Article
Genetics & Heredity
Carlos Palma-Flores, Paola B. Zarate-Segura, J. Manuel Hernandez-Hernandez, Sergio de los Santos, Andrea S. Tejeda-Gomez, Luis Javier Cano-Martinez, Patricia Canto, Jorge Omar Garcia-Rebollar, Ramon M. Coral-Vazquez
Summary: This study demonstrates that (-)-epicatechin upregulates miRNAs involved in muscle adaptation, induces muscle hypertrophy, and increases the level of myogenic proteins.
Article
Biochemistry & Molecular Biology
Christopher G. Vann, Robert W. Morton, Christopher B. Mobley, Ivan J. Vechetti, Brian K. Ferguson, Cody T. Haun, Shelby C. Osburn, Casey L. Sexton, Carlton D. Fox, Matthew A. Romero, Paul A. Roberson, Sara Y. Oikawa, Chris McGlory, Kaelin C. Young, John J. McCarthy, Stuart M. Phillips, Michael D. Roberts
Summary: This study examined the association between genotype and resistance training-induced changes in lean soft tissue mass and muscle fiber cross-sectional area, identifying potential links between GLI3 gene variant and hypertrophic responses. Future studies are needed to confirm this association.
Article
Genetics & Heredity
Kent M. Reed, Kristelle M. Mendoza, Jiahui Xu, Gale M. Strasburg, Sandra G. Velleman
Summary: Early muscle development involves the proliferation and differentiation of stem cells (satellite cells, SCs) in the mesoderm to form multinucleated myotubes that mature into muscle fibers and fiber bundles. The study aimed to characterize the transcriptional changes induced in turkey SCs undergoing differentiation under thermal challenge. Cold treatment resulted in down regulation of genes involved in regulation of skeletal muscle tissue regeneration and sarcomere organization, while heat stress increased expression of genes reported to regulate myoblast differentiation and survival.
Article
Biochemistry & Molecular Biology
Andre Luis Araujo Minari, Felipe Avila, Lila Missae Oyama, Ronaldo Vagner Thomatieli dos Santos
Summary: This study aimed to evaluate the relationship between exercise inflammation and the peripheral neuroendocrine system, finding that increased nAChR receptors may contribute to skeletal muscle adaption after exercise.
Article
Sport Sciences
Christopher G. Vann, Cody T. Haun, Shelby C. Osburn, Matthew A. Romero, Paul A. Roberson, Petey W. Mumford, C. Brooks Mobley, Hudson M. Holmes, Carlton D. Fox, Kaelin C. Young, Michael D. Roberts
Summary: This study found that one week of active recovery after high-intensity training block instigates marginal molecular differences in skeletal muscle compared to passive recovery. However, from a practical standpoint, both paradigms elicited largely similar responses.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Martina Baraldo, Leonardo Nogara, Georgia Ana Dumitras, Achille Homere Tchampda Dondjang, Alessia Geremia, Marco Scalabrin, Clara Turk, Frederik Telkamp, Lorena Zentilin, Mauro Giacca, Marcus Kruger, Bert Blaauw
Summary: Loss of Raptor diminishes muscle hypertrophy and force increase after Akt activation, indicating mTORC1 as the key mediator of Akt-dependent muscle growth regulating the mitochondrial proteome critical for enhancing muscle force.
Article
Nutrition & Dietetics
J. Max Michel, Kristy K. Lievense, Sam C. Norton, Juliana V. Costa, Kathryn H. Alphin, Lydia A. Bailey, Gary D. Miller
Summary: This study examined the effects of resistance training (RT) and protein intake on muscle in older adults. The results showed that RT improved muscle quality and function, and the type of protein intake did not have a significant impact on the outcomes.
