Article
Optics
Taye Mekonnen, Alexander W. Schill, Christian Zevallos-Delgado, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin
Summary: This study introduces a multifocal acoustic radiation force source for use in reverberant optical coherence elastography (Rev-OCE), which combines an ultrasound transducer and a 3D-printed acoustic lens. The acoustic energy generated by a 1MHz planar ultrasound transducer is spatially distributed by an array of plano-concave acoustic lenses, producing multiple focal spots on a target plane. These focal spots generate reverberant shear wave fields detected by an optical coherence tomography (OCT) system. The effectiveness of the multifocal Rev-OCE system in probing mechanical properties with high resolution is demonstrated in layered gelatin phantoms.
Article
Biochemical Research Methods
Jiahui Luo, Yubao Zhang, Sizhu Ai, Gang Shi, Xiao Han, Yidi Wang, Yanzhi Zhao, Hongwei Yang, Yingjie Li, Xingdao He
Summary: This study used optical coherence elastography and a phase velocity algorithm to investigate the biomechanical properties of the sclera. By mapping the Young's modulus values to the corresponding structure, a two-dimensional elasticity distribution image of the sclera was obtained. The results obtained provide valuable information for sclera elasticity and may be beneficial for the diagnosis of relevant eye diseases.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Biochemical Research Methods
Sizhu Ai, Yubao Zhang, Gang Shi, Yidi Wang, Guo Liu, Xiao Han, Yanzhi Zhao, Hongwei Yang, Xingdao He
Summary: Evaluating the biomechanical properties of the trabecular meshwork (TM) is crucial for understanding the mechanism of aqueous humor circulation and its relationship with eye diseases such as glaucoma. However, the lack of clinical measurement tools has hindered relevant studies. This paper presents the development of an acoustic radiation force optical coherence elastography (ARF-OCE) system, which offers noninvasive detection, high resolution, high sensitivity, and high-speed imaging capabilities to accurately quantify the elastic modulus of porcine and human TMs. As the first OCE imaging of TM, our study demonstrates that ARF-OCE may serve as an effective approach to advance the research of diseases related to aqueous humor circulation.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Chemistry, Analytical
Yanzhi Zhao, Yirui Zhu, Yongbo Wang, Hongwei Yang, Xingdao He, Tomas Gomez Alvarez-Arenas, Yingjie Li, Guofu Huang
Summary: The purpose of this study was to compare the changes in corneal biomechanics after SMILE and FLEx surgeries using ARF-OCE and to analyze the impact of corneal cap on corneal biomechanical properties. Lamb waves were generated in corneal tissue using a custom ring array ultrasound transducer. Depth-resolved elastic modulus images of the post-surgery cornea were obtained based on the phase velocity of Lamb waves. The study found that SMILE preserved the integrity of corneal biomechanical properties better than FLEx, highlighting the value of corneal biomechanical properties as indicators for evaluating the safety of refractive surgery.
Article
Engineering, Biomedical
Hsiao-Chuan Liu, Bipin Gaihre, Piotr Kijanka, Lichun Lu, Matthew W. W. Urban
Summary: Hydrogel scaffolds have become an important platform for cellular therapy and tissue engineering in regenerative medicine. However, the current standard method to characterize mechanical properties of hydrogels, called dynamic mechanical analysis (DMA), has limitations. In this study, a novel technique called acoustic force elastography microscopy (AFEM) was proposed. AFEM can evaluate the elastic properties of tissue engineering scaffolds in a non-contact and non-destructive manner, providing a promising technique for quantifying elastic properties and exploring elastic changes in cell-laden scaffolds.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Ophthalmology
Yanzhi Zhao, Hongwei Yang, Yingjie Li, Yongbo Wang, Xiao Han, Yirui Zhu, Yubao Zhang, Guofu Huang
Summary: This study developed a technique called acoustic radiation force optical coherence elastography to evaluate the biomechanical properties of keratoconus (KC) corneas. The study found clear differences in biomechanical properties between different regions of the cornea, with the conical region showing the most significant weakening. This technique has potential for noninvasive evaluation and early detection of KC.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiao Han, Yubao Zhang, Yirui Zhu, Yanzhi Zhao, Hongwei Yang, Guo Liu, Sizhu Ai, Yidi Wang, Chengfeng Xie, Jiulin Shi, Tianyu Zhang, Guofu Huang, Xingdao He
Summary: This study introduces a novel method to evaluate the elasticity of corneal scars and validated it on ex vivo rabbit and human corneas. The experiment successfully characterized the Young's modulus of scarred and normal regions, providing a spatial distribution of elasticity in scarred corneas.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Optics
Yanzhi Zhao, Yongbo Wang, Yueyuan Xu, Yunjiang Zhang, Hongwei Yang, Xiao Han, Yirui Zhu, Yubao Zhang, Guofu Huang
Summary: ARF-OCE, demonstrated in ex vivo human eyes, shows the feasibility and reliability in detecting corneal biomechanical properties, potentially effective for rebuilding corneal elasticity and future application in clinical ophthalmology.
