期刊
APPLIED SURFACE SCIENCE
卷 300, 期 -, 页码 22-28出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2014.01.174
关键词
Molecular imprinting; Nanoparticles; Photocoupling; X-ray photoelectron spectroscopy; Immobilization
类别
资金
- European Commission via the Initial Training Network SMALL [MCITN-238804]
- Swedish Research Council (VR) [2010-5080]
- NSF [CHE-1112436]
- NIH [R01GM080295]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1112436] Funding Source: National Science Foundation
In this work, we report a method that allows the deterministic, photo-controlled covalent assembly of nanoparticles directly on surface. As a model system, we study the conjugation of molecularly imprinted polymer (MIP) nanoparticles on a glass surface and confirm that the immobilized nanoparticles maintain their molecular recognition functionality. The glass slide was first modified with perfluorophenylazide and then used to bind MIP nanoparticles under UV irradiation. After each step the surface was analyzed by water contact angle measurement, fluorescence microscopy, scanning electron microscopy, and/or synchrotron-based X-ray photoelectron spectroscopy. The MIP nanoparticles immobilized on the glass surface remained stable and maintained specific binding for the template molecule, propranolol. The method developed in this work allows MIP nanoparticles to be directly coupled to a flat surface, offering a straightforward means to construct robust chemical sensors. Using the reported photo conjugation method, it is possible to generate patterned assembly of nanoparticles using a photomask. Since perfluorophenylazide-based photochemistry works with all kinds of organic material, the method developed in this work is expected to enable immobilization of not only MIPs but also other kinds of organic and inorganic-organic core-shell particles for various applications involving photon or electron transfer. (C) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
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