期刊
APPLIED PHYSICS LETTERS
卷 100, 期 15, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4704143
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资金
- National Science Foundation [ECCS-1102354]
- Wagner McGee Research Fund
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1102354] Funding Source: National Science Foundation
A controlled release device is developed by embedding nanofluidic biomolecule reservoirs into a polymer network of a stimuli-responsive hydrogel. The reservoirs are made of liquid core-polymer shell nanofibers using co-electrospinning. The mechanism of controlled release is based on buckling instability of the polymer shell under combined axial and radial compression, caused by volume changes of hydrogel responding to a specific stimulus. The device decouples releasable biomolecules from a hydrogel polymer matrix, avoiding chemical interactions between biomolecules and hydrogel polymer chains, and thus, alleviating nontrivial chemical and biological engineering design of hydrogel formulations. Temperature-sensitive hydrogel is used as a model hydrogel. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4704143]
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