Article
Multidisciplinary Sciences
Joyita Bhadra, Nakul Sridhar, Apresio Kefin Fajrial, Nia Hammond, Ding Xue, Xiaoyun Ding
Summary: An Acoustic Gym on a chip was created using surface acoustic wave microfluidic technology to precisely control swimming exercise intensity and duration. It was found that accurately dosed swimming exercise enabled by acoustic streaming can reduce neuronal loss in two neurodegenerative disease models. These findings highlight the importance of optimal exercise conditions for effective neuronal protection and provide avenues for drug target identification.
Article
Agriculture, Multidisciplinary
Peng Jiang, Zongzhen Zhai, Linxian Zhao, Kai Zhang, Liwei Duan
Summary: This research found that α-lipoic acid (LA) has a protective effect against ulcerative colitis (UC) by alleviating UC symptoms and reducing the production of pro-inflammatory cytokines. LA treatment can also inhibit intestinal cell apoptosis and oxidative stress. In addition, it regulates the Keap1-Nrf2 signaling pathway and inhibits ferroptosis. LA can attenuate endoplasmic reticulum stress and apoptosis in erastin-induced ferroptosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Food Science & Technology
Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand, Javad Heshmati
Summary: The study demonstrated that alpha-lipoic acid supplementation significantly reduced Malondialdehyde (MDA) levels, but had no significant effect on other antioxidant enzymes and oxidative stress parameters. Overall, it suggested that alpha-lipoic acid supplementation might improve lipid peroxidation, and recommended a daily intake of less than 800 mg for controlling lipid peroxidation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Jae Sang Han, Ye Lin Kim, Hyo Jeong Yu, Jung Mee Park, Yeonji Kim, So Young Park, Shi Nae Park
Summary: The study confirmed the safety and efficacy of α-lipoic acid (ALA) therapy for noise-induced hearing loss, especially through intratympanic administration (IT-ALA), which showed better recovery than intraperitoneal injection (IP-ALA) and intratympanic dexamethasone (IT-DEX) in terms of organ of Corti morphology and hearing levels.
Article
Biochemistry & Molecular Biology
Beata Skibska, Anna Goraca, Agnieszka Skibska, Andrzej Stanczak
Summary: This study evaluated the effects of alpha-lipoic acid (alpha-LA) on oxidative stress parameters and inflammation in the ventricles and atria of the heart in rats. The results suggest that alpha-LA administration can effectively prevent inflammation and oxidative stress in the ventricles and atria of the heart.
Review
Biochemistry & Molecular Biology
Max Denisson Mauricio Viana, Pedro Santana Sales Lauria, Alyne Almeida de Lima, Luiza Carolina Franca Opretzka, Henrique Rodrigues Marcelino, Cristiane Flora Villarreal
Summary: Neuropathic pain is a common and debilitating form of chronic pain, with limited effectiveness of current treatments, making the exploration of ALA as a therapeutic agent for managing NP promising. Further research is needed to explore its analgesic mechanisms and clinical applications.
Article
Environmental Sciences
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li
Summary: Alpha-lipoic acid exhibits protective effects against chronic ammonia stress in crucian carp by alleviating oxidative stress and endoplasmic reticulum stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Zihao Yan, Jiwu Wan, Jia Liu, Baolan Yao, Yuqian Lu, Zhengyao Guo, Yuehong Li
Summary: This study investigated the protective effects of alpha-lipoic acid against chronic ammonia stress in crucian carp. The results showed that alpha-lipoic acid effectively induced humoral immunity, alleviated oxidative stress and endoplasmic reticulum stress, and ultimately reduced liver injury caused by ammonia poisoning.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Hafiz Muhammad Rashad Javeed, Mazhar Ali, Milan Skalicky, Fahim Nawaz, Rafi Qamar, Atique Ur Rehman, Maooz Faheem, Muhammad Mubeen, Muhammad Mohsin Iqbal, Muhammad Habib ur Rahman, Pavla Vachova, Marian Brestic, Alaa Baazeem, Ayman El Sabagh
Summary: The application of exogenous LA + MT significantly improved growth performance and physiological parameters of canola seedlings under salinity stress.
