Article
Clinical Neurology
Shijing Wang, Francesco Leri, Sakina J. Rizvi
Summary: Anhedonia, a core symptom of major depressive disorder, extends beyond impaired consummatory pleasure to deficits in various functions, with dopamine and other neurotransmitters playing key roles. While extensive research has explored reward anticipation and outcome, there are translational gaps in understanding reward motivation, effort, valuation, and learning.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Julia Klawohn, Kreshnik Burani, Alec Bruchnak, Nicholas Santopetro, Greg Hajcak
Summary: Individuals with major depressive disorder (MDD) exhibit reduced reward positivity (RewP) and blunted neural responses to pleasant pictures, which may relate to anhedonia and decreased emotional engagement. The deficits in RewP and late positive potential (LPP) are independent neural markers of MDD and can help improve its classification.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Psychiatry
Angela Pisoni, Simon W. Davis, Moria Smoski
Summary: Anhedonia, the loss of pleasure or motivation, is a transdiagnostic symptom with implications for mental health. Research suggests increased anhedonia is associated with hyperactivity of the Salience Network in resting and negative stimuli contexts, and a lack of global engagement in positive stimuli contexts. Targeted treatments within the Triple Network Model of Psychopathology and future research directions are discussed.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Qi Liu, Benjamin A. Ely, Joshua J. Schwartz, Carmen M. Alonso, Emily R. Stern, Vilma Gabbay
Summary: This study found that lack of pleasure (anhedonia) in adolescent patients with depression may be a predictor of future depression and suicidal ideation. Specifically, activation in the left angular gyrus was associated with future depression, while activation in key salience and pain network regions was associated with future anhedonia.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Riccardo De Marco, Andrew W. Barritt, Mara Cercignani, Giulia Cabbai, Alessandro Colasanti, Neil A. Harrison
Summary: Inflammation can rapidly change motivational state and impair mood, leading to avoidance of pleasurable activities and increased sensitivity to negative stimuli, which can result in major depressive episodes. This study investigated whether minocycline inhibits the effects of lipopolysaccharide on reward/punishment sensitivity in humans, and found that it attenuated the inflammation-induced shift in reward versus punishment sensitivity.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychology, Clinical
Laura Murray, Elana S. Israel, Emma G. Balkind, Brianna Pastro, Nathaniel Lovell-Smith, Scott E. Lukas, Erika E. Forbes, Diego A. Pizzagalli, Christian A. Webb
Summary: Anhedonia is a core symptom of depression that predicts worse treatment outcomes. Dysfunction in neural reward circuits is thought to contribute to anhedonia. This study examined whether laboratory-based assessments of anhedonia and reward-related neural function were associated with adolescents' subjective affective experiences in daily life, and found that there was a relationship between them.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Sarah T. Wieman, Kimberly A. Arditte Hall, Helen Z. MacDonald, Matthew W. Gallagher, Michael K. Suvak, Alora A. Rando, Gabrielle Liverant
Summary: This study explored the interrelationships among sleep disturbance, depressive symptoms, anhedonia, and reward responsiveness, and found unique associations between sleep disturbance and elements of reward responsiveness, highlighting new treatment mechanisms for anhedonia and depression.
