Review
Biochemistry & Molecular Biology
Silvia Moreira, Ricardo Silva, David F. Carrageta, Marco G. Alves, Vicente Seco-Rovira, Pedro F. Oliveira, Maria de Lourdes Pereira
Summary: Carbamates, widely used as pesticides, have both medical applications and adverse effects on the male reproductive system. Their inhibitory effect on acetylcholine hydrolyzation can lead to male fertility problems and disrupt the male endocrine system. The molecular mechanisms behind these effects are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bruno Garcia Montagnini, Simone Forcato, Karine Vandressa Pernoncine, Mariana Cunha Monteiro, Marina Rangel Ferro Pereira, Nathalia Orlandini Costa, Estefania Gastadello Moreira, Janete Aparecida Anselmo-Franci, Daniela Cristina Ceccatto Gerardin
Summary: The study found that TCS may act as an endocrine disruptor for the reproductive system. Exposure to TCS was shown to decrease sperm viability and motility, potentially related to the programming of reproductive cells during fetal/neonatal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Christian Giommi, Hamid R. Habibi, Michela Candelma, Oliana Carnevali, Francesca Maradonna
Summary: This study investigated the impact of a probiotic mixture on BPA-induced effects on reproduction in zebrafish. The results demonstrated that in fish exposed to the combination of BPA and probiotic, most transcripts were closer to control or probiotic-treated levels, suggesting the potential of the probiotic mixture to counteract BPA toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Gal Vered, Noa Shenkar
Summary: This study exposed the reproductive products of four tropical coral-reef invertebrates to environmentally-relevant concentrations of plastic additives (PAs). The results showed that apart from 4-NP, none of the other tested PAs had significant effects on the exposed organisms at environmentally-relevant concentrations in seawater. However, high laboratory concentrations of PAs had negative effects on all examined species.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Livia Interdonato, Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Endometriosis, an estrogen-dependent gynecologic illness, is potentially influenced by endocrine-disrupting chemicals (EDCs). This review examines human evidence on EDCs and endometriosis, specifically focusing on chemical amounts in women. Dioxins, BPA, Phthalates, and other EDCs are implicated as environmental causes of endometriosis, highlighting the need for prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Divya Jyoti, Reshma Sinha
Summary: Personal care products (PCPs) have become an emerging category of environmental contaminants due to their higher accumulation in the environment and potential to induce physiological effects on non-target organisms. This review analyzed over 300 articles from 2000 to 2023 to discuss the fate and accumulation of PCPs, environmental risks associated with them, and the current regulations and gaps in knowledge. The study found that certain constituents of PCPs, such as plasticizers and UV filters, have toxic impacts on aquatic organisms. The continuous release of these constituents interferes with the physiological systems of non-target organisms. The review highlights the need for further research and evaluation of the potential impacts of PCPs on aquatic ecosystems and human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Tamer Hafez, Fernando Villate, Maren Ortiz-Zarragoitia
Summary: This study investigated the effects of 17 alpha-ethinylestradiol (EE2) on two copepod species in estuaries. The results showed that EE2 reduced the survival rate and reproductive output of copepods in high concentrations.
Article
Environmental Sciences
Samantha Schildroth, Lauren A. Wise, Amelia K. Wesselink, Traci N. Bethea, Victoria Fruh, Kyla W. Taylor, Antonia M. Calafat, Donna D. Baird, Birgit Claus Henn
Summary: This study found that personal care product use, diet, and contraceptive measures may be the main sources of exposure to multiple non-persistent endocrine disrupting chemicals among reproductive-aged Black women.
Review
Biochemistry & Molecular Biology
Hyekyoung Hannah You, Gwonhwa Song
Summary: Research has evaluated the adverse effects of endocrine disruptors on the reproductive systems of humans, zebrafish, and mice, exploring the impacts and mechanisms on reproductive systems in different animal models.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vinay Kumar, Neha Sharma, Preeti Sharma, Ritu Pasrija, Komalpreet Kaur, Mridul Umesh, Basheer Thazeem
Summary: Endocrine disrupting compounds mimic natural hormones and activate signaling cycles, leading to uncontrolled growth. Pesticides are endocrine disruptors that cause cancer, birth defects, and reproductive defects in non-target organisms. However, there is a lack of critical analysis on pesticide toxicity and its role as an endocrine disruptor. This review aims to understand the role of pesticides as endocrine disruptors and discusses their effects on non-target organisms, including neurological disruption, genotoxicity, and ROS-induced toxicity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Gaspari, Francoise Paris, Nicolas Kalfa, Marie-Odile Soyer-Gobillard, Charles Sultan, Samir Hamamah
Summary: Previous studies indicate the potential for transgenerational inheritance of disease susceptibility due to endocrine disruptors. While there is substantial evidence on the multigenerational and transgenerational effects of TCDD, studies on its impact on human reproductive health are limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sheila I. Pena-Corona, Juan I. Chavez-Corona, Luis E. Perez-Caltzontzin, Dinorah Vargas-Estrada, C. Adriana Mendoza-Rodriguez, Edgar Ramos-Martinez, Jose L. Cerbon-Gutierrez, Jose A. Herrera-Barragan, David Quintanar-Guerrero, Gerardo Leyva-Gomez
Summary: Bisphenols are widely used plasticizers, but exposure to them is related to infertility and other pathologies. This study compared the protective effects of melatonin and vitamins against bisphenol-induced damage on reproductive variables. The results showed that melatonin improved sperm concentration and viability, while vitamins had negative effects on sperm concentration, testis weight, and testosterone levels. Molecular docking simulations suggested that vitamin E had the best binding affinity with androgen and estrogen receptors. These findings indicate that vitamins could act as endocrine disruptors, while melatonin is most effective in protecting against the toxic effects of bisphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Raquel N. Corniuk, Jennifer M. Lynch, Michael D. Arendt, Joanne Braun-McNeill, David W. Owens, Roldan A. Valverde, John R. Kucklick, Patricia D. McClellan-Green
Summary: This study investigated the presence and concentrations of VTG in plasma of loggerhead sea turtles from the northwestern Atlantic Ocean. The results showed that VTG was present in nesting females, in-water adult females, subadult females, smaller females, unknown sex, and males, in descending order of concentration. Additionally, the study found a weak correlation between blood PCB concentrations and semiquantified VTG concentrations in turtles less than 77 cm. The study suggests the need for further investigation into the causes of abnormal VTG expression in wild sea turtles.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Biochemical Research Methods
Brett R. Blackwell, Gerald T. Ankley
Summary: This study developed a method for the simultaneous measurement of thirteen endogenous steroids in small sample volumes without derivatization, validating the concentrations of steroids and demonstrating potential application in aquatic toxicology studies for identifying EDCs.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Engineering, Environmental
Marta Sendra, Patricia Pereiro, Maria Pilar Yeste, Beatriz Novoa, Antonio Figueras
Summary: This study analyzed the toxicogenomic effects of face masks at different stages of degradation in zebrafish larvae. The results showed that degradation products from face masks could act as endocrine disruptors, affecting reproduction, immune-related genes, and metabolic processes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)