Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Nongnuch Singrang, Thassanai Sitthiyotha, Nusara Chomanee, Chaninat Watthanasak, Surasak Chunsrivirot, Kittikhun Wangkanont
Summary: By studying zebrafish intelectin-2, we have gained insights into its basic biochemical properties and bacterial binding specificities, providing essential knowledge for the aquaculture industry and laying a foundation for further application of DrIntL-2 in bacteria detection and identification.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Oncology
Frederique St-Pierre, Shailender Bhatia, Sunandana Chandra
Summary: Cancer immunotherapy has traditionally focused on adaptive immunity, but there is increasing recognition of the important role innate immunity plays in the body's response to neoplastic cells. Targeting natural killer (NK) cells, a key component of the innate immune response, for cancer treatment shows promise in developing innovative strategies for immunotherapy.
Article
Oncology
Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wohr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik B. Thoren
Summary: This study found that the NKG2A gene variant is associated with enhanced NK cell effector function and improved outcome of IL-2-based immunotherapy in AML.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Rayoun Ramendra, Mathieu Mancini, Jose-Mauricio Ayala, Lin Tze Tung, Stephane Isnard, John Lin, Jean-Pierre Routy, Anastasia Nijnik, David Langlais
Summary: The study demonstrates that BDG induces glutathione synthesis and metabolism in monocytes, which is a major promoter of the acute functional response of monocytes to infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Michel B. Verwoolde, Jurgen van Baa, Christine A. Jansen, Elisabeth A. M. Graat, David M. Lamot, Aart Lammers, Lieske van Eck
Summary: This study is the first to investigate the impact of stimulating the maternal innate immune system with lipopolysaccharides (LPS) or beta-glucan on growth performance and immune responses in the next generation. The findings show that offspring of LPS-treated broiler breeders have higher feed efficiency post-NE challenge, with more intestinal lesions observed. Additionally, both LPS and beta-glucan maternal treatments resulted in transgenerational effects on blood-derived monocytes, indicating a potential impact on immune responsiveness in the offspring.
Article
Immunology
Caiyun Qi, Fang Liu, Wenjun Zhang, Yali Han, Nan Zhang, Qiang Liu, Handong Li
Summary: This study identified a distinct subset of NK cells and its potential involvement in Alzheimer's disease (AD) through analyzing single-cell RNA sequencing data and flow cytometry. The unique NK cell subset was found to be associated with the progression of AD and negatively correlated with cognitive function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Stefano Persano, Francesco Vicini, Alessandro Poggi, Jordi Leonardo Castrillo Fernandez, Giusy Maria Rita Rizzo, Helena Gavilan, Niccolo Silvestri, Teresa Pellegrino
Summary: The study found that local mild thermal treatment can induce immunogenic cell death in U87 glioblastoma cells, modulating their immune profile and increasing their susceptibility to macrophage killing. Additionally, it was demonstrated that mild thermal treatment can modulate the expression of inhibitory and activating NK cell ligands in U87 cells, enhancing their susceptibility to NK cell killing.
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Dearbhla M. Murphy, Kingston H. G. Mills, Sharee A. Basdeo
Summary: Trained immunity, also known as innate immune training, involves the medium-term epigenetic and metabolic reprogramming of innate immune cells in response to an initial challenge, resulting in altered responses to subsequent challenges. It can lead to increased production of proinflammatory mediators, affect T cell responses, and create a new immune pattern that interacts with adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Peng Peng, Yue Lou, Shicheng Wang, Junjun Wang, Zelu Zhang, Peishan Du, Jiamin Zheng, Ping Liu, Lisa X. Xu
Summary: This study demonstrates that cryo-thermal therapy can induce effective CD4(+) Th1-dominant antitumor immunity by activating NK cells to reprogram MDSCs, offering a promising therapeutic strategy for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Simona Martinotti, Marcela Bucekova, Juraj Majtan, Elia Ranzato
CURRENT MEDICINAL CHEMISTRY
(2019)
Article
Agriculture, Multidisciplinary
Jana Godocikova, Veronika Bugarova, Christina Kast, Viktor Majtan, Juraj Majtan
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
Article
Biochemistry & Molecular Biology
Juraj Majtan, Martin Sojka, Helena Palenikova, Marcela Bucekova, Viktor Majtan
Article
Food Science & Technology
Marcela Bucekova, Veronika Bugarova, Jana Godocikova, Juraj Majtan
Article
Microbiology
Maros Laho, Maria Sediva, Juraj Majtan, Jaroslav Klaudiny
Summary: The study found that fructose and trehalose at specific concentrations can significantly enhance the spore yields of P. larvae strains, mostly by improving the germination ability of the produced spores. Glucose, maltose, and sucrose at lower concentrations also support sporulation, but to a lesser extent and not in all strains and media.