Article
Biochemistry & Molecular Biology
Klaudia Sztolsztener, Katarzyna Hodun, Adrian Chabowski
Summary: This study aimed to evaluate the potential protective effect of chronic alpha-lipoic acid supplementation on myocardial inflammation and oxidative stress in obesity-related cardiovascular dysfunction. The results showed that alpha-lipoic acid significantly reduced arachidonic acid content, decreased the synthesis of pro-inflammatory mediators, and increased the levels of antioxidative markers, thus ameliorating the inflammation and oxidative stress induced by cardiac obesity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Deniz Ceylanli, Ahmet Ozer Sehirli, Sevgi Gencosman, Kerem Terali, Huseyin Sah, Nurhayat Gulmez, Serkan Sayiner
Summary: This study found that ALA has potential protective benefits against 5-FU-induced gastrointestinal mucositis. ALA can reduce inflammation and oxidative stress caused by mucositis, promote tissue repair, and have significant implications for cancer patients, especially those receiving 5-FU therapy.
Article
Agriculture, Dairy & Animal Science
Jiabin Shi, Xiaocui Chang, Hui Zou, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Jianchun Bian
Summary: Cadmium poses harmful effects on global health. Protective effects of alpha-lipoic acid (alpha-LA) and chlorogenic acid (CGA) against cadmium toxicity in vivo in three-yellow chickens were evaluated, showing that they could partially or fully reverse Cd-induced liver injury, with their combination being even more effective.
Article
Nutrition & Dietetics
Ghedeir M. Alshammari, Mohamed Anwar Abdelhalim, Mohammed S. Al-Ayed, Laila Naif Al-Harbi, Mohammed Abdo Yahya
Summary: This study found that gold nanoparticles (AuNPs) induced liver damage in rats by causing oxidative stress and inflammation. However, co-supplement of alpha-lipoic acid (alpha-LA) attenuated the liver damage caused by AuNPs by upregulating/activating Nrf2.
Article
Nutrition & Dietetics
Yuki Hashimoto, Katsuhiko Yoshizawa, Yuka Kaido, Akiko Takenouchi, Keiji Terao, Hiroyuki Yasui, Yutaka Yoshikawa
Summary: Studies have shown that the antioxidant capacity of the complex of gamma-cyclodextrin (CD) and alpha-lipoic acid (ALA) is higher than that of free ALA. Supplementation with CD/ALA can improve antioxidant activity and performance during high-intensity exercise.
Article
Endocrinology & Metabolism
Eatemad A. Awadalla, Abd El-Kader M. Abd El-Kader, Samia A. Gbr, Amna H. Nour, Mohammed H. Hassan
Summary: The study aimed to evaluate the protective effects of α-lipoic acid against octylphenol-induced male infertility. The results showed that octylphenol caused abnormalities in serum reproductive hormone levels and oxidative stress levels, as well as histopathological and histochemical abnormalities in hypothalamus, pituitary, and testicular tissues. However, these derangements were successfully reversed by α-lipoic acid through its antioxidant and anti-inflammatory properties.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Chemistry, Medicinal
Leandro Vinicius Fernandes de Morais, Jefferson Romaryo Duarte da Luz, Thayse Evellyn Silva do Nascimento, Marcelo Arrison dos Santos Azevedo, Walicyranison Plinio da Silva Rocha, Gabriel Araujo-Silva, Marcela Abbott Galvao Ururahy, Guilherme Maranhao Chaves, Jose Brandao-Neto, Jorge A. Lopez, Elizabeth Cristina Gomes Santos, Maria das Gracas Almeida
Summary: This study evaluated the phenolic composition, toxicity, and antimicrobial activity of Licania rigida Benth, showing significant amounts of phenolic compounds and total flavonoids in the extract and fraction, with effective antimicrobial activity against gram-positive bacteria and fungi, but no observed toxicity effects in animals during the experiment.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Pediatrics
Thamara R. Melo, Karla S. C. Souza, Marcela A. G. Ururahy, Raul H. Bortolin, Joao F. Bezerra, Marcos F. de Oliveira Galvao, Rosario D. C. Hirata, Mario H. Hirata, Ricardo F. Arrais, Maria das Gracas Almeida, Adriana A. Rezende, Vivian N. Silbiger
Summary: This study found an association between Toll-like receptor (TLR) inflammatory cascade and the development of diabetic kidney disease (DKD) in children and adolescents with type 1 diabetes (T1D). The mRNA expressions of TLR2, TLR4, MYD88, NFKB, MCP1/CCL2 and IL18 were significantly increased in T1D patients. Furthermore, ACR was also increased in the T1D group, suggesting the onset of DKD.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jefferson Romaryo Duarte da Luz, Eder A. Barbosa, Thayse Evellyn Silva do Nascimento, Adriana Augusto de Rezende, Marcela Abbott Galvao Ururahy, Adriana da Silva Brito, Gabriel Araujo-Silva, Jorge A. Lopez, Maria das Gracas Almeida
Summary: The anti-inflammatory properties of Turnera subulata have been evaluated in this study. The extracts of T. subulata were found to modulate the inflammatory response in vitro and inhibit the production of inflammatory mediators. These findings highlight the potential of T. subulata as a herbal option for treating and preventing chronic diseases.
