Article
Biology
Ameeq Ul Mushtaq, Jorgen Aden, Luke A. Clifton, Hanna Wacklin-Knecht, Mario Campana, Artur P. G. Dingeldein, Cecilia Persson, Tobias Sparrman, Gerhard Grobner
Summary: Researchers utilized neutron reflectometry and NMR spectroscopy to study intact Bcl-2 protein residing at the mitochondrial outer membrane, revealing that the active full-length protein is mainly embedded in the membrane with a highly flexible regulatory loop. This membrane location and conformational state of Bcl-2 are crucial for its cell-protecting activity, with the protein often upregulated in cancers.
COMMUNICATIONS BIOLOGY
(2021)
Article
Parasitology
Shanming Hu, Yanan Wang, Zhengmao Xu, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Jinlin Zhou
Summary: The study found that the transcription levels of the RhBax gene in ticks increase significantly at all developmental stages, while the transcription levels of both RhBcl-2 and RhBax increase more significantly in the female salivary glands. Inhibiting RhBcl-2 expression significantly inhibited tick feeding, while interference with RhBax had no effect on tick feeding.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Natalia Glatzel-Plucinska, Katarzyna Ratajczak-Wielgomas, Katarzyna Nowinska, Sylwia Borska
Summary: Resveratrol may have anticarcinogenic effects by inhibiting human pancreatic cancer cell proliferation and affecting the levels of Bcl-2 proteins. However, its activity is specific to each tested cell line, with the most significant changes observed in the mitoxantrone-resistant cells.
Article
Oncology
Ayat Moradipour, Hassan Dariushnejad, Changiz Ahmadizadeh, Hamed Esmaiil Lashgarian
Summary: The study demonstrated that carvacrol induces apoptosis in MCF-7 cells by increasing the expression of P53 and Bax, and decreasing the expression of Bcl-2. Experimental results showed the inhibitory effect of carvacrol on the growth of breast cancer cells.
Article
Agriculture, Dairy & Animal Science
Reshma S. Raj, D. N. Das, S. Mondal, M. Ashokan, Lakshmi Narasimha Thota, T. Karuthadurai, Nikhil Kumar J. Tej, Kerekoppa P. Ramesha
Summary: This study aimed to analyze the expression of pro-apoptotic BAX and anti-apoptotic BCL-2 genes on lactation performance in Bos indicus and HF crossbred cows during early lactation. The results showed that BCL-2 gene promotes milk production while BAX gene opposes milk production. Bos indicus cows are more sensitive to apoptosis compared to HF crossbreds.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
A. Alzu'bi, M. S. Al Zoubi, G. T. Abdelhady, B. Al-Trad, S. Omari, M. Abualarjah, W. El-Huneidi, D. R. Alzu'bi, J. M. Bani-Issa, G. J. Clowry
Summary: This study found that exposure to nicotine during pregnancy can lead to decreased fetal growth and weight, as well as reduced placental size. This is accompanied by increased apoptosis within the placenta, while the expression of angiogenic factors remains unchanged.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Andrology
Majid Shokoohi, Arash Khaki, Ayda Roudi Rasht Abadi, Linda MohammadZadeh Boukani, Sepideh Hassanpour Khodaie, Hossein Kalarestaghi, Amir Afshin Khaki, Maryam Moghimian, Hamid Reza Niazkar, Hamed Shoorei
Summary: The current study aimed to assess the effects of Minocycline on testicular injury caused by varicocele, focusing on apoptotic-related genes and oxidative stress. The results demonstrated that Minocycline administration improved testicular injury and reduced apoptosis rate, possibly through its antioxidant activity.
Article
Environmental Sciences
Mabrouk Attia Abd Eldaim, Eman Ragab Barakat, Mohamed Alkafafy, Samy Ahmed Abd Elaziz
Summary: The study assessed the preventive potential of silymarin against lead-induced hepatorenal toxicity in rats by modulating oxidative stress, lipid oxidation, pathological changes in liver and kidney tissues, improving the antioxidant defense system of the liver and kidneys, and reducing pro-apoptotic gene expression in liver tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kaiming Li, Mark F. van Delft, Grant Dewson
Summary: Apoptotic cell death plays important roles in physiological and pathological processes, especially in cancer therapy and neurodegenerative diseases. Inhibitors of apoptosis have emerged as a potential strategy to combat pathological cell loss, serving as important research tools due to their mechanisms of action, advantages, and limitations.
