期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 501, 期 1, 页码 124-133出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.03.020
关键词
Almond skins; Flavan-3-ols; Conjugated phenolic metabolites; Microbial-derived phenolic metabolites; Hydroxyphenylvalerolactones; Targeted analysis
资金
- Spanish Ministry of Science and Innovation (MICINN) [CSD2007-063, CD06/00161]
- European Social Fund
In this paper, a survey of our studies on almond polyphenols including their chemical characterization and further bioavailability in humans is reported. Combination of analytical techniques (LC-DAD/fluorescence, LC/ESI-MS and MALDI-TOF-MS) allowed us, for the first time, the identification of A- and B-type procyanidin, propelargonidin and prodelphinidin polymers in almond skins. Glucuronide, O-methyl glucuronide, sulfate and O-methyl sulfate derivatives of (epi)catechin, as well as the glucuronide conjugates of naringenin and isorhamnetin, and sulfate conjugates of isorhamnetin, together with conjugates of hydroxyphenylvalerolactones were detected in plasma and urine samples after the intake of almond skin polyphenols. In addition, numerous microbial-derived metabolites, including hydroxyphenylpropionic, hydroxyphenylacetic, hydroxycinnamic, hydroxybenzoic and hydroxyhippuric acids were also identified. Depending of the type of metabolite, maximum urinary excretion was attained at different time in comparison to the control group in the course of the 24-h period of urine excretion, allowing us to establish the onset of microbial metabolism. (C) 2010 Elsevier Inc. All rights reserved.
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