Article
Food Science & Technology
Larissa Marina Pereira Silva, Maria Raquel Cavalcanti Inacio, Gualter Guenter Costa da Silva, Jucier Magson de Souza e Silva, Jefferson Romaryo Duarte da Luz, Maria das Gracas Almeida, Edgar Perin Moraes, Debora Esposito, Leandro De Santis Ferreira, Silvana Maria Zucolotto
Summary: Moringa oleifera leaves are rich in flavonoids, and the highest flavonoid content can be obtained through ultrasound-assisted extraction. The optimal cultivation condition is using mineral soil fertilizer in the drought season, with the optimized extraction conditions being 80% ethanol and 13.4 minutes extraction time. The extract is safe and significantly reduces inflammation, with major compounds derived from apigenin, quercetin, and kaempferol glycosides.
Article
Multidisciplinary Sciences
Tassia Louise Sousa Augusto de Morais, Karla Simone Costa de Souza, Mabelle Alves Ferreira de Lima, Mauricio Galvao Pereira, Jose Bruno de Almeida, Antonio Manuel Gouveia de Oliveira, Karine Cavalcanti Mauricio Sena-Evangelista, Adriana Augusto de Rezende
Summary: This study aims to evaluate the effects of individualized nutritional intervention on proteinuria after kidney transplantation. The study will include a 12-month follow-up period and patients will be randomly assigned to intervention and control groups. The primary outcome measure is the change in log proteinuria assessed through the urinary albumin/creatinine ratio, and secondary measures include body composition, anthropometry, quality of life assessment, physical activity, lipid profile, and glycemic control.
Review
Nutrition & Dietetics
Rannapaula Lawrynhuk Urbano Ferreira, Angela Waleska Freire de Sousa, Antonio Gouveia Oliveira, Adriana Augusto de Rezende, Ricardo Ney Cobucci, Lucia Fatima Campos Pedrosa
Summary: This systematic review evaluated the effects of Se supplementation on glycaemic control in healthy rodents and found that sodium selenite supplementation significantly increased fasting blood glucose levels but did not affect glutathione peroxidase activity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Eduarda Pontes dos Santos Araujo, Severina Carla Vieira da Cunha Lima, Ony Araujo Galdino, Ricardo Fernando Arrais, Karla Simone Costa de Souza, Adriana Augusto de Rezende
Summary: This study investigated the associations between CYP2R1 and VDR gene variants and metabolic syndrome in non-diabetic Brazilian adolescents. The findings suggest that CYP2R1 rs12794714 polymorphism may serve as a potential molecular marker for predicting the risk of metabolic syndrome, while CYP2R1 rs10741657 polymorphism and VDR rs7975232 polymorphism are associated with an increased risk of diabetes and hypertension in overweight/obese adolescents.
Article
Cell Biology
Ana Cristina Vieira de Melo, Karla Simone Costa de Souza, Heglayne Pereira Vital da Silva, Jussara Melo de Cerqueira Maia, Vera Maria Dantas, Joao Felipe Bezerra, Adriana Augusto de Rezende
Summary: This study investigated CFTR variants in CF patients in Northeast Brazil and found that high-throughput sequencing technology could provide a definitive molecular diagnosis in the majority of patients. The results showed that CFTR modulator drugs could be used to treat these patients, improving patient management.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Chemical
Jefferson Romaryo Duarte da Luz, Jorge A. Lopez, Macelia Pinheiro Ferreira, Rubiamara Mauricio de Sousa, Saulo Victor e Silva, Maria das Gracas Almeida, Gabriel Araujo-Silva
Summary: This study evaluated the effects of green tea extract and epigallocatechin-3-gallate on blood clotting, antitumor activity and angiogenesis. The results showed that these substances can inhibit platelet aggregation, reduce melanoma cell growth, suppress blood vessel formation, and inhibit the secretion of certain cytokines. This suggests that green tea extract and epigallocatechin-3-gallate have potential as a treatment for cancer and its side effects.
