Article
Food Science & Technology
Ping Deng, Bei Cui, Hailan Zhu, Buangurn Phommakoun, Dan Zhang, Yiming Li, Fei Zhao, Zhong Zhao
Summary: The study revealed differences in cyanogenic glycoside accumulation among different apricot cultivars and at different developmental stages. The accumulation pattern of cyanogenic glycosides shifted from prunasin-dominated to amygdalin-dominated during bitter apricot kernel development and ripening. Additionally, beta-glucosidase activity was high during kernel development and ripening in all tested apricot cultivars, but was not important for amygdalin accumulation.
Review
Food Science & Technology
Neeraj Kumari, Manoj Radha, Manoj Kumar, Sunil Puri, Baohong Zhang, Nadeem Rais, Ashok Pundir, Deepak Chandran, Priya Raman, Sangram Dhumal, Abhijit Dey, Marisennayya Senapathy, Sunil Kumar, Bishwa Raj Pokharel, Vishal Deshmukh, Rahul D. Damale, Anitha Thiyagarajan, V. Balamurgan, G. Sathish, Surinder Singh, Jose M. Lorenzo
Summary: The seeds and kernels of peaches are rich sources of various important compounds such as sodium, potassium, zinc, copper, iron, fatty acids, fiber, and carbohydrates. They have been found to possess several bioactive properties including anti-aging, protection against oxidative stress, cancer cell inhibition, and diabetes prevention. Peach wastes can be utilized to produce functional foods, pharmaceuticals, animal feed, and cosmetics.
Article
Multidisciplinary Sciences
Matthew S. Bramble, Neerja Vashist, Arthur Ko, Sambhawa Priya, Celeste Musasa, Alban Mathieu, D' Andre Spencer, Michel Lupamba Kasendue, Patrick Mamona Dilufwasayo, Kevin Karume, Joanna Nsibu, Hans Manya, Mary N. A. Uy, Brian Colwell, Michael Boivin, J. P. Banae Mayambu, Daniel Okitundu, Arnaud Droit, Dieudonne Mumba Ngoyi, Ran Blekhman, Desire Tshala-Katumbay, Eric Vilain
Summary: Konzo, a distinct upper motor neuron disease associated with cyanogenic diet and chronic malnutrition, predominantly affects children and women of childbearing age in sub-Saharan Africa. The gut microbiome structure is highly variable depending on region of sampling, and unique enrichments of bacterial species and functional pathways have been identified in prone regions of the Congo that potentially modulate the susceptibility of konzo. Using metagenomic profiling in 180 individuals from the Democratic Republic of the Congo, associations between the gut microbiome and konzo have been found.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Ewa Jaszczak-Wilke, Zaneta Polkowska, Marek Koprowski, Krzysztof Owsianik, Alyson E. Mitchell, Piotr Balczewski
Summary: Amygdalin is a natural cyanogenic glycoside found in the seeds of some edible plants, with both anticancer activity and toxicity due to hydrogen cyanide production. Despite studies on cancer cell lines, clinical evidence for its anticancer properties is not fully confirmed. High dose exposures to amygdalin can lead to cyanide toxicity.
