期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 473, 期 2, 页码 210-217出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.02.013
关键词
calcitonin; CGRP; bone formation; osteoblast; bone resorption; osteoclast
The Calca gene encodes two polypeptides, calcitonin (CT) and alpha-calcitonin gene-related peptide (alpha-CGRP), generated through alternative splicing. While CT, a hormone mainly produced by thyroidal C cells, has been described as a major regulator of bone resorption, alpha-CGRP, a neuropeptide expressed in the cells of the central and peripheral nervous system, is mostly known as a regulator of vascular tone. Surprisingly, the generation and skeletal analyses of two mouse deficiency models has recently uncovered a physiological function for both peptides in the regulation of bone formation. In the first model, where the replacement of exons 2-5 of the Calca gene resulted in the combined deficiency of CT and alpha-CGRP, an increased bone formation rate (BFR) was observed, whereas decreased BFR was found in the second model, where the introduction of a translational termination codon into exon 5 of the Calca gene resulted in the specific absence of alpha-CGRP. (C) 2008 Elsevier Inc. All rights reserved.
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