期刊
APPLIED SURFACE SCIENCE
卷 256, 期 6, 页码 1878-1882出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2009.10.023
关键词
Chondrocyte; Microcontact printing; Tissue engineering
类别
资金
- Natural Science Fund of China [30900294]
- Natural Science Yong Scholars Foundation of Chongqing University [0221001104305]
The present study is to investigate human chondrocytes behavior on microcontact printed bone morphogenetic protein-2 (BMP-2) lines on polystyrene (PS) surface. It was found that the cells aligned with BMP lines and expressed type II and VI collagen. The chondrocytes in vitro cultured on BMP lines were elongated, which resulted in altered cell morphology. Taking all these results into consideration, BMP-2 lines enhance cell adhesion, restrict spreading, and increase type II and VI collagen expression. The results represented in this study may be an approach to the problem of engineering reparative cartilage in vitro. Crown Copyright (C) 2009 Published by Elsevier B. V. All rights reserved.
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