期刊
JAPANESE JOURNAL OF INFECTIOUS DISEASES
卷 68, 期 5, 页码 420-424出版社
NATL INST INFECTIOUS DISEASES
DOI: 10.7883/yoken.JJID.2014.466
关键词
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资金
- Key Infectious Disease Special Program of 12th five-year plan of National Scientific Research Program [2012ZX10003009]
- Chinese National Natural Science Foundation [81000001]
- 309 Hospital of PLA Foundation Project [2014MS-001]
The regulatory mechanism of miRNA induction in response to Mycobacterium tuberculosis (MTB) infection has not been clearly established. Autophagy has recently been identified as an effective way to control intracellular survival of MTB. In the present study, we demonstrate a novel role of miR-30A in the negative regulation of the autophagy-mediated anti-MTB response. We found that overexpression of miR-30A suppresses the elimination of intracellular MTB through the inhibition of autophagy. Furthermore, there was a negative correlation between concentrations of miR-30A and beclin-1 in MTB positive patients and miR-30A expression decreased after anti-TB treatment. Our results indicate that miR-30A plays a key role in immune response against MTB and, therefore, may serve as a potential target for future treatments of tuberculosis infection.
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