JOURNAL OF MODERN OPTICS
(2022)
Article
Engineering, Biomedical
Hsiao-Chuan Liu, Mehdi Abbasi, Yong Hong Ding, Tuhin Roy, Margherita Capriotti, Yang Liu, Sean Fitzgerald, Karen M. Doyle, Murthy Guddati, Matthew W. Urban, Waleed Brinjikji
Summary: Thromboembolism in cerebral blood vessels has high morbidity and mortality rates. Mechanical thrombectomy is often performed to remove emboli, and the selection of surgical devices can impact success rates during embolectomy. This study investigated how clots of different compositions can be characterized using acoustic radiation force optical coherence elastography (ARF-OCE) and compared with ultrasound shear wave elastography (SWE). The research found that wave group velocities generally decrease as red blood cell content increases in both ARF-OCE and SWE, with good agreement between the two methods when RBC composition is larger than 39%. Utilizing phase velocity dispersion analysis, ARF-OCE showed better ability than ultrasound-based methods in discriminating clot compositions, especially in clots with low RBC content.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuyang Gu, Viksit Kumar, E. G. Sunethra K. Dayavansha, Scott Schoen Jr, Ernest Feleppa, Rimon Tadross, Michael H. Wang, Michael J. Washburn, Kai Thomenius, Anthony E. Samir
Summary: ADAPT is an acoustic diffraction-resistant adaptive profile technology that can generate a propagation-invariant beam with high flexibility. It has applications in various fields such as medicine, biology, and material science.
Article
Biotechnology & Applied Microbiology
Taye Mekonnen, Christian Zevallos-Delgado, Hongqiu Zhang, Manmohan Singh, Salavat R. R. Aglyamov, Kirill V. V. Larin
Summary: The study assessed the viscoelastic properties of the lens and found that the intact lens with the capsule had higher surface elastic wave velocity, Young's modulus, and shear viscosity coefficient compared to the lens without the capsule. These findings suggest that the lens capsule plays a critical role in determining the viscoelastic properties of the crystalline lens.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Yirui Zhu, Yanzhi Zhao, Jiulin Shi, Tomas E. Alvarez-arenas, Hongwei Yang, Hongling Cai, Dong Zhang, Xingdao He, Xiaoshan Wu
Summary: We developed a novel acoustic radiation force optical coherence elastography (ARF-OCE) using a ultrasmall ultrasound transducer to evaluate the biomechanics of in vivo cornea. The ARF-OCE system employed a custom single-sided meta-ultrasonic transducer and a 3D printed holder for ultrasound excitation and detection. The results showed that the proposed ARF-OCE has good clinical translation potential for assessing corneal biomechanics.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Engineering, Chemical
Zhenghui Qiao, Xiaojun Pan, Shaohua Liang, Xiaolong Bi, Juan Wang, Wei Xie, Kang Wang, Yanwen Wang, Jun Fang, Xuefei Zhu, Shaoxin Sun, Shaohui Li
Summary: This study aims to analyze the interaction process of rice-husk fired smoke particulates and annular waveguide acoustic system. The complex process involves particle aggregation and fragmentation, with the control mechanism being the balanced modulation of acoustic radiation force and secondary radiation force. The findings can enhance the application of aerodynamic acoustic-particulate-fluid systems in environmental protection, energy conversion, and industrial production.
