Article
Biology
Dongmei Jiang, Guilin Mo, Yilong Jiang, Bo Kang
Summary: Exogenous spermidine can modulate polyamine homeostasis in the mouse hypothalamus by regulating the expression of genes and proteins related to polyamine metabolism.
OPEN LIFE SCIENCES
(2021)
Article
Marine & Freshwater Biology
Xinxin Lu, Kai Wang, Xiaozhen Mou
Summary: Short-chained aliphatic polyamines are important carbon, nitrogen, and energy sources for marine bacterioplankton. Metagenomic responses of bacterioplankton in the Gulf of Mexico to different PA compounds show that the transformations are carried out by a broad range of taxa and have diverse pathways. PA-transforming genes and taxa vary among different sites, but remain similar among individual compound-amended metagenomes.
MARINE LIFE SCIENCE & TECHNOLOGY
(2022)
Article
Developmental Biology
Haley E. Brown, Brandon P. Weasner, Bonnie M. Weasner, Justin P. Kumar
Summary: This study reveals that reduced Polycomb expression leads to abnormal development in Drosophila imaginal discs, causing the transformation of eyes into wings. Disruption of the Vestigial-Scalloped complex not only blocks wing formation, but also results in the organization of multiple domains into other imaginal discs and tissues.
Article
Biochemistry & Molecular Biology
Orsolya Kinga Gondor, Judit Tajti, Kamiran Aron Hamow, Imre Majlath, Gabriella Szalai, Tibor Janda, Magda Pal
Summary: This study aimed to investigate the influence of polyamine metabolism under different light conditions. It was found that polyamines had varying effects on photosynthesis under different light regimes, suggesting a complex relationship between polyamines and plant adaptation to light conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Nelly C. Munoz-Esparza, Oriol Comas-Baste, M. Luz Latorre-Moratalla, M. Teresa Veciana-Nogues, M. Carmen Vidal-Carou
Summary: Human milk is rich in polyamines, which are essential for intestinal maturation and immune system development, while infant formulas have significantly lower levels of polyamines compared to human milk. Spermidine and spermine levels in human milk decrease over lactation, while putrescine remains relatively constant.
Article
Nutrition & Dietetics
Nelly C. Munoz-Esparza, Edgar M. Vasquez-Garibay, Elizabeth Guzman-Mercado, Alfredo Larrosa-Haro, Oriol Comas-Baste, M. Luz Latorre-Moratalla, M. Teresa Veciana-Nogues, M. Carmen Vidal-Carou
Summary: The study evaluated the influence of different breastfeeding factors on the polyamine levels in human milk, finding that polyamine levels varied significantly between mothers and tended to decrease over time. Spermidine and spermine concentrations were higher in hindmilk compared to foremilk, and decreased significantly as lactation progressed.
