Article
Biochemical Research Methods
Zahra Saffari, Mina Sepahi, Reza Ahangari-Cohan, Mehdi Khoobi, Mojtaba Hamidi-Fard, Amir Ghavidel, Mohammad Reza Aghasadeghi, Dariush Norouzian
Summary: A QCM biosensor was developed for the label-free detection of HBsAg. The biosensor showed excellent detection performance with a wide dynamic range, high sensitivity, and selectivity, comparable with ELISA. It can detect HBsAg in human sera and has the advantages of regeneration ability and low cost.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Ece Yarali, Arzum Erdem
Summary: In this study, cobalt phthalocyanine and ionic liquid modified pencil graphite electrodes were successfully used to detect sequence-selective DNA hybridization related to Hepatitis B virus. Surface characterization and electrochemical behavior of the electrodes were investigated using SEM, EIS, and CV techniques, with voltammetric detection of hybridization through DPV. The biosensor implementation in serum samples and the selectivity testing of HBV DNA hybridization in the presence of other DNA sequences were also conducted.
Article
Chemistry, Analytical
Hui Jean Lim, Tridib Saha, Beng Ti Tey, Wen Siang Tan, Sharifah Syed Hassan, Chien Wei Ooi
Summary: In this study, a dopamine self-polymerisation method was used to functionalise the QCM crystal surface with a molecularly imprinted polydopamine (MIPDA) sensing film for detecting the hepatitis B core antigen (HBcAg). The MIPDA-QCM biosensor showed selective affinity and low detection limit for HBcAg.
Article
Engineering, Electrical & Electronic
Prathapaneni Manusha, Sellappan Senthilkumar
Summary: A redox-active ionic liquid, Fc-PF6-IL, was designed and utilized for the electrochemical determination of NADH, showing excellent electrocatalytic behavior with wide linear range and high sensitivity. The developed sensor exhibited good stability, anti-interference ability, reproducibility, and was successfully applied in real samples for NADH sensing.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Polymer Science
Unchalee Kongintr, Benchaporn Lertanantawong, Chamras Promptmas
Summary: In this study, a label-free electrochemical biosensor for reliable detection of serum homocysteine (Hcy) was developed using a molecularly imprinted polymer (MIP) and nanocomposite. The Hcy-MIP biosensor showed high sensitivity, with a linear response range of 5.0 to 150 μM and a limit of detection of 1.2 μM. It demonstrated low cross-reactivity with other compounds and achieved good recoveries and repeatability. This novel biosensor offers a new and effective method for Hcy assay compared to existing techniques.
Article
Biophysics
Anabel Villalonga, Itziar Estabiel, Ana M. Perez-Calabuig, Beatriz Mayol, Concepcion Parrado, Reynaldo Villalonga
Summary: The novel amperometric aptasensor constructed for the specific detection of cardiac troponin I (cTnI) showed high sensitivity, specificity, and wide applicability for detecting the cardiac biomarker in a broad concentration range. It utilized a sandwich-type structure for detection and provided a detection limit of 0.6 pg/mL, along with high reproducibility and stability for quantifying cTnI in reconstituted human serum samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Rahman Hallaj, Mahsa Mottaghi, Zhaleh Ghafary, Fahimeh Jalali
Summary: This study presents a sandwich-type electrochemical immunosensor for the detection of hepatitis B virus surface antigen. By incorporating magnetic nanoparticles and gold nanoparticles, an amplified electrical signal is achieved, allowing for successful quantification of HBsAg concentration in serum.
MICROCHEMICAL JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Ashraf Maher, Mohamed S. Mahmoud, Ashraf Mahroos Said Saba
Summary: The main goal of this study was to fabricate smart nanocomposite transparent conductive biophysiological electrodes based on modified graphene oxide (GO). GO was synthesized and used with PVA and Gl in the nanocomposite to enhance its flexibility and conductivity. The results showed that the GO/Gl/PVA transparent electrode exhibited improved efficiency in synthesizing electrocardiogram (ECG) signals and produced higher conductivity and lower noise in electrodermal (EDA) signals compared to a commercial electrode.