Article
Clinical Neurology
Joseph R. Cohen, Hena Thakur
Summary: The study explored the variation of adolescent depressive symptoms, depressed mood, and anhedonia across intersecting identities over time. The findings suggest that the impact of identity on depression outcomes is tenfold that of temporal effects, and certain groups, such as multiracial, late adolescent, and female adolescents, are particularly vulnerable to depression. Limitations include the exclusion of certain facets of identity and the use of a unidimensional measure of poverty.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Kevin G. Saulnier, Natalie S. Marr, Camilla van Geen, Dara E. Babinski, Dahlia Mukherjee
Summary: Offspring of depressed parents are at an increased risk for depression. Reward- and punishment-based systems might be mechanisms linking maternal outcomes to offspring depression and anhedonia. The study investigated the intergenerational relations between maternal markers of reward and punishment responsiveness and their offspring's depression and anhedonia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Karina Quevedo, Jia Yuan Teoh, Guanmin Liu, Carmen Santana-Gonzalez, Erika E. Forbes, Maggie Engstrom
Summary: Adolescence is a period of neural plasticity in self-processing substrates, and understanding the altered substrates of self-processing in depressed adolescents with suicide attempts is critical for targeted prevention and treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
C. E. Schiller, E. Walsh, T. A. Eisenlohr-Moul, J. Prim, G. S. Dichter, L. Schiff, J. Bizzell, S. L. Slightom, E. C. Richardson, A. Belger, P. Schmidt, D. R. Rubinow
Summary: This double-blinded pharmaco-fMRI study shows that adding back and withdrawing hormones increases anhedonia in women without pleasure. Both hormone sensitive and non-hormone sensitive individuals exhibit decreased reward-related brain function during withdrawal.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Family Studies
Jackson M. A. Hewitt, Bita Zareian, Joelle Lemoult
Summary: The current study examined the psychometric properties of the Dimensional Anhedonia Rating Scale (DARS) in adolescents. Overall, the DARS demonstrated good convergent and discriminant validity, but had sub-optimal concurrent validity. The strengths and limitations of the DARS as a measure of adolescent anhedonia and future directions for the development of new measures were discussed.
JOURNAL OF EARLY ADOLESCENCE
(2023)
Article
Psychology, Multidisciplinary
Michael R. R. Gallagher, Taban Salem, E. Samuel Winer
Summary: Individuals with depression focus on negativity and avoid positive and potentially rewarding stimuli. Reward Devaluation Theory (RDT) provides an alternative framework to understand cognitive/affective biases in depression. This article reviews the theoretical foundations of RDT and examines the empirical evidence surrounding positivity avoidance and depression.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Hong Cai, Zong-Lei Li, Fan He, Shu-Ying Li, Yan-Jie Zhao, Wu-Yang Zhang, Yao Zhang, Zhaohui Su, Todd Jackson, Yu-Tao Xiang
Summary: This study found close associations between anhedonia and suicidal ideation (SI) among adolescent patients with recurrent depressive disorder (depression). Network analysis revealed that anhedonia was directly related to SI, as well as guilt, sad mood, and motor disturbances. Sad mood and fatigue were the main bridge nodes linking anhedonia and SI. This study is important for guiding interventions to reduce the risk of SI among clinically stable adolescents with depression during the COVID-19 pandemic.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Andreas B. Wulff, Phylicia Cooper, Emmanuela Kodjo, Eliana Abel, Scott M. Thompson
Summary: The sucrose preference test is widely used to study stress-sensitive reward behaviors and antidepressant treatments in rodents. Our analysis of licking microstructure in mice during the test revealed that stress-naive mice showed longer and more frequent bouts of drinking at the sucrose bottle compared to the water bottle. Manipulations of caloric content and need did not affect preference or drinking behavior. Chronic stress impaired sucrose location memory and reduced the number of drinking bouts, explaining the loss of sucrose preference in stress susceptible mice. Female mice showed similar drinking behavior to males but may be less susceptible to chronic stress and have better memory performance.
Article
Psychology, Clinical
Glenn Kiekens, Penelope Hasking, Ronny Bruffaerts, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Corina Benjet, Mark Boyes, Wai Tat Chiu, Laurence Claes, Pim Cuijpers, David D. Ebert, Arthur Mak, Philippe Mortier, Siobhan O'Neill, Nancy A. Sampson, Dan J. Stein, Gemma Vilagut, Matthew K. Nock, Ronald C. Kessler
Summary: Non-suicidal self-injury (NSSI) is common among college students and is a behavioral marker of various common mental disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Philippe Mortier, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Corina Benjet, Ronny Bruffaerts, Pim Cuijpers, David D. Ebert, Jennifer Greif Green, Penelope Hasking, Eirini Karyotaki, Glenn Kiekens, Arthur Mak, Matthew K. Nock, Siobhan O'Neill, Stephanie Pinder-Amaker, Nancy A. Sampson, Dan J. Stein, Gemma Vilagut, Chelsey Wilks, Alan M. Zaslavsky, Patrick Mair, Ronald C. Kessler
Summary: The study found that childhood adversities are associated with lifetime suicidal thoughts and behaviors among incoming college students, with the exact number of adversity types and the frequency of specific types playing a significant role in explaining the associations.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychology, Developmental
Arthur D. P. Mak, Sue Lee, Nancy A. Sampson, Yesica Albor, Jordi Alonso, Randy P. Auerbach, Harald Baumeister, Corina Benjet, Ronny Bruffaerts, Pim Cuijpers, David D. Ebert, Raul A. Gutierrez-Garcia, Penelope Hasking, Coral Lapsley, Christine Lochner, Ronald C. Kessler
Summary: The study found a significant prevalence of ADHD among college students, with nearly 60% having comorbid disorders. Different disorder classes independently predict severe role impairment. Eliminating ADHD may reduce severe role impairment, but must also consider the factors of other comorbid disorders.
