期刊
APPLIED RADIATION AND ISOTOPES
卷 69, 期 9, 页码 1212-1217出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.04.010
关键词
Alzheimer's disease (AD); PET; Carbon-11; Methyl triflate; PIB
[C-11]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [C-11]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75 degrees C, 4 mg/mL precursor yielding at 48.0 +/- 2.7% (EOS, based on [C-11]CH3OTf, corrected for decay), 183 +/- 14 GBq/mu mol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation. (C) 2011 Elsevier Ltd. All rights reserved.
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