Review
Nutrition & Dietetics
Edoardo Parrella, Cristina Gussago, Vanessa Porrini, Marina Benarese, Marina Pizzi
Summary: Polyphenols are a crucial family of molecules found in plants that have beneficial effects on health, potentially protecting against cancer, cardiovascular diseases, and stroke. Research indicates that polyphenols impact the cardio- and cerebrovascular systems and may also have neuroprotective effects in preclinical stroke models. Studies suggest that polyphenolic compounds could be used to aid in the recovery of stroke patients.
Review
Biochemistry & Molecular Biology
Adele Chimento, Arianna De Luca, Maria D'Amico, Francesca De Amicis, Vincenzo Pezzi
Summary: Various literature data suggest that a diet rich in vegetables can reduce the incidence of cancer by utilizing the natural polyphenols present in them. Polyphenols possess various pharmacological actions such as anti-inflammatory, anti-oxidant, antibiotic, antiseptic, anti-allergic, cardioprotective, and even anti-tumor properties. The anti-tumor action of polyphenols involves multiple mechanisms associated with cell proliferation, differentiation, migration, angiogenesis, metastasis, and cell death. This review aims to provide an updated understanding of the apoptotic molecular mechanisms induced by representative polyphenols in cancer cells, which can be utilized in the development of new therapeutic strategies against cancer involving polyphenols as adjuvants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Aisha Kafoud, Zoya Salahuddin, Raghad Sabaawi Ibrahim, Reem Al-Janahi, Alena Mazurakova, Peter Kubatka, Dietrich Buesselberg
Summary: Neuroblastoma is a common malignancy in infants and children, and the current treatment often leads to relapse and long-term side effects. Polyphenols, including the subclass of flavonoids, have shown potential in inducing apoptosis in neuroblastoma cells. This review explores the use of various polyphenols and their mechanisms of action, suggesting significant potential for in vivo research.
Review
Biochemistry & Molecular Biology
Ana L. Becerril-Sanchez, Baciliza Quintero-Salazar, Octavio Dublan-Garcia, Hector B. Escalona-Buendia
Summary: Honey has been used since ancient times for its sensory, nutritional, and therapeutic properties, which are related to its physical and chemical composition. Phenolic compounds play a significant role in honey, influencing its antioxidant activity, botanical-geographical origin, and sensory characteristics. Researchers are increasingly interested in the study of phenolic compounds and their impact on honey's biological and functional activity.
Article
Biochemistry & Molecular Biology
Grazyna Kowalska, Tomasz Baj, Radoslaw Kowalski, Jolanta Szymanska
Summary: This study optimized the extraction conditions of polyphenols, flavonoids, and chlorophyll from peppermint and common nettle leaves using green chemistry. The use of glycerol-water systems resulted in higher concentrations of these active compounds compared to traditional solvents like water and ethanol. Extraction temperature was found to significantly influence the concentration of the components in the extracts.
Article
Plant Sciences
Ashwini Sushil Narvekar, Nishanth Tharayil
Summary: This study revealed that nitrogen fertilization influenced the quantity, composition, and tissue association of phenolics in strawberry leaves, with different classes of phenolic compounds showing varying degrees of response to nitrogen treatment, highlighting the potential of precise nitrogen management to enhance bioactive compounds in crops.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Arslan Iftikhar, Rimsha Nausheen, Humaira Muzaffar, Muhammad Ahsan Naeem, Muhammad Farooq, Mohsin Khurshid, Ahmad Almatroudi, Faris Alrumaihi, Khaled S. Allemailem, Haseeb Anwar
Summary: Honey, rich in antioxidants, is considered a potent pharmaceutical candidate for multiple neurological disorders, with various constituent polyphenols exhibiting multiple antioxidant effects.
