Article
Clinical Neurology
Qihui Zhang, Xiaobin Zhao, Peng Lei, Hank F. Kung, Zhi Yang, Lin Zhu, Shujing Wang, Hua Zhu, Xiangxi Meng, Yunyun Duan, Li Sun, Jianwei Pan, Ruixue Ma, Haiyan Hong, Xingquan Zhao, Andrew Demchuk, Eric E. Smith, Yongjun Wang
Summary: This study investigated the distribution of the novel PET ligand [68Ga] Ga-p14-032 in patients diagnosed clinically with probable CAA and found that it exhibited stronger cortical retention in CAA patients compared to AD and NC patients. The results suggest that [68Ga] Ga-p14-032 may be a useful tracer for diagnosing CAA by preferentially binding to vascular amyloid.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Poul F. Hoilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Kasper P. Kepp, Rudolph J. Castellani, George Perry, Abass Alavi, Jorge R. Barrio
Summary: In June 2021, the FDA accelerated approved aducanumab and in January 2023 also lecanemab, based on perceived drug-induced removal of cerebral amyloid-beta as assessed by amyloid-PET and, in the case of lecanemab, limited clinical efficacy assumption. Approval for donanemab is pending further data. However, published trial data indicate minimal and uncertain clinical benefits, similar to conventional medication. Additionally, amyloid-PET signal decrease may reflect increased cell damage instead of amyloid removal, as supported by increased amyloid-related imaging abnormalities and brain volume loss in treated patients compared to placebo. We also question the current AD diagnostic criteria based on amyloid-PET imaging biomarkers and recommend future anti-AD therapy trials to incorporate (1) diagnosis based on cognitive decline and decreased cerebral metabolism assessed by FDA-approved FDG-PET, (2) therapy efficacy determined by cognitive ability, cerebral metabolism by FDG-PET, and brain volumes by MRI, and (3) neuropathologic examination of all deaths occurring in these trials.
Article
Medicine, General & Internal
Shizuo Hatashita, Daichi Wakebe
Summary: This study found that some initially amyloid-negative non-demented subjects converted to globally amyloid-positive during a long-term follow-up, with some association with the APOE epsilon 4 allele. Early regional increases in PIB DVR were most frequently observed in the right lateral temporal cortex.
Review
Medicine, General & Internal
Miriam Conte, Maria Silvia De Feo, Marko Magdi Abdou Sidrak, Ferdinando Corica, Joana Gorica, Giorgia Maria Granese, Luca Filippi, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: This article provides a systematic review of current and novel PET tracers for tauopathies. The results indicate that PET imaging can serve as a valuable tool for diagnosis, although further research on promising ligands is needed for differential diagnosis.
Review
Neurosciences
Baosheng Chen, Bernadette Marquez-Nostra, Erika Belitzky, Takuya Toyonaga, Jie Tong, Yiyun Huang, Zhengxin Cai
Summary: This study reviews the current state of preclinical PET imaging using animal models of Alzheimer's disease (AD), highlighting its importance in understanding AD pathogenesis/progression and the development of novel treatments. Future research directions are also suggested.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto
Summary: This study aimed to evaluate the effect of removing Aβ from blood plasma on the accumulation of amyloid plaques in the brain. The results showed a reduction in Aβ levels in the plasma and insoluble brain fractions, as well as a decrease in amyloid plaque burden and changes in plaque size distribution in the cortex and hippocampus. These findings support the importance of targeting Aβ in the periphery and suggest plasma exchange as a potential non-pharmacological strategy for slowing down AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Sarah K. Royse, Davneet S. Minhas, Brian J. Lopresti, Alice Murphy, Tyler Ward, Robert A. Koeppe, Santiago Bullich, Susan DeSanti, William J. Jagust, Susan M. Landau
Summary: This study addressed challenges in multisite studies using multiple beta-amyloid radiotracers by deriving standardized Centiloid transformations and internally consistent positivity thresholds for [F-18]florbetaben (FBB) and [F-18]florbetapir (FBP) PET data. The findings demonstrate the feasibility of harmonized PET acquisition and analysis and the internal consistency of positivity thresholds in standardized units, contributing to improved replicability in research and clinical trials.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Chemistry, Multidisciplinary
Stina Syvanen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjo, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin
Summary: Positron emission tomography (PET) is a medical imaging technique that has become important in clinical trials of drugs against Alzheimer's disease (AD). PET data contributed to the approval of aducanumab, an antibody targeting amyloid-beta (A beta) aggregates, by showing a dose-dependent reduction in brain amyloid. PET is also useful in preclinical studies with animal models of A beta pathology. It allows for longitudinal studies and has high translatability between species.
PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Physical
Fatih Tok, Begum Nurpelin Saglik, Yusuf Ozkay, Zafer Asim Kaplancikli, Bedia Kocyigit-Kaymakcioglu
Summary: A new series of 6-chloro-N'-(substituted benzylidene)nicotinohydrazide compounds were synthesized and evaluated for their enzyme inhibitory activity and plaque inhibitory potency. Compound P5 showed significant activity, particularly against AChE and BACE-1, and demonstrated high blood-brain barrier permeation.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Neurosciences
Jacob M. Basak, Aura Ferreiro, Lucy S. Cohen, Patrick W. Sheehan, Collin J. Nadarajah, Michael F. Kanan, Kimberley V. Sukhum, Gautam Dantas, Erik S. Musiek
Summary: The study reveals that sepsis may exacerbate amyloid plaque deposition and plaque-related inflammation, potentially leading to increased dementia in older sepsis survivors.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Wojciech K. Panek, David M. Murdoch, Margaret E. Gruen, Freya M. Mowat, Robert D. Marek, Natasha J. Olby
Summary: Similar neurological disorders associated with aging, such as Alzheimer's disease and canine cognitive dysfunction syndrome, have been observed in both humans and dogs. The concentrations of A beta 42 and A beta 40 in plasma increase with age in both species, but decrease in individuals with the diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Editorial Material
Neurosciences
Poul F. Hoilund-Carlsen, Mona-Elisabeth Revheim, Abass Alavi, Nagichettiar Satyamurthy, Jorge R. Barrio
Summary: Using amyloid PET imaging as the primary efficacy measure in Alzheimer's disease immunotherapy trials is unjustified due to lack of specificity and questionable quantification models. The FDA should require rigorous evidence and documentation before granting approval to other immunotherapy candidates.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Olga Krasnovskaya, Aina Kononova, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Elena Beloglazkina
Summary: There are over 55 million people with dementia worldwide and nearly 10 million new cases every year. Alzheimer's disease is the most common neurodegenerative disease that causes personality changes, cognitive impairment, memory loss, and physical disability. Early detection methods are important for early treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Patrick Oeckl, Marina Bluma, Marco Bucci, Steffen Halbgebauer, Konstantinos Chiotis, Anna Sandebring-Matton, Nicholas J. Ashton, Guglielmo Di Molfetta, Lana Grotschel, Miia Kivipelto, Kaj Blennow, Henrik Zetterberg, Irina Savitcheva, Agneta Nordberg, Markus Otto
Summary: Plasma beta-synuclein levels were found to be higher in individuals with Alzheimer's disease and mild cognitive impairment with amyloid-beta positivity. It demonstrated good discrimination and prediction of amyloid-beta status. The correlation between plasma beta-synuclein and amyloid-beta PET was observed in multiple cortical regions. These findings suggest that beta-synuclein is not a direct marker of amyloid-beta pathology and highlight the different longitudinal dynamics of synaptic degeneration and amyloid deposition in Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Sung-Eun Chung, Hyung-Ji Kim, Sungyang Jo, Sunju Lee, Yoojin Lee, Jee Hoon Roh, Jae-Hong Lee
Summary: Accumulation of aggregated amyloid-beta (A beta) in the brain is considered the first pathological event within the pathogenesis of Alzheimer's disease (AD). This study found that the posterior cingulate/precuneus and the lateral temporal and parietal cortices may be the earliest areas to be affected by A beta accumulation.