Editorial Material
Biochemistry & Molecular Biology
Juraj Majtan, Marcela Bucekova, Milos Jesenak
Article
Infectious Diseases
Veronika Bugarova, Jana Godocikova, Marcela Bucekova, Robert Brodschneider, Juraj Majtan
Summary: Honey is a functional food with health-promoting properties and is widely used in wound care. Natural honey samples exhibit higher antibacterial activity compared to bee-processed syrups. The content of glucose oxidase is higher in bee-processed syrups, but there are no significant differences in honey samples.
Article
Food Science & Technology
Juraj Majtan, Marcela Bucekova, Ioannis Kafantaris, Piotr Szweda, Katherine Hammer, Dimitris Mossialos
Summary: Honey is considered a functional food with health-promoting properties, primarily due to its potent antibacterial and antibiofilm effects. Current honey quality parameters adopted in the European Union do not include biological properties, highlighting the need for revision and establishment of more effective quality control measures. The importance and efficacy of honey as an antibacterial agent is supported by in vitro and in vivo experiments, as well as human clinical studies.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jacob A. Bauer, Monika Zamocka, Juraj Majtan, Vladena Bauerova-Hlinkova
Summary: Glucose oxidase (GOx) is a significant enzyme with important roles in biological processes. It is known for its fast mechanism of action, high stability, specificity, and antimicrobial effect. This review provides a summary of the structure, function, production strains, and biophysical and biochemical properties of GOx, as well as its applications in various industries and medical fields.
Article
Food Science & Technology
Eleni Tsavea, Fotini-Paraskevi Vardaka, Elisavet Savvidaki, Abdessamie Kellil, Dimitrios Kanelis, Marcela Bucekova, Spyros Grigorakis, Jana Godocikova, Panagiota Gotsiou, Maria Dimou, Sophia Loupassaki, Ilektra Remoundou, Christina Tsadila, Tilemachos G. Dimitriou, Juraj Majtan, Chrysoula Tananaki, Eleftherios Alissandrakis, Dimitris Mossialos
Summary: This study aims to investigate the physicochemical parameters, antioxidant, and antibacterial activity of pine honey samples produced in Greece. The study found that these pine honeys have good physicochemical characteristics and show comparable or even superior antibacterial activity.
Article
Food Science & Technology
Karolina Pelka, Marcela Bucekova, Jana Godocikova, Piotr Szweda, Juraj Majtan
Summary: Bee pollen and bee bread aqueous extracts have antibacterial activity, which is significantly enhanced in bee bread extracts in the presence of glucose. Immunoblot analysis revealed the presence of MRJP1 and glucose oxidase (GOX) in these extracts. Treatment of extracts with catalase restored bacterial growth, but only in samples where glucose supplementation caused an enhancement of antibacterial activity.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Review
Food Science & Technology
Juraj Deglovic, Nora Majtanova, Juraj Majtan
Summary: The successful application of honey in wound care management has led to its increasing usage in dental medicine for the prevention of dental caries. Laboratory studies have shown the antibacterial and antibiofilm effects of honey, particularly against Streptococcus mutans. Despite promising results, further clinical studies are needed to determine the effectiveness of honey in preventing dental caries.
Letter
Pediatrics
Juraj Deglovic, Nora Majtanova, Marcela Bucekova, Juraj Majtan
Article
Multidisciplinary Sciences
Marcela Bucekova, Jana Godocikova, Romain Gueyte, Celine Chambrey, Juraj Majtan
Summary: This study characterized the physicochemical and antibacterial properties of New Caledonian honey samples and found that they showed strong antibacterial activity primarily based on the action of hydrogen peroxide (H2O2). These honey samples could be a suitable source for medical-grade honey.
Article
Medicine, General & Internal
Nora Majtanova, Petra Kriskova, Petra Keri, Zlatica Fellner, Juraj Majtan, Petr Kolar
Summary: HSV-1 keratitis occurred in COVID-19 patients, showing similar ocular symptoms. Treatment with antiviral therapy was effective in all cases, leading to complete symptom reduction within 2 weeks.
MEDICINA-LITHUANIA
(2021)