JOURNAL OF ATTENTION DISORDERS
(2022)
Editorial Material
Psychology, Developmental
Randy P. Auerbach
Summary: The Research Domain Criteria (RDoC) framework proposed by the National Institute of Mental Health aims to classify psychiatric disorders, identify transdiagnostic factors, inform early detection of mental health disturbances, and provide novel targets for interventions. Another goal is to clarify developmental processes and illness trajectories by operationalizing dimensional constructs during sensitive periods of neurofunctional development to capture the early emergence of behavioral alterations and impairment. Through targeted funding opportunities, NIMH has shepherded developmental-oriented research resulting in promising phenotypes and biological markers related to psychiatric illness.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Psychology, Clinical
Mathilde M. Husky, Ekaterina Sadikova, Sue Lee, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Ronny Bruffaerts, Pim Cuijpers, David D. Ebert, Raul Gutierrez Garcia, Penelope Hasking, Arthur Mak, Margaret McLafferty, Nancy A. Sampson, Dan J. Stein, Ronald C. Kessler
Summary: This study examines the relationship between childhood adversities and lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students. The findings suggest that childhood adversities are associated with the onset and impairment of mental disorders, but not with disorder persistence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Kira L. Alqueza, David Pagliaccio, Katherine Durham, Apoorva Srinivasan, Jeremy G. Stewart, Randy P. Auerbach
Summary: This study examined the correlates of suicidal thoughts and behaviors (STBs) among psychiatric inpatients. The results showed that suicidal ideation occurred during early adolescence, with more than half of the patients making a plan and one-third attempting suicide. The strongest correlates were depressive disorders, physical abuse, and non-suicidal self-injury. Knowing a peer with a history of suicide attempts also increased the likelihood of attempting suicide.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Psychology, Clinical
Nicholas A. Hubbard, Randy P. Auerbach, Viviana Siless, Nicole Lo, Isabelle R. Frosch, Danielle E. Clark, Robert Jones, Rebecca Kremens, Megan Pinaire, Flavia Vaz-DeSouza, Satrajit S. Ghosh, Aude Henin, Stefan G. Hofmann, Diego A. Pizzagalli, Isabelle M. Rosso, Anastasia Yendiki, Susan Whitfield-Gabrieli, John D. E. Gabrieli
Summary: Adolescents with anxiety or depression show cognitive biases towards negative emotional information processing. This study found that reduced changes in brain connectivity patterns between conditions where adolescents needed to ignore or attend to fearful faces were associated with a shared dimension of anxious and depressive symptoms. The findings suggest a failure to adapt communication patterns with sensory-representation areas in the presence of negative emotional information, which may explain the biases common to anxiety and depression in adolescents.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Psychology, Clinical
Eirini Karyotaki, Anke M. Klein, Marketa Ciharova, Felix Bolinski, Lisa Krijnen, Lisa de Koning, Leonore de Wit, Claudia M. van der Heijde, David D. Ebert, Heleen Riper, Neeltje Batelaan, Peter Vonk, Randy P. Auerbach, Ronald C. Kessler, Ronny Bruffaerts, Sascha Struijs, Reinout W. Wiers, Pim Cuijpers
Summary: Common mental disorders such as depression and anxiety often emerge in college students during the transition to early adulthood. Offering internet-based interventions to college students with mental health problems could be a promising way to provide accessible treatment. However, this study found no evidence of the effectiveness of guided web-based transdiagnostic individually tailored Cognitive Behavioral Therapy (iCBT) compared to treatment as usual for college students with depression and/or anxiety symptoms.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Psychology, Developmental
Emma M. Millon, Kira L. Alqueza, Rahil A. Kamath, Rachel Marsh, David Pagliaccio, Hilary P. Blumberg, Jeremy G. Stewart, Randy P. Auerbach