Article
Multidisciplinary Sciences
Chi-Chang Weng, Zi-An Chen, Ko-Ting Chao, Ting-Wei Ee, Kun-Ju Lin, Ming-Huan Chan, Ing-Tsung Hsiao, Tzu-Chen Yen, Mei-Ping Kung, Ching-Han Hsu, Shiaw-Pyng Wey
Article
Biotechnology & Applied Microbiology
Hsuan-Ming Huang, Ing-Tsung Hsiao
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peng Li, Ing-Tsung Hsiao, Chia-Yih Liu, Chia-Hsiang Chen, She-Yao Huang, Tzu-Chen Yen, Kuan-Yi Wu, Kun-Ju Lin
Article
Behavioral Sciences
Kuan-Yi Wu, Kun-Ju Lin, Chia-Hsiang Chen, Cheng-Sheng Chen, Chia-Yih Liu, Sheng-Yao Huang, Tzu-Chen Yen, Ing-Tsung Hsiao
BRAIN AND BEHAVIOR
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kuo-Lun Huang, Jung-Lung Hsu, Kun-Ju Lin, Chien-Hung Chang, Yi-Ming Wu, Ting-Yu Chang, Yeu-Jhy Chang, Chi-Hung Liu, Meng-Yang Ho, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Ing-Tsung Hsiao, Tsong-Hai Lee
Article
Multidisciplinary Sciences
Jung-Lung Hsu, Wen-Chuin Hsu, Chiung-Chih Chang, Kun-Ju Lin, Ing-Tsung Hsiao, Yen-Chun Fan, Chyi-Huey Bai
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Sheng-Yao Huang, Jung-Lung Hsu, Kun-Ju Lin, Ho-Ling Liu, Shiaw-Pying Wey, Ing-Tsung Hsiao
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Hsu Jung Lung, Yi-Hsin Weng, Ming-Ching Wen, Ing-Tsung Hsiao, Kun-Ju Lin
SCIENTIFIC REPORTS
(2018)
Article
Medicine, General & Internal
Kuo-Lun Huang, Ing-Tsung Hsiao, Hung-Chou Kuo, Chia-Ju Hsieh, Yu-Chen Hsieh, Yi-Ming Wu, Shiaw-Pyng Wey, Tzu-Chen Yen, Kun-Ju Lin, Chin-Chang Huang
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2019)
Article
Nanoscience & Nanotechnology
Yai-Ping Hsiao, Chung-Hsiung Huang, Yu-Chin Lin, Tong-Rong Jan
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Multidisciplinary Sciences
Chia-Hsiung Cheng, Kun-Ju Lin, Chien-Tai Hong, Dean Wu, Hung-Ming Chang, Cheng-Huan Liu, Ing-Tsung Hsiao, Chih-Ping Yang, Yu-Chuan Liu, Chaur-Jong Hu
SCIENTIFIC REPORTS
(2019)
Article
Nanoscience & Nanotechnology
Yai-Ping Hsiao, Hui-Ting Chen, Yu-Chih Liang, Tse-En Wang, Kai-Hung Huang, Cheng-Chih Hsu, Hong-Jen Liang, Chung-Hsiung Huang, Tong-Rong Jan
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Agriculture, Dairy & Animal Science
Tong-Rong Jan, Chen-Si Lin, Sheng-Yao Wang, Wen-Yuan Yang
Summary: This study investigated the mechanisms of a live attenuated vaccine against Salmonella Enteritidis (SE) infection. The results showed that the vaccine reduced inflammatory responses and modulated the cecal microbiome, providing protection against SE infection.
Article
Chemistry, Inorganic & Nuclear
R. Galea, K. Moore
Summary: In this study, the solution of 225Ac was standardized using the TDCR method. The counting efficiencies were calculated to be approximately 500% for the NRC TDCR system. The relative uncertainty for the activity concentration was determined to be 0.25%. The measured half-life of 225Ac was found to be consistent with previous measurements.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
N. C. Ramirez, S. M. Collins
Summary: In this paper, the authors determined the half-life of 68Ga using ionisation chambers measurements and HPGe gamma-ray spectrometry. They reviewed the current literature and identified possible causes of inconsistency within the dataset. The findings suggest that addressing these issues could lead to a significant improvement in future evaluations of the half-life.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
C. P. Mano, C. Chapelle, Der Mesrobian Kabakian, H. Paradis, O. Delaune, L. Patryl
Summary: CEA/DAM is developing new beta-gamma measurement systems to enhance the reliability of the Comprehensive Nuclear Test Ban Treaty's verification regime. A new spectral unmixing algorithm for full-spectrum analysis was tested to improve analysis methods for nuclear activities with low statistics.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Junyoung Lee, Geunsub Kim, Hyegang Chang, Sangmin Lee, Sung-Joon Ye
Summary: The study applied the convolution/superposition method to calculate the dose distribution of boron neutron capture therapy and compared it with the Monte Carlo method. The results showed that the C/S method has a fast calculation speed and reasonable accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Victor H. Elvira, Marie-Christine Lepy, Yves Menesguen, Stephanie Melhem
Summary: In this study, a cryogenic electrical-substitution radiometer was utilized for the primary calibration of monochromatic photon beams at a synchrotron facility, in order to determine the intrinsic efficiency and dead layer thickness of an HPGe detector. This calibration method allowed for the calculation of efficiency up to 55 keV, where the active thickness of the detector is not a determining factor. Geometrical efficiency was also determined through measurements of a radioactive source at various distances.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Ali Pashazadeh, Hamid Reza Baghani, Mostafa Robatjazi, Prajit Kadavil
