期刊
APPLIED SURFACE SCIENCE
卷 257, 期 12, 页码 5259-5264出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2010.11.090
关键词
Deposition; Polymer; Drug delivery
类别
资金
- CNCSIS-UEFISCSU [140/09.08.2010, FOTOPOL 71-111]
In this work, we show successful use of matrix-assisted pulsed laser evaporation (MAPLE) for obtaining thin films of PEG: PLGA blends, in the view of their use for controlled drug delivery. In particular, we investigate the influence of the blending ratios on the characteristics of the films. We show that the roughness of the polymeric films is affected by the ratio of each polymer within the blend. In addition, we perform Fourier transformed infrared spectroscopy (FTIR) measurements and we find that the intensities ratios of the infrared absorption bands of the two polymers are consistent with the blending ratios. Finally, we assess the optical constants of the polymeric films by spectroscopic ellipsometry (SE). We point out that the blending ratios exert an influence on the optical characteristics of the films and we validate the SE results by atomic force microscopy and UV-vis spectrophotometry. In all, we stress that the ratios in which the two polymers are blended have significant impact on the morphology, chemical structure and optical characteristics of the polymeric films deposited by MAPLE. (C) 2010 Elsevier B.V. All rights reserved.
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