Article
Chemistry, Multidisciplinary
Mehrvash Varnasseri, Howbeer Muhamadali, Yun Xu, Paul I. C. Richardson, Nick Byrd, David Ellis, Pavel Matousek, Royston Goodacre
Summary: The study explored the use of Raman spectroscopy and SORS technology for the non-destructive detection of adulteration in extra virgin olive oil. Results demonstrated that these methods have significant potential for rapid and accurate analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Spectroscopy
Karlis Berzins, Samuel D. L. Harrison, Claudia Leong, Sara J. Fraser-Miller, Michelle J. Harper, Aly Diana, Rosalind S. Gibson, Lisa A. Houghton, Keith C. Gordon
Summary: Raman and ATR-FTIR spectroscopy were used to analyze 208 breast milk samples as part of a larger research study. Comprehensive qualitative and quantitative analysis was carried out using chemometric methods, revealing the relationship between macronutrients and sample metadata. The study location and primary food sources were found to have a stronger impact on fat composition than its absolute content, highlighting the limitations and challenges of using spectroscopic techniques for this type of analysis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Food Science & Technology
Jingjing Wang, Quansheng Chen, Tarun Belwal, Xingyu Lin, Zisheng Luo
Summary: The study explores the use of Raman spectroscopy and SERS in food safety and quality control assays, emphasizing on the importance of chemometric algorithms. It covers spectral preprocessing, qualitative and quantitative algorithms, and highlights the applicability in monitoring various contaminants in different food matrices. The review also discusses the potential of Raman spectroscopy/SERS technique in achieving simultaneous and fast detection of multiple analytes in food matrices.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Spectroscopy
Doroteja Vaitiekunaite, Daniel Dodoo, Valentinas Snitka
Summary: Food traceability is a significant issue in the industry. This study successfully differentiated bilberries from 4 different geographical regions using SERS and chemometric analyses. The investigation also explored the potential impact of nucleobase methylation on the observed DNA variation. Although inconclusive, the research provides valuable insights into simulated and experimental DNA spectra.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Food Science & Technology
Omar Alajil, Vidya R. Sagar, Charanjit Kaur, Shalini Gaur Rudra, Sujata Vasudev, Deepak Chandran, Kanika Sharma, Manoj Kumar, Jose M. Lorenzo
Summary: This study reports the composition of amino acids, fatty acids, and phytochemicals in the seed kernels of six apricot genotypes. The kernels contain high levels of oleic acid, linoleic acid, aspartic acid, and tyrosine. Some genotypes also contain amygdalin, a toxic glycoside compound, and exhibit antioxidant activity. These findings suggest that apricot kernels can be a valuable source of health-promoting substances for the development of functional foods.
FOOD ANALYTICAL METHODS
(2022)
Article
Spectroscopy
Mahendra K. Shukla, Philippa Wilkes, Norma Bargary, Katherine Meagher, Dikshitkumar Khamar, Donal Bailey, Sarah P. Hudson
Summary: Monoclonal antibodies are highly specific and effective therapies for chronic diseases. However, traditional identification methods for therapeutic proteins have limitations such as lengthy sample preparation, contamination risks, and sample destruction. In this study, Raman spectroscopy combined with chemometrics was used to develop a rapid and non-destructive identification technique for monoclonal antibody-based drug substances, demonstrating its potential in the biopharmaceutical industry.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Food Science & Technology
Mourad Kharbach, Mohammed Alaoui Mansouri, Mohammed Taabouz, Huiwen Yu
Summary: In today's era of increased food consumption, consumers are demanding higher safety and quality standards for the food products they consume. Advanced spectroscopic techniques, such as hyperspectral and multispectral imaging, NMR, Raman, IR, UV, visible, fluorescence, and X-ray-based methods, offer a promising alternative to traditional analytical techniques for food analysis. These methods provide rapid, non-destructive, cost-effective, and environmentally friendly means of analyzing various aspects of food properties. However, interpreting spectroscopy data can be complex without the assistance of statistical and innovative chemometric approaches.
Article
Chemistry, Analytical
Wenqian Yan, Jiayi Yao, Zilin Yue, Hong Lin, Lei Wang, Kaiqiang Wang, Jinjie Li
Summary: This study investigated the use of Raman spectroscopy combined with multivariate analysis to monitor the freshness of sea bass fillets. PLSR models outperformed PCR and SVMR models in monitoring the TVB-N values of the fillets. The combination of Raman spectroscopy and chemometrics provided a new tool for the non-destructive evaluation of fish quality.
MICROCHEMICAL JOURNAL
(2023)
Review
Food Science & Technology
Raouf Aslam, Sajeev Rattan Sharma, Jaspreet Kaur, Afthab Saeed Panayampadan, Owias Iqbal Dar
Summary: Food safety and authenticity are major concerns for consumers worldwide. To combat economically motivated food fraud, there is a growing demand for more sensitive and accurate methods of detecting deliberate adulteration. This review article provides an overview of the current state of adulterated foods, common adulterants, and non-destructive detection methods.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Chemistry, Analytical
Wei Huang, Desheng Fan, Wangfang Li, Yaoyong Meng, Timon Cheng-yi Liu
Summary: This study proposes a rapid and non-destructive method for evaluating milk acidity based on Raman spectroscopy and chemometrics. It utilizes nonlinear modeling to predict the acidity and can detect illegal neutralization of milk acidity.