Article
Engineering, Biomedical
Lorne W. Hofstetter, Henrik Odeen, Bradley D. Bolster, Douglas A. Christensen, Allison Payne, Dennis L. Parker
Summary: This study presents a novel MR shear wave elastography technique that combines transient acoustic radiation force impulses with sinusoidal-shaped MR displacement encoding. An analytic expression for calculating shear wave speed in a heterogeneous medium was derived, and the feasibility of using this technique was confirmed experimentally. The study demonstrated the accuracy of the method in measuring shear wave speed values in different mediums, showing potential applications in clinical settings.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Physical
Zhixin Liu, Weidong Liu, Qi Chen, Yongzheng Hu, Yurun Li, Xiaoya Zheng, Dian Fang, Hai Liu, Cuiru Sun
Summary: In this study, a real-time and high-resolution viscoelastic response-optical coherence elastography (VisR-OCE) method based on acoustic radiation force (ARF) excitation and optical coherence tomography (OCT) imaging was proposed. The optimal experimental parameters were determined through numerical simulation, and the influences of material parameters were evaluated. The accuracy of the VisR-OCE method was validated by comparing with the tensile test, showing a difference of about 3% in the relaxation time constant of phantoms.
Article
Chemistry, Analytical
Asma Khalid, Lu Peng, Azim Arman, Stephen C. Warren-Smith, Erik P. Schartner, Georgina M. Sylvia, Mark R. Hutchinson, Heike Ebendorff-Heidepriem, Robert A. McLaughlin, Brant C. Gibson, Jiawen Li
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Optics
Jiawen Li, Simon Thiele, Bryden C. Quirk, Rodney W. Kirk, Johan W. Verjans, Emma Akers, Christina A. Bursill, Stephen J. Nicholls, Alois M. Herkommer, Harald Giessen, Robert A. McLaughlin
LIGHT-SCIENCE & APPLICATIONS
(2020)
Article
Engineering, Electrical & Electronic
Peipei Jia, Depeng Kong, Jiawen Li, Erik Schartner, Heike Ebendorff-Heidepriem
Summary: The researchers have successfully developed a plasmonic spectroscopy platform that combines a gradient-index microlens and a single-mode optical fiber, allowing for large-area and uniform illumination, precise excitation of surface plasmon resonance, and excellent performance.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Optics
Lu Peng, Linh Viet Nguyen, Jiawen Li, Nicolas Riesen, Dale Otten, David G. Lancaster, Heike Ebendorff-Heidepriem, Stephen C. Warren-Smith
Summary: A novel technique for detecting and measuring micron-scale optical scatterers using a few-mode exposed-core microstructured optical fiber is proposed, which allows for simultaneous mapping of scatterers with both longitudinal and transverse information.
Article
Chemistry, Multidisciplinary
Patrick K. Capon, Jiawen Li, Aimee J. Horsfall, Suliman Yagoub, Erik P. Schartner, Asma Khalid, Rodney W. Kirk, Malcolm S. Purdey, Kylie R. Dunning, Robert A. McLaughlin, Andrew D. Abell
Summary: A new fiber functionalization architecture enables simultaneous imaging and sensing, providing significant insights into complex biological systems.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Jiawen Li, Nicholas J. Montarello, Ayla Hoogendoorn, Johan W. Verjans, Christina A. Bursill, Karlheinz Peter, Stephen J. Nicholls, Robert A. McLaughlin, Peter J. Psaltis
Summary: This review examines emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation, aiming to advance clinical approaches for predicting atherothrombotic events and improving the treatment of coronary atherosclerosis.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Optics
Lu Peng, Nicolas Riesen, Jiawen Li, Mengke Han, Linh Viet Nguyen, Heike Ebendorff-Heidepriem, Stephen C. Warren-Smith
Summary: This study proposes a new WGM coupling scheme using an exposed-core silica fiber (ECF) to overcome the challenges of using fragile fiber tapers. By varying the mode launching conditions in this few-mode ECF, in combination with a Fano resonance effect, a high degree of tunability in the reflection spectrum is demonstrated. Additionally, multi-particle WGM excitation is shown to occur either simultaneously or separately through controlling the ECF mode launching conditions, offering potential applications in optical switches, modulators, biosensing, and multi-point lasing.
