Article
Oncology
Yu Gao, Qi Luo, Zhichen Sun, Hannan Gao, Yue Yu, Yining Sun, Xiaotu Ma, Chuanhui Han, Jiyun Shi, Fan Wang
Summary: A new SPECT/CT imaging probe Tc-99m-sum IL-2 was developed to target tumor-infiltrating T cells and predict immune response and guide immunotherapy. The probe successfully identified tumor-infiltrating T cells and showed treatment efficacy through imaging.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Medicine, General & Internal
Jeremy McGale, Sakshi Khurana, Alice Huang, Tina Roa, Randy Yeh, Dorsa Shirini, Parth Doshi, Abanoub Nakhla, Maria Bebawy, David Khalil, Andrew Lotfalla, Hayley Higgins, Amit Gulati, Antoine Girard, Francois-Clement Bidard, Laurence Champion, Phuong Duong, Laurent Dercle, Romain-David Seban
Summary: HER2-positive breast cancer, characterized by amplification of the HER2 gene, is associated with aggressive tumor growth, increased metastatic risk, and poorer prognosis compared to other subtypes. HER2 expression is a crucial tumor feature for breast cancer diagnosis and treatment. Advancements in HER2 in vivo imaging techniques like PET and SPECT may enhance the role of HER2 status in guiding breast cancer management, enabling determination of tumor size, location, and evaluation of treatment effectiveness. This review explores the current and future role of HER2 imaging in personalized care for breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Mirela Gherghe, Mario-Demian Mutuleanu, Adina Elena Stanciu, Ionela Irimescu, Alexandra Maria Lazar, Radu Valeriu Toma, Oana Gabriela Trifanescu, Rodica Maricela Anghel
Summary: By quantitatively interpreting SPECT-CT images, we can better demonstrate changes in radiotracer uptake between baseline and follow-up scans in breast cancer patients with metastatic bone disease, compared to qualitative assessment. This method provides a standardized and robust approach for patient follow-up evaluation, which is particularly important for research purposes.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Meixin Zhao, Weifang Zhang
Summary: Duodenobiliary reflux is considered a cause of recurrent bacterial cholangitis. A case report of a 65-year-old woman with intermittent epigastric pain for 20 years, diagnosed with cholelithiasis and suspected of duodenobiliary reflux, showed abnormal radioactivity in the common bile duct on imaging.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Annemiek Dickhout, Pieter van de Vijver, Nicole Bitsch, Stefan J. van Hoof, Stella L. G. D. Thomassen, Steffen Massberg, Peter Timmerman, Frank Verhaegen, Rory R. Koenen, Ingrid Dijkgraaf, Tilman M. Hackeng
Summary: This study improved and validated an imaging probe based on α2-AP in a mouse thrombosis model. The results showed that in the stenosis model, the A16 imaging probe could serve as a molecular tracer corresponding to clot formation in the vena cava.
Article
Immunology
Roisin McMorrow, Giorgia Zambito, Alex Nigg, Karishma Lila, Thierry P. P. van den Bosch, Clemens W. G. M. Lowik, Laura Mezzanotte
Summary: In this study, a dual color bioluminescent mouse model was used to investigate the location and function of T-cells during tumor growth and checkpoint blockade treatment. The results showed differences in total T-cell bioluminescence between highly infiltrated 'hot' tumors and poorly infiltrated 'cold' tumors. An increase in bioluminescence signal was observed in the tumor-draining lymph nodes after checkpoint blockade treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Narmin Ghaffari Laleh, Chiara Maria Lavinia Loeffler, Julia Grajekid, Katerina Stankova, Alexander T. Pearson, Hannah Sophie Muti, Christian Trautwein, Heiko Enderling, Jan Poleszczuk, Jakob Nikolas Kather
Summary: This study fitted differential equation models to tumor volume measurements of patients undergoing chemotherapy or cancer immunotherapy. The Gompertz model provided the best fit to the data and the general Bertalanffy and Gompertz models performed best in predicting treatment outcome. The study provides a benchmark for classical textbook models and state-of-the-art models of human tumor growth.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jon Ander Simon, Emilia Utomo, Felix Pareja, Maria Collantes, Gemma Quincoces, Aaron Otero, Margarita Ecay, Juan Dominguez-Robles, Eneko Larraneta, Ivan Penuelas
Summary: The use of intranasal implantable drug delivery systems has great potential for sustained drug delivery. This study presents a novel approach using radiolabeled risperidone intranasal implants, which can provide valuable data for the optimization of drug delivery systems. The implants were successfully administered to rats and showed a slow and steady release of the drug over a month. This experimental approach enables high-resolution imaging of drug release, contributing to the development of improved pharmaceuticals.
