Atherogenic index of plasma and atherogenic coefficient are increased in major depression and bipolar disorder, especially when comorbid with tobacco use disorder

Background: There is a robust comorbidify between mood cl sorclers and cardiovascular disorder (CVD). The atherogenic index of plasma (ALP) and the atherogenic coefficient (AC) are important atherogenic indexes. The aims of this study were to delineate whether AIP and AC are increased in mood disorders especially when comorbid with tobacco use disorder (TUD). Methods: In this case control study we included 134 patients with mood disorders, bipolar disorder and unipolar depression (cases), and 197 individuals without mood disorder (controls) divided into those with and without TUD (defined as never smokers), Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDLc) and low density lipoprotein cholesterol (LDLc) were measured. RIP and AC were computed as log (TG/HDLc) and non-HDLc/HDLc, respectively. Results: The AIP and AC indexes were significantly increased in patients with mood disorders versus conirols, both in depression and bipolar disorder. PaLienis with mood disorder wiLhoui TUD and paLienis with TUD without mood disorder showed higher ALP and AC values than never smokers while those with comorbid mood disorders and TUD showed significanily higher ALP and AC levels Lhan all other individuals. A large parL of the variance in Lhe AlC (26.4%) and AC (204%) was explained by mood disorders, TUD, male gender and body mass index. Conclusions: The findings suggest that lipid abnormalifics leading Lo an increased aiherogenic poLenLial are involved in the pathophysiology of mood disorders (depression and bipolar disorder) and especially comorbid mood disorder and TUD. The comorbidity between mood disorders and CVD may be partly explained increased through AIP and AC indexes, impacting increments in atherogenic potential. (C) 2014 Elsevier B.V. All rights reserved.