4.7 Article

Temperature and magnetic field responsive hyaluronic acid particles with tunable physical and chemical properties

期刊

APPLIED SURFACE SCIENCE
卷 257, 期 7, 页码 2669-2676

出版社

ELSEVIER
DOI: 10.1016/j.apsusc.2010.10.040

关键词

Temperature-sensitive HA particles; Magnetic composite; Drug release; Modifiable HA particles

资金

  1. Scientific and Technological Council of Turkey [108T133]
  2. Turkish Academy of Science

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We report the preparation and characterization of thiolated-temperature-responsive hyaluronic acid-cysteamine-N-isopropyl acrylamide (HA-CYs-NIPAm) particles and thiolated-magnetic-responsive hyaluronic acid (HA-Fe-CYs) particles. Linear hyaluronic acid (HA) crosslinked with divinyl sulfone as HA particles was prepared using a water-in-oil micro emulsion system which were then oxidized HA-O with NaIO4 to develop aldehyde groups on the particle surface. HA-O hydrogel particles were then reacted with cysteamine (CYs) which interacted with aldehydes on the HA surface to form HA particles with cysteamine (HA-CYs) functionality on the surface. HA-CYs particles were further exposed to radical polymerization with NIPAm to obtain temperature responsive HA-CYs-NIPAm hydrogel particles. To acquire magnetic field responsive HA composites, magnetic iron particles were included in HA to form HA-Fe during HA particle preparation. HA-Fe hydrogel particles were also chemically modified. The prepared HA-CYs-NIPAm demonstrated temperature dependent size variations and phase transition temperature. HA-CYs-NIPAm and HA-Fe-CYs particles can be used as drug delivery vehicles. Sulfamethoxazole (SMZ), an antibacterial drug, was used as a model drug for temperature-induced release studies from these particles. (C) 2010 Elsevier B.V. All rights reserved.

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