期刊
ARCHIV DER PHARMAZIE
卷 341, 期 4, 页码 240-246出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200700202
关键词
fused quinolines; pharmacological screening; pyrimidoselenolo quinolines; quinolines
Several selenolo[2,3-b]quinolines and pyrimido[4',S':4,5]selenolo[2,3-b]quinolines were prepared by annulations via reaction of NaSeH with 2-chloro-3-cyano-4-methylquinoline 1 followed by reactions with aromatic aldehydes, cycloalkanones, and acetic anhydride. Spectroscopic (IR, H-1-NMR, and MS) properties of the synthesized compounds are reported. Some selected compounds 5a, 7b, 7c, 8b-d, 9a, 11b, and 11d were investigated for their anti-inflammatory and analgesic activities; in addition, the most active compounds were tested for their ulcerogenicity and acute toxicity. Moreover, some of the test compounds 7c, 9a, 11b, and 11d were screened for their antibacterial and antifungal activities.
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