期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 474, 期 2, 页码 302-317出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.01.026
关键词
glucosamine-6P synthase; GlmS regulation; Gfat1; amidotransferase; enzyme mechanism; type 2 diabetes; hexosamine pathway; inhibition; X-ray structure
L-Glutamine:D-fructose-6-phosphate amidotransferase, also known as glucosamine-6-phosphate synthase (GlcN6P synthase), which catalyzes the first step in a pathway leading to the formation of uridine 5'-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), is a key point in the metabolic control of the biosynthesis of amino sugar-containing macromolecules. The molecular mechanism of the reaction catalyzed by G1cN6P synthase is complex and involves amide bond cleavage followed by ammonia channeling and sugar isomerization. This article provides a comprehensive overview of the present knowledge on this multi-faceted enzyme emphasizing the progress made during the last five years. (c) 2008 Elsevier Inc. All rights reserved.
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