Article
Genetics & Heredity
Bruna Petry, Gabriel Costa Monteiro Moreira, Aline Goncalves Lio Copola, Marcela Maria de Souza, Fernanda Cristina da Veiga, Erika Cristina Jorge, Jane de Oliveira Peixoto, Monica Correa Ledur, James E. Koltes, Luiz Lehmann Coutinho
Summary: This study investigated the role of SAP30 gene in muscle development by downregulating it in C2C12 muscle cell culture and analyzing its impact on morphometric traits and gene expression. The results showed that modulation of SAP30 expression increased myotube area, indicating its involvement in muscle hypertrophy. RNA-seq analysis further supported the role of SAP30 gene in regulating muscle development.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Vinaya Simha, Ian R. Lanza, Surendra Dasari, Katherine A. Klaus, Nathan Le Brasseur, Ivan Vuckovic, Marcello C. Laurenti, Claudio Cobelli, John D. Port, K. Sreekumaran Nair
Summary: Familial partial lipodystrophy (FPL) is characterized by muscle hypertrophy and insulin resistance. However, FPL patients do not show increased muscle strength despite their muscularity, and experience earlier fatigue during exercise. This is accompanied by impaired mitochondrial function and altered gene expression, which may explain the metabolic abnormalities and skeletal muscle dysfunction in FPL patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Natany G. Reis, Ana P. Assis, Natalia Lautherbach, Dawit A. Goncalves, Wilian A. Silveira, Henrique J. N. Morgan, Rafael R. Valentim, Lucas F. Almeida, Lilian C. Heck, Neusa M. Zanon, Tatiana E. Koike, Audrei R. Santos, Elen H. Miyabara, Isis C. Kettelhut, Luiz C. Navegantes
Summary: This study found that maternal vitamin D deficiency selectively affects the development of type-II muscle fibers in male offspring rats, leading to muscle atrophy. However, compensatory increase in vitamin D content in adult age may increase fiber size and fatigue resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Physiology
Elena Monti, Luana Toniolo, Lorenzo Marcucci, Michela Bondi, Ivan Martellato, Bostjan Simunic, Paolo Toninello, Martino V. Franchi, Marco V. Narici, Carlo Reggiani
Summary: The study indicates that muscle hypertrophy in body builders does not negatively impact force generation capacity, as increases in fiber size and force are proportional once the differential swelling response is accounted for.
Article
Sport Sciences
Shalender Bhasin, Disa L. Hatfield, Jay R. Hoffman, William J. Kraemer, Michele Labotz, Stuart M. Phillips, Nicholas A. Ratamess
Summary: This consensus statement acknowledges the lawful and ethical therapeutic use of anabolic-androgenic steroids (AAS) but condemns the illicit use of AAS for enhancing performance and appearance, especially among competitive athletes. It updates the science behind how AAS work metabolically/biochemically, discusses potential side effects, prevalence of use among athletes, and AAS use in clinical scenarios.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Physiology
Caroline Barbe, Audrey Loumaye, Pascale Lause, Olli Ritvos, Jean-Paul Thissen
Summary: Myostatin, a negative regulator of muscle development, inhibits muscle growth and requires activation of specific signaling pathways. Pak1 has been identified as a potential mediator of Myostatin action on skeletal muscle mass, playing a permissive role in the skeletal muscle mass increase caused by Myostatin inhibition.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Gehlert, Patrick Weinisch, Werner Romisch-Margl, Richard T. Jaspers, Anna Artati, Jerzy Adamski, Kenneth A. Dyar, Thorben Aussieker, Daniel Jacko, Wilhelm Bloch, Henning Wackerhage, Gabi Kastenmueller
Summary: Resistance training affects human skeletal muscle metabolism by increasing protein breakdown, altering ATP and NAD metabolism, and influencing growth processes. It also leads to muscle hypertrophy, with an increase in the diameter of different types of muscle fibers. The changes in metabolism before and after training indicate that training induces multiple adaptive metabolic changes.
