期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 30, 页码 16518-16524出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b03956
关键词
multimodal assay; reaction,based; dopamine assay; fluorescence assay; colorimetric assay; gold nanoparticles
资金
- Chinese Academy of Agricultural Sciences [2015ZL042, 2060302]
- National Key Basic Research Program of China (973 Program) from Ministry of Science and Technology of China [2014CB932200]
A simple and dual chemical reaction-based multimodal assay for dopamine with high sensitivity and selectivity using two types of functionalized gold nanoparticles (FB-AuNPs/NsNHS-AuNPs), i.e. fluorescein modified gold nanoparticles (FB-AuNPs) and Nile blue modified gold nanoparticles (NsNHS-AuNPs), was successfully fabricated. This assay for dopamine presents colorimetric visualization and double channel fluorescence enhancement at 515 and 665 nm. The absorbance and fluorescence changes were linearly proportional to the amounts of dopamine in the range of nanomolar scale (5-100 nM). The detection limits for absorbance and fluorescence were as low as 1.2 nM and 2.9 nM (S/N = 3), respectively. Furthermore, the extent application of this multimodal assay has been successfully demonstrated in human urine samples with high reliability and applicability, showing remarkable promise in diagnostic purposes.
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