Article
Environmental Sciences
Reham M. Abd-Elsalam, Shymaa A. El Badawy, Hanan A. Ogaly, Faten M. Ibrahim, Ola M. Farag, Kawkab A. Ahmed
Summary: Eruca sativa seed extract (ESS) has a protective effect on acrylamide-induced hypogonadism in male rats, improving sperm quality, restoring testosterone level, and reducing testicular degeneration and cell death.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li, Yan Wang
Summary: The study demonstrated that LIPUS can improve POF induced by VCD by promoting follicular development, increasing sex hormone secretion, inhibiting excessive follicular atresia, and GCs apoptosis, possibly through increasing Bcl-2 protein expression and decreasing Bax expression in the ovaries.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Roya Malekloo, Setayesh Nematollahi, Abbas Ali Vafaei, Ali Rashidy-Pour
Summary: Chronic morphine impairs cued fear extinction, but forced exercise with light to moderate intensity can enhance fear extinction and restore hippocampal BDNF levels. Exercise shifts the balance between pro-apoptotic and anti-apoptotic factors, leading to increased cell survival. These findings suggest the importance of exercise in the recovery of cued fear extinction and its potential role in addicted individuals.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Kniphoff da Silva Lawisch, Vanderlei Biolchi, Gabriela Kaufmann, Gabriela Nicolai, Eduarda Capitaneo, Thais Regina Rosembach, Janaina Zang, Ilma Simoni Brum, Jose Artur Bogo Chies
Summary: This study investigated the association of FASL, BCL-2, and BAX gene polymorphisms with prostate cancer (PCA) and benign prostatic hyperplasia (BPH) in Southern Brazilian patients. The findings suggest that the FASL CC genotype may be a risk factor for PCA, while the BCL-2 CC genotype may act as a protective factor.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Integrative & Complementary Medicine
Yueh-Ting Tsai, Hui-Chi Huang, Shung-Te Kao, Tung-Ti Chang, Chin-Yi Cheng
Summary: This study found that Alpinia oxyphylla Miq (AOM) has a protective effect against cell apoptosis after transient middle cerebral artery occlusion (MCAo), and it achieves this by regulating the signaling pathways within the cells. AOM inhibits mitochondria-related apoptosis and promotes cell survival.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chunfeng Wang, Na Wang, Na Li, Qiuying Yu, Fangyu Wang
Summary: The combination of resveratrol and vitamin E had a significant inhibitory effect on colorectal cancer cells, promoting cell apoptosis and altering the expression of apoptosis-related proteins. This study demonstrates the positive synergy of resveratrol and vitamin E in inhibiting cancer cell growth and proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Isabela Coelho de Castro, Danielle Cristina Tonello Pequito, Gina Borghetti, Adriana Aya Yamaguchi, Gleisson Alisson Pereira de Brito, Ricardo Key Yamazaki, Laura Cristina Jardim Porto, Terezila Machado Coimbra, Luiz Claudio Fernandes, Ricardo Fernandez
Summary: The present study compared the effects of a high-carbohydrate diet and a high-fat diet on obesity characteristics in mice, and found that the high-carbohydrate diet was able to induce an obesity model, but with a delayed development compared to the high-fat diet.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Alana Gabrielle D'Ornelas, Betina Aisengart de Siqueira, Glaucia Tobaldini, Katya Naliwaiko, Fabiola Iagher, Luana Fischer
Summary: This study found that dietary fish oil can decrease inflammatory pain, whether consumed during adulthood or exposure during prenatal development and lactation. Further research is needed to confirm the therapeutic potential of fish oil in humans and develop public policies promoting a diet rich in fish oil.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Neurosciences
Ana Paula Farias Waltrick, Alvaro Henrique Bernardo de Lima Silva, Milene Cristina de Carvalho, Bruna Aparecida Comotti de Oliveira, Katya Naliwaiko, Joice Maria da Cunha, Janaina Menezes Zanoveli
Summary: This study aimed to investigate the effect of fish oil on depression-like behaviors and brain monoamines levels in juvenile rats with type-1 diabetes mellitus (T1DM). The results showed that pre-treatment with fish oil combined with antidepressants significantly improved depressive-like behaviors, especially in the case of drugs that increased serotonin availability.
NEUROSCIENCE LETTERS
(2022)
Review
Geriatrics & Gerontology
Everson A. Nunes, Lauren Colenso-Semple, Sean R. McKellar, Thomas Yau, Muhammad Usman Ali, Donna Fitzpatrick-Lewis, Diana Sherifali, Claire Gaudichon, Daniel Tome, Philip J. Atherton, Maria Camprubi Robles, Sandra Naranjo-Modad, Michelle Braun, Francesco Landi, Stuart M. Phillips
Summary: A systematic review and meta-analysis showed that increasing daily protein ingestion may contribute to gains in lean body mass (LBM) and muscle strength, especially in subjects participating in resistance exercise training. However, the effects on handgrip strength and physical function test performance are unclear.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cell Biology
Matheus Felipe Zazula, Barbara Zanardini de Andrade, Carolina De Toni Boaro, Christian Bergmann Kirsch, Aline Reginato, Ana Luiza Peretti, Rose Meire Costa, Gladson Ricardo Flor Bertolini, Katya Naliwaiko, Ana Tereza Bittencourt Guimaraes, Lucineia de Fatima Chasko Ribeiro
Summary: This study aims to propose a histopathological index for quantitatively assessing skeletal muscle changes induced by experimental protocols in Rodentia's models. Through statistical analysis and experimental validation, the proposed index demonstrates good fitness and parsimony, and can be easily replicated by other researchers.