Article
Physiology
Madison L. Mattingly, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason C. Mcintosh, Morgan A. Smith, Daniel L. Plotkin, J. Max Michel, Derick A. Anglin, Nicholas J. Kontos, Shengyi Fei, Stuart M. Phillips, C. Brooks Mobley, Ivan Vechetti, Christopher G. Vann, Michael D. Roberts
Summary: This study investigated the effects of acute and subchronic resistance training on skeletal muscle protein lactylation levels. The results showed that exercise did not significantly alter muscle protein lactylation levels in both human and mouse participants. These findings challenge the hypothesis that lactate plays a role in promoting skeletal muscle hypertrophy.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Renato Barroso, Everton Crivoi do Carmo, Carl Foster, Philip Skiba, Augusto Carvalho Barbosa
Summary: The study aimed to investigate the impact of physiological adaptations, specifically critical speed and distance above critical speed (D '), on the performance of a world-class female long-distance swimmer. It also sought to determine whether a model involving the expenditure and recovery of D ' could explain swimming pacing. The findings suggest that critical speed is of paramount importance for long-distance swimming performance, while the work capacity above critical speed does not directly correlate with 800-m performance.
INTERNATIONAL JOURNAL OF SPORTS SCIENCE & COACHING
(2023)
Article
Geriatrics & Gerontology
Lucas Melo Neves, Raphael Ritti-Dias, Valeria Juday, Raquel Marquesini, Aline Mendes Gerage, Gilberto Candido Laurentino, Renato Hoffmann Nunes, Brendon Stubbs, Carlos Ugrinowitsch
Summary: Brain atrophy, a decrease in brain volume, is associated with cognitive health in older adults. Insufficient moderate and vigorous physical activity (MVPA) has been linked to lower brain volume. This study found that meeting weekly MVPA recommendations helps preserve the volume of over 30 brain areas and structures in older adults. Additionally, cardiorespiratory fitness is an important predictor of brain volume preservation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Physiology
Adriano A. L. Carmo, Karine N. O. Goulart, Christian E. T. Cabido, Ygor A. T. Martins, Gabriela C. F. Santos, Felipe L. T. Shang, Luciano S. Prado, Danusa D. Soares, Marco T. de Mello, Thiago T. Mendes, Emerson Silami-Garcia, Samuel P. Wanner
Summary: This study investigated the effects of an active warm-up and time-of-day variation on repeated-sprint performance and post-exercise recovery. The results showed that a warm-up improved sprint performance, and sprints performed in the late afternoon were better. Additionally, warm-up also led to faster post-exercise recovery.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Rehabilitation
Isadora Grade, Henrique Andrade, Renato Guerreiro, Eduardo Stieler, Flavia R. da Silva, Hesojy G. V. da Silva, Roberto Vital, Renan A. Resende, Dawit A. P. Goncalves, Andre G. Andrade, Marco T. de Mello, Andressa Silva
Summary: A systematic review found that Paralympic athletes have poor sleep quality and quantity, with high rates of daytime sleepiness. Subjective questionnaires are commonly used to assess their sleep.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Physiology
Marlene Salvina Fernandes da Costa, Vinicius de Oliveira Damasceno, Marco Tulio de Melo, Marcos Andre Moura dos Santos, Wlaldemir Roberto dos Santos, Fernanda Veruska Narciso, Walmir Romario dos Santos, Saulo Fernandes Melo de Oliveira, Pedro Pinheiro Paes
Summary: This study aims to investigate the direct influence of training load on sleep behavior during the tapering phase of training for young swimmers. The results show that there is no significant influence of training load on sleep variables. However, a strong association between total sleep time (TST) and external load (EL) was observed in the irregular sleep group.