Article
Engineering, Biomedical
Julia Walther, Jonas Golde, Marius Albrecht, Bryden C. Quirk, Loretta Scolaro, Rodney W. Kirk, Yuliia Gruda, Christian Schnabel, Florian Tetschke, Korinna Joehrens, Dominik Haim, Michaela Buckova, Jiawen Li, Robert A. McLaughlin
Summary: This study presents a highly miniaturized, handheld probe developed for rapid assessment of soft tissue using optical coherencetomography (OCT). The probe combines an all-fiber optical design with a light-weight magnetic scanning mechanism to provide easy access to the oral cavity. The results demonstrate the feasibility of using a small, lightweight probe to identify pathological features in oral soft tissue.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Chemistry, Analytical
Kathy Beaudette, Jiawen Li, Joseph Lamarre, Lucas Majeau, Caroline Boudoux
Summary: This study provides a technological review on the combination of multiple sensing functionalities and imaging modalities using double-clad fibers (DCF). The working principles of DCF-based sensors, relevant instrumentation, fiber probe designs, and functionalization schemes are discussed. Various applications of DCF-based probes for multifunctional sensing and multimodal bioimaging are also reviewed.
Article
Chemistry, Multidisciplinary
Jiawen Li, Simon Thiele, Rodney W. Kirk, Bryden C. Quirk, Ayla Hoogendoorn, Yung Chih Chen, Karlheinz Peter, Stephen J. Nicholls, Johan W. Verjans, Peter J. Psaltis, Christina Bursill, Alois M. Herkommer, Harald Giessen, Robert A. McLaughlin
Summary: Multimodal microendoscopes enable simultaneous structural and molecular measurements in vivo, providing valuable insights into pathological changes associated with diseases. However, different optical imaging modalities have conflicting requirements for lens design, posing a challenge for the fabrication of miniaturized imaging probes. This study demonstrates an optical design using two-photon 3D printing to create a miniaturized lens that is optimized for both fluorescence and optical coherence tomography (OCT) imaging. The lens-in-lens design shows significant improvement in fluorescence sensitivity compared to conventional fiber-optic design approaches, and is successfully integrated into an intravascular catheter probe for simultaneous OCT and fluorescence imaging of a mouse artery in vivo.
Article
Biochemical Research Methods
Loretta Scolaro, Dirk Lorenser, Bryden C. Quirk, Rodney W. Kirk, Louisa A. Ho, Elizabeth Thomas, Jiawen Li, Christobel M. Saunders, David D. Sampson, Rebecca O. Fuller, Robert A. McLaughlin
Summary: This article introduces a multimodal imaging needle that can differentiate cell types through simultaneous optical coherence tomography (OCT) and fluorescence imaging. By conducting experiments on ER+ and ER- breast cancer cells, it is demonstrated that this miniaturized imaging probe can successfully image live cells and differentiate cancer cells.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Jiawen Li, Giuseppe Di Giovanni, Peter J. Psaltis
Summary: This article reviews the application of automated segmentation techniques in coronary optical coherence tomography (OCT) over the past five years, with a focus on their use in the three-dimensional reconstruction and simulation of blood vessels. The potential areas for future innovation and translation are also discussed.
Proceedings Paper
Optics
Jonas Golde, Julia Walther, Jiawen Li, Robert A. McLaughlin, Edmund Koch
Summary: The method presented utilizes polarization-sensitive optical coherence tomography for depth-resolved retardation measurements with a single-mode fiber-based common-path probe, reconstructing round-trip measurements using constrained polarization evolution and the mirror state phenomenon.
OPTICAL COHERENCE IMAGING TECHNIQUES AND IMAGING IN SCATTERING MEDIA IV
(2021)
Article
Chemistry, Multidisciplinary
Patrick K. Capon, Aimee J. Horsfall, Jiawen Li, Erik P. Schartner, Asma Khalid, Malcolm S. Purdey, Robert A. McLaughlin, Andrew D. Abell
Summary: A new coating procedure for optical fibre sensors suitable for protein analytes detection was presented in this study. The detection of streptavidin by binding to functionalised D-biotin was demonstrated, with stability to washing and long-term exposure to water. Different coating methods were employed to isolate SBP-biotin on the outer surface of the silk layer for optimal detection.
Proceedings Paper
Engineering, Electrical & Electronic
Lu Peng, Linh Viet Nguyen, Nicolas Riesen, Jiawen Li, Dale Otten, David G. Lancaster, Robert A. McLaughlin, Heike Ebendorff-Heidepriem, Stephen C. Warren-Smith
2020 CONFERENCE ON LASERS AND ELECTRO-OPTICS PACIFIC RIM (CLEO-PR)
(2020)