Article
Biochemistry & Molecular Biology
Sameep Sonvane, Prafulla Choudhari, Omprakash Bhusnuare
Summary: Neuropathic pain is often associated with lesions or diseases of the somatosensory system, and its initiation and maintenance are regulated by the peripheral nervous system rather than the central nervous system. Flavonoids and polyphenols have promising effects in neuropathic pain, and structural modifications of certain compounds may yield potent Nav1.7 inhibitors for peripheral pain management.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Cell Biology
Ozal Beylerli, Aferin Beilerli, Alina Shumadalova, Xiaoxiong Wang, Mingchun Yang, Hanran Sun, Lei Teng
Summary: Glioblastoma is a common and aggressive tumor of the central nervous system with limited treatment options, and combination therapies may be more effective. Natural polyphenolic compounds show potential as anticancer drugs, but their effectiveness is limited by bioavailability and blood-brain barrier permeability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Zein Najjar, Jaleel Kizhakkayil, Hira Shakoor, Carine Platat, Constantinos Stathopoulos, Meththa Ranasinghe
Summary: This study explores the use of date seeds, a byproduct of the food industry, as a means to improve the nutritional value and antioxidant activity of cookies. The results show that the seeds contain high levels of polyphenols and flavonoids, and substituting flour with ground date seed enhances the cookies' antioxidant properties.
Article
Biophysics
Annalisa Scroccarello, Bernardo Molina-Hernandez, Flavio Della Pelle, Johnny Ciancetta, Giovanni Ferraro, Emiliano Fratini, Luca Valbonetti, Clemencia Chaves Copez, Dario Compagnone
Summary: An in-depth study on the antifungal performances of silver nanoparticles synthesized with different phenolic compounds reveals that the type of compound significantly affects the toxicity of AgNPs. This research provides insights into the rational use of phenolic compounds for applications involving AgNPs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Medicine, Research & Experimental
Yasemin Acar, Duygu Agagunduz, Paola De Cicco, Raffaele Capasso
Summary: This paper provides a literature review on the neurological roles of flavonoids, one of the most abundant phytochemical families, in Parkinson's disease (PD). Flavonoids have been shown to have beneficial effects on PD, such as protecting dopaminergic neurons, improving motor and cognitive abilities, regulating signaling pathways, and modulating oxidative stress and neuroinflammation. In addition, flavonoids can also promote the growth of beneficial strains and reduce pathogenic strains by changing the composition of bacteria in gut microbiota.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Aleksandra Bojarczuk, Magdalena Dzitkowska-Zabielska
Summary: Antioxidants in sports exercise training are a controversial topic in research. Athletes often use plant-derived polyphenol supplements to minimize exercise-induced oxidative stress, enhance muscle recovery, and improve performance. However, the existing literature lacks definitive evidence supporting the promotion of dietary polyphenols specifically among athletes. This review highlights the limited evidence suggesting the benefits of antioxidant substances for athletes and emphasizes the need for further research on their impact on exercise-induced oxidative stress and optimal dosing methods.
Article
Biochemistry & Molecular Biology
Alan-Misael Alonso, Oscar Kevin Reyes-Maldonado, Ana Maria Puebla-Perez, Martha Patricia Gallegos Arreola, Sandra Fabiola Velasco-Ramirez, Victor Zuniga-Mayo, Rosa E. Sanchez-Fernandez, Jorge-Ivan Delgado-Saucedo, Gilberto Velazquez-Juarez
Summary: This study characterized different tissues of Pelargonium peltatum and evaluated their antioxidant and antimicrobial activities. The ethyl acetate fractions showed higher activity and lower minimum inhibitory concentrations against certain bacterial strains. The main compounds identified were 1,2,3-Benzenetriol and ethyl gallate.
Article
Biochemistry & Molecular Biology
Pravin Kumar Sahu, Ana Cervera-Mata, Suryakant Chakradhari, Khageshwar Singh Patel, Erick K. Towett, Jose J. Quesada-Granados, Pablo Martin-Ramos, Jose A. Rufian-Henares
Summary: This work reports the chemical composition and physicochemical properties of 155 Indian seeds belonging to 49 families. The study found significant variations in the content of total polyphenols, flavonoids, and mineral elements among the seeds. The botanical and taxonomical variations of the examined seeds are also discussed.
