期刊
APPLIED PHYSICS LETTERS
卷 103, 期 1, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4812987
关键词
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资金
- NSF [CMMI-0856391]
- NIH/NCRR-Indiana Clinical and Translational Sciences Institute-TL1 Program [TL1 RR025759]
- Indiana University Medical Scientist Training Program under NIH [GM077229]
A label-free kinase detection system was fabricated by the adsorption of gold nanoparticles functionalized with kinase inhibitor onto AlGaN/GaN high electron mobility transistors (HEMTs). The HEMTs were operated near threshold voltage due to the greatest sensitivity in this operational region. The Au NP/HEMT biosensor system electrically detected 1 pM SRC kinase in ionic solutions. These results are pertinent to drug development applications associated with kinase sensing. (C) 2013 AIP Publishing LLC.
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