期刊
ARCHIV DER PHARMAZIE
卷 341, 期 9, 页码 568-577出版社
WILEY-BLACKWELL
DOI: 10.1002/ardp.200700231
关键词
angiogenesis; bastadin; marine sponge; structure-activity relationship
资金
- Ministry of Education, Science, Sport, and Culture of Japan
- Takeda Science Foundation
- Tokyo Biochemical Research Foundation
A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
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