Article
Oncology
Wei Mu, Lei Jiang, Yu Shi, Ilke Tunali, Jhanelle E. Gray, Evangelia Katsoulakis, Jie Tian, Robert J. Gillies, Matthew B. Schabath
Summary: The study suggests that quantitative imaging can serve as an alternative to immunohistochemistry for predicting PD-L1 expression status in NSCLC patients treated with immune checkpoint inhibitors. The developed deeply learned score was able to accurately predict durable clinical benefit, progression-free survival, and overall survival in retrospective and prospective cohorts of patients. The findings support the use of this score as a surrogate for PD-L1 measurement in guiding individual treatment decisions.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Editorial Material
Medicine, General & Internal
Adrien Holzgreve, Matthias P. Fabritius, Thomas Knoesel, Lena M. Mittlmeier, Johannes Ruebenthaler, Reinhold Tiling, Christoph J. Auernhammer, Peter Bartenstein, Marcus Unterrainer
Summary: This case demonstrates the importance of molecular imaging findings in correctly diagnosing diseases related to brown tumors.
Editorial Material
Immunology
Michelle Leung, Nicholas McGranahan
Summary: Tumor mutation burden (TMB) is an established immune checkpoint blockade (ICB) response predictor, but there is room for improvement. In a recent study published in Nature Medicine, Niknafs et al. demonstrate that persistent mutation burden, a subset of TMB, can better predict patient outcomes in ICB therapy.
Article
Engineering, Electrical & Electronic
Hongki Lim, Yuni K. Dewaraja, Jeffrey A. Fessler
Summary: This study introduces a trained regularizer for SPECT reconstruction using CT imaging, which improves the imaging effect of low-count SPECT by incorporating CT-side information. Experimental results show that this method outperforms conventional methods in activity quantification, noise reduction, and root mean square error.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2023)
Review
Cell Biology
Thaise Goncalves Araujo, Sara Teixeira Soares Mota, Helen Soares Valenca Ferreira, Matheus Alves Ribeiro, Luiz Ricardo Goulart, Lara Vecchi
Summary: Annexin A1, initially known for its anti-inflammatory properties, has been found to switch to pro-inflammatory activity in the context of cancer. It exhibits pro-invasive and pro-tumoral effects in several cancers by inducing a favorable tumor microenvironment.