REVISTA BRASILEIRA DE MEDICINA DO ESPORTE
(2023)
Article
Multidisciplinary Sciences
Saulo Gil, Bruno Gualano, Adriana Ladeira de Araujo, Gersiel Nascimento de Oliveira Junior, Rodolfo Furlan Damiano, Fabio Pinna, Marta Imamura, Vanderson Rocha, Esper Kallas, Linamara Rizzo Batistella, Orestes Forlenza, Carlos R. R. de Carvalho, Geraldo Filho Busatto, Hamilton Roschel
Summary: The aim of this cohort study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. The study found that patients with one or more persistent PASC symptoms have greater odds of being physically inactive than those without any persistent symptoms. Dyspnea, fatigue, insomnia, post-traumatic stress, and severe muscle/joint pain were specifically associated with greater odds of physical inactivity. These findings suggest that PASC is associated with physical inactivity, which may have implications for interventions and patient care.
SCIENTIFIC REPORTS
(2023)
Article
Sport Sciences
Igor Longobardi, Karla Goessler, Gersiel Nascimento de Oliveira Jr, Danilo Marcelo Leite do Prado, Jhonnatan Vasconcelos Pereira Santos, Matheus Molina Meletti, Danieli Castro Oliveira de Andrade, Saulo Gil, Joao Antonio Spott de Oliveira Boza, Fernanda Rodrigues Lima, Bruno Gualano, Hamilton Roschel
Summary: This study investigated the effects of a home-based exercise training (HBET) programme on the health-related quality of life (HRQoL) and outcomes in survivors of severe/critical COVID-19. The results showed that HBET can improve the physical functioning, body condition and persistent symptoms in survivors, indicating that it is an effective and safe intervention.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Nutrition & Dietetics
Gabriel P. Esteves, Bruna Caruso Mazzolani, Fabiana Infante Smaira, Heloisa C. Santo Andre, Amanda Yuri Iraha, Camilla Astley, Isabela Gouveia Marques, Milla Cordeiro Amarante, Nathalia Saffioti Rezende, Sofia Mendes Sieczkowska, Tathiane Christine Franco, Luana Cristina do Amaral Miranda, Livia Lindoso, Alberto Carame Helito, Jane Oba, Ligia Bruni Queiroz, Rosa Maria R. Pereira, Lucia Maria A. Campos, Nadia E. Aikawa, Hamilton Roschel, Clovis A. Silva, Bruno Gualano
Summary: This study investigated the impact of the COVID-19 pandemic on the eating habits of adolescents and found that the dietary patterns of adolescents with immunocompromised chronic diseases may be more relevant. The findings suggest that diet quality may have an influence on health-related quality of life and sleep quality, which is important for clinical practitioners and policy makers to consider in immunocompromised youths.
FRONTIERS IN NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Bruno Gualano, Sofia M. Sieczkowska, Italo Ribeiro Lemes, Rafael Pires da Silva, Ana J. Pinto, Bruna C. Mazzolani, Fabiana I. Smaira, Nadia E. Aikawa, Leonard V. K. Kupa, Sandra G. Pasoto, Ana C. Medeiros-Ribeiro, Carla G. S. Saad, Emily F. N. Yuk, Clovis A. Silva, Paul Swinton, Pedro C. Hallal, Hamilton Roschel, Eloisa Bonfa
Summary: Physical activity is associated with improved immunogenicity after vaccination in patients with autoimmune rheumatic diseases (ARD). A study found that physically active patients had higher odds of better antibody responses to CoronaVac booster dose compared to inactive patients. These results support the recommendation of physical activity to enhance vaccination responses in immunocompromised individuals.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Sport Sciences
Carolina F. Nicoletti, Hamilton Roschel, Carlos Merege-Filho, Alisson P. Lima, Saulo Gil, Marcela A. S. Pinhel, Natalia Y. Noronha, Marco A. Santo, Amalia Jacome, Ana B. Crujeiras, Bruno Gualano, Carla B. Nonino
Summary: Exercise training and bariatric surgery can independently modulate DNA methylation profile in genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who underwent bariatric surgery. Epigenome Wide Association Analysis showed significant changes in methylation levels of CpG sites related to Th17 cell differentiation pathway after exercise training. These findings suggest that exercise training can lead to epigenetic modifications in specific CpG sites in post-bariatric women.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Review