Article
Biochemistry & Molecular Biology
Jailane de Souza Aquino, Kamila Sabino Batista, Gabriel Araujo-Silva, Darlan Coutinho dos Santos, Naira Josele Neves de Brito, Jorge A. Lopez, Joao Andrade da Silva, Maria das Graca Almeida, Carla Guzman Pincheira, Marciane Magnani, Debora C. Nepomuceno de Pontes Pessoa, Tania L. Montenegro Stamford
Summary: This study aimed to assess the effects of buriti oil intake in iron-overloaded rats by FeSO4 administration. It was found that buriti oil showed systemic and hepatic antioxidant protection in iron-overloaded rats, which may be related to its high carotenoid, tocopherol, and fatty acid profile.
Article
Multidisciplinary Sciences
George Harisson Felinto Sampaio, Andressa Noronha Barbosa da Silva, Christiane Carlos Araujo de Negreiros, Nathan Ravi Medeiros Honorato, Rand Randall Martins, Lucia Maria Abrantes Aguiar, Leticia Mikardya Lima Sales, Carlos Ramon do Nascimento Brito, Paulo Marcos da Matta Guedes, Antonia Claudia Jacome da Camara, Lucia Maria da Cunha Galvao
Summary: Entomological surveillance and control of vectors in an endemic area of Brazil have been discontinued over the past decade, necessitating more effective public policies to prevent the risk of T. cruzi infection for humans and domestic animals.
Article
Multidisciplinary Sciences
Priscilla Karilline Vale Bezerra, Jessica Escorel Chaves Cavalcanti, Solimar Ribeiro Carlete Filho, Sarah Dantas Viana Medeiros, Antonio Gouveia Oliveira, Rand Randall Martins
Summary: This study aimed to characterize the drug-related problems (DRPs) in high-risk pregnant women with hypertension and gestational diabetes mellitus. The results showed that DRPs were frequent and mainly related to therapeutic ineffectiveness and the occurrence of adverse events.
Article
Pharmacology & Pharmacy
Ramon Weyler Duarte Leopoldino, Lucas Vinicius Silva de Oliveira, Flavia Evelyn Medeiros Fernandes, Haline Tereza Matias de Lima Costa, Leticia Martins Pereira Vale, Antonio Gouveia Oliveira, Rand Randall Martins
Summary: This study compared the performance of two algorithms (Du algorithm and Naranjo algorithm) in causality assessment of adverse drug reactions (ADRs) in a neonatal intensive care unit (NICU). The results showed that the Du algorithm was more suitable for diagnosing ADRs, but had lower reproducibility; while the Naranjo algorithm had a lower proportion of definite ADRs, but good reproducibility. There was no significant correlation between the two algorithms in ADR causality classification.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Review
Biotechnology & Applied Microbiology
Carla Talita Azevedo Ginani, Jefferson Romaryo Duarte da Luz, Kleyton Santos de Medeiros, Ayane Cristine Alves Sarmento, Fabio Coppede, Maria das Gracas Almeida
Summary: This systematic review and meta-analysis found that the MTHFR C677T polymorphism is associated with maternal risk for Down syndrome (DS), while the A1298C polymorphism is not. The association is more significant in the Asian population and is not observed in Europeans. Further studies are needed to explain these differences.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Marilia Cristina Santos de Medeiros, Karla Simone Costa de Souza, Ony Araujo Galdino, Ricardo Ney Cobucci, Adriana Augusto de Rezende
Summary: This article aims to summarize the impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus (SLE). Observational studies including adult SLE patients who were overweight and obese or not will be searched and analyzed. The results will help clinicians manage disease activity and remission in SLE patients to optimize disease outcomes and patient quality of life.