Article
Nanoscience & Nanotechnology
Colin Blackadar, Ka-Yee Grace Choi, Mary F. Embree, Heather M. Hennkens, Cristina Rodriguez-Rodriguez, Robert E. W. Hancock, Katayoun Saatchi, Urs O. Hafeli
Summary: Single-photon emission computed tomography (SPECT) is a useful tool for noninvasively visualizing the biodistribution of silver-containing compounds in rodents. The study found that antimicrobial silver nanoparticles, formed by neutron irradiation of palladium foil, can be stably incorporated into the lungs of mice without significant uptake in other organs. In a mouse model of pulmonary Pseudomonas aeruginosa infection, the nanoparticles effectively reduced bacterial burden without inducing excessive inflammation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sohee Park, Sang Min Lee, Seonok Kim, Sehoon Choi, Wooil Kim, Kyung-Hyun Do, Joon Beom Seo
Summary: The study found that the performance of radiomics models for predicting DFS in NSCLC patients was not significantly affected by CT slice thickness. The models showed consistent performance across different slice thickness datasets and the mixed slice thickness dataset, indicating that CT slice thickness does not impact the prognostic accuracy of radiomics models.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samaneh Azargoshasb, Imke Boekestijn, Meta Roestenberg, Gijs H. KleinJan, Jos A. van der Hage, Henk G. van der Poel, Daphne D. D. Rietbergen, Matthias N. van Oosterom, Fijs W. B. van Leeuwen
Summary: This study investigates the impact of signal-to-background ratios (SBR) on surgical performance using kinematics analysis. The results show that below SBR 1.5, task completion time, time spent in fluorescence-imaging mode, and total pathlength increase significantly, and handling errors become more frequent. The values of Dx and DM indicate that proficiency can only be achieved at SBR> 1.55.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jean-Pierre Pouget, Mark Konijnenberg, Uta Eberlein, Gerhard Glatting, Pablo Minguez Gabina, Ken Herrmann, Soren Holm, Lidia Strigari, Fijs W. B. van Leeuwen, Michael Lassmann
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Berrens, Matthias N. van Oosterom, Leon J. Slof, Fijs W. B. van Leeuwen, Henk G. van der Poel, Tessa Buckle
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Parasitology
Clarize Maria de Korne, Lisette van Lieshout, Fijs Willem Bernhard van Leeuwen, Meta Roestenberg
Summary: Imaging technology is essential for diagnosing parasitic diseases and has played a crucial role in developing antiparasitic strategies. The advancement of novel imaging technologies has revolutionized various fields of medicine and has also provided new ways to visualize parasites.
TRENDS IN PARASITOLOGY
(2023)
Article
Veterinary Sciences
Stephanie Scheemaeker, Marine Inglebert, Sylvie Daminet, Martina Dettwiler, Anna Letko, Cord Drogemuller, Martin Kessler, Richard Ducatelle, Sven Rottenberg, Miguel Campos
Summary: Organoid cultures were established as an in vitro model to study new treatments for canine medullary thyroid carcinoma (cMTC) and evaluate the effects of antitumor drugs on the viability of organoids.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Microbiology
Vaiva Gradauskaite, Marine Inglebert, John Doench, Melanie Scherer, Martina Dettwiler, Marianne Wyss, Neeta Shrestha, Sven Rottenberg, Philippe Plattet
Summary: Oncolytic viruses have gained attention as an alternative treatment for cancers. The Onderstepoort strain of canine distemper virus (CDV-OP), a safe and efficient vaccine for distemper in dogs, has shown promising oncolytic properties. By conducting a genome-wide CRISPR/Cas9 knockout screen, LRP6 was identified as a key receptor for CDV-OP entry in multiple cancer cell lines.
Article
Medicine, Research & Experimental
Marco Erreni, Francesca D'Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cecile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Summary: Nanobodies (Nbs) have been identified as an elegant alternative to conventional monoclonal antibodies for cancer therapy, but there is a lack of detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers, especially for the targeting of pro-tumoral tumor-associated macrophages (TAMs) located in less penetrable tumor regions.
Article
Cell & Tissue Engineering
M. M. Welling, K. Warbroek, C. Khurshid, M. N. van Oosterom, D. D. D. Rietbergen, M. G. J. de Boer, R. G. H. H. Nelissen, F. W. B. van Leeuwen, B. G. Pijls, T. Buckle
Summary: In this study, the ability of a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) to visualize the bacterial load on femoral implants using clinical-grade image guidance methods was evaluated. The results showed that this hybrid tracer allowed effective bacterial staining and combined qualitative real-time fluorescence guidance with nuclear imaging for quantitative monitoring of the effectiveness of cleaning strategies.