Article
Construction & Building Technology
Wei Wang, Xinsheng Li, Junan Shen, Fugen Yuan
Summary: Low temperature cracking is a common issue in asphalt pavements, especially in cold areas. Butyl acrylate (BA) and vinyl acetate (VAc) polymers significantly enhance the ductility of asphalt binders. The optimal modification scheme is a 6% BA-VAc polymer with a BA/VAc ratio of 6:4, produced at a shear temperature of 130 degrees C, a shear time of 5 min, and a shear rate of 1000 r/min.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Chemistry, Analytical
Sofia M. V. Cerqueira, Ruben Fernandes, Felismina T. C. Moreira, M. Goreti F. Sales
Summary: This research focused on developing and optimizing an electrochemical biosensor using molecularly-imprinted polymers for monitoring the melanoma biomarker Gal-3. The sensor recognized Gal-3 through electropolymerization and removal of the protein, showing affinity for Gal-3. Analytical performance was evaluated with positive results in terms of detection limit, response time, and reproducibility.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Cong Wang, Tan Wang, Zhen Li, Xianbao Xu, Xiaoshuan Zhang, Daoliang Li
Summary: A SPEC/AuNPs/PMB modified electrode was prepared and used for indirect measurement of ammonia nitrogen content in water samples. The biosensor exhibited good sensitivity and stability under certain conditions.
Article
Biophysics
Heru Agung Saputra, Jae Heun Chung, Seong Hoon Yoon, Kyeong-Deok Seo, Deog-Su Park, Yoon-Bo Shim
Summary: A disposable amperometric biosensor with a dual monomers-based bioconjugate was developed for the detection of granzyme B (GzmB) and monitoring the cancer progression of patients before and after immunotherapy. The sensor showed high sensitivity and specificity, allowing for monitoring of GzmB levels in patient serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Prinjaporn Teengam, Weena Siangproh, Sitt Tontisirin, Amorn Jiraseree-amornkun, Natthaya Chuaypen, Pisit Tangkijvanich, Charles S. Henry, Nattaya Ngamrojanavanich, Orawon Chailapakul
Summary: An NFC-operated electrochemical sensor controlled by a smartphone was developed for detecting HBV, showing high sensitivity and accuracy. The sensor has a great potential as a portable and cost-effective tool for assessing health indicators with the convenience of smartphone operation.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Yuuki Inoue, Yeji Kim, Hijiri Hasegawa, Yasukazu Yoshida, Keita Sakakibara, Yoshinobu Tsujii
Summary: We developed a novel electrochemical biosensor electrode by constructing an original conductive substrate modified with a double-layered polymer brush structure. The experimental results showed that the gold electrode with a double-layered polymer brush structure and carboxyl groups exhibited a linear correlation with potential difference and hydrogen ion concentration. This is the first application of the double-layered polymer brush structure in electrochemical biosensing and it is expected to be an excellent surface modification method for reducing background noise.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Lanfang Wang, Ruifang Ding, Yanqing Hao, Yujia Li, Wenjiao Liu, Wenbo Lu, Xiaohong Xu
Summary: A novel light-driven non-enzymatic glucose sensor based on AuNi nanodendrites has been successfully developed. The nanodendritic structure provides a large surface area and excellent electron transfer for glucose oxidation. Under visible light illumination, this hierarchical hybrid structure exhibits remarkable photoelectrocatalytic activity.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Natalia Bastos-Bitencourt, Marilia Velo, Tatiana Nascimento, Cassiana Scotti, Maria Gardennia da Fonseca, Luiz Goulart, Lucio Castellano, Sergio Ishikiriama, Juliana Bombonatti, Salvatore Sauro
Summary: This study found that the addition of bioactive nanofibers in desensitizing agents for dentin can increase permeability and surface deposition, but there was no significant difference among the groups after treatment and acid challenge.
Article
Biochemistry & Molecular Biology
Ana Cristina Honorato de Castro, Leandro Toshio Kochi, Jose Manuel Rodrigueiro Flauzino, Marcia Maria Costa Nunes Soares, Valeria Almeida Alves, Luis Antonio da Silva, Joao Marcos Madurro, Ana Graci Brito-Madurro
Summary: In this study, a novel electrochemical device was developed for molecular diagnosis of hepatitis B virus in the blood plasma of infected patients. The device showed high sensitivity, good selectivity, low sample volume, and fast assay time, making it a promising tool for diagnosing hepatitis B virus in blood plasma.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Francielli C. C. Melo, Renata P. Alves, Anderson L. Valle, Fabiana de A. A. Santos, Ana Carolina S. Dias, Isabela M. B. Goulart, Eduardo G. A. Oliveira, Guedmiller S. Oliveira, Luciano P. Rodrigues, Luiz R. Goulart
Summary: This research explores the use of 4-dimethylaminoantipyrine (4-DMAA)-mediated interfacing as a general indicator in electrochemical immunoassays, demonstrating its broad application for the specific diagnosis of four infectious diseases.