Rehabilitation
Eduardo Stieler, Marco T. de Mello, Ingrid L. B. Lobo, Dawit A. Goncalves, Renan Resende, Andre G. Andrade, Thiago F. Lourenco, Anselmo A. C. Silva, Henrique A. Andrade, Renato Guerreiro, Andressa Silva
Summary: This review examines the methods used to assess external load in Paralympic sports, aiming to provide scientific evidence for multidisciplinary teams to prescribe and monitor athlete's development, enhance performance, and reduce injury/illness risks. The study identified 8 methods to quantify external load in 8 different Paralympic sports and highlights the need for further research to validate the effectiveness and reliability of these methods.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Nutrition & Dietetics
Ronaldo Angelo Dias da Silva, Leszek Antoni Szmuchrowski, Joao Paulo Pereira Rosa, Marcos Antonio Pereira dos Santos, Marco Tulio de Mello, Lucas Savoi, Yves Ferreira Porto, Francisco de Assis Dias Martins, Marcos Daniel Motta Drummond
Summary: Intermittent fasting (IF) is commonly used by combat sports athletes for weight loss but may decrease performance. This study examined the effects of IF on body weight and Taekwondo performance. The results showed that IF led to a decrease in body weight in the first two weeks but stabilized afterwards. Performance in vertical jumping had different patterns in fed and fasted states. Despite the decrease in body weight, IF did not significantly impact performance.
Article
Physiology
Livia de Souza Goncalves, Wagner Ribeiro Pereira, Rafael Pires da Silva, Guilherme Carvalho Yamaguchi, Victor Henrique Carvalho, Bianca Scigliano Vargas, Leonardo Jensen, Marisa Helena Gennari de Medeiros, Hamilton Roschel, Guilherme Giannini Artioli
Summary: This study demonstrates the presence of anserine in the human heart ventricle and confirms its low expression in human skeletal muscle.
PHYSIOLOGICAL REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Fabiana Infante Smaira, Bruna Caruso Mazzolani, italo Ribeiro Lemes, Rafael Pires da Silva, Ana J. Pinto, Sofia M. Sieczkowska, Nadia E. Aikawa, Sandra G. Pasoto, Ana C. Medeiros-Ribeiro, Carla G. S. Saad, Emily F. N. Yuk, Clovis A. Silva, Paul Swinton, Leonard de Vinci Kanda Kupa, Pedro C. Hallal, Hamilton Roschel, Bruno Gualano, Eloisa Bonfa
Summary: This study investigated the association between physical activity and immunogenicity in SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases before and after receiving the Sinovac inactivated vaccine. The results showed no association between physical activity and immunogenicity before and after vaccination. These findings suggest that previous SARS-CoV-2 infection may override the positive association between physical activity and antibody responses seen in immunocompromised individuals following vaccination, and this association does not extend to natural immunity.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Rheumatology
Sofia Mendes Sieczkowska, Fabiana Infante Smaira, Bruna Caruso Mazzolani, Marina Romero, Sandra Gofinet Pasoto, Ana Lucia de Sa Pinto, Fernanda Rodrigues Lima, Victor Rodrigues De Oliveira, Serli Ueda, Fabiana Braga Benatti, Hamilton Roschel, Bruno Gualano
Summary: There is a lack of studies evaluating multidisciplinary interventions for addressing physical inactivity/sedentary behavior and poor dietary habits in SLE patients. The Living well with Lupus (LWWL) is a randomized controlled trial aimed at investigating the effectiveness of a six-month lifestyle change intervention in improving cardiometabolic risk factors among SLE patients with low disease activity and high cardiovascular risk. The study will also assess the safety, efficacy, and feasibility of the intervention, as well as its impact on secondary outcomes.
RHEUMATOLOGY INTERNATIONAL
(2023)