BONE & JOINT RESEARCH
(2023)
Article
Virology
Anne Monod, Christoph Koch, Christoph Jindra, Maarten Haspeslagh, Denise Howald, Christian Wenker, Vinzenz Gerber, Sven Rottenberg, Kerstin Hahn
Summary: This study suggests that CRISPR/Cas9 can be used for targeted editing of BPV-1 in equine sarcoids, resulting in a reduction of BPV-1 load. Deletion of the highly expressed equine Vimentin (VIM) also significantly decreases the number of BPV-1 episomes. These findings provide a new research tool for further unraveling the pathogenesis of equine sarcoids.
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthias N. van Oosterom, Samaneh Azargoshasb, Leon J. Slof, Fijs W. B. van Leeuwen
Summary: With the increasing use of robotic platforms in laparoscopic surgery, radioguidance has the potential to play a crucial role in improving surgical precision. Although there are challenges and limitations, recent developments have shown progress in integrating radioguidance with robotic laparoscopic surgery.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Surgery
Matthias N. van Oosterom, Sven van Leeuwen, Elio Mazzone, Paolo Dell'Oglio, Tessa Buckle, Florian van Beurden, Michael Boonekamp, Huybert van de Stadt, Kevin Bauwens, Herve Simon, Pim J. van Leeuwen, Henk G. van der Poel, Fijs W. B. van Leeuwen
Summary: This study engineered a 'click-on' fluorescence detector that transforms standard robotic instruments into molecular sensing devices, enabling the detection of near-infrared fluorescence in a white-light setting. The detector showed promising performance in detecting blood vessels, assessing vascularization, and localizing lymph nodes during robotic surgery in pigs and human specimen evaluation.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Chemistry, Inorganic & Nuclear
R. Galea, K. Moore
Summary: In this study, the solution of 225Ac was standardized using the TDCR method. The counting efficiencies were calculated to be approximately 500% for the NRC TDCR system. The relative uncertainty for the activity concentration was determined to be 0.25%. The measured half-life of 225Ac was found to be consistent with previous measurements.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
N. C. Ramirez, S. M. Collins
Summary: In this paper, the authors determined the half-life of 68Ga using ionisation chambers measurements and HPGe gamma-ray spectrometry. They reviewed the current literature and identified possible causes of inconsistency within the dataset. The findings suggest that addressing these issues could lead to a significant improvement in future evaluations of the half-life.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
C. P. Mano, C. Chapelle, Der Mesrobian Kabakian, H. Paradis, O. Delaune, L. Patryl
Summary: CEA/DAM is developing new beta-gamma measurement systems to enhance the reliability of the Comprehensive Nuclear Test Ban Treaty's verification regime. A new spectral unmixing algorithm for full-spectrum analysis was tested to improve analysis methods for nuclear activities with low statistics.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Junyoung Lee, Geunsub Kim, Hyegang Chang, Sangmin Lee, Sung-Joon Ye
Summary: The study applied the convolution/superposition method to calculate the dose distribution of boron neutron capture therapy and compared it with the Monte Carlo method. The results showed that the C/S method has a fast calculation speed and reasonable accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Victor H. Elvira, Marie-Christine Lepy, Yves Menesguen, Stephanie Melhem
Summary: In this study, a cryogenic electrical-substitution radiometer was utilized for the primary calibration of monochromatic photon beams at a synchrotron facility, in order to determine the intrinsic efficiency and dead layer thickness of an HPGe detector. This calibration method allowed for the calculation of efficiency up to 55 keV, where the active thickness of the detector is not a determining factor. Geometrical efficiency was also determined through measurements of a radioactive source at various distances.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Ali Pashazadeh, Hamid Reza Baghani, Mostafa Robatjazi, Prajit Kadavil