VIBRATIONAL SPECTROSCOPY
(2022)
Article
Environmental Sciences
J. Aramendia, M. Tuite, K. Castro, J. M. Madariaga
Summary: Various criteria or parameters have been proposed to determine the maturity of carbonaceous matter (CM) in geological samples using Raman spectroscopy. However, these methods involve the mathematical decomposition of Raman bands, which can be influenced by the specific method, software, or user. Pre-treatment of spectra and the use of chemometric methods, such as principal component analysis (PCA), can reduce uncertainty and bias. By considering the entire spectrum, not just specific regions, this approach allows for the comparison of CM based on maturity or H:C ratio.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Tanveer Ahmed Shaik, Alba Alfonso-Garcia, Xiangnan Zhou, Katherine M. Arnold, Anne K. Haudenschild, Christoph Krafft, Leigh G. Griffiths, Juergen Popp, Laura Marcu
ANALYTICAL CHEMISTRY
(2020)
Review
Biochemical Research Methods
Ghayathri Balasundaram, Christoph Krafft, Ruochong Zhang, Kapil Dev, Renzhe Bi, Mohesh Moothanchery, Juwrgen Popp, Malini Olivo
Summary: Breast conserving surgery is popular but incomplete tumor removal may require reoperation. Biophotonic technologies are evolving to be an intraoperative tool for assessing breast cancer surgical margins.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Chemistry, Analytical
Tanveer Ahmed Shaik, Joao L. Lagarto, Enrico Baria, Melis Goktas, Patrick Igoche Onoja, Kerstin G. Blank, Francesco S. Pavone, Juergen Popp, Christoph Krafft, Riccardo Cicchi
Summary: The study demonstrates the potential of nondestructive optical imaging techniques such as SHG, RS, and FLIM in monitoring collagen degradation and assessing mechanical properties in tissues. These techniques can provide label-free monitoring of collagen degradation and rough evaluation of mechanical properties in a nondestructive manner.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Eric Boateng Osei, Liliia Paniushkina, Konrad Wilhelm, Juergen Popp, Irina Nazarenko, Christoph Krafft
Summary: Extracellular vesicles (EVs) ranging in size from 60 to 800 nm were isolated from plasma of control and prostate cancer patients using differential centrifugation and ultrafiltration techniques. Spontaneous Raman and surface-enhanced Raman spectroscopy (SERS) were employed to identify fractions that best discriminate between control and cancer patients, with results showing that EV12 and EV120 fractions provide the most effective separation.
Article
Chemistry, Analytical
Tanveer Ahmed Shaik, Enrico Baria, Xinyue Wang, Florian Korinth, Joao L. Lagarto, Christiane Hoeppener, Francesco S. Pavone, Volker Deckert, Juergen Popp, Riccardo Cicchi, Christoph Krafft
Summary: This study investigated the biochemical, structural, and biomechanical effects of genipin (GE) cross-linking on equine pericardium (EP) using optical imaging techniques and atomic force microscopy (AFM). Results showed that GE cross-linking led to a decrease in second-harmonic signal and an increase in autofluorescence, indicating changes in biochemical and structural properties. Additionally, cross-linking increased the Young's modulus of EP.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Dana Cialla-May, Christoph Krafft, Petra Roesch, Tanja Deckert-Gaudig, Torsten Frosch, Izabella J. Jahn, Susanne Pahlow, Clara Stiebing, Tobias Meyer-Zedler, Thomas Bocklitz, Iwan Schie, Volker Deckert, Juergen Popp
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Karina Kocot, Katarzyna Pytlakowska, Ewa Talik, Christoph Krafft, Rafal Sitko
Summary: In this study, ss-cyclodextrin/graphene oxide (GO-ss-CD) was used as an effective adsorbent for dispersive micro-solid phase extraction (DMSPE) of uranyl ions (UO22+) from water samples. The adsorption capacity and resistance to high ionic strength make it a potential method for preconcentration of UO22+ ions. The accuracy of the method was verified by analyzing certified reference material and spiked water samples.