Summary: This study investigated the effect of patch source geometric parameters on the depth dose distribution in skin tissue through Monte Carlo simulation. The results showed that increasing the source-to-skin distance, patch thickness, and patch diameter will reduce the depth dose distribution, with the source-to-skin distance having the most significant impact on dose gradient.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Yueli Song, Fengqun Zhou, Yajuan Hao, Xiaopeng Zhang, Pengfei Ji, Yong Li
Summary: In this study, the cross section values of the 109Ag(n,2n)108mAg reaction at different neutron energies were measured using the activation technique and off-line gamma-ray spectrometry. The results were compared with experimental data, evaluated data from libraries, and theoretical values to validate their accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhongkai Fan, Tao Hu, Xiangming Cai, Ruomei Xie, Haoxuan Li, Fengdi Qin, Shoukang Qiu, Yanliang Tan, Jian Shan
Summary: The high-precision measurement of Rn-220 is crucial for assessing and preventing thoron radiological hazards. By adding a ZnS(Ag)-coated clapboard, the issue of reduced Rn-220 concentrations due to decreased air pressure can be addressed, leading to improved detection efficiency. Experimental and simulation results provide valuable references for establishing the Rn-220 calibration factor.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
R. Han, Z. Chen, Y. Nie, B. Liu, G. Tian, X. Zhang, F. Shi, H. Sun, Z. Zhang, Y. Ding, X. Ruan, J. Ren, S. Zhang
Summary: The leakage neutron spectra of Lead samples were measured using a TOF technique, and MCNP simulations with different nuclear data libraries showed that JENDL-5.0 and JEFF-3.3 libraries have better agreement with experimental data. Differences in spectra mainly stem from variations in neutron reaction channels across the libraries, with ENDF/B-VIII.0 and CENDL-3.2 libraries being overestimated in certain energy ranges.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Nissren Tamam, Maryam Al Huwayz, Z. A. Alrowaili, Norah Alwadai, Khadijah Mohammedsaleh Katubi, Mohammed S. Alqahtani, I. O. Olarinoye, M. S. Al-Buriahi
Summary: This study investigates the radiation shielding properties and radiation protection applications of borotellurite glasses. The results show that the addition of TeO2 can enhance the glass's ability to absorb photons and fast neutrons, and effectively suppress photon buildup. These glasses also exhibit exceptional gamma radiation and fast neutron moderating abilities, making them suitable for designing lead-free, transparent, and efficient radiation protection structures.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
S. Chasapoglou, M. Kokkoris, R. Vlastou, M. Diakaki, V. Michalopoulou, A. Kalamara, G. Gkatis, A. Stamatopoulos, M. Axiotis, S. Harissopulos, A. Lagoyannis, M. I. Savva, T. Vasilopoulou, C. Lederer-Woods, N. Patronis, K. Kaperoni
Summary: This study investigated the accuracy and limitations of theoretical corrections in neutron-induced reactions on isotopically enriched Ge targets. Experimental cross-section measurements were conducted on several reactions using Ge-nat and isotopically enriched Ge targets. The results showed that the methodology using isotopically enriched targets provided accurate results without the need for theoretical corrections.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
P. G. Konstantinidis, G. S. Polymeris, E. Tsoutsoumanos, G. Kitis
Summary: This study investigates an altered version of an existing protocol to study the mechanisms and phenomena of stimulated luminescence. The protocol allows for the examination of recombination mechanisms and trapping parameters of the traps, as well as the observation of potential transitions between two different states.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Quanzhi Yu
Summary: This study obtained the broad neutron spectrum of the Atmospheric Neutron Irradiation Spectrometer (ANIS) through Monte Carlo simulation and provided an analytic expression. By calculating the Single Error Rate (SER) and ratio, the reliability of the ANIS neutron spectrum was evaluated.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
D. Glavic Cindro, M. Korun, T. Petrovic, B. Vodenik, B. Zorko
Summary: In gamma-ray spectrometric measurements, the decision threshold is determined by the observed value of the measurand. However, this dependence restricts its application to measurements with non-expressive indications. To address this issue, a recalculation of the decision thresholds based on the peak widths corresponding to expressive indications is proposed.
APPLIED RADIATION AND ISOTOPES
(2024)