Summary: This study investigated the effect of patch source geometric parameters on the depth dose distribution in skin tissue through Monte Carlo simulation. The results showed that increasing the source-to-skin distance, patch thickness, and patch diameter will reduce the depth dose distribution, with the source-to-skin distance having the most significant impact on dose gradient.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Yueli Song, Fengqun Zhou, Yajuan Hao, Xiaopeng Zhang, Pengfei Ji, Yong Li
Summary: In this study, the cross section values of the 109Ag(n,2n)108mAg reaction at different neutron energies were measured using the activation technique and off-line gamma-ray spectrometry. The results were compared with experimental data, evaluated data from libraries, and theoretical values to validate their accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhongkai Fan, Tao Hu, Xiangming Cai, Ruomei Xie, Haoxuan Li, Fengdi Qin, Shoukang Qiu, Yanliang Tan, Jian Shan
Summary: The high-precision measurement of Rn-220 is crucial for assessing and preventing thoron radiological hazards. By adding a ZnS(Ag)-coated clapboard, the issue of reduced Rn-220 concentrations due to decreased air pressure can be addressed, leading to improved detection efficiency. Experimental and simulation results provide valuable references for establishing the Rn-220 calibration factor.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
R. Han, Z. Chen, Y. Nie, B. Liu, G. Tian, X. Zhang, F. Shi, H. Sun, Z. Zhang, Y. Ding, X. Ruan, J. Ren, S. Zhang
Summary: The leakage neutron spectra of Lead samples were measured using a TOF technique, and MCNP simulations with different nuclear data libraries showed that JENDL-5.0 and JEFF-3.3 libraries have better agreement with experimental data. Differences in spectra mainly stem from variations in neutron reaction channels across the libraries, with ENDF/B-VIII.0 and CENDL-3.2 libraries being overestimated in certain energy ranges.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Nissren Tamam, Maryam Al Huwayz, Z. A. Alrowaili, Norah Alwadai, Khadijah Mohammedsaleh Katubi, Mohammed S. Alqahtani, I. O. Olarinoye, M. S. Al-Buriahi
Summary: This study investigates the radiation shielding properties and radiation protection applications of borotellurite glasses. The results show that the addition of TeO2 can enhance the glass's ability to absorb photons and fast neutrons, and effectively suppress photon buildup. These glasses also exhibit exceptional gamma radiation and fast neutron moderating abilities, making them suitable for designing lead-free, transparent, and efficient radiation protection structures.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
S. Chasapoglou, M. Kokkoris, R. Vlastou, M. Diakaki, V. Michalopoulou, A. Kalamara, G. Gkatis, A. Stamatopoulos, M. Axiotis, S. Harissopulos, A. Lagoyannis, M. I. Savva, T. Vasilopoulou, C. Lederer-Woods, N. Patronis, K. Kaperoni
Summary: This study investigated the accuracy and limitations of theoretical corrections in neutron-induced reactions on isotopically enriched Ge targets. Experimental cross-section measurements were conducted on several reactions using Ge-nat and isotopically enriched Ge targets. The results showed that the methodology using isotopically enriched targets provided accurate results without the need for theoretical corrections.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
P. G. Konstantinidis, G. S. Polymeris, E. Tsoutsoumanos, G. Kitis
Summary: This study investigates an altered version of an existing protocol to study the mechanisms and phenomena of stimulated luminescence. The protocol allows for the examination of recombination mechanisms and trapping parameters of the traps, as well as the observation of potential transitions between two different states.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Quanzhi Yu
Summary: This study obtained the broad neutron spectrum of the Atmospheric Neutron Irradiation Spectrometer (ANIS) through Monte Carlo simulation and provided an analytic expression. By calculating the Single Error Rate (SER) and ratio, the reliability of the ANIS neutron spectrum was evaluated.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
D. Glavic Cindro, M. Korun, T. Petrovic, B. Vodenik, B. Zorko
Summary: In gamma-ray spectrometric measurements, the decision threshold is determined by the observed value of the measurand. However, this dependence restricts its application to measurements with non-expressive indications. To address this issue, a recalculation of the decision thresholds based on the peak widths corresponding to expressive indications is proposed.
APPLIED RADIATION AND ISOTOPES
(2024)