Article
Multidisciplinary Sciences
Julia Sophie Boeke, Juergen Popp, Christoph Krafft
Summary: This study utilized O-PTIR technology for the detection and identification of microplastic particles, analyzing the spectra of various plastic materials and introducing a novel two-dimensional identification method for better recognition of microplastic particles in environmental and biological samples.
SCIENTIFIC REPORTS
(2022)
Review
Optics
Christoph Krafft, Jurgen Popp
Summary: Modern optical and spectral technologies have the potential to characterize tissues at a molecular level, enabling the identification of pathological tissues and the grading and staging of tumors without the need for labeling. The current tools for intraoperative tumor assessment, as well as the requirements for tissue visualization from a medical and optical perspective, are described. Approaches utilizing optical and spectral techniques for ex vivo and in vivo monitoring are introduced, and proof-of-concept studies utilizing linear and nonlinear spectroscopy and imaging modalities are presented. The use of modern artificial intelligence and deep learning concepts to analyze spectroscopic and imaging datasets has contributed to the advancements in each technique. Finally, the article provides an outlook on the opportunities and prospects of clinical translation.
Article
Oncology
Christoph Krafft, Juergen Popp, Peter Bronsert, Arkadiusz Miernik
Summary: Raman spectroscopy allows for label-free assessment of bladder tissue in intraoperative applications. In a retrospective study, Raman microspectroscopic images were used to identify different components of bladder tissue, including normal bladder, bladder cancer, necrosis, epithelium, and lipid inclusions. Additionally, foreign materials such as microplastic particles and pigments were detected in the specimens. This study demonstrates the potential of Raman spectroscopy for tumor detection and material identification in complex matrices.
Article
Chemistry, Analytical
Tanveer Ahmed Shaik, Anuradha Ramoji, Nils Milis, Juergen Popp, Christoph Krafft
Summary: This study demonstrates how the O-PTIR technique can overcome the limitations of direct mid-infrared spectroscopic imaging of single cells in an aqueous buffer. By using an indirect detection principle, the technique achieves high-resolution discrete wavenumber imaging and fingerprint spectroscopy of cultivated cells. The study also shows the potential applications of O-PTIR in high-content screening and subcellular analysis.
Article
Chemistry, Physical
Stefan Kranz, Markus Heyder, Stephan Mueller, Andre Guellmar, Christoph Krafft, Sandor Nietzsche, Caroline Tschirpke, Volker Herold, Bernd Sigusch, Markus Reise
Summary: The study investigated the effect of a zinc carbonate-hydroxyapatite-containing dentifrice on demineralized enamel and dentin surfaces. The results showed no significant differences in enamel surfaces, but a reduction in roughness and minor mineral precipitation on dentin surfaces.
Article
Spectroscopy
Thomas G. Mayerhoefer, Christoph Krafft
Summary: The spectroscopic literature often suggests that peak shifts are generally correlated with structural changes on the molecular or unit cell level, but there are also situations where peaks shift for reasons unrelated to chemical structural changes. To avoid misinterpretations, practitioners should be aware of these reasons.
Article
Chemistry, Analytical
Florian Korinth, Tanveer Ahmed Shaik, Jurgen Popp, Christoph Krafft
Summary: The study utilized the SERDS technique to process GE-crosslinked EP samples, revealing that the difference spectra generated by SERDS had clearer collagen and GE pigment bands with lower standard deviation, and could be applied to Raman studies on samples with strong fluorescence backgrounds.
Proceedings Paper
Medical Laboratory Technology
Christoph Krafft, Eric Boateng Osei, Jurgen Popp, Irina Nazarenko
BIOMEDICAL VIBRATIONAL SPECTROSCOPY 2020: ADVANCES IN RESEARCH AND INDUSTRY
(2020)
