期刊
APPLIED RADIATION AND ISOTOPES
卷 70, 期 8, 页码 1691-1697出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2012.03.004
关键词
Microfluidics; Radiochemistry; Autoradiolysis; Radiotracer synthesis; Lab-on-chip; PET
类别
资金
- Leading-Edge Cluster m4
- German Federal Ministry of Education and Research
Autoradiolysis describes the degradation of radioactively labeled compounds due to the activity of the labeled compounds themselves. It scales with activity concentration and is of importance for high activity and microfluidic PET tracer synthesis. This study shows that microfluidic devices can be shaped to reduce autoradiolysis by geometric exclusion of positron interaction. A model is developed and confirmed by demonstrating in-capillary storage of non-stabilized [F-18]FDG (2-[F-18]Fluoro-2-deoxy-D-glucose) at max. 23 GBq/ml while maintaining > 90% radiochemical purity over 14 h. (C) 2012 Elsevier Ltd. All rights reserved.
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