Article
Cell Biology
Lara Vecchi, Sara Teixeira Soares Mota, Mariana Alves Pereira Zoia, Isabella Castro Martins, Jessica Brito de Souza, Tiago Goss Santos, Adriano de Oliveira Beserra, Victor Piana de Andrade, Luiz Ricardo Goulart, Thaise Goncalves Araujo
Summary: Annexin A1 and interleukin-6 are both overexpressed in breast cancer tissue, indicating a correlation between the two. The activation of the AnxA1/FPR1 autocrine axis plays a crucial role in the IL-6 signaling pathway and has an impact on the tumor microenvironment.
Article
Agriculture, Dairy & Animal Science
Simone Sommerfeld, Antonio Vicente Mundim, Rogerio Reis Silva, Jessica Santos Queiroz, Maisa Paschoal Rios, Fabiana Oliveira Notario, Alessandra Aparecida Medeiros Ronchi, Marcelo Emilio Beletti, Rodrigo Rodrigues Franco, Foued Salmen Espindola, Luiz Ricardo Goulart, Belchiolina Beatriz Fonseca
Summary: This study aimed to verify whether chicken embryos of different ages have specific responses to viruses and drugs, and emphasizes the importance of standardization in using the model.
Article
Chemistry, Multidisciplinary
Ana C. H. Castro, Italo R. S. Bezerra, Aline M. Pascon, Gabriela H. da Silva, Eric A. Philot, Vivian L. de Oliveira, Rodrigo S. N. Mancini, Gabriel R. Schleder, Carlos E. Castro, Luciani R. S. de Carvalho, Bianca H. V. Fernandes, Eduardo M. Cilli, Paulo R. S. Sanches, Murilo Santhiago, Ives Charlie-Silva, Diego S. T. Martinez, Ana L. Scott, Wendel A. Alves, Renato S. Lima
Summary: In this study, a peptide sequence that can recognize S protein antibodies with higher sensitivity was synthesized by mimicking the molecular recognition of antibodies against the SARS-CoV-2 virus. A label-free biosensor was developed by adsorbing the peptide sequence onto an electrode, enabling fast and simple analysis. The peptide was found to bind to the antibody through hydrogen bonds and hydrophobic interactions, and exhibited good stability. With the help of machine learning, this sensor achieved accurate differentiation between COVID-19 infected and healthy samples.
Article
Biochemistry & Molecular Biology
Alinne T. F. Silva, Claudia M. Rodrigues, Izabella C. C. Ferreira, Leticia L. D. Santos, Donizeti W. Santos, Thaise G. Araujo, Paula P. L. Canto, Carlos E. Paiva, Luiz R. Goulart, Yara C. P. Maia
Summary: In this study, we analyzed the presence of circulating tumor cells (CTCs) in the blood to identify markers for the diagnosis and monitoring of breast cancer. By determining the transcriptional levels and flow cytometry profiles, we developed a method that shows high sensitivity and specificity for breast cancer detection and therapy monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jessica G. Brussasco, Pedro H. G. Guedes, Anna C. R. Moco, Dayane D. Moraes, Jose M. R. Flauzino, Heliane S. Silva, Atair C. Silva, Jonathan P. Silva, Joao M. Madurro, Ana G. Brito-Madurro
Summary: This study reports the construction of a novel nanostructured immunosensor for detection of troponin I biomarker. The immunosensor exhibited a wide work range and low detection limit, as well as good selectivity and specificity in real samples. Furthermore, the immunosensor showed the possibility of reuse and featured a simplified and inexpensive platform, demonstrating excellent potential for application in the early diagnosis of acute myocardial infarction.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Veterinary Sciences
Fabiana de Almeida Araujo Santos, Patricia Tiemi Fujimura, Emilia Rezende Vaz, Ana Cristina Honorato de Castro, Ana Graci Brito-Madurro, Vivian Alonso-Goulart, Luciana Machado Bastos, Belchiolina Beatriz Fonseca, Anna Monteiro Correia Lima, Luiz Ricardo Goulart
Summary: This study demonstrates the effectiveness of mimetic epitopes of B. abortus in developing new platforms for diagnosing brucellosis. Additionally, a fast test based on an electrochemical sensor using graphite modified with poly-3-hydroxyphenylacetic acid is proposed.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Leticia L. D. Santos, Alinne T. F. Silva, Izabella C. C. Ferreira, Adriele Souza, Allisson B. Justino, Donizeti W. Santos, Luiz Ricardo Goulart, Carlos Eduardo Paiva, Foued S. Espindola, Yara C. P. Maia
Summary: This study investigates the relationship between infrared spectrum wavenumbers obtained by ATR-FTIR and the levels of redox status markers in women with HER2+ breast cancer, HER2- breast cancer, and benign breast disease. The results show that HER2+ breast cancer can be distinguished from HER2- breast cancer and benign breast disease based on lower serum antioxidant capacity. These findings contribute to our understanding of the biochemical changes associated with HER2+ breast cancer and offer potential for early detection and monitoring of the tumor.
