shaona Wang, Hao Du
Summary: The main ROS generated in phosphoric acid solution from oxygen microbubbles was identified as H2O2, with its production dependent on temperature and phosphoric acid concentration. Under optimal conditions, the production of H2O2 from microbubbles facilitated the oxidation of ferrous ions and significantly reduced the reaction activation energy.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Review
Chemistry, Analytical
Wanchao Yu, Lixia Zhao
Summary: ROS, as important oxidizing species in ecosystems, play various roles and monitoring their concentration is crucial for the environment. The chemiluminescence method has attracted attention for ROS detection due to its high sensitivity and simplicity, showing advances in recent years.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Rohini Kumari, Daphika S. Dkhar, Supratim Mahapatra, Divya, Rahul Kumar, Pranjal Chandra
Summary: Reactive oxygen species play an important role in cell signaling but excessive production is associated with various diseases. Traditional detection methods have limitations, while biosensing technology has emerged as a major approach. This review discusses recent biosensors for monitoring reactive oxygen species and highlights the progress of nanotechnology and biomimetic engineering in biosensing.
MICROCHEMICAL JOURNAL
(2022)
Article
Environmental Sciences
Chaoqun Tan, Tianyu Sheng, Qinglong Xu, Tianhui Xu, Kechun Sun, Lin Deng, Wei Xu
Summary: Cobalt doped iron oxychloride (Co-FeOCl) was synthesized and used as a catalyst in Fenton degradation of paracetamol (APAP) and phenacetin (PNCT) for the first time. The study found that the catalyst showed high removal efficiency under certain conditions, and identified the primary reactive oxygen species in the system as well as proposed a possible activation mechanism.
Article
Chemistry, Analytical
Huisi Yang, Juan Zhou, Jing Bao, Yi Ma, Jun Zhou, Caihong Shen, Huibo Luo, Mei Yang, Changjun Hou, Danqun Huo
Summary: The addition of graphene increases the specific surface area of the MoS2/rGO composite, leading to improved detection sensitivity towards H2O2. This composite material, prepared using a simple method, is expected to play a significant role in clinical applications.
MICROCHEMICAL JOURNAL
(2021)
Review
Cell Biology
Bhupesh Singla, Ravi Varma Aithabathula, Sonia Kiran, Shweta Kapil, Santosh Kumar, Udai P. Singh
Summary: The lymphatic system plays a crucial role in immune surveillance and tissue homeostasis, and lymphangiogenesis, the formation of new lymphatic vessels, is involved in various physiological and pathological processes. Recent research progress in the molecular mechanisms of lymphangiogenesis has opened up new possibilities for therapeutic approaches in diseases such as neurological disorders, cardiac repair, autoimmune disease, obesity, and atherosclerosis.
Article
Biochemistry & Molecular Biology
J. Jeffrey Morris, Andrew L. Rose, Zhiying Lu
Summary: Reactive oxygen species (ROS) are omnipresent in the ocean, originating from both biological and non-biological processes. They directly and indirectly impact marine organisms and biogeochemistry, shaping microbial communities and influencing steady-state ROS concentrations. Climate change may increase ROS levels in the ocean, affecting the ecology and chemistry of the future ocean.
Review
Plant Sciences
Ana Jimenez, Francisca Sevilla, Maria Carmen Marti
Summary: Understanding the molecular mechanisms involved in how plants perceive and respond to environmental stimuli is crucial for their adaptation to climate change. The coordination of daily cycles and stress response, as well as the crosstalk between second messengers like Ca2+, ROS, and hormones, play key roles in plant adaptation and survival under stress. The circadian clock, along with Ca2+ and hormone signaling pathways, is crucial in controlling plant adaptation to stress, highlighting the importance of studying the relationship between circadian clocks and ROS homeostasis network.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Multidisciplinary Sciences
Yu Xia, Juan Li, Yuanzheng Zhang, Yongguang Yin, Bolei Chen, Yong Liang, Guibin Jiang, Richard N. Zare
Summary: Spontaneous generation of reactive oxygen species (ROS) occurs when water vapor contacts hydrogen-bonded hydroxyl groups on a silicate surface, which is confirmed by time-resolved FT-IR spectroscopy. The involvement of water vapor in ROS generation is further supported by studying the reaction of D2O vapor and hydroxyl groups on a silicate surface. It is proposed that the change of the hydrogen-bonding network and electron transfer onto the silicate surface during water vapor-solid contact process contribute to ROS production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
E. M. Keizer, I. D. Valdes, B. L. McCann, E. M. Bignell, H. A. B. Wosten, H. de Cock
Summary: Previously, it was believed that DHN-melanin could protect Aspergillus fumigatus against H2O2, but this study showed that DHN-melanin is not involved in protection against H2O2 or superoxide. UV mutagenesis may cause mutations in other genes, such as cat1, which explains the increased sensitivity to H2O2.
Article
Biochemistry & Molecular Biology
Yuri Nagaoka, Kotone Oshiro, Yuta Yoshino, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Summary: This study investigated the effect of intercellular adhesion molecule CLDN1 on the anticancer drug sensitivity of small-cell lung cancer (SCLC) cells. It was found that overexpression of CLDN1 decreased the sensitivity of SCLC cells to anticancer drugs and enhanced their migratory capacity through the activation of the TGF-81/EMT signaling pathway. Treatment with EMT inhibitors showed potential in overcoming the reduced sensitivity to anticancer drugs in CLDN1-overexpressing SCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2024)