Article
Nutrition & Dietetics
David C. Nieman, Giuseppe Valacchi, Laurel M. Wentz, Francesca Ferrara, Alessandra Pecorelli, Brittany Woodby, Camila A. Sakaguchi, Andrew Simonson
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2020)
Review
Nutrition & Dietetics
James A. Betts, Javier T. Gonzalez, Louise M. Burke, Graeme L. Close, Ina Garthe, Lewis J. James, Asker E. Jeukendrup, James P. Morton, David C. Nieman, Peter Peeling, Stuart M. Phillips, Trent Stellingwerff, Luc J. C. van Loon, Clyde Williams, Kathleen Woolf, Ron Maughan, Greg Atkinson
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2020)
Review
Hospitality, Leisure, Sport & Tourism
David C. Nieman, Brandt D. Pence
JOURNAL OF SPORT AND HEALTH SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Camila A. Sakaguchi, David C. Nieman, Etore F. Signini, Raphael M. de Abreu, Claudio D. Silva, Patricia Rehder-Santos, Maria G. A. Carosio, Roberta M. Maria, Carla C. Dato, Heloisa S. S. de Araujo, Tiago Venancio, Antonio G. Ferreira, Aparecida M. Catai
Article
Biochemistry & Molecular Biology
Jana F. Schader, Mark Haid, Alexander Cecil, Julia Schoenfeld, Martin Halle, Arne Pfeufer, Cornelia Prehn, Jerzy Adamski, David C. Nieman, Johannes Scherr
Review
Hospitality, Leisure, Sport & Tourism
David C. Nieman
JOURNAL OF SPORT AND HEALTH SCIENCE
(2020)
Article
Physiology
Amy M. Knab, David C. Nieman, Laura M. Zingaretti, Arnoud J. Groen, Artyom Pugachev
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Immunology
Yue Shi, Tingting Liu, David C. Nieman, Yanqiu Cui, Fei Li, Luyu Yang, Hui Shi, Peijie Chen
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Environmental Sciences
Marcus M. Lawrence, Kevin A. Zwetsloot, Susan T. Arthur, Chase A. Sherman, Joshua R. Huot, Vladimir Badmaev, Mary Grace, Mary Ann Lila, David C. Nieman, R. Andrew Shanely
Summary: The study showed that phytoecdysteroid treatment does not affect muscle mass or fiber type, nor does it activate protein synthesis signaling in sedentary aging mice.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Josep Bassaganya-Riera, Elliot M. Berry, Ellen E. Blaak, Barbara Burlingame, Johannes le Coutre, Willem van Eden, Ahmed El-Sohemy, J. Bruce German, Dietrich Knorr, Christophe Lacroix, Maurizio Muscaritoli, David C. Nieman, Michael Rychlik, Andrew Scholey, Mauro Serafini
Summary: In the past five years, significant progress has been made in nutrition science, such as the integration of Sustainable Development Goals and nutritional science, as well as research on the Human Microbiome. Looking ahead to the next five years, emphasis on health and sustainability will be the main focus of nutrition science.
FRONTIERS IN NUTRITION
(2021)
Editorial Material
Nutrition & Dietetics
David C. Nieman
Article
Biochemistry & Molecular Biology
Martin Osswald, Dario Kohlbrenner, Nora Nowak, Jorg Sporri, Pablo Sinues, David Nieman, Noriane Andrina Sievi, Johannes Scherr, Malcolm Kohler
Summary: This study utilized SESI-HRMS to continuously monitor metabolites in exhaled breath during a graded cycle ergometry cardiopulmonary exercise test, revealing significant changes in various metabolic pathways. Real-time monitoring enabled high-resolution data collection on metabolite shifts from rest to voluntary exhaustion, providing insights into metabolite changes during exercise.
Review
Nutrition & Dietetics
David C. Nieman
Summary: Precision nutrition for athletes aims to improve individualization of nutrition practices to optimize long-term performance and health, involving the acquisition of individual-specific information and the delivery of science-based nutrition advice.
FRONTIERS IN NUTRITION
(2021)
Review
Sport Sciences
David C. Nieman
Summary: Regular physical activity can improve immune surveillance, reduce the risk of COVID-19 infection, and potentially enhance the efficacy of COVID-19 vaccines. Additionally, physical training and rehabilitation can help improve physical fitness, quality of life, and immune health in patients with sustained morbidity from COVID-19.
CURRENT SPORTS MEDICINE REPORTS
(2021)
Review
Sport Sciences
Keri L. Denay, Rebecca G. Breslow, Meredith N. Turner, David C. Nieman, William O. Roberts, Thomas M. Best
CURRENT SPORTS MEDICINE REPORTS
(2020)