Article
Chemistry, Analytical
Pedro H. G. Guedes, Jessica G. Brussasco, Anna C. R. Moco, Dayane D. Moraes, Monica Segatto, Jose M. R. Flauzino, Ana P. Mendes-Silva, Carlos U. Vieira, Joa M. Madurro, Ana G. Brito-Madurro
Summary: Late-Life Depression (LLD) is a common psychiatric disorder in elderly individuals, leading to significant impairment in functioning. Down-regulation of miR-184 (hsa-miR-184) expression can serve as a biomarker for LLD. This study introduces a novel electrochemical genosensor for the rapid diagnosis of LLD based on the detection of miR-184 in plasma using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS).
Article
Chemistry, Analytical
Freddy A. Nunez, Ana C. H. Castro, Isabela P. Daher, Edecio Cunha-Neto, Jorge Kalil, Silvia B. Boscardin, Alexandre J. C. Lanfredi, Vivian L. de Oliveira, Wendel A. Alves
Summary: The evaluation of serological responses to COVID-19 is crucial for population-level surveillance, developing new vaccines, and evaluating the efficacy of different immunization programs. A biosensor based on immobilization of the recombinant S protein on ZnONRs was employed for serological evaluation. The technology shows great potential for vaccine assessment and monitoring seroprevalence.
Article
Chemistry, Physical
Qi-Wen Chen, Ze-Qing Guo, Jian-Ping Zhou
Summary: Multifunctional continuous solid solutions NFMTO-x were successfully synthesized via a one-step hydrothermal method by controlling the ratio of Mg and Fe. The NFMTO-x materials exhibited enhanced visible light response, effective adsorption and photocatalytic degradation of organic pollutants, CO2 methanation capability, and easy recyclability due to their magnetic properties. This research provides a significant multifunctional material for water purification.
APPLIED SURFACE SCIENCE
(2024)
Review
Chemistry, Physical
George E. Stan, Maziar Montazerian, Adam Shearer, Bryan W. Stuart, Francesco Baino, John C. Mauro, Jose M. F. Ferreira
Summary: Bioactive glasses have the ability to form strong bonds with tissues and release therapeutic ions. However, their biomechanical compatibility limits their use in load-bearing applications. The use of magnetron sputtering technology to fabricate BG coatings shows promise in improving their efficacy and potential for application.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Zhaoxuan Wang, Zhicheng Yan, Zhigang Qi, Yu Feng, Qi Chen, Ziqi Song, Meng Huang, Peng Jia, Ki Buem Kim, Weimin Wang
Summary: The corrosion behavior of Fe-60 and Fe-83 ribbons in 0.6 M NaCl was studied. Fe-60 exhibited a local corrosion mode and formed a stable passivation film with higher corrosion resistance, while Fe-83 showed a combination of local and global corrosion modes and had lower corrosion resistance. Controlling the precipitation of nanocrystalline phases and increasing the POx content in the passivation film significantly improved the corrosion resistance of Fe-based glassy alloys.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Hao-Kai Peng, Sheng-Yen Zheng, Wei-Ning Kao, Ting-Chieh Lai, Kai-Sheun Lee, Yung- Hsien Wu
Summary: This study investigates the effects of high energy/fluence proton radiation on the performance of HfZrOx-based FeFETs memory with different Zr content. The results show that the characteristics of FeFETs are influenced by proton radiation, and the extent of the influence depends on the Zr content. FeFETs with 50% Zr content exhibit minimal changes in memory window and demonstrate good endurance and retention performance.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Zongyi Yue, Guangyi Wang, Zengguang Huang, Sihua Zhong
Summary: In this study, AZO and ITO films were successfully tuned as excellent passivation layers for c-Si surfaces, achieving effective minority carrier lifetime and outstanding optical properties through the optimization of annealing temperature and interfacial silicon oxide.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Martin Hruska, Jan Kejzlar, Jaroslav Otta, Premysl Fitl, Michal Novotny, Jakub Cizek, Oksana Melikhova, Matej Micusik, Peter Machata, Martin Vrnata
Summary: This paper presents a detailed study on the hydrogen sensing capabilities of highly nanoporous black gold films. The films exhibit fast response and recovery times at low temperatures. Different levels of nanoporosity were prepared and tested to investigate the sensing properties, and it was found that nanoporous black gold is suitable for hydrogen sensing. The sensitivity of the film depends on its nanoporosity.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Yupu Wang, Gaofeng Teng, Chun To Yiu, Junyi Zhu