Review
Cell Biology
Everson A. Nunes, Tanner Stokes, James McKendry, Brad S. Currier, Stuart M. Phillips
Summary: Muscle disuse or unloading leads to muscle atrophy, primarily due to reduced mechanical load. Endocrine and inflammatory factors can synergistically accelerate atrophy process. Older individuals are more susceptible to muscle disuse and are affected by aging-induced anabolic resistance.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jhyslayne Ignacia Hoff Nunes Maciel, Matheus Felipe Zazula, Diego Francis Saraiva Rodrigues, Caroline De Toni Boaro, Mariana Lais Boaretto, Barbara Zanardini de Andrade, Sara Cristina Sagae Schneider, Katya Naliwaiko, Marcia Miranda Torrejais, Rose Meire Costa, Lucineia de Fatima Chasko Ribeiro, Gladson Ricardo Flor Bertolini
Summary: The negative changes of obesity to the locomotor system are a major concern, and whole-body vibration has been found to be an effective tool for rehabilitating obesity and improving muscle structure and function.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Cinthia R. Correa, Bruno G. G. da Costa, Kelly S. Silva, Nitin Shivappa, Michael D. Wirth, James R. Hebert, Everson A. Nunes
Summary: The study found that a dietary pattern with a higher E-DII score (pro-inflammatory) was positively associated with higher body fat content and markers of central adiposity in both lean and obese young men.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Review
Sport Sciences
Changhyun Lim, Everson A. Nunes, Brad S. Currier, Jonathan C. Mcleod, Aaron C. Q. Thomas, Stuart M. Phillips
Summary: Skeletal muscle plays a critical role in physical function and metabolic health. Resistance exercise is the most effective nonpharmacological method for muscle hypertrophy and countering muscle loss. Future research should focus on the interaction between internal variables (such as skeletal muscle biology) and external variables (such as resistance exercise) to determine the most effective strategies for skeletal muscle hypertrophy.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Biochemistry & Molecular Biology
Henver S. Brunetta, Heather L. Petrick, Iman Momken, Rachel M. Handy, Christopher Pignanelli, Everson A. Nunes, Jerome Piquereau, Mathias Mericskay, Graham P. Holloway
Summary: Dietary nitrate supplementation improves glucose homeostasis and mitochondrial bioenergetics through AMPK and SIRT1 signaling in obesity and insulin resistance models.
Article
Nutrition & Dietetics
Lais Smeha, Angelica Scherlowski Fassula, Yara Maria Franco Moreno, David Alejandro Gonzalez-Chica, Everson A. Nunes
Summary: This study found that a higher dietary acid load is associated with higher insulin resistance and insulin levels but not with other glycaemic parameters. This is the first study to describe the dietary acid load in a population-based sample of adults in Latin America, and further research is needed to establish the causal effect between dietary acid load and insulin resistance.
CLINICAL NUTRITION ESPEN
(2022)
Review
Geriatrics & Gerontology
Stuart M. Phillips, Kyle J. Lau, Alysha C. D'Souza, Everson A. Nunes
Summary: This study reviewed systematic reviews on the effects of HMB supplementation on muscle growth and muscle loss in ageing and clinical populations. The majority of reviews concluded that HMB supplementation did not affect muscle strength or physical function, and there was controversy regarding its impact on increasing muscle mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Allysson Costa, Gleisson A. P. de Brito
Summary: The combination of aerobic exercise and fish oil supplementation has the potential to correct and prevent disorders associated with chronic inflammation in celiac disease patients.
JOURNAL OF NUTRITION AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Matheus Felipe Zazula, Diego Francis Saraiva, Joao Lucas Theodoro, Monica Maciel, Eliel Vieira dos Santos Sepulveda, Barbara Zanardini de Andrade, Mariana Lais Boaretto, Jhyslayne Ignacia Hoff Nunes Maciel, Gabriela Alves Bronczek, Gabriela Moreira Soares, Sara Cristina Sagae Schneider, Gladson Ricardo Flor Bertolini, Marcia Miranda Torrejais, Lucineia Fatima Chasko Ribeiro, Luiz Claudio Fernandes, Katya Naliwaiko
Summary: This study aimed to investigate the early and chronic effects of MSG induction of obesity upon systemic and muscular parameters of Wistar rats. The results showed that early exposure to MSG led to growth retardation, increased adiposity, hyperinsulinemia, and inflammation. In adulthood, peripheral insulin resistance, increased fibrosis, oxidative distress, and reduced muscle mass, oxidative capacity, and neuromuscular junctions were observed, indicating that the metabolic damage established early on had a long-lasting impact.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
S. Fischer, M. H. Appel, K. Naliwaiko, D. D. Pagliosa, D. N. Araujo, A. E. Capote, B. A. C. Oliveira, L. C. Fernandes
Summary: Early introduction of exercise can prevent the adverse effects of obesity on glucose metabolism in adulthood, as it reduces plasma cholesterol levels and inhibits white adipose tissue accumulation and insulin resistance.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)