期刊
APPLIED PHYSICS LETTERS
卷 94, 期 15, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3107265
关键词
atomic force microscopy; biological techniques; biomechanics; biomembranes; cellular biophysics; multilayers; plastic deformation; proteins; stress analysis; Young's modulus; zoology
资金
- COFIN [2005001234]
- Universit Cattolica del Sacro Cuore, Rome, Italy
We have investigated the mechanical properties of the zona pellucida (ZP), a multilayer glycoprotein coat that surrounds mammalian eggs, using atomic force spectroscopy. The response of the membrane to mechanical stress has been reconstructed using a modified Hertz model. The transition from elastic behavior, which occurs when low stress forces are applied (characterized by a Young's modulus E=(22 +/- 5) kPa), toward plastic behavior is observed. The critical indentation necessary to induce plastic deformations occurs at delta(yield)=(550 +/- 50) nm. This high critical value, corresponding to two ZP layers, well supports the noncovalent long lifetimes of interactions that take place between constituent glycoproteins.
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