Article
Biochemistry & Molecular Biology
Magda Pal, Kamiran Aron Hamow, Altafur Rahman, Imre Majlath, Judit Tajti, Orsolya Kinga Gondor, Mohamed Ahres, Fatemeh Gholizadeh, Gabriella Szalai, Tibor Janda
Summary: This study compared the effects of different spectral compositions on polyamine metabolism in plants and found that light quality can optimize plant growth by adjusting polyamine metabolism at the gene expression level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Tracy Murray Stewart, Jackson R. Foley, Cassandra E. Holbert, Maxim Khomutov, Noushin Rastkari, Xianzun Tao, Alex R. Khomutov, R. Grace Zhai, Robert A. Casero Jr
Summary: Snyder-Robinson syndrome (SRS) is a genetic disorder caused by mutations in the spermine synthase (SMS) gene, leading to symptoms such as intellectual disability and osteoporosis. Current treatment options focus on managing symptoms. A study has found that the drug 2-difluoromethylornithine (DFMO) can rebalance the spermidine:spermine ratio in SRS patient cells and improve lifespan in a fruit fly model of the syndrome.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Takeshi Uemura, Miki Matsunaga, Yuka Yokota, Koichi Takao, Takemitsu Furuchi
Summary: The aging of the global population has led to the need for effective anti-aging technologies supported by scientific evidence. Polyamines, such as putrescine, spermidine, and spermine, play crucial roles in cell growth and function. This study investigated the relationship between increased expression of spermine oxidase (SMOX) and cellular senescence, using human-liver-derived HepG2 cells. The results suggest that SMOX-mediated degradation of spermine plays a pivotal role in cellular senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Stefania Biondi, Fabiana Antognoni, Lorenzo Marincich, Mariacaterina Lianza, Ricardo Tejos, Karina B. Ruiz
Summary: The importance of polyamines (PAs) in plant growth and development has been recognized for several decades. PAs play critical roles in cell proliferation, organogenesis, flowering, and fruit development. In recent years, the focus has shifted to understanding their functions in biotic and abiotic stress responses. PAs have been found to contribute to plant tolerance to salinity, drought, chilling, and heavy metal stresses, among others. In addition, their mechanisms of action have been extensively studied, revealing their ability to modulate various cellular processes. This review provides an overview of PA functions in plants and discusses their potential applications in mitigating stress in crop plants, such as seed priming techniques.
SCIENTIA HORTICULTURAE
(2022)
Article
Genetics & Heredity
Bipin Kumar Tripathi, Kenneth D. Irvine
Summary: The Drosophila wing imaginal disc is a crucial tissue for research in animal development, providing a valuable system for genetic studies and understanding various biological processes.
Review
Psychiatry
Hans-Gert Bernstein, Gerburg Keilhoff, Gregor Laube, Henrik Dobrowolny, Johann Steiner
Summary: Polyamines play crucial roles in the etiology and pathology of schizophrenia, with changes in enzyme activity and polyamine levels being associated with the disease. Although the polyamine system may be a promising target for schizophrenia treatment, practical reasons limit the hope for a polyamine-based therapy at present.
WORLD JOURNAL OF PSYCHIATRY
(2021)
Article
Plant Sciences
Rakesh K. Upadhyay, Jonathan Shao, Autar K. Mattoo
Summary: Identification of the polyamine biosynthetic pathway genes in duckweed S. polyrhiza shows the presence of prokaryotic as well as land plant-type ADC pathway but absence of ODC encoding genes. Differential gene expression and transcript abundance of these genes are modulated by exogenous methyl jasmonate, salinity, and acidic pH. The S. polyrhiza genome encodes for complete polyamine biosynthesis pathway and the genes are transcriptionally active in response to changing environmental conditions, suggesting an important role of polyamines in this aquatic plant.
Article
Multidisciplinary Sciences
Yoshiki Hayashi, Soshiro Kashio, Kazutoshi Murotomi, Shinjiro Hino, Woojin Kang, Kenji Miyado, Mitsuyoshi Nakao, Masayuki Miura, Satoru Kobayashi, Masakazu Namihira
Summary: Tissue aging is a major factor contributing to disabilities and shortened lifespan. The mechanism of tissue aging is not completely understood, but this study suggests that the biosynthesis of S-adenosyl-methionine (SAM) can accelerate aging-related defects during Drosophila oogenesis. The study also reveals an aging-related increase in SAM levels in mouse reproductive tissue and the brain.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Julija Armalyte, Albinas Cepauskas, Gabija Sakalyte, Julius Martinkus, Jurate Skerniskyte, Chloe Martens, Edita Suziedeliene, Abel Garcia-Pino, Dukas Jurenas
Summary: This study identifies a novel acetyltransferase, Dpa, in A. baumannii that affects the motility of the bacterium. The expression of Dpa is increased in bacteria that form biofilms and adhere to eukaryotic cells. The crystal structure of Dpa reveals structural and functional differences from other bacterial polyamine acetyltransferases. Overall, this study provides important insights into the regulation of motility in A. baumannii. Rating: 8/10.
NATURE COMMUNICATIONS
(2023)