Summary: In the study of BM-SCO and HSCO thin films, it was found that H vacancies tend to prefer sites near the external surface or oxygen vacancy channels (OVCs), while H interstitials prefer sites of oxygen on a layer that contains six-fold coordinated Co. These findings not only enrich the understanding of complex surface phenomena of defect formation but also provide an explanation for the reversibility during phase transformation.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Jiafeng Lu, Linping Teng, Qinxiao Zhai, Chunhua Wang, Matthieu Lancry, Ye Dai, Xianglong Zeng
Summary: In this study, we achieved full control of fiber nanograting orientation by manipulating laser polarization, and tailored space variant fiber nanogratings, which expanded the diversity in fiber nanograting engineering.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Yibo Liu, Yujie Tao, Yue Liu, Qi Sun, Qinrong Lin, Kexin Kang, Qinghua Zhang, Qingjie Sun
Summary: This study investigates the wettability of the Ti-Cu-Fe multi-metal system, specifically the wetting behaviors of CuSi3 droplets on TC4 and 304SS plates. The results show that the CO2 + Ar gas atmosphere significantly affects interfacial mass transfer, thus influencing the wettability of the systems.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Jimei Liu, Fei Wang, Rong Guo, Yuqi Liu, Mengyu Zhang, Jaka Sunarso, Dong Liu
Summary: This study developed Co/MXene composites with anti-corrosion properties by varying the cobalt content. These composites exhibited remarkable electromagnetic absorption performance and high resistance to corrosion under various corrosive conditions. The study also revealed the mechanism of electron transfer from cobalt to MXene and the electromagnetic dissipation behavior originated from polarization loss alone.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Moujie Huang, Yongsong Ma, Jingbo Yang, Lingyun Xu, Hangqi Yang, Miao Wang, Xin Ma, Xin Xia, Junhao Yang, Deli Wang, Chuang Peng
Summary: Strong metal-support interactions (SMSIs) are important for enhancing catalytic activities and stability in thermal catalysis. This study demonstrates a method to create SMSIs in electrocatalysis using carbon nanotubes and Ru nanoparticles, resulting in excellent catalytic activity and stability.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Ravi Trivedi, Brinti Mondal, Nandini Garg, Brahmananda Chakraborty
Summary: This study explores the potential of biphenylene as a nanocarrier for the delivery of the anticancer drug cisplatin. It is found that biphenylene offers physical stability, rapid release rate, solubility, and bio-compatibilities compared to other nanocarriers. The adsorption of cisplatin on the surface of biphenylene involves charge transfer from cisplatin to biphenylene. The drug is shown to be released at body temperature in an acidic environment. Biphenylene also exhibits excellent cytotoxicity activity and cellular uptake of the drug. Overall, biphenylene shows promise as a potential nanocarrier for cisplatin delivery.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Hyun Jeong, Hyeong Chan Suh, Ga Hyun Cho, Rafael Salas-Montiel, Hayoung Ko, Ki Kang Kim, Mun Seok Jeong
Summary: In this study, a potential platform to enhance Raman scattering and increase the number of observable Raman modes in monolayer transition metal dichalcogenides (TMDs) was proposed. The platform consisted of large-scale arrays of gold micropillars (MPs), which were able to enhance the Raman intensity of TMDs and make difficult-to-detect Raman modes observable. The platform showed great industrial advantages and wide applicability due to its low cost, simple process, large controllable area, and short process time.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Yasir Abbas, Shafqat Ali, Sajjad Ali, Waqar Azeem, Zareen Zuhra, Haoliang Wang, Mohamed Bououdina, Zhenzhong Sun
Summary: In this study, FeOx@SPNO-C core-shell nanospheres as a catalyst for degradation of sulfamethoxazole (SMX) were successfully synthesized. The synergistic interaction between FeOx and SPNO-C, high carbon charge density, and the presence of C = O groups and N/Fe-Nx sites were found to be key factors for the enhanced degradation of SMX.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Qiaoting Yang, Yuxiao Gong, Yan Qian, Zhou-Qing Xiao, Serge Cosnier, Xue-Ji Zhang, Robert S. Marks, Dan Shan
Summary: This study proposes a hierarchical confinement strategy to design Prussian blue nanoparticles (PB NPs) with satisfactory electrocatalytic ability and stability. The catalytic synthesis of PB NPs is achieved through a hydrothermal process, and the as-prepared PB@NH2MIL exhibits efficient electronic transmission and enhanced electrocatalytic properties.
APPLIED SURFACE SCIENCE
(2024)