Summary: Non-suicidal self-injury (NSSI) is a serious public health concern among adolescents, with high prevalence rates. Factors such as depressive disorder, sexual abuse, and comorbidity are associated with experiencing NSSI thoughts and behaviors, and longitudinal studies are needed to investigate interventions that can reduce the persistence of NSSI.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Psychology, Developmental
Randy P. Auerbach, Ranqing Lan, Hanga Galfalvy, Kira L. Alqueza, Jeffrey F. Cohn, Ryann N. Crowley, Katherine Durham, Karla J. Joyce, Lauren E. Kahn, Rahil A. Kamath, Louis-Philippe Morency, Giovanna Porta, Apoorva Srinivasan, Jamie Zelazny, David A. Brent, Nicholas B. Allen
Summary: Suicide is a leading cause of death among adolescents, but there are no clinical tools currently available to detect proximal risk for suicide. This study demonstrates that intensive longitudinal assessment through the use of personal smartphones offers a feasible method to assess variability in adolescents' emotional experiences and suicide risk.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jiahe Zhang, Jovicarole Raya, Francesca Morfini, Zoi Urban, David Pagliaccio, Anastasia Yendiki, Randy P. Auerbach, Clemens C. C. Bauer, Susan Whitfield-Gabrieli
Summary: Adolescents have alarmingly high rates of major depressive disorder (MDD), but current gold-standard treatments are only effective for about 50% of them. Therefore, there is a critical need for novel interventions that target neural mechanisms believed to potentiate depressive symptoms. This study developed a mindfulness-based fMRI neurofeedback (mbNF) for adolescents that aims to reduce default mode network (DMN) hyperconnectivity, which is implicated in the onset and maintenance of MDD. The results demonstrate that personalized mbNF can effectively and non-invasively modulate the intrinsic networks associated with the emergence and persistence of depressive symptoms during adolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Penelope A. Hasking, Kealagh Robinson, Peter Mcevoy, Glenn Melvin, Ronny Bruffaerts, Mark E. Boyes, Randy P. Auerbach, Delia Hendrie, Matthew K. Nock, David A. Preece, Clare Rees, Ronald C. Kessler
Summary: A predictive algorithm was developed to identify college students at risk of suicidal behavior, and telehealth was used to reduce subsequent risk. The algorithm effectively identified high-risk individuals and decreased their likelihood of engaging in suicidal behavior through universal screening and remote intervention.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Grace O. Allison, Rahil A. Kamath, Vivian Carrillo, Kira L. Alqueza, David Pagliaccio, George M. Slavich, Stewart A. Shankman, Randy P. Auerbach
Summary: This study found that self-referential processing biases persist during remission in adults with depression and may contribute to the occurrence of stress and depressive symptoms over time.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Psychology, Clinical
Randy P. Auerbach, Apoorva Srinivasan, Jaclyn S. Kirshenbaum, J. John Mann, Stewart A. Shankman
Summary: Depression recurrence is a significant issue and clinical tools are needed to detect symptom reemergence. This study found that remitted depressed adults have reduced circadian routine and lower average daily distance traveled. Mobile sensing approaches hold promise for improving clinical care for depressive disorders.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2022)
Article
Psychology, Multidisciplinary
Jason Bantjes, Elsie Breet, Wylene Saal, Christine Lochner, Janine Roos, Lian Taljaard, Philippe Mortier, Randy P. Auerbach, Ronny Bruffaerts, Ronald C. Kessler, Dan J. Stein
Summary: This study used a cross-sectional web-based survey and discrete-time survival analysis to estimate the prevalence and predictors of suicidal ideation, plan, and attempt among South African university students. The results showed that the lifetime prevalence of ideation, plan, and attempt were 46.4%, 26.5%, and 8.6% respectively. Multiple primary mental disorders predicted subsequent onset of suicidality and transitions from ideation to plan and attempt. The findings highlight the importance of campus-based suicide prevention, the vulnerability of historically disadvantaged students, and the promotion of mental health in suicide prevention.
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)